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Morpholino Publication Database

This database contains citations and abstracts for research using Morpholino oligos, as well as some review articles incorporating Morpholino data. You can search the content using the filter boxes below.

There are 275 scientific papers returned from the database with the search filters currently being used below.

Peptide-Conjugated Phosphorodiamidate Morpholino Oligomers for In Situ Live-Cell Molecular Imaging of Dengue Virus Replication

Authors:
Victorio CB, Novera W, Tham JY, Watanabe S, Vasudevan SG, Chacko A-M
Citation:
Int J Molec Sci. 2020;21(23):1422-0067 doi:10.3390/ijms21239260
Epub:
Not Epub
Abstract:
Current methods to detect and monitor pathogens in biological systems are largely limited by the tradeoffs between spatial...
Link:
https://www.mdpi.com/1422-0067/21/23/9260
Delivery Method:
peptide-linked
Organism or Cell Type:
cell culture: Vero, BHK-21
Citation Extract:
Victorio CB, Novera W, Tham JY, Watanabe S, Vasudevan SG, Chacko A-M. Peptide-Conjugated Phosphorodiamidate Morpholino Oligomers for In Situ Live-Cell Molecular Imaging of Dengue Virus Replication. Int J Molec Sci. 2020;21(23):1422-0067 doi:10.3390/ijms21239260.

Inhibition of SARS-CoV-2 in Vero cell cultures by peptide-conjugated morpholino oligomers

Authors:
Rosenke K, Leventhal S, Moulton HM, Hatlevig S, Hawman D, Feldmann H, Stein DA
Citation:
J Antimicrob Chemother. 2021 Jan 19;76(2):413-417. doi: 10.1093/jac/dkaa460. PMID: 33164048; PMCID: PMC7717290
Epub:
Yes
Abstract:
Background: As the causative agent of COVID-19, SARS-CoV-2 is a pathogen of immense importance to global public health....
Link:
https://pmc.ncbi.nlm.nih.gov/articles/PMC7717290/
Delivery Method:
peptide-linked
Organism or Cell Type:
cell culture: Vero-E6 and SARS-CoV-2
Citation Extract:
Rosenke K, Leventhal S, Moulton HM, Hatlevig S, Hawman D, Feldmann H, Stein DA. Inhibition of SARS-CoV-2 in Vero cell cultures by peptide-conjugated morpholino oligomers. J Antimicrob Chemother. 2021 Jan 19;76(2):413-417. doi: 10.1093/jac/dkaa460. PMID: 33164048; PMCID: PMC7717290.

Multiplex in situ hybridization within a single transcript: RNAscope reveals dystrophin mRNA dynamics

Authors:
Hildyard JCW, Rawson F, Wells DJ, Piercy RJ
Citation:
PLoS ONE. 2020;15(9):e0239467. doi:10.1371/journal.pone.0239467
Epub:
Not Epub
Abstract:
Dystrophin plays a vital role in maintaining muscle health, yet low mRNA expression, lengthy transcription time and the...
Link:
https://journals.plos.org/plosone/article?id=10.1371/journal.pone.0239467
Delivery Method:
peptide-linked
Organism or Cell Type:
mice
Citation Extract:
Hildyard JCW, Rawson F, Wells DJ, Piercy RJ. Multiplex in situ hybridization within a single transcript: RNAscope reveals dystrophin mRNA dynamics. PLoS ONE. 2020;15(9):e0239467. doi:10.1371/journal.pone.0239467.

In vivo Pharmacokinetic and Biodistribution profile of Peptide-Conjugated Phosphorodiamidate Morpholino Oligonucleotides

Authors:
Burki U, Blain A, Greally E, O’Donovan L, Gait M, Laval S, Straub V
Citation:
Poster at 2015 Oligonucleotide Therapeutics Society meeting
Epub:
Not Epub
Abstract:
Antisense oligonucleotide (AON) induced exon skipping is one of the most promising strategies for treating Duchene muscular...
Link:
https://www.researchgate.net/publication/283047310_In_vivo_Pharmacokinetic_and_Biodistribution_profile_of_Peptide-Conjugated_Phosphorodiamidate_Morpholino_Oligonucleotides [accessed Sep 17 2020]
Delivery Method:
peptide-linked
Organism or Cell Type:
mice
Citation Extract:
Burki U, Blain A, Greally E, O’Donovan L, Gait M, Laval S, Straub V. In vivo Pharmacokinetic and Biodistribution profile of Peptide-Conjugated Phosphorodiamidate Morpholino Oligonucleotides. Poster at 2015 Oligonucleotide Therapeutics Society meeting.

Morpholino Oligomer-Induced Dystrophin Isoforms to Map the Functional Domains in the Dystrophin Protein

Authors:
Li D, Adams AM, Johnsen RD, Fletcher S, Wilton SD
Citation:
Molec Ther. 2020 Aug 21;22:263-272. doi:10.1016/j.omtn.2020.08.019
Epub:
Not Epub
Abstract:
Dystrophin plays a crucial role in maintaining sarcolemma stability during muscle contractions, and mutations that prevent the...
Link:
https://www.sciencedirect.com/science/article/pii/S2162253120302481
Delivery Method:
peptide-linked
Organism or Cell Type:
cell culture: murine H2K mdx myogenic cells, mice
Citation Extract:
Li D, Adams AM, Johnsen RD, Fletcher S, Wilton SD. Morpholino Oligomer-Induced Dystrophin Isoforms to Map the Functional Domains in the Dystrophin Protein. Molec Ther. 2020 Aug 21;22:263-272. doi:10.1016/j.omtn.2020.08.019.

TMPRSS2 and furin are both essential for proteolytic activation of SARS-CoV-2 in human airway cells

Authors:
Bestle D, Heindl MR, Limburg H, Lam van TV, Pilgram O, Moulton H, Stein DA, Hardes K, Eickmann M, Dolnik O, Rohde C, Klenk H-D, Garten W, Steinmetzer T, Böttcher-Friebertshäuser E
Citation:
Life Sci Alliance. 2020;3(9):e202000786 doi:10.26508/lsa.202000786
Epub:
Not Epub
Abstract:
The novel emerged SARS-CoV-2 has rapidly spread around the world causing acute infection of the respiratory tract (COVID-19)...
Link:
https://www.life-science-alliance.org/content/3/9/e202000786
Delivery Method:
peptide-linked
Organism or Cell Type:
cell culture: Calu-3 human airway epithelial cells
Citation Extract:
Bestle D, Heindl MR, Limburg H, Lam van TV, Pilgram O, Moulton H, Stein DA, Hardes K, Eickmann M, Dolnik O, Rohde C, Klenk H-D, Garten W, Steinmetzer T, Böttcher-Friebertshäuser E. TMPRSS2 and furin are both essential for proteolytic activation of SARS-CoV-2 in human airway cells. Life Sci Alliance. 2020;3(9):e202000786 doi:10.26508/lsa.202000786.

Targeted Delivery of Antisense Oligonucleotides Using Neurotensin Peptide

Authors:
Nikan M, Tanowitz M, Dwyer CA, Jackson M, Gaus H, Swayze E, Rigo F, Seth PP, Prakash TP
Citation:
J Med Chem. 2020 Jul 17. doi:10.1021/acs.jmedchem.0c00840. Online ahead of print
Epub:
Not Epub
Abstract:
Despite recent advances, targeted delivery of therapeutic oligonucleotide to extra-hepatic tissues continues to be a...
Link:
https://pubs.acs.org/doi/10.1021/acs.jmedchem.0c00840
Delivery Method:
peptide-linked, intracerebroventricular (i.c.v.) injection in mice
Organism or Cell Type:
cell culture: HEK293, mice
Citation Extract:
Nikan M, Tanowitz M, Dwyer CA, Jackson M, Gaus H, Swayze E, Rigo F, Seth PP, Prakash TP. Targeted Delivery of Antisense Oligonucleotides Using Neurotensin Peptide. J Med Chem. 2020 Jul 17. doi:10.1021/acs.jmedchem.0c00840. Online ahead of print.

Single Exon Skipping Can Address a Multi-Exon Duplication in the Dystrophin Gene

Authors:
Greer K, Johnsen R, Nevo Y, Fellig Y, Fletcher S, Wilton SD
Citation:
Int J Molec Sci. 2020;[Epub] doi:10.3390/ijms21124511
Epub:
Yes
Abstract:
Duchenne muscular dystrophy (DMD) is a severe muscle wasting disease typically caused by protein-truncating mutations that...
Link:
https://www.mdpi.com/1422-0067/21/12/4511
Delivery Method:
cell bathing, peptide-linked
Organism or Cell Type:
cell culture: primary human myoblasts
Citation Extract:
Greer K, Johnsen R, Nevo Y, Fellig Y, Fletcher S, Wilton SD. Single Exon Skipping Can Address a Multi-Exon Duplication in the Dystrophin Gene. Int J Molec Sci. 2020;[Epub] doi:10.3390/ijms21124511.

Development of a Minimized Exons 45-55 Skipping Cocktail for the Treatment of Duchenne Muscular Dystrophy

Authors:
Lim KRQ, Huang Y, Maruyama R, Woo S, Dzierlega K, Moulton H, Yokota T
Citation:
Molec Ther. 2020;28(4S1):113 abstract 237. doi:10.1016/j.ymthe.2020.04.019
Epub:
Not Epub
Abstract:
Duchenne muscular dystrophy (DMD) is a fatal X-linked recessive neuromuscular disorder characterized by...
Link:
https://www.cell.com/action/showPdf?pii=S1525-0016%2820%2930200-8
Delivery Method:
peptide-linked
Organism or Cell Type:
mice
Citation Extract:
Lim KRQ, Huang Y, Maruyama R, Woo S, Dzierlega K, Moulton H, Yokota T. Development of a Minimized Exons 45-55 Skipping Cocktail for the Treatment of Duchenne Muscular Dystrophy. Molec Ther. 2020;28(4S1):113 abstract 237. doi:10.1016/j.ymthe.2020.04.019.

Restoration of Full-Length Dystrophin Expression in the Dup2 Mouse Induced by Systemic Delivery of a Peptide-Conjugated Morpholino Oligomer

Authors:
Gushchina LV, Grounds KM, Huang N, Frair E, Schnell FJ, Hanson GJ, Simmons T, Wein N, Flanigan KM
Citation:
Molec Ther. 2020;28(4S1):20 abstract 39. doi:10.1016/j.ymthe.2020.04.019
Epub:
Not Epub
Abstract:
Duchenne muscular dystrophy (DMD) is an x-linked recessive genetic disorder caused by mutations that disrupt the...
Link:
https://www.cell.com/action/showPdf?pii=S1525-0016%2820%2930200-8
Delivery Method:
peptide-linked
Organism or Cell Type:
mice
Citation Extract:
Gushchina LV, Grounds KM, Huang N, Frair E, Schnell FJ, Hanson GJ, Simmons T, Wein N, Flanigan KM. Restoration of Full-Length Dystrophin Expression in the Dup2 Mouse Induced by Systemic Delivery of a Peptide-Conjugated Morpholino Oligomer. Molec Ther. 2020;28(4S1):20 abstract 39. doi:10.1016/j.ymthe.2020.04.019.

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