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Morpholino Publication Database

This database contains citations and abstracts for research using Morpholino oligos, as well as some review articles incorporating Morpholino data. You can search the content using the filter boxes below.

There are 12176 scientific papers returned from the database with the search filters currently being used below.

Endoderm-derived islet1-expressing cells differentiate into endothelial cells to function as the vascular HSPC niche in zebrafish

Authors:
Nakajima H, Ishikawa H, Yamamoto T, Chiba A, Fukui H, Sako K, Fukumoto M, Mattonet K, Kwon H-B, Hui SP, Dobreva GD, Kikuchi K, Helker CSM, Stainier DYR, Mochizuki N
Citation:
Dev Cell. 2023;[Epub ahead of print] doi:10.1016/j.devcel.2022.12.013
Epub:
Not Epub
Abstract:
Endothelial cells (ECs) line blood vessels and serve as a niche for hematopoietic stem and progenitor cells (HSPCs). Recent...
Link:
https://www.sciencedirect.com/science/article/pii/S1534580722008954
Delivery Method:
microinjection
Organism or Cell Type:
zebrafish
Citation Extract:
Nakajima H, Ishikawa H, Yamamoto T, Chiba A, Fukui H, Sako K, Fukumoto M, Mattonet K, Kwon H-B, Hui SP, Dobreva GD, Kikuchi K, Helker CSM, Stainier DYR, Mochizuki N. Endoderm-derived islet1-expressing cells differentiate into endothelial cells to function as the vascular HSPC niche in zebrafish. Dev Cell. 2023;[Epub ahead of print] doi:10.1016/j.devcel.2022.12.013.

Wnt4 and ephrinB2 instruct apical constriction via Dishevelled and non-canonical signaling

Authors:
Yoon J, Sun J, Lee M, Hwang YS, Daar IO
Citation:
Nat Commun. 2023 Jan 20;14(1):337. doi: 10.1038/s41467-023-35991-6
Epub:
Not Epub
Abstract:
Apical constriction is a cell shape change critical to vertebrate neural tube closure, and the contractile force required for...
Link:
https://www.nature.com/articles/s41467-023-35991-6
Delivery Method:
microinjection
Organism or Cell Type:
Xenopus laevis
Citation Extract:
Yoon J, Sun J, Lee M, Hwang YS, Daar IO. Wnt4 and ephrinB2 instruct apical constriction via Dishevelled and non-canonical signaling. Nat Commun. 2023 Jan 20;14(1):337. doi: 10.1038/s41467-023-35991-6.

Integrative genetic analysis illuminates ALS heritability and identifies risk genes

Authors:
Megat S, Mora N, Sanogo J, Roman O, Catanese A, Alami NO, Freischmidt A, Mingaj X, De Calbiac H, Muratet F, Dirrig-Grosch S, Dieterle S, Van Bakel N, Müller K, Sieverding K, Weishaupt J, Andersen PM, Weber M, Neuwirth C, Margelisch M, Sommacal A, Van Eijk KR, Veldink JH; Project Mine Als Sequencing Consortium; Lautrette G, Couratier P, Camuzat A, Le Ber I, Grassano M, Chio A, Boeckers T, Ludolph AC, Roselli F, Yilmazer-Hanke D, Millecamps S, Kabashi E, Storkebaum E, Sellier C, Dupuis L
Citation:
Nat Commun. 2023 Jan 20;14(1):342. doi: 10.1038/s41467-022-35724-1
Epub:
Not Epub
Abstract:
Amyotrophic lateral sclerosis (ALS) has substantial heritability, in part shared with fronto-temporal dementia (FTD). We show...
Link:
https://www.nature.com/articles/s41467-022-35724-1
Delivery Method:
microinjection
Organism or Cell Type:
zebrafish
Citation Extract:
Megat S, Mora N, Sanogo J, Roman O, Catanese A, Alami NO, Freischmidt A, Mingaj X, De Calbiac H, Muratet F, Dirrig-Grosch S, Dieterle S, Van Bakel N, Müller K, Sieverding K, Weishaupt J, Andersen PM, Weber M, Neuwirth C, Margelisch M, Sommacal A, Van Eijk KR, Veldink JH; Project Mine Als Sequencing Consortium; Lautrette G, Couratier P, Camuzat A, Le Ber I, Grassano M, Chio A, Boeckers T, Ludolph AC, Roselli F, Yilmazer-Hanke D, Millecamps S, Kabashi E, Storkebaum E, Sellier C, Dupuis L. Integrative genetic analysis illuminates ALS heritability and identifies risk genes. Nat Commun. 2023 Jan 20;14(1):342. doi: 10.1038/s41467-022-35724-1.

Structural remodeling of AAA+ ATPase p97 by adaptor protein ASPL facilitates posttranslational methylation by METTL21D

Authors:
Petrović S, Roske Y, Rami B, Phan MHQ, Panáková D, Heinemann U
Citation:
Proc Natl Acad Sci U S A. 2023 Jan 24;120(4):e2208941120. doi:10.1073/pnas.2208941120. Epub 2023 Jan 19
Epub:
Yes
Abstract:
p97 is an essential AAA+ ATPase that extracts and unfolds substrate proteins from membranes and protein complexes. Through its...
Link:
https://www.pnas.org/doi/10.1073/pnas.2208941120
Delivery Method:
microinjection
Organism or Cell Type:
zebrafish
Citation Extract:
Petrović S, Roske Y, Rami B, Phan MHQ, Panáková D, Heinemann U. Structural remodeling of AAA+ ATPase p97 by adaptor protein ASPL facilitates posttranslational methylation by METTL21D. Proc Natl Acad Sci U S A. 2023 Jan 24;120(4):e2208941120. doi:10.1073/pnas.2208941120. Epub 2023 Jan 19.

Morpholino-Mediated Exons 28-29 Skipping of Dysferlin and Characterization of Multiexon-skipped Dysferlin using RT-PCR, Immunoblotting, and Membrane Wounding Assay

Authors:
Anwar S, Yokota T
Citation:
Methods in Molecular Biology . 2023;2587. In: Maruyama R, Yokota T. (eds) Muscular Dystrophy Therapeutics. Humana, New York, NY. doi:10.1007/978-1-0716-2772-3_11
Epub:
Not Epub
Abstract:
Dysferlinopathies are a group of disabling muscular dystrophies that includes limb girdle muscular dystrophy type 2B (LGMD2B...
Link:
https://link.springer.com/protocol/10.1007/978-1-0716-2772-3_11
Organism or Cell Type:
cell culture: fibroblasts
Citation Extract:
Anwar S, Yokota T. Morpholino-Mediated Exons 28-29 Skipping of Dysferlin and Characterization of Multiexon-skipped Dysferlin using RT-PCR, Immunoblotting, and Membrane Wounding Assay. Methods in Molecular Biology . 2023;2587. In: Maruyama R, Yokota T. (eds) Muscular Dystrophy Therapeutics. Humana, New York, NY. doi:10.1007/978-1-0716-2772-3_11.

Unraveling Presenilin 2 Functions in a Knockout Zebrafish Line to Shed Light into Alzheimer’s Disease Pathogenesis

Authors:
Barazzuol L, Cieri D, Facchinello N, Calì T, Washbourne P, Argenton F, Pizzo P
Citation:
Cells. 2023;12(3):376. doi:10.3390/cells12030376
Epub:
Not Epub
Abstract:
Mutations in presenilin 2 (PS2) have been causally linked to the development of inherited Alzheimer’s disease (AD). Besides its...
Link:
https://www.mdpi.com/2073-4409/12/3/376/htm
Delivery Method:
microinjection
Organism or Cell Type:
zebrafish
Citation Extract:
Barazzuol L, Cieri D, Facchinello N, Calì T, Washbourne P, Argenton F, Pizzo P. Unraveling Presenilin 2 Functions in a Knockout Zebrafish Line to Shed Light into Alzheimer’s Disease Pathogenesis. Cells. 2023;12(3):376. doi:10.3390/cells12030376.

Multiple pkd and piezo gene family members are required for atrioventricular valve formation

Authors:
Juan T, Ribeiro da Silva A, Cardoso B, Lim SE, Charteau V, Stainier DYR
Citation:
Nat Commun. 2023;14(1):214. doi:10.1038/s41467-023-35843-3
Epub:
Not Epub
Abstract:
Cardiac valves ensure unidirectional blood flow through the heart, and altering their function can result in heart failure....
Link:
https://www.nature.com/articles/s41467-023-35843-3
Delivery Method:
microinjection
Organism or Cell Type:
zebrafish
Citation Extract:
Juan T, Ribeiro da Silva A, Cardoso B, Lim SE, Charteau V, Stainier DYR. Multiple pkd and piezo gene family members are required for atrioventricular valve formation. Nat Commun. 2023;14(1):214. doi:10.1038/s41467-023-35843-3.

Identification of the Time Period during Which BMP Signaling Regulates Proliferation of Neural Progenitor Cells in Zebrafish

Authors:
Shih H-Y, Chang C-W, Chen Y-C, Cheng Y-C
Citation:
Int J Mol Sci. 2023;24(2):1733. doi:10.3390/ijms24021733
Epub:
Not Epub
Abstract:
Bone morphogenetic protein (BMP) signaling regulates neural induction, neuronal specification, and neuronal differentiation....
Link:
https://www.mdpi.com/1422-0067/24/2/1733
Delivery Method:
microinjection
Organism or Cell Type:
zebrafish
Citation Extract:
Shih H-Y, Chang C-W, Chen Y-C, Cheng Y-C. Identification of the Time Period during Which BMP Signaling Regulates Proliferation of Neural Progenitor Cells in Zebrafish. Int J Mol Sci. 2023;24(2):1733. doi:10.3390/ijms24021733 .

Endothelial cells require functional FLVCR1a during developmental and adult angiogenesis

Authors:
Petrillo S, De Giorgio F, Bertino F, Garello F, Bitonto V, Longo DL, Mercurio S, Ammirata G, Allocco AL, Fiorito V, Chiabrando D, Altruda F, Terreno E, Provero P, Munaron L, Genova T, Nóvoa A, Carlos AR, Cardoso S, Mallo M, Soares MP, Tolosano E
Citation:
Angiogenesis. 2023 Aug;26(3):365-384. doi: 10.1007/s10456-023-09865-w. Epub 2023 Jan 11. PMID: 36631598; PMCID: PMC10328904
Epub:
Not Epub
Abstract:
The Feline Leukemia Virus Subgroup C Receptor 1a (FLVCR1a) is a transmembrane heme exporter essential for embryonic vascular...
Link:
https://pmc.ncbi.nlm.nih.gov/articles/PMC10328904/
Delivery Method:
microinjection
Organism or Cell Type:
zebrafish
Citation Extract:
Petrillo S, De Giorgio F, Bertino F, Garello F, Bitonto V, Longo DL, Mercurio S, Ammirata G, Allocco AL, Fiorito V, Chiabrando D, Altruda F, Terreno E, Provero P, Munaron L, Genova T, Nóvoa A, Carlos AR, Cardoso S, Mallo M, Soares MP, Tolosano E. Endothelial cells require functional FLVCR1a during developmental and adult angiogenesis. Angiogenesis. 2023 Aug;26(3):365-384. doi: 10.1007/s10456-023-09865-w. Epub 2023 Jan 11. PMID: 36631598; PMCID: PMC10328904.

Channel Function of Polycystin-2 in the Endoplasmic Reticulum Protects against Autosomal Dominant Polycystic Kidney Disease

Authors:
Padhy B, Xie J, Wang R, Lin F, Huang CL
Citation:
J Am Soc Nephrol. 2022 Aug;33(8):1501-1516. doi: 10.1681/ASN.2022010053. Epub 2022 Jul 14
Epub:
Not Epub
Abstract:
Background: Mutations of PKD2, which encodes polycystin-2, cause autosomal dominant polycystic kidney disease (ADPKD). The...
Link:
https://journals.lww.com/jasn/Abstract/2022/08000/Channel_Function_of_Polycystin_2_in_the.13.aspx
Delivery Method:
microinjection
Organism or Cell Type:
zebrafish
Citation Extract:
Padhy B, Xie J, Wang R, Lin F, Huang CL. Channel Function of Polycystin-2 in the Endoplasmic Reticulum Protects against Autosomal Dominant Polycystic Kidney Disease. J Am Soc Nephrol. 2022 Aug;33(8):1501-1516. doi: 10.1681/ASN.2022010053. Epub 2022 Jul 14.

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