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Morpholino Publication Database
This database contains citations and abstracts for research using Morpholino oligos, as well as some review articles incorporating Morpholino data. You can search the content using the filter boxes below.
There are 12176 scientific papers returned from the database with the search filters currently being used below.
There are 12176 scientific papers returned from the database with the search filters currently being used below.
Targeting the ERG oncogene with splice-switching oligonucleotides as a novel therapeutic strategy in prostate cancer
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Citation:
Br J Cancer. 2020;[Epub ahead of print]doi:10.1038/s41416-020-0951-2. Online ahead of print Epub:
Yes Abstract:
Background: The ERG oncogene, a member of the ETS family of transcription factor encoding genes, is a genetic driver of... Delivery Method:
Vivo-Morpholino Endo-Porter Organism or Cell Type:
Cell culture MG63, VCaP; xenograft mice; primary human tumor explant Citation Extract: Li L, Hobson L, Perry L, Clark B, Heavey S, Haider A, Sridhar A, Shaw G, Kelly J, Freeman A, Wilson I, Whitaker H, Nurmemmedov E, Oltean S, Porazinski S, Ladomery M. Targeting the ERG oncogene with splice-switching oligonucleotides as a novel therapeutic strategy in prostate cancer. Br J Cancer. 2020;[Epub ahead of print]doi:10.1038/s41416-020-0951-2. Online ahead of print. |
Notch regulates vascular collagen IV basement membrane through modulation of lysyl hydroxylase 3 trafficking
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Citation:
Angiogenesis. 2021 Nov;24(4):789-805. doi: 10.1007/s10456-021-09791-9. Epub 2021 May 6. Erratum in: Angiogenesis. 2021 Nov;24(4):807. doi: 10.1007/s10456-021-09801-w. PMID: 33956260; PMCID: PMC8487879 Epub:
Not Epub Abstract:
Collagen type IV (Col IV) is a basement membrane protein associated with early blood vessel morphogenesis and is essential for... Delivery Method:
microinjection Organism or Cell Type:
zebrafish Citation Extract: Gross SJ, Webb AM, Peterlin AD, Durrant JR, Judson RJ, Raza Q, Kitajewski JK, Kushner EJ. Notch regulates vascular collagen IV basement membrane through modulation of lysyl hydroxylase 3 trafficking. Angiogenesis. 2021 Nov;24(4):789-805. doi: 10.1007/s10456-021-09791-9. Epub 2021 May 6. Erratum in: Angiogenesis. 2021 Nov;24(4):807. doi: 10.1007/s10456-021-09801-w. PMID: 33956260; PMCID: PMC8487879. |
The mevalonate pathway is a crucial regulator of tendon cell specification
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Citation:
Development. 2020 Jun 24;147(12):dev185389. doi:10.1242/dev.185389. Epub:
Not Epub Abstract:
Tendons and ligaments are crucial components of the musculoskeletal system, yet the pathways specifying these fates remain... Delivery Method:
microinjection Organism or Cell Type:
zebrafish Citation Extract: Chen JW, Niu X, King MJ, Noedl M-T, Tabin CJ, Galloway JL. The mevalonate pathway is a crucial regulator of tendon cell specification. Development. 2020 Jun 24;147(12):dev185389. doi:10.1242/dev.185389. . |
HIRA contributes to zygote formation in mice and is implicated in human 1PN zygote phenotype
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Citation:
Reproduction. 2021 May 10;161(6):697-707. doi: 10.1530/REP-20-0636. PMID: 33835048; PMCID: PMC8188263 Epub:
Not Epub Abstract:
Elucidating the mechanisms underpinning fertilisation is essential to optimising IVF procedures. One of the critical steps... Delivery Method:
microinjection Organism or Cell Type:
mouse oocyte Citation Extract: Smith R, Pickering SJ, Kopakaki A, Thong KJ, Anderson RA, Lin CJ. HIRA contributes to zygote formation in mice and is implicated in human 1PN zygote phenotype. Reproduction. 2021 May 10;161(6):697-707. doi: 10.1530/REP-20-0636. PMID: 33835048; PMCID: PMC8188263. |
The neurodevelopmental disorder risk gene DYRK1A is required for ciliogenesis and control of brain size in Xenopus embryos
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Citation:
Development. 2020 Jun 22;147(21):dev189290. doi: 10.1242/dev.189290 Epub:
Not Epub Abstract:
DYRK1A [dual specificity tyrosine-(Y)-phosphorylation-regulated kinase 1 A] is a high-confidence autism risk gene that encodes... Delivery Method:
microinjection Organism or Cell Type:
Xenopus tropicalis Citation Extract: Willsey HR, Xu Y, Everitt A, Dea J, Exner CRT, Willsey AJ, State MW, Harland RM. The neurodevelopmental disorder risk gene DYRK1A is required for ciliogenesis and control of brain size in Xenopus embryos. Development. 2020 Jun 22;147(21):dev189290. doi: 10.1242/dev.189290. |
SPIN90 associates with mDia1 and the Arp2/3 complex to regulate cortical actin organization
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Citation:
Nat Cell Biol. 2020:[Epub ahead of print] doi:10.1038/s41556-020-0531-y Epub:
Yes Abstract:
Cell shape is controlled by the submembranous cortex, an actomyosin network mainly generated by two actin nucleators: the Arp2/... Delivery Method:
microinjection Organism or Cell Type:
Xenopus Citation Extract: Cao L, Yonis A, Vaghela M, Barriga EH, Chugh P, Smith MB, Maufront J, Lavoie G, Méant A, Ferber E, Bovellan M, Alberts A, Bertin A, Mayor R, Paluch EK, Roux PP, Jégou A, Romet-Lemonne G, Charras G. SPIN90 associates with mDia1 and the Arp2/3 complex to regulate cortical actin organization. Nat Cell Biol. 2020:[Epub ahead of print] doi:10.1038/s41556-020-0531-y. |
Pervasive changes of mRNA splicing in upf1-deficient zebrafish identify rpl10a as a regulator of T cell development
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Citation:
Proc Natl Acad Sci U S A. 2020 Jun 22:201917812 [Epub ahead of print]. doi:10.1073/pnas.1917812117 Epub:
Yes Abstract:
The transcriptome of eukaryotic cells is constantly monitored for errors to avoid the production of undesired protein variants... Delivery Method:
microinjection Organism or Cell Type:
zebrafish Citation Extract: Lawir DF, Sikora K, O'Meara CP, Schorpp M, Boehm T. Pervasive changes of mRNA splicing in upf1-deficient zebrafish identify rpl10a as a regulator of T cell development. Proc Natl Acad Sci U S A. 2020 Jun 22:201917812 [Epub ahead of print]. doi:10.1073/pnas.1917812117. |
Drainage of inflammatory macromolecules from the brain to periphery targets the liver for macrophage infiltration
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Citation:
Elife. 2020 Jul 31;9:e58191. doi: 10.7554/eLife.58191. PMID: 32735214; PMCID: PMC7434444 Epub:
Not Epub Abstract:
Many brain pathologies are associated with liver damage, but a direct link has long remained elusive. Here, we establish a new... Delivery Method:
microinjection Organism or Cell Type:
zebrafish Citation Extract: Yang L, Jiménez JA, Earley AM, Hamlin V, Kwon V, Dixon CT, Shiau CE. Drainage of inflammatory macromolecules from the brain to periphery targets the liver for macrophage infiltration. Elife. 2020 Jul 31;9:e58191. doi: 10.7554/eLife.58191. PMID: 32735214; PMCID: PMC7434444. |
Cell stemness is maintained upon concurrent expression of RB and the mitochondrial ribosomal protein S18-2
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Citation:
Proc Natl Acad Sci U S A. 2020:201922535 [Epub ahead of print] . doi: 10.1073/pnas.1922535117 Epub:
Yes Abstract:
Stemness encompasses the capability of a cell for self-renewal and differentiation. The stem cell maintains a balance between... Delivery Method:
microinjection Organism or Cell Type:
zebrafish Citation Extract: Mushtaq M, Kovalevska L, Darekar S, Abramsson A, Zetterberg H, Kashuba V, Klein G, Arsenian-Henriksson M, Kashuba E. Cell stemness is maintained upon concurrent expression of RB and the mitochondrial ribosomal protein S18-2. Proc Natl Acad Sci U S A. 2020:201922535 [Epub ahead of print] . doi: 10.1073/pnas.1922535117. |
WDR34 mutation from anencephaly patients impaired both SHH and PCP signaling pathways
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Citation:
J Hum Genet. 2020;[Epub ahead of print] doi:10.1038/s10038-020-0793-z Epub:
Yes Abstract:
Neural tube defects (NTDs) are debilitating human congenital abnormalities due to failure of neural tube closure. Sonic... Delivery Method:
microinjection Organism or Cell Type:
zebrafish Citation Extract: Yin H, Peng R, Chen Z, Wang H, Zhang T, Zheng Y. WDR34 mutation from anencephaly patients impaired both SHH and PCP signaling pathways. J Hum Genet. 2020;[Epub ahead of print] doi:10.1038/s10038-020-0793-z. |