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Morpholino Publication Database

This database contains citations and abstracts for research using Morpholino oligos, as well as some review articles incorporating Morpholino data. You can search the content using the filter boxes below.

There are 12371 scientific papers returned from the database with the search filters currently being used below.

Drug-free macromolecular therapeutics induce apoptosis in cells isolated from patients with B cell malignancies with enhanced apoptosis induction by pretreatment with gemcitabine

Authors:
Wang J, Li L, Yang J, Clair PM, Glenn MJ, Stephens DM, Christopher Radford D, Kosak KM, Deininger MW, Shami PJ, Kopeček J
Citation:
Nanomedicine. 2019 Jan 9. pii: S1549-9634(19)30004-8. doi: 10.1016/j.nano.2018.12.011. [Epub ahead of print]
Epub:
Yes
Abstract:
Drug-free macromolecular therapeutics (DFMT) is a new paradigm for the treatment of B cell malignancies. Apoptosis is initiated...
Link:
https://www.sciencedirect.com/science/article/pii/S1549963419300048
Organism or Cell Type:
cell culture: primary cultures from B-cell malignancies
Citation Extract:
Wang J, Li L, Yang J, Clair PM, Glenn MJ, Stephens DM, Christopher Radford D, Kosak KM, Deininger MW, Shami PJ, Kopeček J. Drug-free macromolecular therapeutics induce apoptosis in cells isolated from patients with B cell malignancies with enhanced apoptosis induction by pretreatment with gemcitabine. Nanomedicine. 2019 Jan 9. pii: S1549-9634(19)30004-8. doi: 10.1016/j.nano.2018.12.011. [Epub ahead of print].

A Heterologous Model of Thrombospondin Type 1 Domain-Containing 7A-Associated Membranous Nephropathy

Authors:
Tomas NM, Meyer-Schwesinger C, von Spiegel H, Kotb AM, Zahner G, Hoxha E, Helmchen U, Endlich N, Koch-Nolte F, Stahl RAK
Citation:
J Am Soc Nephrol. 2017 Nov;28(11):3262-3277. doi: 10.1681/ASN.2017010030. Epub 2017 Aug 16
Epub:
Not Epub
Abstract:
Thrombospondin type 1 domain-containing 7A (THSD7A) is a target for autoimmunity in patients with membranous nephropathy (MN)....
Link:
https://jasn.asnjournals.org/content/early/2017/08/16/ASN.2017010030
Delivery Method:
microinjection
Organism or Cell Type:
zebrafish
Citation Extract:
Tomas NM, Meyer-Schwesinger C, von Spiegel H, Kotb AM, Zahner G, Hoxha E, Helmchen U, Endlich N, Koch-Nolte F, Stahl RAK. A Heterologous Model of Thrombospondin Type 1 Domain-Containing 7A-Associated Membranous Nephropathy. J Am Soc Nephrol. 2017 Nov;28(11):3262-3277. doi: 10.1681/ASN.2017010030. Epub 2017 Aug 16.

Focal adhesions are essential to drive zebrafish heart valve morphogenesis

Authors:
Gunawan F, Gentile A, Fukuda R, Tsedeke AT, Jiménez-Amilburu V, Ramadass R, Iida A, Sehara-Fujisawa A, Stainier DYR
Citation:
J Cell Biol. 2019 Jan 11. pii: jcb.201807175. doi: 10.1083/jcb.201807175. [Epub ahead of print]
Epub:
Yes
Abstract:
Elucidating the morphogenetic events that shape vertebrate heart valves, complex structures that prevent retrograde blood flow...
Link:
http://jcb.rupress.org/content/early/2019/01/11/jcb.201807175
Delivery Method:
microinjection
Organism or Cell Type:
zebrafish
Citation Extract:
Gunawan F, Gentile A, Fukuda R, Tsedeke AT, Jiménez-Amilburu V, Ramadass R, Iida A, Sehara-Fujisawa A, Stainier DYR. Focal adhesions are essential to drive zebrafish heart valve morphogenesis. J Cell Biol. 2019 Jan 11. pii: jcb.201807175. doi: 10.1083/jcb.201807175. [Epub ahead of print].

DYRK1A-related intellectual disability: a syndrome associated with congenital anomalies of the kidney and urinary tract

Authors:
Blackburn A, Bekheirnia N, Uma VC, Rosenfeld JA, Bainbridge MN, Yang Y, Liu P, Madan-Khetarpal S, Delgado MR, Hudgins L, Ian Krantz I, Rodriguez-Buritica D, Wheeler PG, Al Gazali L, Al Shamsi AMSM, Gomez-Ospina N, Chao H-T, Mirzaa GM, Scheuerle AE, Kukolich MK, Scaglia F, Eng C, Braun MC, Lamb DJ, Miller RK, Bekheirnia MR
Citation:
bioRxiv. 2019;[Preprint] doi:10.1101/516856
Epub:
Not Epub
Abstract:
Purpose: Haploinsufficiency of DYRK1A causes a recognizable clinical syndrome. The goal of this paper is to investigate...
Link:
https://www.biorxiv.org/content/early/2019/01/10/516856
Delivery Method:
microinjection
Organism or Cell Type:
Xenopus laevis
Citation Extract:
Blackburn A, Bekheirnia N, Uma VC, Rosenfeld JA, Bainbridge MN, Yang Y, Liu P, Madan-Khetarpal S, Delgado MR, Hudgins L, Ian Krantz I, Rodriguez-Buritica D, Wheeler PG, Al Gazali L, Al Shamsi AMSM, Gomez-Ospina N, Chao H-T, Mirzaa GM, Scheuerle AE, Kukolich MK, Scaglia F, Eng C, Braun MC, Lamb DJ, Miller RK, Bekheirnia MR. DYRK1A-related intellectual disability: a syndrome associated with congenital anomalies of the kidney and urinary tract. bioRxiv. 2019;[Preprint] doi:10.1101/516856.

Xenopus slc7a5 is essential for notochord function and eye development

Authors:
Katada T, Sakurai H
Citation:
Mech Dev. 2019 Jan 6. pii: S0925-4773(18)30135-7. doi: 10.1016/j.mod.2019.01.001. [Epub ahead of print]
Epub:
Yes
Abstract:
slc7a5 (also known as LAT1), largely accepted as an amino acid transporter, has been shown to play important roles in cancer...
Link:
https://www.sciencedirect.com/science/article/pii/S0925477318301357
Organism or Cell Type:
Xenopus laevis
Citation Extract:
Katada T, Sakurai H. Xenopus slc7a5 is essential for notochord function and eye development. Mech Dev. 2019 Jan 6. pii: S0925-4773(18)30135-7. doi: 10.1016/j.mod.2019.01.001. [Epub ahead of print].

Partial uniparental isodisomy of chromosome 16 unmasks a deleterious biallelic mutation in IFT140 that causes Mainzer-Saldino syndrome

Authors:
Helm BM, Willer JR, Sadeghpour A, Golzio C, Crouch E, Vergano SS, Katsanis N, Davis EE
Citation:
Hum Genomics. 2017 Jul 19;11(1):16. doi: 10.1186/s40246-017-0111-9
Epub:
Not Epub
Abstract:
BACKGROUND: The ciliopathies represent an umbrella group of >50 clinical entities that share both clinical features and...
Link:
https://humgenomics.biomedcentral.com/articles/10.1186/s40246-017-0111-9
Delivery Method:
microinjection
Organism or Cell Type:
zebrafish
Citation Extract:
Helm BM, Willer JR, Sadeghpour A, Golzio C, Crouch E, Vergano SS, Katsanis N, Davis EE. Partial uniparental isodisomy of chromosome 16 unmasks a deleterious biallelic mutation in IFT140 that causes Mainzer-Saldino syndrome. Hum Genomics. 2017 Jul 19;11(1):16. doi: 10.1186/s40246-017-0111-9.

The Role of the Wnt/PCP Formin Daam1 in Renal Ciliogenesis

Authors:
Corkins ME, Krneta-Stankic V, Kloc M, McCrea PD, Gladden AB, Miller RK
Citation:
bioRxiv. 2019;[Preprint] doi:10.1101/512533
Epub:
Not Epub
Abstract:
Kidneys are composed of numerous ciliated epithelial tubules called nephrons. Each nephron functions to reabsorb nutrients and...
Link:
https://www.biorxiv.org/content/early/2019/01/04/512533
Delivery Method:
microinjection
Organism or Cell Type:
Xenopus
Citation Extract:
Corkins ME, Krneta-Stankic V, Kloc M, McCrea PD, Gladden AB, Miller RK. The Role of the Wnt/PCP Formin Daam1 in Renal Ciliogenesis. bioRxiv. 2019;[Preprint] doi:10.1101/512533 .

Dual regulation of lin28a by Myc is necessary during zebrafish retina regeneration

Authors:
Mitra S, Sharma P, Kaur S, Khursheed MA, Gupta S, Chaudhary M, Kurup AJ, Ramachandran R
Citation:
J Cell Biol. 2019 Jan 3. pii: jcb.201802113. doi: 10.1083/jcb.201802113. [Epub ahead of print]
Epub:
Yes
Abstract:
Cellular reprogramming leading to induction of Muller glia-derived progenitor cells (MGPCs) with stem cell characteristics is...
Link:
http://jcb.rupress.org/content/early/2019/01/03/jcb.201802113
Delivery Method:
injection and electroporation
Organism or Cell Type:
zebrafish
Citation Extract:
Mitra S, Sharma P, Kaur S, Khursheed MA, Gupta S, Chaudhary M, Kurup AJ, Ramachandran R. Dual regulation of lin28a by Myc is necessary during zebrafish retina regeneration. J Cell Biol. 2019 Jan 3. pii: jcb.201802113. doi: 10.1083/jcb.201802113. [Epub ahead of print].

Methods of Calpain Inhibition to Determine the Role of Calpains in Embryo Development in Amphibians

Authors:
Antoniades I, Charalambous A, Christodoulou N, Zanardelli S, Skourides PA
Citation:
Methods Mol Biol. 2019;1915:249-259. doi: 10.1007/978-1-4939-8988-1_19
Epub:
Not Epub
Abstract:
Calpains are a family of calcium-dependent intracellular cysteine proteases that regulate important physiological processes by...
Link:
https://link.springer.com/protocol/10.1007%2F978-1-4939-8988-1_19
Organism or Cell Type:
Xenopus laevis
Citation Extract:
Antoniades I, Charalambous A, Christodoulou N, Zanardelli S, Skourides PA. Methods of Calpain Inhibition to Determine the Role of Calpains in Embryo Development in Amphibians. Methods Mol Biol. 2019;1915:249-259. doi: 10.1007/978-1-4939-8988-1_19.

Arid3a regulates nephric tubule regeneration via evolutionarily conserved regeneration signal-response enhancers

Authors:
Suzuki N, Hirano K, Ogino H, Ochi H
Citation:
eLife. 2019;8:e43186 doi:10.7554/eLife.43186
Epub:
Not Epub
Abstract:
Amphibians and fish have the ability to regenerate numerous tissues, whereas mammals have a limited regenerative capacity....
Link:
https://elifesciences.org/articles/43186
Delivery Method:
microinjection
Organism or Cell Type:
Xenopus laevis
Citation Extract:
Suzuki N, Hirano K, Ogino H, Ochi H. Arid3a regulates nephric tubule regeneration via evolutionarily conserved regeneration signal-response enhancers. eLife. 2019;8:e43186 doi:10.7554/eLife.43186.

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