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Morpholino Publication Database

This database contains citations and abstracts for research using Morpholino oligos, as well as some review articles incorporating Morpholino data. You can search the content using the filter boxes below.

There are 12371 scientific papers returned from the database with the search filters currently being used below.

Chemical screens in a zebrafish model of CHARGE syndrome identifies small molecules that ameliorates disease like phenotypes in embryo

Authors:
Asad Z, Sachidanandan C
Citation:
Eur J Med Genet. 2019 Apr 30. pii: S1769-7212(19)30015-1. doi: 10.1016/j.ejmg.2019.04.018. [Epub ahead of print]
Epub:
Yes
Abstract:
CHARGE syndrome is an autosomal dominant congenital disorder caused primarily by mutations in the CHD7 gene. Using a small...
Link:
https://www.sciencedirect.com/science/article/pii/S1769721219300151
Organism or Cell Type:
zebrafish
Citation Extract:
Asad Z, Sachidanandan C. Chemical screens in a zebrafish model of CHARGE syndrome identifies small molecules that ameliorates disease like phenotypes in embryo. Eur J Med Genet. 2019 Apr 30. pii: S1769-7212(19)30015-1. doi: 10.1016/j.ejmg.2019.04.018. [Epub ahead of print].

Combinatorial control of gene function with wavelength-selective caged morpholinos

Authors:
Pattanayak S, Vázquez-Maldonado LA, Deiters A, Chen JK
Citation:
Meth Enzymol. 2019;624:69-88. doi: 10.1016/bs.mie.2019.04.007
Epub:
Yes
Abstract:
Caged morpholino oligonucleotides (cMOs) are useful research tools in developmental biology because they allow spatiotemporal...
Link:
https://www.sciencedirect.com/science/article/pii/S0076687919301223
Citation Extract:
Pattanayak S, Vázquez-Maldonado LA, Deiters A, Chen JK. Combinatorial control of gene function with wavelength-selective caged morpholinos. Meth Enzymol. 2019;624:69-88. doi: 10.1016/bs.mie.2019.04.007.

The Alternative Splicing Regulator Nova2 Constrains Vascular Erk Signaling to Limit Specification of the Lymphatic Lineage

Authors:
Baek S, Oh TG, Secker G, Sutton DL, Okuda KS, Paterson S, Bower NI, Toubia J, Koltowska K, Capon SJ, Baillie GJ, Simons C, Muscat GEO, Lagendijk AK, Smith KA, Harvey NL, Hogan BM
Citation:
Dev Cell. 2019 Apr 22;49(2):279-292.e5. doi:10.1016/j.devcel.2019.03.017
Epub:
Not Epub
Abstract:
The correct assignment of cell fate within fields of multipotent progenitors is essential for accurate tissue diversification....
Link:
https://www.sciencedirect.com/science/article/abs/pii/S153458071930228X
Delivery Method:
microinjection
Organism or Cell Type:
zebrafish
Citation Extract:
Baek S, Oh TG, Secker G, Sutton DL, Okuda KS, Paterson S, Bower NI, Toubia J, Koltowska K, Capon SJ, Baillie GJ, Simons C, Muscat GEO, Lagendijk AK, Smith KA, Harvey NL, Hogan BM. The Alternative Splicing Regulator Nova2 Constrains Vascular Erk Signaling to Limit Specification of the Lymphatic Lineage. Dev Cell. 2019 Apr 22;49(2):279-292.e5. doi:10.1016/j.devcel.2019.03.017.

Mannose Phosphate Isomerase and Mannose Regulate Hepatic Stellate Cell Activation and Fibrosis in Zebrafish and Humans

Authors:
DeRossi C, Bambino K, Morrison J, Sakarin I, Villacorta-Martin C, Zhang C, Ellis JL, Fiel MI, Ybanez M, Lee YA, Huang KL, Yin C, Sakaguchi TF, Friedman SL, Villanueva A, Chu J
Citation:
Hepatology. 2019 Dec;70(6):2107-2122. doi: 10.1002/hep.30677. Epub 2019 May 24. PMID: 31016744; PMCID: PMC6812593
Epub:
Not Epub
Abstract:
The growing burden of liver fibrosis and lack of effective antifibrotic therapies highlight the need for identification of...
Link:
https://pmc.ncbi.nlm.nih.gov/articles/PMC6812593/
Delivery Method:
microinjection
Organism or Cell Type:
zebrafish
Citation Extract:
DeRossi C, Bambino K, Morrison J, Sakarin I, Villacorta-Martin C, Zhang C, Ellis JL, Fiel MI, Ybanez M, Lee YA, Huang KL, Yin C, Sakaguchi TF, Friedman SL, Villanueva A, Chu J. Mannose Phosphate Isomerase and Mannose Regulate Hepatic Stellate Cell Activation and Fibrosis in Zebrafish and Humans. Hepatology. 2019 Dec;70(6):2107-2122. doi: 10.1002/hep.30677. Epub 2019 May 24. PMID: 31016744; PMCID: PMC6812593.

AP endonuclease 1 (Apex1) influences brain development linking oxidative stress and DNA repair

Authors:
Pei D-S, Jia P-P, Luo J-J, Liu W, Strauss PR
Citation:
Cell Death Dis. 2019:10(5):348. doi:10.1038/s41419-019-1578-1
Epub:
Not Epub
Abstract:
Brain and neurons are particularly sensitive to reactive oxygen species (ROS). Oxidative damage from ROS results in increased 8...
Link:
https://www.nature.com/articles/s41419-019-1578-1
Delivery Method:
microinjection
Organism or Cell Type:
zebrafish
Citation Extract:
Pei D-S, Jia P-P, Luo J-J, Liu W, Strauss PR . AP endonuclease 1 (Apex1) influences brain development linking oxidative stress and DNA repair. Cell Death Dis. 2019:10(5):348. doi:10.1038/s41419-019-1578-1.

penner/lgl2 is required for the integrity of the photoreceptor layer in the zebrafish retina

Authors:
Kujawski S, Sonawane M, Knust E
Citation:
Bio Open. 2019;8:bio041830 doi:10.1242/bio.041830
Epub:
Not Epub
Abstract:
The vertebrate retina is a complex tissue built from multiple neuronal cell types, which develop from a pseudostratified...
Link:
http://bio.biologists.org/content/8/4/bio041830.long
Delivery Method:
microinjection
Organism or Cell Type:
zebrafish
Citation Extract:
Kujawski S, Sonawane M, Knust E. penner/lgl2 is required for the integrity of the photoreceptor layer in the zebrafish retina. Bio Open. 2019;8:bio041830 doi:10.1242/bio.041830.

Synthesis of Nucleobase-Functionalized Morpholino Monomers

Authors:
Nandi B, Pattanayak S, Paul S, Kundu J, Sinha S
Citation:
Methods Mol Biol. 2019;1973:107-130. doi: 10.1007/978-1-4939-9216-4_7
Epub:
Not Epub
Abstract:
Morpholino antisense oligonucleotides are used as routine tools in developmental biology to investigate gene function during...
Link:
https://link.springer.com/protocol/10.1007%2F978-1-4939-9216-4_7
Citation Extract:
Nandi B, Pattanayak S, Paul S, Kundu J, Sinha S. Synthesis of Nucleobase-Functionalized Morpholino Monomers. Methods Mol Biol. 2019;1973:107-130. doi: 10.1007/978-1-4939-9216-4_7.

Oligonucleotide-directed STAT3 alternative splicing switch drives anti-tumorigenic outcomes in MCF10 human breast cancer cells

Authors:
Tano V, Jans DA, Bogoyevitch MA
Citation:
Biochem Biophys Res Commun. 2019 Apr 19. pii: S0006-291X(19)30682-5. doi: 10.1016/j.bbrc.2019.04.054. [Epub ahead of print]
Epub:
Yes
Abstract:
Signal transducer and activator of transcription 3 (STAT3), a transcription factor responsive to the activation of cytokine...
Link:
https://www.sciencedirect.com/science/article/pii/S0006291X19306825
Organism or Cell Type:
cell culture: human MCF10CA1h
Citation Extract:
Tano V, Jans DA, Bogoyevitch MA. Oligonucleotide-directed STAT3 alternative splicing switch drives anti-tumorigenic outcomes in MCF10 human breast cancer cells. Biochem Biophys Res Commun. 2019 Apr 19. pii: S0006-291X(19)30682-5. doi: 10.1016/j.bbrc.2019.04.054. [Epub ahead of print].

Manipulation of Gene Function in Mexican Cavefish

Authors:
Stahl BA, Jaggard JB, Chin JS, Kowalko JE, Keene AC, Duboué ER
Citation:
J Vis Exp. 2019;146:e59093, doi:10.3791/59093
Epub:
Not Epub
Abstract:
Cave animals provide a compelling system for investigating the evolutionary mechanisms and genetic bases underlying changes in...
Link:
https://www.jove.com/video/59093/manipulation-of-gene-function-in-mexican-cavefish
Delivery Method:
microinjection
Organism or Cell Type:
Astyanax mexicanus (Mexican cavefish)
Citation Extract:
Stahl BA, Jaggard JB, Chin JS, Kowalko JE, Keene AC, Duboué ER. Manipulation of Gene Function in Mexican Cavefish. J Vis Exp. 2019;146:e59093, doi:10.3791/59093.

Prostaglandin signaling regulates renal multiciliated cell specification and maturation

Authors:
Marra AN, Adeeb BD, Chambers BE, Drummond BE, Ulrich M, Addiego A, Springer M, Poureetezadi SJ, Chambers JM, Ronshaugen M, Wingert RA
Citation:
Proc Natl Acad Sci U S A. 2019 Apr 4. pii: 201813492. doi: 10.1073/pnas.1813492116. [Epub ahead of print]
Epub:
Yes
Abstract:
Multiciliated cells (MCCs) are specialized epithelia with apical bundles of motile cilia that direct fluid flow. MCC...
Link:
https://www.pnas.org/content/116/17/8409.abstract
Delivery Method:
microinjection
Organism or Cell Type:
zebrafish
Citation Extract:
Marra AN, Adeeb BD, Chambers BE, Drummond BE, Ulrich M, Addiego A, Springer M, Poureetezadi SJ, Chambers JM, Ronshaugen M, Wingert RA. Prostaglandin signaling regulates renal multiciliated cell specification and maturation. Proc Natl Acad Sci U S A. 2019 Apr 4. pii: 201813492. doi: 10.1073/pnas.1813492116. [Epub ahead of print].

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