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Morpholino Publication Database
This database contains citations and abstracts for research using Morpholino oligos, as well as some review articles incorporating Morpholino data. You can search the content using the filter boxes below.
There are 12176 scientific papers returned from the database with the search filters currently being used below.
There are 12176 scientific papers returned from the database with the search filters currently being used below.
Antibody-oligonucleotide conjugate achieves central nervous system delivery in animal models for spinal muscular atrophy
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Citation:
JCI Insight. 2022 Nov 8:e154142. doi: 10.1172/jci.insight.154142. Online ahead of print Epub:
Yes Abstract:
Antisense oligonucleotides (ASOs) have emerged as one of the most innovative new genetic drug modalities. However, their high... Delivery Method:
antibody-linked Organism or Cell Type:
mice Citation Extract: Hammond SM, Abendroth F, Goli L, Stoodley J, Burrell M, Thom G, Gurrell I, Ahlskog N, Gait MJ, Wood MJ, Webster CI. Antibody-oligonucleotide conjugate achieves central nervous system delivery in animal models for spinal muscular atrophy. JCI Insight. 2022 Nov 8:e154142. doi: 10.1172/jci.insight.154142. Online ahead of print. |
Membrane potential drives the exit from pluripotency and cell fate commitment via calcium and mTOR
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Citation:
Nat Commun. 2022 Nov 5;13(1):6681. doi: 10.1038/s41467-022-34363-w Epub:
Not Epub Abstract:
Transitioning from pluripotency to differentiated cell fates is fundamental to both embryonic development and adult tissue... Delivery Method:
microinjection Organism or Cell Type:
Xenopus tropicalis Citation Extract: Sempou E, Kostiuk V, Zhu J, Cecilia Guerra M, Tyan L, Hwang W, Camacho-Aguilar E, Caplan MJ, Zenisek D, Warmflash A, Owens NDL, Khokha MK. Membrane potential drives the exit from pluripotency and cell fate commitment via calcium and mTOR. Nat Commun. 2022 Nov 5;13(1):6681. doi: 10.1038/s41467-022-34363-w. |
Convergence of coronary artery disease genes onto endothelial cell programs
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Citation:
Nature. 2024 Feb;626(8000):799-807. doi: 10.1038/s41586-024-07022-x. Epub 2024 Feb 7. PMID: 38326615; PMCID: PMC10921916 Epub:
Not Epub Abstract:
Linking variants from genome-wide association studies (GWAS) to underlying mechanisms of disease remains a challenge1-3. For... Organism or Cell Type:
zebrafish Citation Extract: Schnitzler GR, Kang H, Fang S, Angom RS, Lee-Kim VS, Ma XR, Zhou R, Zeng T, Guo K, Taylor MS, Vellarikkal SK, Barry AE, Sias-Garcia O, Bloemendal A, Munson G, Guckelberger P, Nguyen TH, Bergman DT, Hinshaw S, Cheng N, Cleary B, Aragam K, Lander ES, Finucane HK, Mukhopadhyay D, Gupta RM, Engreitz JM. Convergence of coronary artery disease genes onto endothelial cell programs. Nature. 2024 Feb;626(8000):799-807. doi: 10.1038/s41586-024-07022-x. Epub 2024 Feb 7. PMID: 38326615; PMCID: PMC10921916. |
Sensory axons induce epithelial lipid microdomain remodeling and determine the distribution of junctions in the epidermis
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Citation:
Mol Biol Cell. 2022;[Epub ahead of print] doi:10.1091/mbc.E22-09-0396 Epub:
Not Epub Abstract:
Epithelial cell properties are determined by the polarized distribution of membrane lipids, the cytoskeleton, and adhesive... Delivery Method:
microinjection Organism or Cell Type:
zebrafish Citation Extract: Rosa JB, Nassman KY, Sagasti A. Sensory axons induce epithelial lipid microdomain remodeling and determine the distribution of junctions in the epidermis. Mol Biol Cell. 2022;[Epub ahead of print] doi:10.1091/mbc.E22-09-0396. |
Primordial germ cells adjust their protrusion type while migrating in different tissue contexts in vivo
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Citation:
Development. 2023 Jan 15;150(2):dev200603. doi: 10.1242/dev.200603. Epub 2023 Jan 16. PMID: 36515556; PMCID: PMC10110502 Epub:
Not Epub Abstract:
In both physiological processes and disease contexts, migrating cells have the ability to adapt to conditions in their... Delivery Method:
microinjection Organism or Cell Type:
zebrafish Citation Extract: Truszkowski L, Batur D, Long H, Tarbashevich K, Vos BE, Trappmann B, Raz E. Primordial germ cells adjust their protrusion type while migrating in different tissue contexts in vivo. Development. 2023 Jan 15;150(2):dev200603. doi: 10.1242/dev.200603. Epub 2023 Jan 16. PMID: 36515556; PMCID: PMC10110502. |
Rab8, Rab11, and Rab35 coordinate lumen and cilia formation during zebrafish left-right organizer development
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Citation:
PLoS Genet. 2023 May 15;19(5):e1010765. doi: 10.1371/journal.pgen.1010765. PMID: 37186603; PMCID: PMC10212091 Epub:
Not Epub Abstract:
An essential process during Danio rerio's left-right organizer (Kupffer's Vesicle, KV) formation is the formation of... Delivery Method:
microinjection Organism or Cell Type:
zebrafish Citation Extract: Aljiboury AA, Ingram E, Krishnan N, Ononiwu F, Pal D, Manikas J, Taveras C, Hall NA, Da Silva J, Freshour J, Hehnly H. Rab8, Rab11, and Rab35 coordinate lumen and cilia formation during zebrafish left-right organizer development. PLoS Genet. 2023 May 15;19(5):e1010765. doi: 10.1371/journal.pgen.1010765. PMID: 37186603; PMCID: PMC10212091. |
Tamalin Function Is Required for the Survival of Neurons and Oligodendrocytes in the CNS
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Citation:
Int J Mol Sci. 2022. 23:13395. doi:10.3390/ijms232113395 Epub:
Not Epub Abstract:
Tamalin is a post-synaptic scaffolding protein that interacts with group 1 metabotropic glutamate receptors (mGluRs) and... Delivery Method:
microinjection Organism or Cell Type:
zebrafish Citation Extract: Seo Y, Mo S, Kim S, Kim H, Park H-C. Tamalin Function Is Required for the Survival of Neurons and Oligodendrocytes in the CNS. Int J Mol Sci. 2022. 23:13395. doi:10.3390/ijms232113395. |
Homologous gene regulatory networks control development of apical organs and brains in Bilateria
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Citation:
Sci Adv. 2022 Nov 4;8(44):eabo2416. doi: 10.1126/sciadv.abo2416. Epub 2022 Nov 2 Epub:
Not Epub Abstract:
Apical organs are relatively simple larval nervous systems. The extent to which apical organs are evolutionarily related to the... Delivery Method:
microinjection Organism or Cell Type:
Strongylocentrotus purpuratus (sea urchin) Citation Extract: Feuda R, Peter IS. Homologous gene regulatory networks control development of apical organs and brains in Bilateria. Sci Adv. 2022 Nov 4;8(44):eabo2416. doi: 10.1126/sciadv.abo2416. Epub 2022 Nov 2. |
Dorsal lip maturation and initial archenteron extension depend on Wnt11 family ligands
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Citation:
Dev Biol. 2022 Nov 2:S0012-1606(22)00202-0. doi: 10.1016/j.ydbio.2022.10.013. Online ahead of print Epub:
Not Epub Abstract:
Wnt11 family proteins are ligands that activate a type of Dishevelled-mediated, non-canonical Wnt signaling pathway. Loss of... Delivery Method:
microinjection Organism or Cell Type:
Xenopus laevis Citation Extract: Van Itallie ES, Field CM, Mitchison TJ, Kirschner MW. Dorsal lip maturation and initial archenteron extension depend on Wnt11 family ligands. Dev Biol. 2022 Nov 2:S0012-1606(22)00202-0. doi: 10.1016/j.ydbio.2022.10.013. Online ahead of print. |
Evaluation of two gene ablation methods for the analysis of pregnenolone function in zebrafish embryonic development
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Citation:
Biochem Biophys Res Commun. 2022 Oct 21;636(Pt 1):84-88. doi:10.1016/j.bbrc.2022.10.067. Online ahead of print Epub:
Not Epub Abstract:
Pregnenolone (P5) is a steroid that functions in the brain and in zebrafish embryogenesis. It is synthesized from cholesterol... Delivery Method:
microinjection Organism or Cell Type:
zebrafish Citation Extract: Kolas V, Mathieu G, Wu YT, Chung BC. Evaluation of two gene ablation methods for the analysis of pregnenolone function in zebrafish embryonic development. Biochem Biophys Res Commun. 2022 Oct 21;636(Pt 1):84-88. doi:10.1016/j.bbrc.2022.10.067. Online ahead of print. |