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Morpholino Publication Database
This database contains citations and abstracts for research using Morpholino oligos, as well as some review articles incorporating Morpholino data. You can search the content using the filter boxes below.
There are 32 scientific papers returned from the database with the search filters currently being used below.
There are 32 scientific papers returned from the database with the search filters currently being used below.
Basic peptide-morpholino oligomer conjugate that is very effective in killing bacteria by gene-specific and nonspecific modes
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Citation:
PNAS. 2011;108(40):16582-7 doi:10.1073/pnas.1112561108 Epub:
Not Epub Abstract:
Basic peptides covalently linked to nucleic acids, or chemically modified nucleic acids, enable the insertion of such a... Delivery Method:
peptide-coupled Organism or Cell Type:
Bacteria, various Citation Extract: Wesolowski D, Tae HS, Gandotra N, Llopis P, Shen N, Altman S. Basic peptide-morpholino oligomer conjugate that is very effective in killing bacteria by gene-specific and nonspecific modes. PNAS. 2011;108(40):16582-7 doi:10.1073/pnas.1112561108. |
Combined effect of a peptide-morpholino oligonucleotide conjugate and a cell-penetrating peptide as an antibiotic
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Citation:
PNAS. 2013 May 21;110(21):8686-9. doi: 10.1073/pnas.1306911110. Epub 2013 May 6 Epub:
Not Epub Abstract:
A cell-penetrating peptide (CPP)–morpholino oligonucleotide (MO) conjugate (PMO) that has an antibiotic effect in culture had... Delivery Method:
peptide-coupled Organism or Cell Type:
Bacteria, various Citation Extract: Wesolowski D, Alonso D, Altman S. Combined effect of a peptide-morpholino oligonucleotide conjugate and a cell-penetrating peptide as an antibiotic. PNAS. 2013 May 21;110(21):8686-9. doi: 10.1073/pnas.1306911110. Epub 2013 May 6. |
Antisense peptide-phosphorodiamidate morpholino oligomer conjugate: dose-response in mice infected with Escherichia coli
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Citation:
J Antimicrob Chemother. 2007 Jan;59(1):66-73. Epub 2006 Oct 31. Epub:
Not Epub Abstract:
OBJECTIVES: Phosphorodiamidate morpholino oligomers (PMOs) are DNA analogues that inhibit translation by an antisense mechanism... Delivery Method:
peptide-coupled Organism or Cell Type:
Escherichia coli Citation Extract: Tilley LD, Mellbye BL, Puckett SE, Iversen PL, Geller BL. Antisense peptide-phosphorodiamidate morpholino oligomer conjugate: dose-response in mice infected with Escherichia coli. J Antimicrob Chemother. 2007 Jan;59(1):66-73. Epub 2006 Oct 31.. |
Gene-Specific Effects of Antisense Phosphorodiamidate Morpholino Oligomer-Peptide Conjugates on Escherichia coli and Salmonella enterica Serovar Typhimurium in Pure Culture and in Tissue Culture
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Citation:
Antimicrob Agents Chemother. 2006 Aug;50(8):2789-96 Epub:
Not Epub Abstract:
The objective was to improve efficacy of antisense phosphorodiamidate morpholino oligomers (PMOs) by improving their uptake... Delivery Method:
peptide-coupled Organism or Cell Type:
Escherichia coli, Salmonella enterica serovar typhimurium Citation Extract: Tilley LD, Hine OS, Kellogg JA, Hassinger JN, Weller DD, Iversen PL, Geller BL. Gene-Specific Effects of Antisense Phosphorodiamidate Morpholino Oligomer-Peptide Conjugates on Escherichia coli and Salmonella enterica Serovar Typhimurium in Pure Culture and in Tissue Culture. Antimicrob Agents Chemother. 2006 Aug;50(8):2789-96. |
Inactivation of expression of several genes in a variety of bacterial species by EGS technology
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Citation:
Proc Natl Acad Sci U S A. 2009 Apr 30. [Epub ahead of print] Epub:
Not Epub Abstract:
The expression of gene products in bacteria can be inhibited by the use of RNA external guide sequences (EGSs) that hybridize... Delivery Method:
peptide-coupled Organism or Cell Type:
Bacteria: Escherichia, Enterococcus, Bacillus, Citation Extract: Shen N, Ko JH, Xiao G, Wesolowski D, Shan G, Geller B, Izadjoo M, Altman S. Inactivation of expression of several genes in a variety of bacterial species by EGS technology. Proc Natl Acad Sci U S A. 2009 Apr 30. [Epub ahead of print]. |
A peptide-morpholino oligomer conjugate targeting Staphylococcus aureus gyrA mRNA improves healing in an infected mouse cutaneous wound model
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Citation:
Int J Pharmaceutics. 2013;[Epub ahead of print] doi:10.1016/j.ijpharm.2013.05.041 Epub:
Not Epub Abstract:
Management of skin wound infections presents a serious problem in the clinic, in the community, and in both civilian and... Delivery Method:
peptide-coupled Organism or Cell Type:
Bacteria: Staphylococcus aureus in mouse Citation Extract: Sawyer AJ, Wesolowski D, Gandotra N, Stojadinovic A, Izadjoo M, Altman S, Kyriakides TR. A peptide-morpholino oligomer conjugate targeting Staphylococcus aureus gyrA mRNA improves healing in an infected mouse cutaneous wound model. Int J Pharmaceutics. 2013;[Epub ahead of print] doi:10.1016/j.ijpharm.2013.05.041. |
Bacterial Resistance to Antisense Peptide-Phosphorodiamidate Morpholino Oligomers
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Citation:
Antimicrob Agents Chemother. 2012 Sep 17. [Epub ahead of print] Epub:
Not Epub Abstract:
Peptide phosphorodiamidate morpholino oligomers (PPMO) are synthetic DNA mimics that bind complementary RNA and inhibit... Delivery Method:
peptide-coupled Organism or Cell Type:
Escherichia coli Citation Extract: Puckett SE, Reese KA, Mitev GM, Mullen V, Johnson RC, Pomraning KR, Mellbye BL, Tilley LD, Iversen PL, Freitag M, Geller BL. Bacterial Resistance to Antisense Peptide-Phosphorodiamidate Morpholino Oligomers. Antimicrob Agents Chemother. 2012 Sep 17. [Epub ahead of print]. |
Peptide Conjugated Phosphorodiamidate Morpholino Oligomers Increase Survival of Mice Challenged with Ames Bacillus anthracis
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Citation:
Nucleic Acid Therapeutics. 2012;[Epub ahead of print] doi:10.1089/nat.2012.0362 Epub:
Not Epub Abstract:
Targeting bacterial essential genes using antisense phosphorodiamidate morpholino oligomers (PMOs) represents an important... Delivery Method:
peptide-coupled Organism or Cell Type:
Bacillus anthracis Citation Extract: Panchal RG, Geller BL, Mellbye B, Lane D, Iversen PL, Bavari S. Peptide Conjugated Phosphorodiamidate Morpholino Oligomers Increase Survival of Mice Challenged with Ames Bacillus anthracis. Nucleic Acid Therapeutics. 2012;[Epub ahead of print] doi:10.1089/nat.2012.0362. |
In Vivo Delivery of Morpholino Oligos by Cell-Penetrating Peptides
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Citation:
Curr Pharm Des. 2013;19(16):2963-9 Epub:
Not Epub Abstract:
Morpholino oligos (Morpholinos) are widely used tools for knocking down gene expression and are currently in a clinical trial... Delivery Method:
peptide-coupled Citation Extract: Moulton HM. In Vivo Delivery of Morpholino Oligos by Cell-Penetrating Peptides. Curr Pharm Des. 2013;19(16):2963-9. |
Inhibition of Intracellular Growth of Salmonella enterica serovar typhimurium in Tissue Culture by Antisense Peptide-Phosphorodiamidate Morpholino Oligomer
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Citation:
Antimicrob Agents Chemother. 2009 Jul 6. [Epub ahead of print] Epub:
Not Epub Abstract:
Two types of phosphorodiamidate morpholino oligomers (PMOs) were tested for inhibition of growth of Salmonella enterica serovar... Delivery Method:
peptide-coupled Organism or Cell Type:
Salmonella enterica serovar typhimurium & infected macrophages Citation Extract: Mitev GM, Mellbye BL, Iversen PL, Geller BL. Inhibition of Intracellular Growth of Salmonella enterica serovar typhimurium in Tissue Culture by Antisense Peptide-Phosphorodiamidate Morpholino Oligomer. Antimicrob Agents Chemother. 2009 Jul 6. [Epub ahead of print]. |