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Morpholino Publication Database
This database contains citations and abstracts for research using Morpholino oligos, as well as some review articles incorporating Morpholino data. You can search the content using the filter boxes below.
There are 12511 scientific papers returned from the database with the search filters currently being used below.
There are 12511 scientific papers returned from the database with the search filters currently being used below.
Antisense oligonucleotides targeting exon 11 are able to partially rescue the NF2-related schwannomatosis phenotype in vitro
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Citation:
Mol Ther Nucleic Acids. 2022 Nov 4;30:493-505. doi: 10.1016/j.omtn.2022.10.026. eCollection 2022 Dec 13. Epub:
Not Epub Abstract:
NF2-related schwannomatosis (NF2-related SWN) is an autosomal dominant condition caused by loss of function variants in the NF2... Delivery Method:
Endo-Porter Organism or Cell Type:
cell culture: human patient-derived fibroblasts Citation Extract: Catasús N, Rosas I, Bonache S, Negro A, Torres-Martin M, Plana-Pla A, Salvador H, Serra E, Blanco I, Castellanos E, on behalf of the NF2-related SWN Spanish National Reference Centre HUGTP-ICO-IGTP. Antisense oligonucleotides targeting exon 11 are able to partially rescue the NF2-related schwannomatosis phenotype in vitro. Mol Ther Nucleic Acids. 2022 Nov 4;30:493-505. doi: 10.1016/j.omtn.2022.10.026. eCollection 2022 Dec 13.. |
Systemic PPMO-mediated dystrophin expression in the Dup2 mouse model of Duchenne muscular dystrophy
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Citation:
Mol Ther Nucleic Acids. 2022 Nov 9;30:479-492. doi: 10.1016/j.omtn.2022.10.025. eCollection 2022 Dec 13. Epub:
Not Epub Abstract:
Duchenne muscular dystrophy (DMD) is a devastating muscle-wasting disease that arises due to the loss of dystrophin expression... Delivery Method:
peptide-linked; intravenous (i.v.) Organism or Cell Type:
mice: C57Bl/6 & Dup2 Citation Extract: Gushchina LV, Vetter TA, Frair EC, Bradley AJ, Grounds KM, Lay JW, Huang N, Suhaiba A, Schnell FJ, Hanson G, Simmons TR, Wein N, Flanigan KM. Systemic PPMO-mediated dystrophin expression in the Dup2 mouse model of Duchenne muscular dystrophy. Mol Ther Nucleic Acids. 2022 Nov 9;30:479-492. doi: 10.1016/j.omtn.2022.10.025. eCollection 2022 Dec 13.. |
Expression patterns and biological function of BCL2L10 during mouse preimplantation development
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Citation:
Gene Expr Patterns. 2022;46:119285. doi:10.1016/j.gep.2022.119285 Epub:
Not Epub Abstract:
BCL2-like 10 (BCL2L10) is abundantly expressed in mammalian oocytes and plays a crucial role in the completion of oocyte... Delivery Method:
microinjection Organism or Cell Type:
mouse pronuclear embryo Citation Extract: Liu Y, Xin J, Zhang S, Li Q, Wang W, Chen J, Ming X, Wu X, Cao X, Cui W, Wang H, Li W. Expression patterns and biological function of BCL2L10 during mouse preimplantation development. Gene Expr Patterns. 2022;46:119285. doi:10.1016/j.gep.2022.119285. |
Multiciliated cells use filopodia to probe tissue mechanics during epithelial integration in vivo
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Citation:
Nat Commun. 2022 Oct 28;13(1):6423. doi: 10.1038/s41467-022-34165-0 Epub:
Not Epub Abstract:
During embryonic development, regeneration, and homeostasis, cells have to migrate and physically integrate into the target... Delivery Method:
microinjection Organism or Cell Type:
Xenopus laevis Citation Extract: Ventura G, Amiri A, Thiagarajan R, Tolonen M, Doostmohammadi A, Sedzinski J. Multiciliated cells use filopodia to probe tissue mechanics during epithelial integration in vivo. Nat Commun. 2022 Oct 28;13(1):6423. doi: 10.1038/s41467-022-34165-0. |
DMD antisense oligonucleotide mediated exon skipping efficiency is affected by flanking intron retention time and target position within the exon
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Citation:
bioRxiv. 2022;[preprint] doi:10.1101/2022.10.28.514237 Epub:
Not Epub Abstract:
Mutations in the DMD gene are causative for Duchenne muscular dystrophy (DMD). Antisense oligonucleotide (AON) mediated exon... Delivery Method:
electroporation Organism or Cell Type:
cell culture: human myotubes, DMD and healthy sources Citation Extract: Goossens R, Verwey N, Ariyurek Y, Schnell F, Aartsma-Rus A. DMD antisense oligonucleotide mediated exon skipping efficiency is affected by flanking intron retention time and target position within the exon. bioRxiv. 2022;[preprint] doi:10.1101/2022.10.28.514237. |
Intermediate cells of in vitro cellular reprogramming and in vivo tissue regeneration require desmoplakin
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Citation:
Sci Adv. 2022 Oct 28;8(43):eabk1239. doi: 10.1126/sciadv.abk1239. Epub 2022 Oct 28 Epub:
Not Epub Abstract:
Amphibians and fish show considerable regeneration potential via dedifferentiation of somatic cells into blastemal cells. In... Delivery Method:
microinjection Organism or Cell Type:
zebrafish Citation Extract: Ha J, Kim BS, Min B, Nam J, Lee JG, Lee M, Yoon BH, Choi YH, Im I, Park JS, Choi H, Baek A, Cho SM, Lee MO, Nam KH, Mun JY, Kim M, Kim SY, Son MY, Kang YK, Lee JS, Kim JK, Kim J. Intermediate cells of in vitro cellular reprogramming and in vivo tissue regeneration require desmoplakin. Sci Adv. 2022 Oct 28;8(43):eabk1239. doi: 10.1126/sciadv.abk1239. Epub 2022 Oct 28. |
Embryonic microRNAs are essential for bovine preimplantation embryo development
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Citation:
Proc Natl Acad Sci U S A. 2022 Nov 8;119(45):e2212942119. doi: 10.1073/pnas.2212942119. Epub 2022 Nov 2 Epub:
Not Epub Abstract:
MicroRNAs (miRNAs) are small, noncoding RNAs that regulate gene expression after transcription. miRNAs are present in... Delivery Method:
microinjection Organism or Cell Type:
Bos taurus (cattle) embryo Citation Extract: Paulson EE, Fishman EL, Schultz RM, Ross PJ. Embryonic microRNAs are essential for bovine preimplantation embryo development. Proc Natl Acad Sci U S A. 2022 Nov 8;119(45):e2212942119. doi: 10.1073/pnas.2212942119. Epub 2022 Nov 2. |
The microbiota promotes social behavior by modulating microglial remodeling of forebrain neurons
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Citation:
PLoS Biol. 2022;20(11):e3001838. doi:10.1371/journal.pbio.3001838 Epub:
Not Epub Abstract:
Host-associated microbiotas guide the trajectory of developmental programs, and altered microbiota composition is linked to... Delivery Method:
microinjection Organism or Cell Type:
zebrafish Citation Extract: Bruckner JJ, Stednitz SJ, Grice MZ, Zaidan D, Massaquoi MS, Larsch J, Tallafuss A, Guillemin K, Washbourne P, Eisen JS. The microbiota promotes social behavior by modulating microglial remodeling of forebrain neurons. PLoS Biol. 2022;20(11):e3001838. doi:10.1371/journal.pbio.3001838. |
Artificial Control of the Prunus Self-incompatibility System Using Antisense Oligonucleotides Against Pollen Genes
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Citation:
Hort J. 2022;91(4):437-47. doi:10.2503/hortj.QH-002 Epub:
Not Epub Abstract:
Prunus (Rosaceae) includes many commercially important fruit crop species that exhibit self-incompatibility (SI), including... Delivery Method:
pollen bathing Organism or Cell Type:
Prunus sp. pollen Citation Extract: Ono K, Masui K, Tao R. Artificial Control of the Prunus Self-incompatibility System Using Antisense Oligonucleotides Against Pollen Genes. Hort J. 2022;91(4):437-47. doi:10.2503/hortj.QH-002. |
ASO targeting temperature-controlled RBM3 poison exon splicing prevents neurodegeneration in vivo
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Citation:
bioRxiv. 2022;[preprint] doi:10.1101/2022.10.26.513170 Epub:
Not Epub Abstract:
Neurodegenerative diseases become increasingly prevalent in the aging population and currently no cure is available. Increasing... Delivery Method:
Endo-Porter Organism or Cell Type:
cell culture: HEK293 Citation Extract: Preußner M, Smith HL, Zhang M, Hughes D, Emmerichs A-K, Scalzitti S, Peretti D, Swinden D, Neumann A, Haltenhof T, Mallucci GR, Heyd F
. ASO targeting temperature-controlled RBM3 poison exon splicing prevents neurodegeneration in vivo. bioRxiv. 2022;[preprint] doi:10.1101/2022.10.26.513170. |