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Morpholino Publication Database

This database contains citations and abstracts for research using Morpholino oligos, as well as some review articles incorporating Morpholino data. You can search the content using the filter boxes below.

There are 12176 scientific papers returned from the database with the search filters currently being used below.

p53 Protects Cells from Death at the Heatstroke Threshold Temperature

Authors:
Gong L, Zhang Q, Pan X, Chen S, Yang L, Liu B, Yang W, Yu L, Xiao ZX, Feng XH, Wang H, Yuan ZM, Peng J, Tan WQ, Chen J
Citation:
Cell Rep. 2019 Dec 10;29(11):3693-3707.e5. doi: 10.1016/j.celrep.2019.11.032
Epub:
Not Epub
Abstract:
When the core body temperature is higher than 40°C, life is threatened due to heatstroke. Tumor repressor p53 is required for...
Link:
https://www.cell.com/cell-reports/fulltext/S2211-1247(19)31514-1
Delivery Method:
microinjection
Organism or Cell Type:
zebrafish
Citation Extract:
Gong L, Zhang Q, Pan X, Chen S, Yang L, Liu B, Yang W, Yu L, Xiao ZX, Feng XH, Wang H, Yuan ZM, Peng J, Tan WQ, Chen J. p53 Protects Cells from Death at the Heatstroke Threshold Temperature. Cell Rep. 2019 Dec 10;29(11):3693-3707.e5. doi: 10.1016/j.celrep.2019.11.032.

On-Site Ribosome Remodeling by Locally Synthesized Ribosomal Proteins in Axons

Authors:
Shigeoka T, Koppers M, Wong HH, Lin JQ, Cagnetta R, Dwivedy A, de Freitas Nascimento J, van Tartwijk FW, Ströhl F, Cioni JM, Schaeffer J, Carrington M, Kaminski CF, Jung H, Harris WA, Holt CE
Citation:
Cell Rep. 2019 Dec 10;29(11):3605-3619.e10. doi: 10.1016/j.celrep.2019.11.025
Epub:
Not Epub
Abstract:
Ribosome assembly occurs mainly in the nucleolus, yet recent studies have revealed robust enrichment and translation of mRNAs...
Link:
https://www.sciencedirect.com/science/article/pii/S2211124719314962
Delivery Method:
NeuroPORTER, microinjeciton, electroporation
Organism or Cell Type:
cell culture: Xenopus cells and explants, Xenopus embryos
Citation Extract:
Shigeoka T, Koppers M, Wong HH, Lin JQ, Cagnetta R, Dwivedy A, de Freitas Nascimento J, van Tartwijk FW, Ströhl F, Cioni JM, Schaeffer J, Carrington M, Kaminski CF, Jung H, Harris WA, Holt CE. On-Site Ribosome Remodeling by Locally Synthesized Ribosomal Proteins in Axons. Cell Rep. 2019 Dec 10;29(11):3605-3619.e10. doi: 10.1016/j.celrep.2019.11.025.

Atg7-Mediated Autophagy Is Involved in the Neural Crest Cell Generation in Chick Embryo

Authors:
Wang G, Chen EN, Liang C, Liang J, Gao LR, Chuai M, Münsterberg A, Bao Y, Cao L, Yang X
Citation:
Mol Neurobiol. 2018 Apr;55(4):3523-3536. doi: 10.1007/s12035-017-0583-6. Epub 2017 May 16
Epub:
Not Epub
Abstract:
Autophagy plays a very important role in numerous physiological and pathological events. However, it still remains unclear...
Link:
https://link.springer.com/article/10.1007%2Fs12035-017-0583-6
Delivery Method:
electroporation
Organism or Cell Type:
Gallus gallus (chick)
Citation Extract:
Wang G, Chen EN, Liang C, Liang J, Gao LR, Chuai M, Münsterberg A, Bao Y, Cao L, Yang X. Atg7-Mediated Autophagy Is Involved in the Neural Crest Cell Generation in Chick Embryo. Mol Neurobiol. 2018 Apr;55(4):3523-3536. doi: 10.1007/s12035-017-0583-6. Epub 2017 May 16.

Hcfc1a regulates neural precursor proliferation and asxl1 expression in the developing brain

Authors:
Castro VL, Reyes JF, Reyes-Nava NG, Paz D, Quintana AM
Citation:
BMC Neurosci. 2020 Jun 10;21(1):27. doi: 10.1186/s12868-020-00577-1. PMID: 32522152; PMCID: PMC7288482
Epub:
Not Epub
Abstract:
Background: Precise regulation of neural precursor cell (NPC) proliferation and differentiation is essential to ensure proper...
Link:
https://link.springer.com/article/10.1186/s12868-020-00577-1
Delivery Method:
microinjection
Organism or Cell Type:
zebrafish
Citation Extract:
Castro VL, Reyes JF, Reyes-Nava NG, Paz D, Quintana AM. Hcfc1a regulates neural precursor proliferation and asxl1 expression in the developing brain. BMC Neurosci. 2020 Jun 10;21(1):27. doi: 10.1186/s12868-020-00577-1. PMID: 32522152; PMCID: PMC7288482.

Hand2 inhibits kidney specification while promoting vein formation within the posterior mesoderm

Authors:
Perens EA, Garavito-Aguilar ZV, Guio-Vega GP, Peña KT, Schindler YL, Yelon D
Citation:
Elife. 2016 Nov 2;5. pii: e19941. doi: 10.7554/eLife.19941
Epub:
Not Epub
Abstract:
Proper organogenesis depends upon defining the precise dimensions of organ progenitor territories. Kidney progenitors originate...
Link:
https://elifesciences.org/articles/19941
Delivery Method:
microinjection
Organism or Cell Type:
zebrafish
Citation Extract:
Perens EA, Garavito-Aguilar ZV, Guio-Vega GP, Peña KT, Schindler YL, Yelon D. Hand2 inhibits kidney specification while promoting vein formation within the posterior mesoderm. Elife. 2016 Nov 2;5. pii: e19941. doi: 10.7554/eLife.19941.

Endosome-Mediated Epithelial Remodeling Downstream of Hedgehog-Gli Is Required for Tracheoesophageal Separation

Authors:
Nasr T, Mancini P, Rankin SA, Edwards NA, Agricola ZN, Kenny AP, Kinney JL, Daniels K, Vardanyan J, Han L, Trisno SL, Cha SW, Wells JM, Kofron MJ, Zorn AM
Citation:
Dev Cell. 2019 Nov 20. pii: S1534-5807(19)30911-6. doi: 10.1016/j.devcel.2019.11.003. [Epub ahead of print]
Epub:
Yes
Abstract:
The trachea and esophagus arise from the separation of a common foregut tube during early fetal development. Mutations in key...
Link:
https://www.sciencedirect.com/science/article/abs/pii/S1534580719309116
Delivery Method:
microinjection
Organism or Cell Type:
Xenopus laevis
Citation Extract:
Nasr T, Mancini P, Rankin SA, Edwards NA, Agricola ZN, Kenny AP, Kinney JL, Daniels K, Vardanyan J, Han L, Trisno SL, Cha SW, Wells JM, Kofron MJ, Zorn AM. Endosome-Mediated Epithelial Remodeling Downstream of Hedgehog-Gli Is Required for Tracheoesophageal Separation. Dev Cell. 2019 Nov 20. pii: S1534-5807(19)30911-6. doi: 10.1016/j.devcel.2019.11.003. [Epub ahead of print].

Isl1 Regulation of Nkx2.1 in the Early Foregut Epithelium Is Required for Trachea-Esophageal Separation and Lung Lobation

Authors:
Kim E, Jiang M, Huang H, Zhang Y, Tjota N, Gao X, Robert J, Gilmore N, Gan L, Que J
Citation:
Dev Cell. 2019 Nov 20. pii: S1534-5807(19)30910-4. doi: 10.1016/j.devcel.2019.11.002. [Epub ahead of print]
Epub:
Yes
Abstract:
The esophagus and trachea arise from the dorsal and ventral aspects of the anterior foregut, respectively. Abnormal trachea-...
Link:
https://www.sciencedirect.com/science/article/abs/pii/S1534580719309104
Organism or Cell Type:
Xenopus laevis
Citation Extract:
Kim E, Jiang M, Huang H, Zhang Y, Tjota N, Gao X, Robert J, Gilmore N, Gan L, Que J. Isl1 Regulation of Nkx2.1 in the Early Foregut Epithelium Is Required for Trachea-Esophageal Separation and Lung Lobation. Dev Cell. 2019 Nov 20. pii: S1534-5807(19)30910-4. doi: 10.1016/j.devcel.2019.11.002. [Epub ahead of print].

The histone methyltransferase KMT2D, mutated in Kabuki syndrome patients, is required for neural crest cell formation and migration

Authors:
Schwenty-Lara J, Nehl D, Borchers A
Citation:
Hum Mol Genet. 2019 Dec 9. pii: ddz284. doi: 10.1093/hmg/ddz284. [Epub ahead of print]
Epub:
Yes
Abstract:
Kabuki syndrome is an autosomal dominant developmental disorder with high similarities to CHARGE syndrome. It is characterized...
Link:
https://academic.oup.com/hmg/advance-article/doi/10.1093/hmg/ddz284/5650456
Delivery Method:
microinjection
Organism or Cell Type:
Xenopus
Citation Extract:
Schwenty-Lara J, Nehl D, Borchers A. The histone methyltransferase KMT2D, mutated in Kabuki syndrome patients, is required for neural crest cell formation and migration. Hum Mol Genet. 2019 Dec 9. pii: ddz284. doi: 10.1093/hmg/ddz284. [Epub ahead of print].

High-throughput custom capture sequencing identifies novel mutations in coloboma-associated genes: Mutation in DNA-binding domain of retinoic acid receptor beta affects nuclear localization causing ocular coloboma

Authors:
Kalaskar VK, Alur RP, Li LK, Thomas JW, Sergeev YV, Blain D, Hufnagel RB, Cogliati T, Brooks BP
Citation:
Hum Mutat. 2019 Dec 9. doi: 10.1002/humu.23954. [Epub ahead of print]
Epub:
Yes
Abstract:
Uveal coloboma is a potentially blinding congenital ocular malformation caused by the failure of optic fissure closure during...
Link:
https://onlinelibrary.wiley.com/doi/full/10.1002/humu.23954
Delivery Method:
microinjection
Organism or Cell Type:
zebrafish
Citation Extract:
Kalaskar VK, Alur RP, Li LK, Thomas JW, Sergeev YV, Blain D, Hufnagel RB, Cogliati T, Brooks BP. High-throughput custom capture sequencing identifies novel mutations in coloboma-associated genes: Mutation in DNA-binding domain of retinoic acid receptor beta affects nuclear localization causing ocular coloboma. Hum Mutat. 2019 Dec 9. doi: 10.1002/humu.23954. [Epub ahead of print].

The master transcription factor SOX2, mutated in anophthalmia/microphthalmia, is post-transcriptionally regulated by the conserved RNA-binding protein RBM24 in vertebrate eye development

Authors:
Dash S, Brastrom LK, Patel SD, Scott CA, Slusarski DC, Lachke SA
Citation:
Hum Mol Genet. 2019 Dec 9. pii: ddz278. doi: 10.1093/hmg/ddz278. [Epub ahead of print]
Epub:
Yes
Abstract:
Mutations in the key transcription factor, SOX2, alone account for 20% of anophthalmia (no eye) and microphthalmia (small eye)...
Link:
https://academic.oup.com/hmg/advance-article-abstract/doi/10.1093/hmg/ddz278/5650469
Organism or Cell Type:
zebrafish
Citation Extract:
Dash S, Brastrom LK, Patel SD, Scott CA, Slusarski DC, Lachke SA. The master transcription factor SOX2, mutated in anophthalmia/microphthalmia, is post-transcriptionally regulated by the conserved RNA-binding protein RBM24 in vertebrate eye development. Hum Mol Genet. 2019 Dec 9. pii: ddz278. doi: 10.1093/hmg/ddz278. [Epub ahead of print].

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