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Morpholino Publication Database

This database contains citations and abstracts for research using Morpholino oligos, as well as some review articles incorporating Morpholino data. You can search the content using the filter boxes below.

There are 12455 scientific papers returned from the database with the search filters currently being used below.

The ciliary transition zone protein TMEM218 synergistically interacts with the NPHP module and its reduced dosage leads to a wide range of syndromic ciliopathies

Authors:
Epting D, Decker E, Ott E, Eisenberger T, Bader I, Bachmann N, Bergmann C
Citation:
Hum Mol Genet. 2022 Feb 6:ddac027. doi: 10.1093/hmg/ddac027. Online ahead of print
Epub:
Not Epub
Abstract:
Mutations in genes that lead to dysfunctional cilia can cause a broad spectrum of human disease phenotypes referred to as...
Link:
https://academic.oup.com/hmg/advance-article-abstract/doi/10.1093/hmg/ddac027/6523245
Organism or Cell Type:
zebrafish
Citation Extract:
Epting D, Decker E, Ott E, Eisenberger T, Bader I, Bachmann N, Bergmann C. The ciliary transition zone protein TMEM218 synergistically interacts with the NPHP module and its reduced dosage leads to a wide range of syndromic ciliopathies. Hum Mol Genet. 2022 Feb 6:ddac027. doi: 10.1093/hmg/ddac027. Online ahead of print.

Distinct mechanisms of germ cell factor regulation for an inductive germ cell fate

Authors:
Foster F, Oulhen N, Fresques T, Zaki H, Wessel G
Citation:
bioRxiv. 2022;[preprint] doi:10.1101/2022.02.04.479164
Epub:
Not Epub
Abstract:
Specification of primordial germ cells (PGCs), the lineage which gives rise to eggs and sperm, is essential for sexually...
Link:
https://www.biorxiv.org/content/10.1101/2022.02.04.479164v1
Delivery Method:
microinjection
Organism or Cell Type:
Patiria miniata (sea star)
Citation Extract:
Foster F, Oulhen N, Fresques T, Zaki H, Wessel G. Distinct mechanisms of germ cell factor regulation for an inductive germ cell fate. bioRxiv. 2022;[preprint] doi:10.1101/2022.02.04.479164 .

Somite morphogenesis is required for axial blood vessel formation during zebrafish embryogenesis

Authors:
Paulissen E, Palmisano NJ, Waxman JS, Martin BL
Citation:
eLife. 2022;11:e74821. doi:10.7554/eLife.74821
Epub:
Not Epub
Abstract:
Angioblasts that form the major axial blood vessels of the dorsal aorta and cardinal vein migrate toward the embryonic midline...
Link:
https://elifesciences.org/articles/74821
Delivery Method:
microinjection
Organism or Cell Type:
zebrafish
Citation Extract:
Paulissen E, Palmisano NJ, Waxman JS, Martin BL. Somite morphogenesis is required for axial blood vessel formation during zebrafish embryogenesis. eLife. 2022;11:e74821. doi:10.7554/eLife.74821.

Proof of concept of peptide-linked blockmiR-induced MBNL functional rescue in myotonic dystrophy type 1 mouse model

Authors:
Overby SJ, Cerro-Herreros E, González-Martínez I, Varela MA, Seoane-Miraz D, Jad Y, Raz R, Møller T, Pérez-Alonso M, Wood MJ, Llamusí B, Artero R
Citation:
Mol Ther Nucleic Acids. 2022:[Epub ahead of print] doi:10.1016/j.omtn.2022.02.003
Epub:
Yes
Abstract:
Myotonic dystrophy type 1 is a debilitating neuromuscular disease causing muscle weakness, myotonia, and cardiac dysfunction....
Link:
https://www.cell.com/molecular-therapy-family/nucleic-acids/fulltext/S2162-2531(22)00031-2
Delivery Method:
peptide-linked
Organism or Cell Type:
mice
Citation Extract:
Overby SJ, Cerro-Herreros E, González-Martínez I, Varela MA, Seoane-Miraz D, Jad Y, Raz R, Møller T, Pérez-Alonso M, Wood MJ, Llamusí B, Artero R. Proof of concept of peptide-linked blockmiR-induced MBNL functional rescue in myotonic dystrophy type 1 mouse model. Mol Ther Nucleic Acids. 2022:[Epub ahead of print] doi:10.1016/j.omtn.2022.02.003.

Cell-Penetrating d-Peptides Retain Antisense Morpholino Oligomer Delivery Activity

Authors:
Schissel CK, Farquhar CE, Malmberg AB, Loas A, Pentelute BL
Citation:
ACS Bio Med Chem Au. 2022 Feb 16;2(2):150-160. doi: 10.1021/acsbiomedchemau.1c00053. PMID: 37101743; PMCID: PMC10114648
Epub:
Yes
Abstract:
Cell-penetrating peptides (CPPs) can cross the cell membrane to enter the cytosol and deliver otherwise nonpenetrant...
Link:
https://pmc.ncbi.nlm.nih.gov/articles/PMC10114648/
Delivery Method:
peptide-linked
Organism or Cell Type:
cell culture: HeLa 654
Citation Extract:
Schissel CK, Farquhar CE, Malmberg AB, Loas A, Pentelute BL. Cell-Penetrating d-Peptides Retain Antisense Morpholino Oligomer Delivery Activity. ACS Bio Med Chem Au. 2022 Feb 16;2(2):150-160. doi: 10.1021/acsbiomedchemau.1c00053. PMID: 37101743; PMCID: PMC10114648.

Silent mutations reveal therapeutic vulnerability in RAS Q61 cancers

Authors:
Kobayashi Y, Chhoeu C, Li J, Price KS, Kiedrowski LA, Hutchins JL, Hardin AI, Wei Z, Hong F, Bahcall M, Gokhale PC, Jänne PA
Citation:
Nature. 2022 Mar 2. doi: 10.1038/s41586-022-04451-4. Online ahead of print
Epub:
Yes
Abstract:
RAS family members are the most frequently mutated oncogenes in human cancers. Although KRAS(G12C)-specific inhibitors show...
Link:
https://www.nature.com/articles/s41586-022-04451-4
Delivery Method:
Vivo-Morpholino
Organism or Cell Type:
xenograft in mice
Citation Extract:
Kobayashi Y, Chhoeu C, Li J, Price KS, Kiedrowski LA, Hutchins JL, Hardin AI, Wei Z, Hong F, Bahcall M, Gokhale PC, Jänne PA. Silent mutations reveal therapeutic vulnerability in RAS Q61 cancers. Nature. 2022 Mar 2. doi: 10.1038/s41586-022-04451-4. Online ahead of print.

Disruption of miR-18a Alters Proliferation, Photoreceptor Replacement Kinetics, Inflammatory Signaling, and Microglia/Macrophage Numbers During Retinal Regeneration in Zebrafish

Authors:
Magner E, Sandoval-Sanchez P, Kramer AC, Thummel R, Hitchcock PF, Taylor SM
Citation:
Mol Neurobiol. 2022 Mar 4. doi: 10.1007/s12035-022-02783-w. Online ahead of print
Epub:
Yes
Abstract:
In mammals, photoreceptor loss causes permanent blindness, but in zebrafish (Danio rerio), photoreceptor loss reprograms Müller...
Link:
https://link.springer.com/article/10.1007/s12035-022-02783-w
Delivery Method:
microinjection
Organism or Cell Type:
zebrafish
Citation Extract:
Magner E, Sandoval-Sanchez P, Kramer AC, Thummel R, Hitchcock PF, Taylor SM. Disruption of miR-18a Alters Proliferation, Photoreceptor Replacement Kinetics, Inflammatory Signaling, and Microglia/Macrophage Numbers During Retinal Regeneration in Zebrafish. Mol Neurobiol. 2022 Mar 4. doi: 10.1007/s12035-022-02783-w. Online ahead of print.

The plasminogen receptor directs maintenance of spermatogonial stem cells by targeting BMI1

Authors:
Zhou H, Shen C, Guo Y, Huang X, Zheng B, Wu Y
Citation:
Mol Biol Rep. 2022 Feb 27. doi: 10.1007/s11033-022-07289-1. Online ahead of print
Epub:
Yes
Abstract:
Background: Spermatogonial stem cells (SSCs) are unique stem cells that account for the whole reproductive life of males and...
Link:
https://link.springer.com/article/10.1007/s11033-022-07289-1
Delivery Method:
Vivo-Morpholino
Organism or Cell Type:
murine explants
Citation Extract:
Zhou H, Shen C, Guo Y, Huang X, Zheng B, Wu Y. The plasminogen receptor directs maintenance of spermatogonial stem cells by targeting BMI1. Mol Biol Rep. 2022 Feb 27. doi: 10.1007/s11033-022-07289-1. Online ahead of print.

Maternal thyroid hormone increases neural cell diversity during zebrafish spinal cord neurodevelopment

Authors:
Silva N, Campinho MA
Citation:
bioRxiv. 2022;[preprint] doi:10.1101/2022.02.26.482108
Epub:
Not Epub
Abstract:
Maternally derived thyroid hormone (MT3) is a fundamental factor for vertebrate neurodevelopment. In humans, mutations on the...
Link:
https://www.biorxiv.org/content/10.1101/2022.02.26.482108v1.full
Delivery Method:
microinjection
Organism or Cell Type:
zebrafish
Citation Extract:
Silva N, Campinho MA. Maternal thyroid hormone increases neural cell diversity during zebrafish spinal cord neurodevelopment. bioRxiv. 2022;[preprint] doi:10.1101/2022.02.26.482108.

Zebrafish her3 knockout impacts developmental and cancer-related gene signatures

Authors:
Kent MR, Calderon D, Silvius KM, LaVigne CA, Cannon MV, Kendall GC
Citation:
bioRxiv. 2022;[preprint] doi:10.1101/2022.02.25.482038
Epub:
Not Epub
Abstract:
HES3 is a basic helix-loop-helix transcription factor that regulates neural stem cell renewal during development. HES3...
Link:
https://www.biorxiv.org/content/10.1101/2022.02.25.482038v1.full
Delivery Method:
microinjection
Organism or Cell Type:
zebrafish
Citation Extract:
Kent MR, Calderon D, Silvius KM, LaVigne CA, Cannon MV, Kendall GC. Zebrafish her3 knockout impacts developmental and cancer-related gene signatures. bioRxiv. 2022;[preprint] doi:10.1101/2022.02.25.482038.

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