You are here
Morpholino Publication Database
This database contains citations and abstracts for research using Morpholino oligos, as well as some review articles incorporating Morpholino data. You can search the content using the filter boxes below.
There are 275 scientific papers returned from the database with the search filters currently being used below.
There are 275 scientific papers returned from the database with the search filters currently being used below.
Peptide Conjugated Morpholinos for Management of The Huanglongbing Pathosystem
|
Citation:
Pest Manag Sci. 2020 May 1. doi: 10.1002/ps.5877. [Epub ahead of print] Epub:
Yes Abstract:
BACKGROUND: 'Candidatus Liberibacter asiaticus' (CLas) is the causal agent of the devastating citrus disease... Delivery Method:
peptide-linked Organism or Cell Type:
Candidatus Liberibacter asiaticus, Wolbachia Citation Extract: Sandoval-Mojica AF, Altman S, Hunter WB, Pelz-Stelinski KS. Peptide Conjugated Morpholinos for Management of The Huanglongbing Pathosystem. Pest Manag Sci. 2020 May 1. doi: 10.1002/ps.5877. [Epub ahead of print]. |
TMPRSS2 and furin are both essential for proteolytic activation of SARS-CoV-2 in human airway cells
|
Citation:
Life Sci Alliance. 2020 Jul 23;3(9):e202000786. doi: 10.26508/lsa.202000786. PMID: 32703818; PMCID: PMC7383062 Epub:
Not Epub Abstract:
The novel emerged SARS-CoV-2 has rapidly spread around the world causing acute infection of the respiratory tract (COVID-19)... Delivery Method:
peptide-linked Organism or Cell Type:
cell culture: Calu-3 Citation Extract: Bestle D, Heindl MR, Limburg H, Van Lam van T, Pilgram O, Moulton H, Stein DA, Hardes K, Eickmann M, Dolnik O, Rohde C, Klenk HD, Garten W, Steinmetzer T, Böttcher-Friebertshäuser E. TMPRSS2 and furin are both essential for proteolytic activation of SARS-CoV-2 in human airway cells. Life Sci Alliance. 2020 Jul 23;3(9):e202000786. doi: 10.26508/lsa.202000786. PMID: 32703818; PMCID: PMC7383062. |
Interpretable Deep Learning for De Novo Design of Cell-Penetrating Abiotic Polymers
|
Citation:
bioRxiv. 2020;[preprint] doi:10.1101/2020.04.10.036566 Epub:
Not Epub Abstract:
There are more amino acid permutations within a 40-residue sequence than atoms on Earth. This vast chemical search space... Delivery Method:
peptide-linked Organism or Cell Type:
cell culture: HeLa, human renal proximal tublule epithelial cells, mice Citation Extract: Schissel CK, Mohapatra S, Wolfe JM, Fadzen CM, Bellovoda K, Wu C-L, Wood JA, Malmberg AB, Loas A, Gomez-Bombarelli R, Pentelute BL.. Interpretable Deep Learning for De Novo Design of Cell-Penetrating Abiotic Polymers. bioRxiv. 2020;[preprint] doi:10.1101/2020.04.10.036566. |
Combined treatment with peptide-conjugated phosphorodiamidate morpholino oligomer-PPMO and AAV-U7 rescues the severe DMD phenotype in mice
|
Citation:
Molec Ther Methods Clin Devel. 2020;17:695-708. doi:10.1016/j.omtm.2020.03.011 Epub:
Not Epub Abstract:
Duchenne muscular dystrophy (DMD) is a devastating neuromuscular disease caused by an absence of the dystrophin protein, which... Delivery Method:
peptide-linked Organism or Cell Type:
mice Citation Extract: Forand A, Muchir A, Mougenot N, Sevoz-Couche C, Peccate C, Lemaitre M, Izabelle C, Wood MJA, Lorain SL, Piétri-Rouxel F. Combined treatment with peptide-conjugated phosphorodiamidate morpholino oligomer-PPMO and AAV-U7 rescues the severe DMD phenotype in mice. Molec Ther Methods Clin Devel. 2020;17:695-708. doi:10.1016/j.omtm.2020.03.011. |
Uniform sarcolemmal dystrophin expression is required to prevent extracellular microRNA release and improve dystrophic pathology
|
Citation:
J Cachexia Sarcopenia Musc. 2019;[Epub] doi:10.1002/jcsm.12506 Epub:
Yes Abstract:
Background: Duchenne muscular dystrophy (DMD) is a fatal muscle‐wasting disorder caused by genetic loss of dystrophin protein.... Delivery Method:
peptide-linked Organism or Cell Type:
mice Citation Extract: van Westering TLE, Lomonosova Y, Coenen‐Stass AML, Betts CA, Bhomra A, Hulsker M, Clark LE, McClorey G, Aartsma‐Rus A, van Putten M, Wood MJA, Roberts TC. Uniform sarcolemmal dystrophin expression is required to prevent extracellular microRNA release and improve dystrophic pathology. J Cachexia Sarcopenia Musc. 2019;[Epub] doi:10.1002/jcsm.12506. |
The ETS transcription factor ELF1 regulates a broadly antiviral program distinct from the type I interferon response
|
Citation:
PLoS Pathog. 2019 Nov 4;15(11):e1007634. doi: 10.1371/journal.ppat.1007634. PMID: 31682641; PMCID: PMC6932815 Epub:
Not Epub Abstract:
Induction of vast transcriptional programs is a central event of innate host responses to viral infections. Here we report a... Delivery Method:
intranasal peptide-linked Organism or Cell Type:
mice Citation Extract: Seifert LL, Si C, Saha D, Sadic M, de Vries M, Ballentine S, Briley A, Wang G, Valero-Jimenez AM, Mohamed A, Schaefer U, Moulton HM, García-Sastre A, Tripathi S, Rosenberg BR, Dittmann M. The ETS transcription factor ELF1 regulates a broadly antiviral program distinct from the type I interferon response. PLoS Pathog. 2019 Nov 4;15(11):e1007634. doi: 10.1371/journal.ppat.1007634. PMID: 31682641; PMCID: PMC6932815. |
Multiplex in situ hybridization within a single transcript: RNAscope reveals dystrophin mRNA dynamics
|
Citation:
bioRxiv. 2019;[preprint] doi:10.1101/791780 Epub:
Not Epub Abstract:
Dystrophin plays a vital role in maintaining muscle health, yet low mRNA expression, lengthy transcription time and the... Delivery Method:
peptide-linked Organism or Cell Type:
mice Citation Extract: Hildyard JCW, Rawson F, Wells DJ, Piercy RJ. Multiplex in situ hybridization within a single transcript: RNAscope reveals dystrophin mRNA dynamics. bioRxiv. 2019;[preprint] doi:10.1101/791780 . |
Hexose potentiates peptide-conjugated morpholino oligomer efficacy in cardiac muscles of dystrophic mice in an age-dependent manner
|
Citation:
Mol Ther Nucl Acids. 2019 Sep 23;18:341-350. doi: 10.1016/j.omtn.2019.09.012. [Epub ahead of print] Epub:
Not Epub Abstract:
Insufficient delivery of oligonucleotides to muscle and heart remains a barrier for clinical implementation of antisense... Delivery Method:
peptide-linked Organism or Cell Type:
mice mdx Citation Extract: Han G, Gu B, Lin C, Ning H, Song J, Gao X, Moulton HM, Yin HF. Hexose potentiates peptide-conjugated morpholino oligomer efficacy in cardiac muscles of dystrophic mice in an age-dependent manner. Mol Ther Nucl Acids. 2019 Sep 23;18:341-350. doi: 10.1016/j.omtn.2019.09.012. [Epub ahead of print]. |
Reduction of integrin alpha 4 activity through splice modulating antisense oligonucleotides
|
Citation:
Sci Rep. 2019;9(1):12994. doi:10.1038/s41598-019-49385-6 Epub:
Not Epub Abstract:
With recent approvals of antisense oligonucleotides as therapeutics, there is an increasing interest in expanding the... Delivery Method:
in vitro lipofectamine (fibroblasts) electroporation (Jurkat) , in vivo peptide-linked Organism or Cell Type:
cell culture: primary dermal fibroblasts, Jurkat; autoimmune encephalomyelitis mouse model of multiple sclerosis Citation Extract: Aung-Htut MT, Comerford I, Johnsen R, Foyle K, Fletcher S, Wilton SD. Reduction of integrin alpha 4 activity through splice modulating antisense oligonucleotides. Sci Rep. 2019;9(1):12994. doi:10.1038/s41598-019-49385-6. |
Peptide-conjugated oligonucleotides evoke long-lasting myotonic dystrophy correction in patient-derived cells and mice
|
Citation:
J Clin Invest. 2019 Nov 1;129(11):4739-4744. doi: 10.1172/JCI128205 Epub:
Not Epub Abstract:
Antisense oligonucleotides (ASOs) targeting pathologic RNAs have shown promising therapeutic corrections for many genetic... Delivery Method:
peptide-linked Organism or Cell Type:
cell culture: patient-derived muscle DM1 mice Citation Extract: Klein AF, Varela MA, Arandel L, Holland A, Naouar N, Arzumanov A, Seoane D, Revillod L, Bassez G, Ferry A, Jauvin D, Gourdon G, Puymirat J, Gait MJ, Furling D, Wood MJA. Peptide-conjugated oligonucleotides evoke long-lasting myotonic dystrophy correction in patient-derived cells and mice. J Clin Invest. 2019 Nov 1;129(11):4739-4744. doi: 10.1172/JCI128205. |