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Morpholino Publication Database

This database contains citations and abstracts for research using Morpholino oligos, as well as some review articles incorporating Morpholino data. You can search the content using the filter boxes below.

There are 12390 scientific papers returned from the database with the search filters currently being used below.

Knockdown of type 3 iodothyronine deiodinase severely perturbs both embryonic and early larval development in zebrafish

Authors:
Heijlen M, Houbrechts AM, Bagci E, Van Herck SL, Kersseboom S, Esguerra CV, Blust R, Visser TJ, Knapen D, Darras VM
Citation:
Endocrinology. 2014 Jan 27:en20131660. [Epub ahead of print]
Epub:
Not Epub
Abstract:
Exposure to appropriate levels of thyroid hormones (THs) at the right time is of key importance for normal development in all...
Delivery Method:
microinjection
Organism or Cell Type:
zebrafish
Citation Extract:
Heijlen M, Houbrechts AM, Bagci E, Van Herck SL, Kersseboom S, Esguerra CV, Blust R, Visser TJ, Knapen D, Darras VM. Knockdown of type 3 iodothyronine deiodinase severely perturbs both embryonic and early larval development in zebrafish. Endocrinology. 2014 Jan 27:en20131660. [Epub ahead of print].

Plakophilin-3 Catenin Associates with the ETV1/ER81 Transcription Factor to Positively Modulate Gene Activity

Authors:
Munoz WA, Lee M, Miller RK, Ahmed Z, Ji H, Link TM, Lee GR, Kloc M, Ladbury JE, McCrea PD
Citation:
PLoS ONE. 2014;9(1):e86784. doi:10.1371/journal.pone.0086784
Epub:
Not Epub
Abstract:
Members of the plakophilin-catenin sub-family (Pkp-1, -2, and -3) facilitate the linkage of desmosome junctional components to...
Delivery Method:
microinjection
Organism or Cell Type:
Xenopus laevis
Citation Extract:
Munoz WA, Lee M, Miller RK, Ahmed Z, Ji H, Link TM, Lee GR, Kloc M, Ladbury JE, McCrea PD. Plakophilin-3 Catenin Associates with the ETV1/ER81 Transcription Factor to Positively Modulate Gene Activity. PLoS ONE. 2014;9(1):e86784. doi:10.1371/journal.pone.0086784.

The function of DrPax1b gene in the embryonic development of zebrafish

Authors:
Liu X, Wang H, Li G, Huang HZ, Wang YQ
Citation:
Genes Genet Syst. 2013;88(4):261-9
Epub:
Not Epub
Abstract:
Vertebrate Pax1 gene is a member of Pax gene family and encodes a transcription factor associated with crucial roles in the...
Delivery Method:
microinjection
Organism or Cell Type:
zebrafish
Citation Extract:
Liu X, Wang H, Li G, Huang HZ, Wang YQ. The function of DrPax1b gene in the embryonic development of zebrafish. Genes Genet Syst. 2013;88(4):261-9.

Vascular endothelial growth factor signaling regulates the segregation of artery and vein via ERK activity during vascular development

Authors:
Kim SH, Schmitt CE, Woolls MJ, Holland MB, Kim JD, Jin SW
Citation:
Biochem Biophys Res Commun. 2013 Jan 25;430(4):1212-6. doi: 10.1016/j.bbrc.2012.12.076. Epub 2012 Dec 22
Epub:
Not Epub
Abstract:
Segregation of two axial vessels, the dorsal aorta and caudal vein, is one of the earliest patterning events occur during...
Delivery Method:
microinjection
Organism or Cell Type:
zebrafish
Citation Extract:
Kim SH, Schmitt CE, Woolls MJ, Holland MB, Kim JD, Jin SW. Vascular endothelial growth factor signaling regulates the segregation of artery and vein via ERK activity during vascular development. Biochem Biophys Res Commun. 2013 Jan 25;430(4):1212-6. doi: 10.1016/j.bbrc.2012.12.076. Epub 2012 Dec 22.

Essential role of AWP1 in neural crest specification in Xenopus

Authors:
Seo J-H, Park D-S, Hong M, Chang E-J, Choi S-C
Citation:
Int J Dev Biol. 2014;[Epub ahead of print] doi:10.1387/ijdb.130109sc
Epub:
Yes
Abstract:
The neural crest (NC) comprises a transient and multipotent embryonic cell population, which gives rise to a wide variety of...
Delivery Method:
microinjection
Organism or Cell Type:
Xenopus laevis
Citation Extract:
Seo J-H, Park D-S, Hong M, Chang E-J, Choi S-C. Essential role of AWP1 in neural crest specification in Xenopus. Int J Dev Biol. 2014;[Epub ahead of print] doi:10.1387/ijdb.130109sc.

Novel Ex Vivo Culture Method for the Study of Dupuytren's Disease: Effects of TGFβ Type 1 Receptor Modulation by Antisense Oligonucleotides

Authors:
Karkampouna S, Kruithof BP, Kloen P, Obdeijn MC, van der Laan AM, Tanke HJ, Kemaladewi DU, Hoogaars WM, 't Hoen PA, Aartsma-Rus A, Clark IM, Ten Dijke P, Goumans MJ, Kruithof-de Julio M
Citation:
Mol Ther Nucleic Acids. 2014 Jan 21;3:e142. doi: 10.1038/mtna.2013.69
Epub:
Not Epub
Abstract:
Dupuytren's disease (DD) is a benign fibroproliferative disease of the hand. It is characterized by the excessive...
Delivery Method:
Vivo-Morpholino
Organism or Cell Type:
Human explant cultures
Citation Extract:
Karkampouna S, Kruithof BP, Kloen P, Obdeijn MC, van der Laan AM, Tanke HJ, Kemaladewi DU, Hoogaars WM, 't Hoen PA, Aartsma-Rus A, Clark IM, Ten Dijke P, Goumans MJ, Kruithof-de Julio M. Novel Ex Vivo Culture Method for the Study of Dupuytren's Disease: Effects of TGFβ Type 1 Receptor Modulation by Antisense Oligonucleotides. Mol Ther Nucleic Acids. 2014 Jan 21;3:e142. doi: 10.1038/mtna.2013.69.

Essential role of SH3-domain GRB2-like 3 for vascular lumen maintenance in zebrafish

Authors:
Zhao Y, Lin S
Citation:
Arterioscler Thromb Vasc Biol. 2013 Jun;33(6):1280-6. doi: 10.1161/ATVBAHA.112.301025. Epub 2013 Mar 28
Epub:
Not Epub
Abstract:
OBJECTIVE: Studying the underlying molecular mechanisms for maintaining stereotyped vascular lumen diameters should help toward...
Delivery Method:
microinjection
Organism or Cell Type:
zebrafish
Citation Extract:
Zhao Y, Lin S. Essential role of SH3-domain GRB2-like 3 for vascular lumen maintenance in zebrafish. Arterioscler Thromb Vasc Biol. 2013 Jun;33(6):1280-6. doi: 10.1161/ATVBAHA.112.301025. Epub 2013 Mar 28.

Molecular cloning and knockdown of galactocerebrosidase in zebrafish: New insights into the pathogenesis of Krabbe’s disease

Authors:
Zizioli D, Guarienti M, Tobia C, Gariano G, Borsani G, Bresciani R, Ronca R, Giacopuzzi E, Preti A, Gaudenzi G, Belleri M, Di Salle E, Fabrias G, Casas J, Ribatti D, Monti E, Presta M
Citation:
Biochim Biophys Acta. 2014;[Epub ahead of print] http://dx.doi.org/10.1016/j.bbadis.2014.01.008
Epub:
Yes
Abstract:
The lysosomal hydrolase galactocerebrosidase (GALC) catalyzes the removal of galactose from galactosylceramide and from other...
Delivery Method:
microinjection
Organism or Cell Type:
zebrafish
Citation Extract:
Zizioli D, Guarienti M, Tobia C, Gariano G, Borsani G, Bresciani R, Ronca R, Giacopuzzi E, Preti A, Gaudenzi G, Belleri M, Di Salle E, Fabrias G, Casas J, Ribatti D, Monti E, Presta M. Molecular cloning and knockdown of galactocerebrosidase in zebrafish: New insights into the pathogenesis of Krabbe’s disease. Biochim Biophys Acta. 2014;[Epub ahead of print] http://dx.doi.org/10.1016/j.bbadis.2014.01.008.

Expression and Functional Characterization of Smyd1a in Myofibril Organization of Skeletal Muscles

Authors:
Gao J, Li J, Li B-J, Yagil E, Zhang J, Du SJ
Citation:
PLoS ONE. 2014;9(1): e86808. doi:10.1371/journal.pone.0086808
Epub:
Not Epub
Abstract:
Background: Smyd1, the founding member of the Smyd family including Smyd-1, 2, 3, 4 and 5, is a SET and MYND domain containing...
Delivery Method:
microinjection
Organism or Cell Type:
zebrafish
Citation Extract:
Gao J, Li J, Li B-J, Yagil E, Zhang J, Du SJ. Expression and Functional Characterization of Smyd1a in Myofibril Organization of Skeletal Muscles. PLoS ONE. 2014;9(1): e86808. doi:10.1371/journal.pone.0086808.

Interplay between pre-mRNA splicing and microRNA biogenesis within the supraspliceosome

Authors:
Agranat-Tamir L, Shomron N, Sperling J, Sperling R
Citation:
Nucl Acids Res. 2014;[Epub ahead of print] doi:10.1093/nar/gkt1413
Epub:
Yes
Abstract:
MicroRNAs (miRNAs) are central regulators of gene expression, and a large fraction of them are encoded in introns of RNA...
Delivery Method:
Endo-Porter
Organism or Cell Type:
cell culture: HeLa
Citation Extract:
Agranat-Tamir L, Shomron N, Sperling J, Sperling R. Interplay between pre-mRNA splicing and microRNA biogenesis within the supraspliceosome. Nucl Acids Res. 2014;[Epub ahead of print] doi:10.1093/nar/gkt1413 .

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