You are here

Morpholino Publication Database

This database contains citations and abstracts for research using Morpholino oligos, as well as some review articles incorporating Morpholino data. You can search the content using the filter boxes below.

There are 12449 scientific papers returned from the database with the search filters currently being used below.

TMBIM4 affects left-right patterning via pluripotency exit during gastrulation

Authors:
Diab NS, Kostiuk V, Tyan L, Mis E, Zenisek D, Khokha MK
Citation:
Dev Biol. 2025 Jul 29:S0012-1606(25)00209-X. doi: 10.1016/j.ydbio.2025.07.018. Epub ahead of print. PMID: 40744297
Epub:
Not Epub
Abstract:
Congenital heart disease (CHD) is the most prevalent congenital defect, but its underlying genetic and developmental mechanisms...
Link:
https://www.sciencedirect.com/science/article/abs/pii/S001216062500209X
Delivery Method:
microinjection
Organism or Cell Type:
Xenopus tropicalis
Citation Extract:
Diab NS, Kostiuk V, Tyan L, Mis E, Zenisek D, Khokha MK. TMBIM4 affects left-right patterning via pluripotency exit during gastrulation. Dev Biol. 2025 Jul 29:S0012-1606(25)00209-X. doi: 10.1016/j.ydbio.2025.07.018. Epub ahead of print. PMID: 40744297.

A novel function for Prdm12 during neural crest migration reveals a link between Wnt and N-cadherin

Authors:
Seal S, Milet C, Zhou C, Monsoro-Burq A-H
Citation:
bioRxiv [preprint] 2025.07.28.667246; doi: https://doi.org/10.1101/2025.07.28.667246
Epub:
Not Epub
Abstract:
The delamination of neural crest cells is a critical developmental event shaping the vertebrate head and peripheral nervous...
Link:
https://www.biorxiv.org/content/10.1101/2025.07.28.667246v1.full
Delivery Method:
microinjection
Organism or Cell Type:
Xenopus laevis
Citation Extract:
Seal S, Milet C, Zhou C, Monsoro-Burq A-H. A novel function for Prdm12 during neural crest migration reveals a link between Wnt and N-cadherin. bioRxiv [preprint] 2025.07.28.667246; doi: https://doi.org/10.1101/2025.07.28.667246.

Biallelic MED29 variants cause pontocerebellar hypoplasia with cataracts

Authors:
Arkush L, van Woerden GM, Ziv L, Marek-Yagel D, Fonseca R, Brevé E, Barel O, Shalva N, Veber A, Anikster Y, Ben-Ami Raichman D, Musallam B, Marcu S, Nissenkorn A, Mandel H, Kushner SA, Ben Zeev B, Heimer G
Citation:
Eur J Hum Genet. 2025 Jul 31. doi: 10.1038/s41431-025-01918-6. Epub ahead of print. PMID: 40745490
Epub:
Not Epub
Abstract:
Pontocerebellar hypoplasia (PCH) represents a group of disorders characterized by cerebellum and pons hypoplasia, variable...
Link:
https://www.nature.com/articles/s41431-025-01918-6
Delivery Method:
microinjection
Organism or Cell Type:
zebrafish
Citation Extract:
Arkush L, van Woerden GM, Ziv L, Marek-Yagel D, Fonseca R, Brevé E, Barel O, Shalva N, Veber A, Anikster Y, Ben-Ami Raichman D, Musallam B, Marcu S, Nissenkorn A, Mandel H, Kushner SA, Ben Zeev B, Heimer G. Biallelic MED29 variants cause pontocerebellar hypoplasia with cataracts. Eur J Hum Genet. 2025 Jul 31. doi: 10.1038/s41431-025-01918-6. Epub ahead of print. PMID: 40745490.

Targeting GLP-1 Signaling Ameliorates Cystogenesis in a Zebrafish Model of Nephronophthisis

Authors:
Eckert P, Nöller M, Müller M, Haas R, Ruf J, Franz H, Moos K, Yu, J-a, Zhao D, Xie W, Boerries M, Walz G, Yakulov TA
Citation:
International Journal of Molecular Sciences. 2025; 26(15):7366. https://doi.org/10.3390/ijms26157366
Epub:
Not Epub
Abstract:
Nephronophthisis (NPH) is the leading genetic cause of end-stage renal disease in children and young adults, but no effective...
Link:
https://www.mdpi.com/1422-0067/26/15/7366
Delivery Method:
microinjection
Organism or Cell Type:
zebrafish
Citation Extract:
Eckert P, Nöller M, Müller M, Haas R, Ruf J, Franz H, Moos K, Yu, J-a, Zhao D, Xie W, Boerries M, Walz G, Yakulov TA. Targeting GLP-1 Signaling Ameliorates Cystogenesis in a Zebrafish Model of Nephronophthisis. International Journal of Molecular Sciences. 2025; 26(15):7366. https://doi.org/10.3390/ijms26157366.

Formation control between leader and migratory follower tissues allows coordinated growth

Authors:
Kawanishi T, Sushida T, Tsai TY, Takeda H, Megason SG
Citation:
Sci Adv. 2025 Aug;11(31):eads2310. doi: 10.1126/sciadv.ads2310. Epub 2025 Jul 30. PMID: 40737421; PMCID: PMC12309693
Epub:
Not Epub
Abstract:
Coordinated growth of multiple tissues is fundamental to shaping our body, but the underlying mechanisms remain underexplored....
Link:
https://www.science.org/doi/10.1126/sciadv.ads2310
Delivery Method:
microinjection
Organism or Cell Type:
zebrafish
Citation Extract:
Kawanishi T, Sushida T, Tsai TY, Takeda H, Megason SG. Formation control between leader and migratory follower tissues allows coordinated growth. Sci Adv. 2025 Aug;11(31):eads2310. doi: 10.1126/sciadv.ads2310. Epub 2025 Jul 30. PMID: 40737421; PMCID: PMC12309693.

Self-Assembling Multi-Antigen T Cell Hybridizers for Precision Immunotherapy of Multiple Myeloma

Authors:
Li S, Li J, Faruque HA, Shami P, Knoechel B, Lohr J, Sborov D, Yang J, Kopeček J
Citation:
Adv Healthc Mater. 2025 Aug 1:e02156. doi: 10.1002/adhm.202502156. Epub ahead of print. PMID: 40747784
Epub:
Not Epub
Abstract:
Bispecific T-cell engagers show promise in treating multiple myeloma (MM), but challenges remain in adaptability and targeting...
Link:
https://advanced.onlinelibrary.wiley.com/doi/10.1002/adhm.202502156
Delivery Method:
Fab-linked; mice: intravenous (i.v.) injection
Organism or Cell Type:
Multiple myeloma cells (MM.1S, MM.1R, RPMI-8226, ANBL-6, and U266), human PBMCs, primary T cells; mice: NRG (NOD-Rag1−/−IL2Rγnull)
Citation Extract:
Li S, Li J, Faruque HA, Shami P, Knoechel B, Lohr J, Sborov D, Yang J, Kopeček J. Self-Assembling Multi-Antigen T Cell Hybridizers for Precision Immunotherapy of Multiple Myeloma. Adv Healthc Mater. 2025 Aug 1:e02156. doi: 10.1002/adhm.202502156. Epub ahead of print. PMID: 40747784.

Two Centrins and Their Posttranslational Modification Modulate the Cell Cycle of Giardia lamblia

Authors:
Yeo HR, Shin MY, Kim J, Park SJ
Citation:
Microbiologyopen. 2025 Aug;14(4):e70038. doi: 10.1002/mbo3.70038. PMID: 40734239; PMCID: PMC12307541
Epub:
Not Epub
Abstract:
Centrins, Ca2+-binding proteins conserved in eukaryotes, are the key components of the microtubule-organizing center. Giardia...
Link:
https://onlinelibrary.wiley.com/doi/10.1002/mbo3.70038
Delivery Method:
electroporation
Organism or Cell Type:
Giardia lamblia
Citation Extract:
Yeo HR, Shin MY, Kim J, Park SJ. Two Centrins and Their Posttranslational Modification Modulate the Cell Cycle of Giardia lamblia. Microbiologyopen. 2025 Aug;14(4):e70038. doi: 10.1002/mbo3.70038. PMID: 40734239; PMCID: PMC12307541.

FBRSL1 regulates the expression of chromatin regulators BRPF1 and KAT6A

Authors:
Kastens G, Berger-Santangelo H, Gerstner S, Ufartes R, Mischak M, Borchers A, Pauli S
Citation:
Hum Genet. 2025 Jul 14. doi: 10.1007/s00439-025-02760-y. Epub ahead of print. PMID: 40658195
Epub:
Not Epub
Abstract:
FBRSL1-associated syndrome is a rare congenital malformation and intellectual disability syndrome caused by heterozygous...
Link:
https://link.springer.com/article/10.1007/s00439-025-02760-y
Delivery Method:
microinjection
Organism or Cell Type:
Xenopus laevis
Citation Extract:
Kastens G, Berger-Santangelo H, Gerstner S, Ufartes R, Mischak M, Borchers A, Pauli S. FBRSL1 regulates the expression of chromatin regulators BRPF1 and KAT6A. Hum Genet. 2025 Jul 14. doi: 10.1007/s00439-025-02760-y. Epub ahead of print. PMID: 40658195.

Morpholino-Mediated Exon Inclusion for Spinal Muscular Atrophy (SMA)

Authors:
Zhou H, Muntoni F
Citation:
Methods Mol Biol. 2025;2964:433-444. doi: 10.1007/978-1-0716-4730-1_28. PMID: 40720035
Epub:
Not Epub
Abstract:
The application of antisense oligonucleotides (AONs) to modify pre-messenger RNA splicing has great potential for treating...
Link:
https://link.springer.com/protocol/10.1007/978-1-0716-4730-1_28
Organism or Cell Type:
SMA mice
Citation Extract:
Zhou H, Muntoni F. Morpholino-Mediated Exon Inclusion for Spinal Muscular Atrophy (SMA). Methods Mol Biol. 2025;2964:433-444. doi: 10.1007/978-1-0716-4730-1_28. PMID: 40720035.

Systemic Injection of Antisense Oligos into Spinal Muscular Atrophy (SMA) Mice and Evaluation

Authors:
Aslesh T, Maruyama R, Yokota T
Citation:
Methods Mol Biol. 2025;2964:421-431. doi: 10.1007/978-1-0716-4730-1_27. PMID: 40720034
Epub:
Not Epub
Abstract:
Spinal muscular atrophy (SMA) is the most common genetic cause of infantile death caused by mutations in the SMN1 gene....
Link:
https://link.springer.com/protocol/10.1007/978-1-0716-4730-1_27
Delivery Method:
intracerebroventricular (i.c.v.) injection
Organism or Cell Type:
SMA mice
Citation Extract:
Aslesh T, Maruyama R, Yokota T. Systemic Injection of Antisense Oligos into Spinal Muscular Atrophy (SMA) Mice and Evaluation. Methods Mol Biol. 2025;2964:421-431. doi: 10.1007/978-1-0716-4730-1_27. PMID: 40720034.

Pages