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Morpholino Publication Database

This database contains citations and abstracts for research using Morpholino oligos, as well as some review articles incorporating Morpholino data. You can search the content using the filter boxes below.

There are 12378 scientific papers returned from the database with the search filters currently being used below.

Manipulation of zebrafish embryogenesis by phosphorodiamidate morpholino oligomers indicates minimal non-specific teratogenesis

Authors:
Iversen PL, Newbry S
Citation:
Curr Opin Mol Ther 2005 7(2):104-8
Epub:
Not Epub
Abstract:
The incidence of teratogenicity caused by therapeutic agents is a significant concern in drug development. Approaches to...
Organism or Cell Type:
zebrafish
Citation Extract:
Iversen PL, Newbry S. Manipulation of zebrafish embryogenesis by phosphorodiamidate morpholino oligomers indicates minimal non-specific teratogenesis. Curr Opin Mol Ther 2005 7(2):104-8.

Mind bomb is a ubiquitin ligase that is essential for efficient activation of Notch signaling by Delta

Authors:
Itoh M, Kim CH, Palardy G, Oda T, Jiang YJ, Maust D, Yeo SY, Lorick K, Wright GJ, Ariza-McNaughton L, Weissman AM, Lewis J, Chandrasekharappa SC, Chitnis AB
Citation:
Dev Cell. 2003 Jan;4(1):67-82
Epub:
Not Epub
Abstract:
Lateral inhibition, mediated by Notch signaling, leads to the selection of cells that are permitted to become neurons within...
Delivery Method:
Microinjection
Organism or Cell Type:
zebrafish
Citation Extract:
Itoh M, Kim CH, Palardy G, Oda T, Jiang YJ, Maust D, Yeo SY, Lorick K, Wright GJ, Ariza-McNaughton L, Weissman AM, Lewis J, Chandrasekharappa SC, Chitnis AB. Mind bomb is a ubiquitin ligase that is essential for efficient activation of Notch signaling by Delta. Dev Cell. 2003 Jan;4(1):67-82.

Mutations in connexin43 (GJA1) perturb bone growth in zebrafish fins

Authors:
Iovine MK, Higgins EP, Hindes A, Coblitz B, Johnson SL
Citation:
Dev Biol. 2005 Feb 1;278(1):208-19.
Epub:
Not Epub
Abstract:
Mechanisms that regulate the size and shape of bony structures are largely unknown. The molecular identification of the fin...
Delivery Method:
Microinjection
Organism or Cell Type:
zebrafish
Citation Extract:
Iovine MK, Higgins EP, Hindes A, Coblitz B, Johnson SL. Mutations in connexin43 (GJA1) perturb bone growth in zebrafish fins. Dev Biol. 2005 Feb 1;278(1):208-19..

Nemo-like kinase suppresses Notch signalling by interfering with formation of the Notch active transcriptional complex

Authors:
Ishitani T, Hirao T, Suzuki M, Isoda M, Ishitani S, Harigaya K, Kitagawa M, Matsumoto K, Itoh M
Citation:
Nat Cell Biol. 2010 Mar;12(3):278-85. doi: 10.1038/ncb2028. Epub 2010 Jan 31.
Epub:
Not Epub
Abstract:
The Notch signalling pathway has a crucial function in determining cell fates in multiple tissues within metazoan organisms. On...
Organism or Cell Type:
zebrafish
Citation Extract:
Ishitani T, Hirao T, Suzuki M, Isoda M, Ishitani S, Harigaya K, Kitagawa M, Matsumoto K, Itoh M. Nemo-like kinase suppresses Notch signalling by interfering with formation of the Notch active transcriptional complex. Nat Cell Biol. 2010 Mar;12(3):278-85. doi: 10.1038/ncb2028. Epub 2010 Jan 31..

Nrarp functions to modulate neural-crest-cell differentiation by regulating LEF1 protein stability

Authors:
Ishitani T, Matsumoto K, Chitnis AB, Itoh M
Citation:
Nat Cell Biol. 2005 Nov;7(11):1106-12
Epub:
Not Epub
Abstract:
Nrarp (Notch-regulated ankyrin repeat protein) is a small protein that has two ankyrin repeats. Although Nrarp is known to be...
Delivery Method:
Microinjection
Organism or Cell Type:
zebrafish
Citation Extract:
Ishitani T, Matsumoto K, Chitnis AB, Itoh M. Nrarp functions to modulate neural-crest-cell differentiation by regulating LEF1 protein stability. Nat Cell Biol. 2005 Nov;7(11):1106-12.

Phosphorodiamidate morpholino oligomers: favorable properties for sequence-specific gene inactivation

Authors:
Iversen PL
Citation:
Curr Opin Mol Ther 2001 Jun;3(3):235-8
Epub:
Not Epub
Abstract:
The phosphorodiamidate morpholino oligomers (PMOs) are a distinct class of oligonucleotide analogs. They bind to RNA and...
Citation Extract:
Iversen PL. Phosphorodiamidate morpholino oligomers: favorable properties for sequence-specific gene inactivation. Curr Opin Mol Ther 2001 Jun;3(3):235-8.

Proteomic analysis of mechanisms of hypoxia-induced apoptosis in trophoblastic cells

Authors:
Ishioka S, Ezaka Y, Umemura K, Hayashi T, Endo T, Saito T
Citation:
Int J Med Sci. 2006 Dec 29;4(1):36-44
Epub:
Not Epub
Abstract:
Preeclampsia is often accompanied by hypoxia of the placenta and this condition induces apoptosis in trophoblastic cells. The...
Delivery Method:
Special Delivery
Organism or Cell Type:
cell culture: Human JAR choriocarcinoma
Citation Extract:
Ishioka S, Ezaka Y, Umemura K, Hayashi T, Endo T, Saito T. Proteomic analysis of mechanisms of hypoxia-induced apoptosis in trophoblastic cells. Int J Med Sci. 2006 Dec 29;4(1):36-44.

PTBP1-dependent regulation of USP5 alternative RNA splicing plays a role in glioblastoma tumorigenesis

Authors:
Izaguirre DI, Zhu W, Hai T, Cheung HC, Krahe R, Cote GJ
Citation:
Mol Carcinog. 2012 Nov;51(11):895-906. doi: 10.1002/mc.20859. Epub 2011 Oct 4.
Epub:
Not Epub
Abstract:
Aberrant RNA splicing is thought to play a key role in tumorigenesis. The assessment of its specific contributions is limited...
Organism or Cell Type:
cell culture: glioblastoma (GBM) cell line
Citation Extract:
Izaguirre DI, Zhu W, Hai T, Cheung HC, Krahe R, Cote GJ. PTBP1-dependent regulation of USP5 alternative RNA splicing plays a role in glioblastoma tumorigenesis. Mol Carcinog. 2012 Nov;51(11):895-906. doi: 10.1002/mc.20859. Epub 2011 Oct 4..

RBP4 Disrupts Vitamin A Uptake Homeostasis in a STRA6-Deficient Animal Model for Matthew-Wood Syndrome

Authors:
Isken A, Golczak M, Oberhauser V, Hunzelmann S, Driever W, Imanishi Y, Palczewski K, von Lintig J
Citation:
Cell Metab. 2008 Mar;7(3):258-68
Epub:
Not Epub
Abstract:
The cellular uptake of vitamin A from its RBP4-bound circulating form (holo-RBP4) is a homeostatic process that evidently...
Organism or Cell Type:
zebrafish
Citation Extract:
Isken A, Golczak M, Oberhauser V, Hunzelmann S, Driever W, Imanishi Y, Palczewski K, von Lintig J. RBP4 Disrupts Vitamin A Uptake Homeostasis in a STRA6-Deficient Animal Model for Matthew-Wood Syndrome. Cell Metab. 2008 Mar;7(3):258-68.

Self-regulation of the head-inducing properties of the Spemann organizer

Authors:
Inui M, Montagner M, Ben-Zvi D, Martello G, Soligo S, Manfrin A, Aragona M, Enzo E, Zacchigna L, Zanconato F, Azzolin L, Dupont S, Cordenonsi M, Piccolo S
Citation:
Proc Natl Acad Sci U S A. 2012 Sep 18;109(38):15354-9. Epub 2012 Sep 4.
Epub:
Not Epub
Abstract:
The Spemann organizer stands out from other signaling centers of the embryo because of its broad patterning effects. It defines...
Delivery Method:
Microinjection
Organism or Cell Type:
Xenopus laevis
Citation Extract:
Inui M, Montagner M, Ben-Zvi D, Martello G, Soligo S, Manfrin A, Aragona M, Enzo E, Zacchigna L, Zanconato F, Azzolin L, Dupont S, Cordenonsi M, Piccolo S. Self-regulation of the head-inducing properties of the Spemann organizer. Proc Natl Acad Sci U S A. 2012 Sep 18;109(38):15354-9. Epub 2012 Sep 4..

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