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Morpholino Publication Database

This database contains citations and abstracts for research using Morpholino oligos, as well as some review articles incorporating Morpholino data. You can search the content using the filter boxes below.

There are 12371 scientific papers returned from the database with the search filters currently being used below.

Mutations of the Transcriptional Corepressor ZMYM2 Cause Syndromic Urinary Tract Malformations

Authors:
Connaughton DM, Dai R, Owen DJ, Marquez J, Mann N, Graham-Paquin AL, Nakayama M, Coyaud E, Laurent EMN, St-Germain JR, Blok LS, Vino A, Klämbt V, Deutsch K, Wu CW, Kolvenbach CM, Kause F, Ottlewski I, Schneider R, Kitzler TM, Majmundar AJ, Buerger F, Onuchic-Whitford AC, Youying M, Kolb A, Salmanullah D, Chen E, van der Ven AT, Rao J, Ityel H, Seltzsam S, Rieke JM, Chen J, Vivante A, Hwang DY, Kohl S, Dworschak GC, Hermle T, Alders M, Bartolomaeus T, Bauer SB, Baum MA, Brilstra EH, <authors omitted - database size limit exceeded> Rehm HL, MacArthur DG, Lek M, Laricchia KM, Lifton RP, Xu H, Mane SM, Sanna-Cherchi S, Sharrocks AD, Raught B, Fisher SE, Bouchard M, Khokha MK, Shril S, Hildebrandt F
Citation:
Am J Hum Genet. 2020 Oct 1;107(4):727-742. doi: 10.1016/j.ajhg.2020.08.013. Epub 2020 Sep 4. PMID: 32891193; PMCID: PMC7536580.
Epub:
Not Epub
Abstract:
Congenital anomalies of the kidney and urinary tract (CAKUT) constitute one of the most frequent birth defects and represent...
Link:
https://pmc.ncbi.nlm.nih.gov/articles/PMC7536580/
Organism or Cell Type:
Xenopus tropicalis
Citation Extract:
Connaughton DM, Dai R, Owen DJ, Marquez J, Mann N, Graham-Paquin AL, Nakayama M, Coyaud E, Laurent EMN, St-Germain JR, Blok LS, Vino A, Klämbt V, Deutsch K, Wu CW, Kolvenbach CM, Kause F, Ottlewski I, Schneider R, Kitzler TM, Majmundar AJ, Buerger F, Onuchic-Whitford AC, Youying M, Kolb A, Salmanullah D, Chen E, van der Ven AT, Rao J, Ityel H, Seltzsam S, Rieke JM, Chen J, Vivante A, Hwang DY, Kohl S, Dworschak GC, Hermle T, Alders M, Bartolomaeus T, Bauer SB, Baum MA, Brilstra EH, <authors omitted - database size limit exceeded> Rehm HL, MacArthur DG, Lek M, Laricchia KM, Lifton RP, Xu H, Mane SM, Sanna-Cherchi S, Sharrocks AD, Raught B, Fisher SE, Bouchard M, Khokha MK, Shril S, Hildebrandt F. Mutations of the Transcriptional Corepressor ZMYM2 Cause Syndromic Urinary Tract Malformations. Am J Hum Genet. 2020 Oct 1;107(4):727-742. doi: 10.1016/j.ajhg.2020.08.013. Epub 2020 Sep 4. PMID: 32891193; PMCID: PMC7536580..

Col11a1a Expression Is Required for Zebrafish Development

Authors:
Hardy MJ, Reeck JC, Fang M, Adams JS, Oxford JT
Citation:
J Dev Biol. 2020 Aug 28;8(3):E16. doi: 10.3390/jdb8030016
Epub:
Not Epub
Abstract:
The autosomal dominant chondrodystrophies, the Stickler type 2 and Marshall syndromes, are characterized by facial...
Link:
https://www.mdpi.com/2221-3759/8/3/16
Delivery Method:
microinjection
Organism or Cell Type:
zebrafish
Citation Extract:
Hardy MJ, Reeck JC, Fang M, Adams JS, Oxford JT. Col11a1a Expression Is Required for Zebrafish Development. J Dev Biol. 2020 Aug 28;8(3):E16. doi: 10.3390/jdb8030016.

The role of cldnh during the early retinal development in zebrafish

Authors:
Lu J, Liu R, Miao A, Chen X, Xiao W, Wang Y, Cao D, Pan J, Li L, Luo Y
Citation:
Exp Eye Res. 2020 Aug 28:108207. doi: 10.1016/j.exer.2020.108207. Online ahead of print
Epub:
Yes
Abstract:
Claudin-3, an integral component of tight junction, has recently been shown to be expressed in retinal ganglion cells, retinal...
Link:
https://www.sciencedirect.com/science/article/abs/pii/S0014483520304656
Delivery Method:
microinjection
Organism or Cell Type:
zebrafish
Citation Extract:
Lu J, Liu R, Miao A, Chen X, Xiao W, Wang Y, Cao D, Pan J, Li L, Luo Y. The role of cldnh during the early retinal development in zebrafish. Exp Eye Res. 2020 Aug 28:108207. doi: 10.1016/j.exer.2020.108207. Online ahead of print.

Calcium-Mediated In Vitro Transfection Technique of Oligonucleotides with Broad Chemical Modification Compatibility

Authors:
Wada F, Hori SI, Obika S, Yamamoto T
Citation:
Methods Mol Biol. 2020;2176:141-154. doi: 10.1007/978-1-0716-0771-8_10
Epub:
Not Epub
Abstract:
Oligonucleotide drugs (ODs) have gained increasing attention owing to their promising therapeutic potential. One major obstacle...
Link:
https://link.springer.com/protocol/10.1007%2F978-1-0716-0771-8_10
Delivery Method:
calcium enrichment method (CEM)
Organism or Cell Type:
cell culture
Citation Extract:
Wada F, Hori SI, Obika S, Yamamoto T. Calcium-Mediated In Vitro Transfection Technique of Oligonucleotides with Broad Chemical Modification Compatibility. Methods Mol Biol. 2020;2176:141-154. doi: 10.1007/978-1-0716-0771-8_10.

Inhibition of GABAA-ρ receptors induces retina regeneration in zebrafish

Authors:
Kent MR, Kara N, Patton JG
Citation:
Neural Regen Res. 2021 Feb;16(2):367-374. doi: 10.4103/1673-5374.286972
Epub:
Not Epub
Abstract:
A potential treatment for retinal diseases is to induce an endogenous Müller glia (MG)-derived regenerative response to replace...
Link:
http://www.nrronline.org/article.asp?issn=1673-5374;year=2021;volume=16;issue=2;spage=367;epage=374;aulast=Kent
Organism or Cell Type:
zebrafish
Citation Extract:
Kent MR, Kara N, Patton JG. Inhibition of GABAA-ρ receptors induces retina regeneration in zebrafish. Neural Regen Res. 2021 Feb;16(2):367-374. doi: 10.4103/1673-5374.286972.

Physiology and morphological correlates of excitatory transmission are preserved in glutamine transporter SN1- depleted mouse frontal cortex

Authors:
Popek M, Bobula B, Sowa J, Hess G, Frontczak-Baniewicz M, Albrecht J, Zielińska M
Citation:
Neurosci. 2020;[Epub] doi:10.1016/j.neuroscience.2020.08.019
Epub:
Not Epub
Abstract:
Glutamine is an astroglia-derived precursor of the neurotransmitter glutamate, and its astroglia-to-neuron transfer is...
Link:
https://www.sciencedirect.com/science/article/abs/pii/S0306452220305388
Delivery Method:
Vivo-Morpholino
Organism or Cell Type:
mice
Citation Extract:
Popek M, Bobula B, Sowa J, Hess G, Frontczak-Baniewicz M, Albrecht J, Zielińska M. Physiology and morphological correlates of excitatory transmission are preserved in glutamine transporter SN1- depleted mouse frontal cortex. Neurosci. 2020;[Epub] doi:10.1016/j.neuroscience.2020.08.019.

Llgl1 regulates zebrafish cardiac development by mediating Yap stability in cardiomyocytes

Authors:
Flinn MA, Otten C, Brandt ZJ, Bostrom JR, Kenarsary A, Wan TC, Auchampach JA, Abdelilah-Seyfried S, O'Meara CC, Link BA
Citation:
Development. 2020 Aug 25;147(16):dev193581. doi: 10.1242/dev.193581
Epub:
Not Epub
Abstract:
The Hippo-Yap pathway regulates multiple cellular processes in response to mechanical and other stimuli. In Drosophila, the...
Link:
https://dev.biologists.org/content/147/16/dev193581
Delivery Method:
microinjection
Organism or Cell Type:
zebrafish
Citation Extract:
Flinn MA, Otten C, Brandt ZJ, Bostrom JR, Kenarsary A, Wan TC, Auchampach JA, Abdelilah-Seyfried S, O'Meara CC, Link BA. Llgl1 regulates zebrafish cardiac development by mediating Yap stability in cardiomyocytes. Development. 2020 Aug 25;147(16):dev193581. doi: 10.1242/dev.193581.

Molecular Contribution to Embryonic Aneuploidy and Genotypic Complexity During Initial Cleavage Divisions of Mammalian Development

Authors:
Brooks KE, Daughtry BL, Davis B, Yan MY, Fei SS, Carbone L, Chavez SL
Citation:
bioRxiv. 2020;[preprint] doi:10.1101/2020.07.24.220475
Epub:
Not Epub
Abstract:
Embryonic aneuploidy is highly complex, often leading to developmental arrest, implantation failure, or spontaneous miscarriage...
Link:
https://www.biorxiv.org/content/10.1101/2020.07.24.220475v2
Delivery Method:
Endo-Porter DMSO, microinjection
Organism or Cell Type:
cell culture: Madin-Darby Bovine Kidney (MDBK) epithelial line, Bos Taurus (cattle) embryo
Citation Extract:
Brooks KE, Daughtry BL, Davis B, Yan MY, Fei SS, Carbone L, Chavez SL. Molecular Contribution to Embryonic Aneuploidy and Genotypic Complexity During Initial Cleavage Divisions of Mammalian Development. bioRxiv. 2020;[preprint] doi:10.1101/2020.07.24.220475 .

BVES downregulation in non-syndromic tetralogy of fallot is associated with ventricular outflow tract stenosis

Authors:
Shi Y, Li Y, Wang Y, Zhu P, Chen Y, Wang H, Yue S, Xia X, Chen J, Jiang Z, Zhou C, Cai W, Yuan H, Wu Y, Wan Y, Li X, Zhu X, Zhou Z, Dai G, Li F, Mo X, Ye X, Fan X, Zhuang J, Wu X, Yuan W
Citation:
Sci Rep. 2020:(10)1:14167. doi:10.1038/s41598-020-70806-4
Epub:
Not Epub
Abstract:
BVES is a transmembrane protein, our previous work demonstrated that single nucleotide mutations of BVES in tetralogy of fallot...
Link:
https://www.nature.com/articles/s41598-020-70806-4
Delivery Method:
microinjection
Organism or Cell Type:
zebrafish
Citation Extract:
Shi Y, Li Y, Wang Y, Zhu P, Chen Y, Wang H, Yue S, Xia X, Chen J, Jiang Z, Zhou C, Cai W, Yuan H, Wu Y, Wan Y, Li X, Zhu X, Zhou Z, Dai G, Li F, Mo X, Ye X, Fan X, Zhuang J, Wu X, Yuan W. BVES downregulation in non-syndromic tetralogy of fallot is associated with ventricular outflow tract stenosis. Sci Rep. 2020:(10)1:14167. doi:10.1038/s41598-020-70806-4.

Selective dephosphorylation by PP2A-B55 directs the meiosis I - meiosis II transition in oocytes

Authors:
Swartz SZ, Nguyen HT, McEwan BC, Adamo ME, Cheeseman IM, Kettenbach AN
Citation:
bioRxiv. 2020;[preprint] doi:10.1101/2020.08.21.260216
Epub:
Not Epub
Abstract:
Meiosis is a specialized cell cycle that requires sequential changes to the cell division machinery to facilitate changing...
Link:
https://www.biorxiv.org/content/10.1101/2020.08.21.260216v1
Delivery Method:
microinjection
Organism or Cell Type:
Patiria miniata (sea star)
Citation Extract:
Swartz SZ, Nguyen HT, McEwan BC, Adamo ME, Cheeseman IM, Kettenbach AN. Selective dephosphorylation by PP2A-B55 directs the meiosis I - meiosis II transition in oocytes. bioRxiv. 2020;[preprint] doi:10.1101/2020.08.21.260216 .

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