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Morpholino Publication Database
This database contains citations and abstracts for research using Morpholino oligos, as well as some review articles incorporating Morpholino data. You can search the content using the filter boxes below.
There are 12092 scientific papers returned from the database with the search filters currently being used below.
There are 12092 scientific papers returned from the database with the search filters currently being used below.
Predicting the biodistribution of radiolabeled cMORF effector in MORF-pretargeted mice
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Citation:
Eur J Nucl Med Mol Imaging. 2007 Feb;34(2):237-46 Epub:
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PURPOSE: Pretargeting with phosphorodiamidate morpholino oligomers (MORFs) involves administration of a MORF-conjugated anti-... Delivery Method:
Injection Organism or Cell Type:
mice, LS174T Citation Extract: Liu G, Dou S, He J, Liu X, Rusckowski M, Hnatowich DJ. Predicting the biodistribution of radiolabeled cMORF effector in MORF-pretargeted mice. Eur J Nucl Med Mol Imaging. 2007 Feb;34(2):237-46. |
Preparation of (111)In-DTPA morpholino oligomer for low abdominal accumulation
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Citation:
Appl Radiat Isot. 2010 Sep;68(9):1709-14. doi: 10.1016/j.apradiso.2010.03.002 Epub:
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An ability to quantitate the beta cell mass by noninvasive nuclear imaging will be very useful in the prevention, diagnosis,... Citation Extract: Liu G, Dou S, Rusckowski M, Greiner D, Hnatowich D. Preparation of (111)In-DTPA morpholino oligomer for low abdominal accumulation. Appl Radiat Isot. 2010 Sep;68(9):1709-14. doi: 10.1016/j.apradiso.2010.03.002. |
Pretargeting in tumored mice with radiolabeled morpholino oligomer showing low kidney uptake
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Citation:
Eur J Nucl Med Mol Imaging. 2004 Mar;31(3):417-24. Epub 2003 Dec 23 Epub:
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We have recently shown that accumulation in mouse kidneys of technetium-99m labeled phosphorodiamidate morpholinos (MORFs)... Delivery Method:
in vivo: injection Organism or Cell Type:
nude mice Citation Extract: Liu G, He J, Dou S, Gupta S, Vanderheyden JL, Rusckowski M, Hnatowich DJ. Pretargeting in tumored mice with radiolabeled morpholino oligomer showing low kidney uptake. Eur J Nucl Med Mol Imaging. 2004 Mar;31(3):417-24. Epub 2003 Dec 23. |
Pretargeting vs direct targeting of human betalox5 islet cells subcutaneously implanted in mice using an anti-human islet cell antibody
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Citation:
Nucl Med Biol. 2012 Jul;39(5):645-51. doi: 10.1016/j.nucmedbio.2011.12.001. Epub 2012 Feb 10 Epub:
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Introduction Our previous investigation showed the proof-of-concept of islet cell and islet imaging by pretargeting, however,... Delivery Method:
Injection Organism or Cell Type:
mice Citation Extract: Liu G, Dou S, Akalin A, Rusckowski M, Streeter PR, Shultz LD, Greiner DL. Pretargeting vs direct targeting of human betalox5 islet cells subcutaneously implanted in mice using an anti-human islet cell antibody. Nucl Med Biol. 2012 Jul;39(5):645-51. doi: 10.1016/j.nucmedbio.2011.12.001. Epub 2012 Feb 10. |
Radiolabeling morpholino oligo with 99mTc tricarbonyl
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Citation:
Nuclear Techniques 2005 ;28( 7):534-537 (Chinese) Epub:
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采用三羰基锝药盒制备三羰基锝([99mTc(CO)3(OH2)3]+),并以DTPA作为双功能螯合剂,标记人工合成的Morpholino寡核苷酸. 高效液相色谱(HPLC)证实,此方法三羰基锝产率大于90％,且产率稳定;Morpholino... Citation Extract: Liu C, Tian J, Deng J, Qiao H, Wang J. Radiolabeling morpholino oligo with 99mTc tricarbonyl. Nuclear Techniques 2005 ;28( 7):534-537 (Chinese). |
Radiolabeling morpholinos with (90)Y, (111)In, (188)Re and (99m)Tc
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Citation:
Nucl Med Biol 2003 Feb;30(2):207-14 Epub:
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This laboratory is investigating morpholinos (MORF), a DNA analogue, for radiopharmaceutical applications. While we routinely... Delivery Method:
in vivo: injection Organism or Cell Type:
male CD-1 mice Citation Extract: Liu C, Liu G, Liu N, Zhang YM, He J, Rusckowski M, Hnatowich DJ. Radiolabeling morpholinos with (90)Y, (111)In, (188)Re and (99m)Tc. Nucl Med Biol 2003 Feb;30(2):207-14. |
Radiolabeling of MAG(3)-morpholino oligomers with (188)Re at high labeling efficiency and specific radioactivity for tumor pretargeting
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Citation:
Appl Radiat Isot. 2006 Sep;64(9):971-8. Epub 2006 May 30. Epub:
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We are investigating a novel pretargeting approach involving an initial IV injection of antitumor antibody conjugated with a... Delivery Method:
in vivo: injection Organism or Cell Type:
mice, CD-1 Citation Extract: Liu G, Dou S, He J, Yin D, Gupta S, Zhang S, Wang Y, Rusckowski M, Hnatowich DJ. Radiolabeling of MAG(3)-morpholino oligomers with (188)Re at high labeling efficiency and specific radioactivity for tumor pretargeting. Appl Radiat Isot. 2006 Sep;64(9):971-8. Epub 2006 May 30.. |
Radiolabeling oligo nuclieotide with 90Y and its radiolysis
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Citation:
Chinese Journal of Nuclear Medicine. 2005;4: (Chinese) Epub:
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目的用90Y标记人工合成的Morpholino(MORF)寡核苷酸.方法将双功能螯合剂DOTA偶联到MORF 3'末端的氨基上,用90Y进行标记,常规检测其生物活性及体外稳定性.结果高效液相色谱(HPLC)及薄层层析证实,90Y-... Citation Extract: Liu C, Tian J, Zhang J. Radiolabeling oligo nuclieotide with 90Y and its radiolysis. Chinese Journal of Nuclear Medicine. 2005;4: (Chinese). |
Rapid activation of protein tyrosine kinase and phospholipase C-gamma2 and increase in cytosolic free calcium are required by Ehrlichia chaffeensis for internalization and growth in THP-1 cells
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Citation:
Infect Immun. 2002 Feb;70(2):889-98 Epub:
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Ehrlichia chaffeensis, a bacterium that cannot survive outside the eukaryotic cell, proliferates exclusively in human monocytes... Delivery Method:
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cell culture: THP-1 cells Citation Extract: Lin M, Zhu MX, Rikihisa Y. Rapid activation of protein tyrosine kinase and phospholipase C-gamma2 and increase in cytosolic free calcium are required by Ehrlichia chaffeensis for internalization and growth in THP-1 cells. Infect Immun. 2002 Feb;70(2):889-98. |
Replacing 99mTc with 111In improves MORF/cMORF pretargeting by reducing intestinal accumulation
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Citation:
Mol Imaging Biol. 2009 Sep-Oct;11(5):303-7. doi: 10.1007/s11307-009-0209-0. Epub 2009 Mar 27 Epub:
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PURPOSE: To reduce accumulation in the abdomen by MORF/cMORF pretargeting, 111In was compared to 99mTc as the radiolabel.... Delivery Method:
Injection Organism or Cell Type:
mice Citation Extract: Liu G, Cheng D, Dou S, Chen X, Liang M, Pretorius PH, Rusckowski M, Hnatowich DJ. Replacing 99mTc with 111In improves MORF/cMORF pretargeting by reducing intestinal accumulation. Mol Imaging Biol. 2009 Sep-Oct;11(5):303-7. doi: 10.1007/s11307-009-0209-0. Epub 2009 Mar 27. |