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Morpholino Publication Database
This database contains citations and abstracts for research using Morpholino oligos, as well as some review articles incorporating Morpholino data. You can search the content using the filter boxes below.
There are 12176 scientific papers returned from the database with the search filters currently being used below.
There are 12176 scientific papers returned from the database with the search filters currently being used below.
RNA splicing is a key mediator of tumour cell plasticity and a therapeutic vulnerability in colorectal cancer
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Citation:
Nat Commun. 2022 May 19;13(1):2791. doi: 10.1038/s41467-022-30489-z Epub:
Not Epub Abstract:
Tumour cell plasticity is a major barrier to the efficacy of targeted cancer therapies but the mechanisms that mediate it are... Delivery Method:
Vivo-Morpholino Organism or Cell Type:
mouse intestine cells Citation Extract: Hall AE, Pohl SÖ, Cammareri P, Aitken S, Younger NT, Raponi M, Billard CV, Carrancio AB, Bastem A, Freile P, Haward F, Adams IR, Caceres JF, Preyzner P, von Kriegsheim A, Dunlop MG, Din FV, Myant KB. RNA splicing is a key mediator of tumour cell plasticity and a therapeutic vulnerability in colorectal cancer. Nat Commun. 2022 May 19;13(1):2791. doi: 10.1038/s41467-022-30489-z. |
Cachd1 interacts with Wnt receptors and regulates neuronal asymmetry in the zebrafish brain
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Citation:
Science. 2024 May 3;384(6695):573-579. doi: 10.1126/science.ade6970. Epub 2024 May 2. PMID: 38696577; PMCID: PMC7615972 Epub:
Not Epub Abstract:
Neurons on the left and right sides of the nervous system often show asymmetric properties, but how such differences arise is... Delivery Method:
microinjection Organism or Cell Type:
zebrafish Citation Extract: Powell GT, Faro A, Zhao Y, Stickney H, Novellasdemunt L, Henriques P, Gestri G, Redhouse White E, Ren J, Lu W, Young RM, Hawkins TA, Cavodeassi F, Schwarz Q, Dreosti E, Raible DW, Li VSW, Wright GJ, Jones EY, Wilson SW. Cachd1 interacts with Wnt receptors and regulates neuronal asymmetry in the zebrafish brain. Science. 2024 May 3;384(6695):573-579. doi: 10.1126/science.ade6970. Epub 2024 May 2. PMID: 38696577; PMCID: PMC7615972. |
Peripheral NOD-like receptor deficient inflammatory macrophages trigger neutrophil infiltration into the brain disrupting daytime locomotion
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Citation:
Commun Biol. 2022 May 16;5(1):464. doi: 10.1038/s42003-022-03410-z Epub:
Not Epub Abstract:
Inflammation is known to disrupt normal behavior, yet the underlying neuroimmune interactions remain elusive. Here, we... Delivery Method:
microinjection Organism or Cell Type:
zebrafish Citation Extract: Kwon V, Cai P, Dixon CT, Hamlin V, Spencer CG, Rojas AM, Hamilton M, Shiau CE. Peripheral NOD-like receptor deficient inflammatory macrophages trigger neutrophil infiltration into the brain disrupting daytime locomotion. Commun Biol. 2022 May 16;5(1):464. doi: 10.1038/s42003-022-03410-z. |
The Cytoskeletal Protein Zyxin Inhibits Retinoic Acid Signaling by Destabilizing the Maternal mRNA of the RXRγ Nuclear Receptor
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Citation:
Inter J Mol Sci. 2022;23(10):5627. doi:10.3390/ijms23105627 Epub:
Not Epub Abstract:
Zyxin is an LIM-domain-containing protein that regulates the assembly of F-actin filaments in cell contacts. Additionally, as a... Delivery Method:
microinjection Organism or Cell Type:
Xenopus laevis Citation Extract: Parshina EA, Orlov EE, Zaraisky AG, Martynova NY. The Cytoskeletal Protein Zyxin Inhibits Retinoic Acid Signaling by Destabilizing the Maternal mRNA of the RXRγ Nuclear Receptor. Inter J Mol Sci. 2022;23(10):5627. doi:10.3390/ijms23105627. |
Transmembrane Protein 184A and Syndecan-4 function in the same pathway to promote angiogenesis
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Citation:
FASEB J. 2022;[Epub] doi:10.1096/fasebj.2022.36.S1.L8077 Epub:
Not Epub Abstract:
Morpholino (MO) knockdown (KD) of the novel vascular heparin receptor, Transmembrane protein 184A (TMEM184A), increases... Delivery Method:
injection Organism or Cell Type:
zebrafish Citation Extract: Altenburg LM, O'Toole RA, Ciabattoni GO, Papov IV, Pasch LM, Maslonka BE, Lowe-Krentz LJ. Transmembrane Protein 184A and Syndecan-4 function in the same pathway to promote angiogenesis. FASEB J. 2022;[Epub] doi:10.1096/fasebj.2022.36.S1.L8077. |
microRNA-34a modulates the senescence of activated hepatic stellate cells in alcohol-associated liver injury
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Citation:
FASEB J. 2022;[Epub] doi:10.1096/fasebj.2022.36.S1.R4231 Epub:
Not Epub Abstract:
Background: Reversion of activated hepatic stellate cells (HSCs) to quiescence is likely to be a promising pathway in liver... Organism or Cell Type:
mice Citation Extract: Slevin E, Wan Y, Harrison K, Zhang Y, Li X, Li T, Lorenzo SR, Xu W, Klaunig JE, Shetty AK, Meng F. microRNA-34a modulates the senescence of activated hepatic stellate cells in alcohol-associated liver injury. FASEB J. 2022;[Epub] doi:10.1096/fasebj.2022.36.S1.R4231. |
Casimersen for the treatment of Duchenne muscular dystrophy
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Citation:
Trends Pharmacol Sci. 2022 May 14:S0165-6147(22)00089-X. doi: 10.1016/j.tips.2022.04.009. Online ahead of print Epub:
Not Epub Abstract:
Casimersen is a single-stranded, antisense phosphorodiamidate morpholino oligonucleotide where six-membered morpholino rings... Citation Extract: Zakeri SE, Pradeep SP, Kasina V, Laddha AP, Manautou JE, Bahal R. Casimersen for the treatment of Duchenne muscular dystrophy. Trends Pharmacol Sci. 2022 May 14:S0165-6147(22)00089-X. doi: 10.1016/j.tips.2022.04.009. Online ahead of print. |
SRSF3-mediated regulation of N6-methyladenosine modification-related lncRNA ANRIL splicing promotes resistance of pancreatic cancer to gemcitabine
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Citation:
Cell Rep. 2022 May 10;39(6):110813. doi: 10.1016/j.celrep.2022.110813 Epub:
Not Epub Abstract:
Serine/arginine-rich splicing factor 3 (SRSF3) regulates mRNA alternative splicing of more than 90% of protein-coding genes,... Organism or Cell Type:
cell culture: human pancreatic cancer Panc1 and BXPC3 Citation Extract: Wang ZW, Pan JJ, Hu JF, Zhang JQ, Huang L, Huang Y, Liao CY, Yang C, Chen ZW, Wang YD, Shen BY, Tian YF, Chen S. SRSF3-mediated regulation of N6-methyladenosine modification-related lncRNA ANRIL splicing promotes resistance of pancreatic cancer to gemcitabine. Cell Rep. 2022 May 10;39(6):110813. doi: 10.1016/j.celrep.2022.110813. |
The glutathione degrading enzyme, Chac1, is required for calcium signaling in developing zebrafish: redox as an upstream activator of calcium
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Citation:
Biochem J. 2019;476(13):1857-73 Epub:
Not Epub Abstract:
Calcium signaling is essential for embryonic development but the signals upstream of calcium are only partially understood.... Delivery Method:
microinjection Organism or Cell Type:
zebrafish Citation Extract: Yadav S, Chawla B, Khursheed MA, Ramachandran R, Bachhawat AK. The glutathione degrading enzyme, Chac1, is required for calcium signaling in developing zebrafish: redox as an upstream activator of calcium. Biochem J. 2019;476(13):1857-73. |
A Founder Mutation in EHD1 Presents with Tubular Proteinuria and Deafness
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Citation:
J Am Soc Nephrol. 2022 Apr;33(4):732-745. doi:10.1681/ASN.2021101312. Epub 2022 Feb 11 Epub:
Not Epub Abstract:
Background: The endocytic reabsorption of proteins in the proximal tubule requires a complex machinery and defects can lead to... Delivery Method:
microinjection Organism or Cell Type:
zebrafish Citation Extract: Issler N, Afonso S, Weissman I, Jordan K, Cebrian-Serrano A, Meindl K, Dahlke E, Tziridis K, Yan G, Robles-López JM, Tabernero L, Patel V, Kesselheim A, Klootwijk ED, Stanescu HC, Dumitriu S, Iancu D, Tekman M, Mozere M, Jaureguiberry G, Outtandy P, Russell C, Forst AL, Sterner C, Heinl ES, Othmen H, Tegtmeier I, Reichold M, Schiessl IM, Limm K, Oefner P, Witzgall R, Fu L, Theilig F, Schilling A, Shuster Biton E, Kalfon L, Fedida A, Arnon-Sheleg E, Ben Izhak O, Magen D, Anikster Y, Schulze H, Ziegler C, Lowe M, Davies B, Böckenhauer D, Kleta R, Falik Zaccai TC, Warth R. A Founder Mutation in EHD1 Presents with Tubular Proteinuria and Deafness. J Am Soc Nephrol. 2022 Apr;33(4):732-745. doi:10.1681/ASN.2021101312. Epub 2022 Feb 11. |