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Morpholino Publication Database
This database contains citations and abstracts for research using Morpholino oligos, as well as some review articles incorporating Morpholino data. You can search the content using the filter boxes below.
There are 12371 scientific papers returned from the database with the search filters currently being used below.
There are 12371 scientific papers returned from the database with the search filters currently being used below.
Modulation of PKM1/2 levels by steric blocking morpholinos alters the metabolic and pluripotent state of murine pluripotent stem cells
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Citation:
bioRxiv. 2021;[preprint] doi:10.1101/2021.11.23.469697 Epub:
Not Epub Abstract:
Cellular metabolism plays both an active and passive role in embryonic development, pluripotency, and cell-fate decisions.... Delivery Method:
scrape loading Organism or Cell Type:
cell culture: murine embryonic stem cells Citation Extract: Dierolf JG, Hunter HLM, Watson AJ, Betts DH. Modulation of PKM1/2 levels by steric blocking morpholinos alters the metabolic and pluripotent state of murine pluripotent stem cells. bioRxiv. 2021;[preprint] doi:10.1101/2021.11.23.469697. |
Plasma obtained following murine hindlimb ischemic conditioning protects against oxidative stress in zebrafish models through activation of nrf2a and downregulation of duox
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Citation:
PLoS One. 2021 Nov 24;16(11):e0260442. doi:10.1371/journal.pone.0260442. eCollection 2021 Epub:
Not Epub Abstract:
Ischemia/reperfusion of organ systems in trauma patients with resuscitated hemorrhagic shock (HSR) contributes to tissue injury... Delivery Method:
microinjection Organism or Cell Type:
zebrafish Citation Extract: Guan R, Wen XY, Leung CH, Ciano-Oliveira CD, Lam S, Dai SY, Karbassi F, Mauro A, Wang Y, Rotstein O. Plasma obtained following murine hindlimb ischemic conditioning protects against oxidative stress in zebrafish models through activation of nrf2a and downregulation of duox. PLoS One. 2021 Nov 24;16(11):e0260442. doi:10.1371/journal.pone.0260442. eCollection 2021. |
Lysosomal Function Impacts the Skeletal Muscle Extracellular Matrix
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Citation:
J Dev Biol. 2021;9(4):52. doi:10.3390/jdb9040052 Epub:
Not Epub Abstract:
Muscle development and homeostasis are critical for normal muscle function. A key aspect of muscle physiology during... Delivery Method:
microinjection Organism or Cell Type:
zebrafish Citation Extract: Coffey EC, Astumian M, Alrowaished SS, Schaffer C, Henry CA. Lysosomal Function Impacts the Skeletal Muscle Extracellular Matrix. J Dev Biol. 2021;9(4):52. doi:10.3390/jdb9040052. |
INTS7-ABCD3 Interaction Stimulates the Proliferation and Osteoblastic Differentiation of Mouse Bone Marrow Mesenchymal Stem Cells by Suppressing Oxidative Stress
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Citation:
Front Physiol. 2021;12:2004. doi:10.3389/fphys.2021.758607 Epub:
Not Epub Abstract:
Increased adipocyte and decreased osteoblast differentiation, combined with the ectopic proliferation of bone marrow... Delivery Method:
Vivo-Morpholino Organism or Cell Type:
cell cultue: Oricell Strain C57BL/6 Mouse BM-MSCs Citation Extract: Liu Y, Yu X, Huang A, Zhang X, Wang Y, Geng W, Xu R, Li S, He H, Zheng B, Chen G, Xu Y. INTS7-ABCD3 Interaction Stimulates the Proliferation and Osteoblastic Differentiation of Mouse Bone Marrow Mesenchymal Stem Cells by Suppressing Oxidative Stress. Front Physiol. 2021;12:2004. doi:10.3389/fphys.2021.758607. |
5' Half of specific tRNAs feeds back to promote corresponding tRNA gene transcription in vertebrate embryos
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Citation:
Sci Adv. 2021 Nov 19;7(47):eabh0494. doi: 10.1126/sciadv.abh0494. Epub 2021 Nov 19 Epub:
Not Epub Abstract:
5′tRFls are small transfer RNA (tRNA) fragments derived from 5′ half of mature tRNAs. However, it is unknown whether 5′tRFls... Delivery Method:
microinjection Organism or Cell Type:
zebrafish Citation Extract: Chen L, Xu W, Liu K, Jiang Z, Han Y, Jin H, Zhang L, Shen W, Jia S, Sun Q, Meng A. 5' Half of specific tRNAs feeds back to promote corresponding tRNA gene transcription in vertebrate embryos. Sci Adv. 2021 Nov 19;7(47):eabh0494. doi: 10.1126/sciadv.abh0494. Epub 2021 Nov 19. |
Triphenyl phosphate-induced pericardial edema is associated with elevated epidermal ionocytes within zebrafish embryos
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Citation:
Environ Toxicol Pharmacol. 2021 Nov 16:103776. doi: 10.1016/j.etap.2021.103776. Online ahead of print Epub:
Yes Abstract:
Triphenyl phosphate (TPHP) is an organophosphate ester-based plasticizer and flame retardant. The objective of this study was... Delivery Method:
microinjection Organism or Cell Type:
zebrafish Citation Extract: Wiegand J, Cheng V, Reddam A, Avila-Barnard S, Volz DC. Triphenyl phosphate-induced pericardial edema is associated with elevated epidermal ionocytes within zebrafish embryos. Environ Toxicol Pharmacol. 2021 Nov 16:103776. doi: 10.1016/j.etap.2021.103776. Online ahead of print. |
Mir24-2-5p suppresses the osteogenic differentiation with Gnai3 inhibition presenting a direct target via inactivating JNK-p38 MAPK signaling axis
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Citation:
Int J Biol Sci. 2021 Oct 17;17(15):4238-4253. doi: 10.7150/ijbs.60536. eCollection 2021 Epub:
Not Epub Abstract:
Background: Congenital anomalies are increasingly becoming a global pediatric health concern, which requires immediate... Delivery Method:
microinjection Organism or Cell Type:
zebrafish Citation Extract: Meng L, Yuan L, Ni J, Fang M, Guo S, Cai H, Qin J, Cai Q, Zhang M, Hu F, Ma J, Zhang Y. Mir24-2-5p suppresses the osteogenic differentiation with Gnai3 inhibition presenting a direct target via inactivating JNK-p38 MAPK signaling axis. Int J Biol Sci. 2021 Oct 17;17(15):4238-4253. doi: 10.7150/ijbs.60536. eCollection 2021. |
Morpholino-mediated knockdown of the brain mineralocorticoid receptor affects glucocorticoid signaling and neuroplasticity in wild ocellated wrasse (Symphodus ocellatus)
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Citation:
bioRxiv. 2021;[preprint] doi:10.1101/2021.11.17.468986 Epub:
Not Epub Abstract:
Uncovering the genetic, physiological, and developmental mechanisms underlying phenotypic variation is necessary for... Delivery Method:
Vivo-Morpholino Organism or Cell Type:
Symphodus ocellatus (ocellated wrasse) Citation Extract: Nugent BM, Stiver KA, Han J, Kindsvater HK, Marsh-Rollo SE, Hofmann HA, Alonzo SH. Morpholino-mediated knockdown of the brain mineralocorticoid receptor affects glucocorticoid signaling and neuroplasticity in wild ocellated wrasse (Symphodus ocellatus). bioRxiv. 2021;[preprint] doi:10.1101/2021.11.17.468986. |
Cell-Penetrating peptide-conjugated Morpholino rescues SMA in a symptomatic preclinical model
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Citation:
Molec Ther. 2021 Nov 19;S1525-0016(21)00583-9. doi: 10.1016/j.ymthe.2021.11.012 Epub:
Yes Abstract:
Spinal muscular atrophy (SMA) is a motor neuron disease and the leading genetic cause of infant mortality. Recently approved... Link:
Delivery Method:
protein-linked Citation Extract: Bersani M, Rizzuti M, Pagliari E, Garbellini M, Saccomanno D, Moulton HM, Bresolin N, Comi GP, Corti S, Nizzardo M. Cell-Penetrating peptide-conjugated Morpholino rescues SMA in a symptomatic preclinical model. Molec Ther. 2021 Nov 19;S1525-0016(21)00583-9. doi: 10.1016/j.ymthe.2021.11.012. |
Long-Term Safety and Efficacy Data of Golodirsen in Ambulatory Patients with Duchenne Muscular Dystrophy Amenable to Exon 53 Skipping: A First-in-human, Multicenter, Two-Part, Open-Label, Phase 1/2 Trial
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Citation:
Nucleic Acid Ther. 2021 Nov 17. doi: 10.1089/nat.2021.0043. Online ahead of print Epub:
Yes Abstract:
The aim of this Phase 1/2, 2-part, multicenter trial was to report clinical safety and efficacy of long-term golodirsen... Delivery Method:
i.v. infusion Organism or Cell Type:
human Citation Extract: Servais L, Mercuri E, Straub V, Guglieri M, Seferian AM, Scoto M, Leone D, Koenig E, Khan N, Dugar A, Wang X, Han B, Wang D, Muntoni F; SKIP-NMD Study Group
. Long-Term Safety and Efficacy Data of Golodirsen in Ambulatory Patients with Duchenne Muscular Dystrophy Amenable to Exon 53 Skipping: A First-in-human, Multicenter, Two-Part, Open-Label, Phase 1/2 Trial. Nucleic Acid Ther. 2021 Nov 17. doi: 10.1089/nat.2021.0043. Online ahead of print. |