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Dysregulated Protease Homeostasis Defines Primary FSGS

Authors: 
Schmidt J, Sopel N, Rist C, Ohs A, Dawid L, Simm S, Catanese L, Rupprecht H, Jobst-Schwan T, Lehmann J, Daniel C, Kalkhof S, Schiffer M, Müller-Deile J
Citation: 
Kidney360. 2026 Mar 1;7(3):487-500. doi: 10.34067/KID.0000001021. Epub 2025 Nov 10. PMID: 41910486
Abstract: 
Serum proteomics reveals reduced serpin family A member 1 (SERPINA1) in primary FSGS, distinguishing it from other proteinuric kidney diseases. Serpina1 knockdown in zebrafish causes proteinuria and edema, supporting its functional relevance in glomerular disease. SERPINA1 may exert compartment-specific functions, and its decrease may permit protease activity to contribute to podocyte injury in primary FSGS.
Epub: 
Not Epub
Link to Publication: 
https://journals.lww.com/kidney360/fulltext/2026/03000/dysregulated_protease_homeostasis_defines_primary.8.aspx
Organism or Cell Type: 
zebrafish
Delivery Method: 
microinjection