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Morpholino Publication Database

This database contains citations and abstracts for research using Morpholino oligos, as well as some review articles incorporating Morpholino data. You can search the content using the filter boxes below.

There are 12176 scientific papers returned from the database with the search filters currently being used below.

Activating transcription factor 3 coordinates differentiation of cardiac and hematopoietic progenitors by regulating glucose metabolism

Authors:
Yin H-M, Yan L-F, Liu Q, Peng Z, Zhang C-Y, Xia Y, Su D, Gu A-H, Zhou Y
Citation:
Sci Adv. 2020;6(19):eaay9466 doi:10.1126/sciadv.aay9466
Epub:
Not Epub
Abstract:
The cardiac and hematopoietic progenitors (CPs and HPs, respectively) in the mesoderm ultimately form a well-organized...
Link:
https://advances.sciencemag.org/content/6/19/eaay9466
Delivery Method:
microinjection
Organism or Cell Type:
zebrafish
Citation Extract:
Yin H-M, Yan L-F, Liu Q, Peng Z, Zhang C-Y, Xia Y, Su D, Gu A-H, Zhou Y. Activating transcription factor 3 coordinates differentiation of cardiac and hematopoietic progenitors by regulating glucose metabolism. Sci Adv. 2020;6(19):eaay9466 doi:10.1126/sciadv.aay9466.

The Rho guanine nucleotide exchange factor Trio is required for neural crest cell migration and interacts with Dishevelled

Authors:
Kratzer MC, Becker SFS, Grund A, Merks A, Harnoš J, Bryja V, Giehl K, Kashef J, Borchers A
Citation:
Development. 2020 May 4. pii: dev.186338. doi: 10.1242/dev.186338. [Epub ahead of print]
Epub:
Yes
Abstract:
Directional migration during embryogenesis and tumor progression faces the challenge that numerous external signals need to...
Link:
https://dev.biologists.org/content/early/2020/05/01/dev.186338.long
Organism or Cell Type:
Xenopus
Citation Extract:
Kratzer MC, Becker SFS, Grund A, Merks A, Harnoš J, Bryja V, Giehl K, Kashef J, Borchers A. The Rho guanine nucleotide exchange factor Trio is required for neural crest cell migration and interacts with Dishevelled. Development. 2020 May 4. pii: dev.186338. doi: 10.1242/dev.186338. [Epub ahead of print].

Rspo2 antagonizes FGF signaling during vertebrate mesoderm formation and patterning

Authors:
Reis AH, Sokol SY
Citation:
Development. 2020;[Epub ahead of print] dev.189324 doi: 10.1242/dev.189324
Epub:
Yes
Abstract:
R-spondins are a family of secreted proteins that play important roles in embryonic development and cancer. R-spondins have...
Link:
https://dev.biologists.org/content/early/2020/05/01/dev.189324
Organism or Cell Type:
Xenopus
Citation Extract:
Reis AH, Sokol SY. Rspo2 antagonizes FGF signaling during vertebrate mesoderm formation and patterning. Development. 2020;[Epub ahead of print] dev.189324 doi: 10.1242/dev.189324.

Design, Optimization, and Study of Small Molecules That Target Tau Pre-mRNA and Affect Splicing

Authors:
Chen JL, Zhang P, Abe M, Aikawa H, Zhang L, Frank AJ, Zembryski T, Hubbs C, Park HJ, Withka J, Steppan C, Rogers L, Cabral S, Pettersson M, Wager TT, Fountain MA, Rumbaugh G, Childs-Disney JL, Disney MD
Citation:
J Am Chem Soc. 2020;[Epub ahead of print] doi:10.1021/jacs.0c00768
Epub:
Yes
Abstract:
Approximately 95% of human genes are alternatively spliced, and aberrant splicing events can cause disease. One pre-mRNA that...
Link:
https://pubs.acs.org/doi/10.1021/jacs.0c00768
Delivery Method:
Vivo-Morpholino
Organism or Cell Type:
cell culture: HeLa
Citation Extract:
Chen JL, Zhang P, Abe M, Aikawa H, Zhang L, Frank AJ, Zembryski T, Hubbs C, Park HJ, Withka J, Steppan C, Rogers L, Cabral S, Pettersson M, Wager TT, Fountain MA, Rumbaugh G, Childs-Disney JL, Disney MD. Design, Optimization, and Study of Small Molecules That Target Tau Pre-mRNA and Affect Splicing. J Am Chem Soc. 2020;[Epub ahead of print] doi:10.1021/jacs.0c00768.

Peptide Conjugated Morpholinos for Management of The Huanglongbing Pathosystem

Authors:
Sandoval-Mojica AF, Altman S, Hunter WB, Pelz-Stelinski KS
Citation:
Pest Manag Sci. 2020 May 1. doi: 10.1002/ps.5877. [Epub ahead of print]
Epub:
Yes
Abstract:
BACKGROUND: 'Candidatus Liberibacter asiaticus' (CLas) is the causal agent of the devastating citrus disease...
Link:
https://onlinelibrary.wiley.com/doi/abs/10.1002/ps.5877
Delivery Method:
peptide-linked
Organism or Cell Type:
Candidatus Liberibacter asiaticus, Wolbachia
Citation Extract:
Sandoval-Mojica AF, Altman S, Hunter WB, Pelz-Stelinski KS. Peptide Conjugated Morpholinos for Management of The Huanglongbing Pathosystem. Pest Manag Sci. 2020 May 1. doi: 10.1002/ps.5877. [Epub ahead of print].

The vertebrate-specific VENTX/NANOG gene empowers neural crest with ectomesenchyme potential

Authors:
Scerbo P, Monsoro-Burq AH
Citation:
Sci Adv. 2020;6(18):eaaz1469. doi:10.1126/sciadv.aaz1469
Epub:
Not Epub
Abstract:
During Cambrian, unipotent progenitors located at the neural (plate) border (NB) of an Olfactoria chordate embryo acquired the...
Link:
https://advances.sciencemag.org/content/6/18/eaaz1469
Delivery Method:
microinjection
Organism or Cell Type:
Xenopus laevis
Citation Extract:
Scerbo P, Monsoro-Burq AH. The vertebrate-specific VENTX/NANOG gene empowers neural crest with ectomesenchyme potential. Sci Adv. 2020;6(18):eaaz1469. doi:10.1126/sciadv.aaz1469 .

miR-103/107 regulates left-right asymmetry in zebrafish by modulating Kupffer's vesicle development and ciliogenesis

Authors:
Heigwer J, Kutzner J, Haeussler M, Burkhalter MD, Draebing T, Juergensen L, Katus HA, Philipp M, Westhoff JH, Hassel D
Citation:
Biochem Biophys Res Commun. 2020 Apr 22. pii: S0006-291X(20)30792-0. doi: 10.1016/j.bbrc.2020.04.066. [Epub ahead of print]
Epub:
Yes
Abstract:
In zebrafish, cilia movement within the Kupffer's vesicle (KV) generates a fluid flow responsible for accumulating nodal...
Link:
https://www.sciencedirect.com/science/article/abs/pii/S0006291X20307920
Delivery Method:
microinjection
Organism or Cell Type:
zebrafish
Citation Extract:
Heigwer J, Kutzner J, Haeussler M, Burkhalter MD, Draebing T, Juergensen L, Katus HA, Philipp M, Westhoff JH, Hassel D. miR-103/107 regulates left-right asymmetry in zebrafish by modulating Kupffer's vesicle development and ciliogenesis. Biochem Biophys Res Commun. 2020 Apr 22. pii: S0006-291X(20)30792-0. doi: 10.1016/j.bbrc.2020.04.066. [Epub ahead of print].

Fgf-driven Tbx protein activities directly induce myf5 and myod to initiate zebrafish myogenesis

Authors:
Osborn DPS, Li K, Cutty SJ, Nelson AC, Wardle FC, Hinits Y, Hughes SM
Citation:
Development. 2020;147(8):[Epub] doi:10.1242/dev.184689
Epub:
Not Epub
Abstract:
Skeletal muscle derives from dorsal mesoderm formed during vertebrate gastrulation. Fibroblast growth factor (Fgf) signalling...
Link:
https://dev.biologists.org/content/147/8/dev184689
Delivery Method:
microinjection
Organism or Cell Type:
zebrafish
Citation Extract:
Osborn DPS, Li K, Cutty SJ, Nelson AC, Wardle FC, Hinits Y, Hughes SM. Fgf-driven Tbx protein activities directly induce myf5 and myod to initiate zebrafish myogenesis. Development. 2020;147(8):[Epub] doi:10.1242/dev.184689.

Practical Synthesis of Quinoline-Protected Morpholino Oligomers for Light-Triggered Regulation of Gene Function

Authors:
Deodato D, Dore TM
Citation:
Molecules. 2020;25(9):2078. doi:10.3390/molecules25092078
Epub:
Not Epub
Abstract:
Photoactivatable cyclic caged morpholino oligomers (ccMOs) represent a promising tool to selectively regulate gene expression...
Link:
https://www.mdpi.com/1420-3049/25/9/2078
Citation Extract:
Deodato D, Dore TM. Practical Synthesis of Quinoline-Protected Morpholino Oligomers for Light-Triggered Regulation of Gene Function. Molecules. 2020;25(9):2078. doi:10.3390/molecules25092078.

A homozygous MRPL24 mutation causes a complex movement disorder and affects the mitoribosome assembly

Authors:
Nottia MD, Marchese M, Verrigni D, Mutti C, Torraco A, Oliva R, Fernandez-Vizarra E, Morani F, Trani G, Rizza T, Ghezzi D, Ardissone A, Nesti C, Vasco G, Zeviani M, Minczuk M, Bertini E, Santorelli FM, Carrozzo R
Citation:
Neurobiol Dis. 2020 Apr 25:104880. doi: 10.1016/j.nbd.2020.104880. [Epub ahead of print]
Epub:
Yes
Abstract:
Mitochondrial ribosomal protein large 24 (MRPL24) is 1 of the 82 protein components of mitochondrial ribosomes, playing an...
Link:
https://www.sciencedirect.com/science/article/pii/S0969996120301558
Delivery Method:
microinjection
Organism or Cell Type:
zebrafish
Citation Extract:
Nottia MD, Marchese M, Verrigni D, Mutti C, Torraco A, Oliva R, Fernandez-Vizarra E, Morani F, Trani G, Rizza T, Ghezzi D, Ardissone A, Nesti C, Vasco G, Zeviani M, Minczuk M, Bertini E, Santorelli FM, Carrozzo R. A homozygous MRPL24 mutation causes a complex movement disorder and affects the mitoribosome assembly. Neurobiol Dis. 2020 Apr 25:104880. doi: 10.1016/j.nbd.2020.104880. [Epub ahead of print].

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