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Morpholino Publication Database

This database contains citations and abstracts for research using Morpholino oligos, as well as some review articles incorporating Morpholino data. You can search the content using the filter boxes below.

There are 12376 scientific papers returned from the database with the search filters currently being used below.

Tetracycline and Oxacillin Act Synergistically on Biofilms and Display Increased Efficacy In Vivo Against Staphylococcus aureus

Authors:
Tooke AK, Hodges RE, Pyrah JF, Bayles KW, Renshaw SA, Foster SJ
Citation:
Curr Microbiol. 2024 Nov 6;81(12):447. doi: 10.1007/s00284-024-03959-4. PMID: 39505760; PMCID: PMC11541413
Epub:
Not Epub
Abstract:
Oxacillin (bactericidal) and tetracycline (bacteriostatic) are clinically relevant antibiotics that are routinely prescribed to...
Link:
https://pmc.ncbi.nlm.nih.gov/articles/PMC11541413/
Delivery Method:
microinjection
Organism or Cell Type:
zebrafish
Citation Extract:
Tooke AK, Hodges RE, Pyrah JF, Bayles KW, Renshaw SA, Foster SJ. Tetracycline and Oxacillin Act Synergistically on Biofilms and Display Increased Efficacy In Vivo Against Staphylococcus aureus. Curr Microbiol. 2024 Nov 6;81(12):447. doi: 10.1007/s00284-024-03959-4. PMID: 39505760; PMCID: PMC11541413.

Evaluating the involvement and mutual interaction of wbp2 and yap in embryogenesis with an emphasis on liver function in zebrafish embryos

Authors:
Lykov N, Wang H, Panga MJ, Du Z, Chen Z, Chen S, Zhu L, Zhao Y
Citation:
Tissue Cell. 2024 Oct 29;91:102600. doi: 10.1016/j.tice.2024.102600. Epub ahead of print. PMID: 39486132
Epub:
Not Epub
Abstract:
The Yes-associated protein (YAP) and transcriptional coactivator with PDZ-binding motif (TAZ) play complex roles in liver...
Link:
https://www.sciencedirect.com/science/article/abs/pii/S004081662400301X
Delivery Method:
microinjection
Organism or Cell Type:
zebrafish
Citation Extract:
Lykov N, Wang H, Panga MJ, Du Z, Chen Z, Chen S, Zhu L, Zhao Y. Evaluating the involvement and mutual interaction of wbp2 and yap in embryogenesis with an emphasis on liver function in zebrafish embryos. Tissue Cell. 2024 Oct 29;91:102600. doi: 10.1016/j.tice.2024.102600. Epub ahead of print. PMID: 39486132.

Planar cell polarity zebrafish models of congenital scoliosis reveal underlying defects in notochord morphogenesis

Authors:
Wang M, Zhao S, Shi C, Guyot MC, Liao M, Tauer JT, Willie BM, Cobetto N, Aubin CÉ, Küster-Schöck E, Drapeau P, Zhang J, Wu N, Kibar Z
Citation:
Development. 2024 Nov 1;151(21):dev202829. doi: 10.1242/dev.202829. Epub 2024 Nov 12. PMID: 39417583
Epub:
Not Epub
Abstract:
Congenital scoliosis (CS) is a type of vertebral malformation whose etiology remains elusive. The notochord is pivotal for...
Link:
https://journals.biologists.com/dev/article-abstract/151/21/dev202829/362927/Planar-cell-polarity-zebrafish-models-of
Delivery Method:
microinjection
Organism or Cell Type:
zebrafish
Citation Extract:
Wang M, Zhao S, Shi C, Guyot MC, Liao M, Tauer JT, Willie BM, Cobetto N, Aubin CÉ, Küster-Schöck E, Drapeau P, Zhang J, Wu N, Kibar Z. Planar cell polarity zebrafish models of congenital scoliosis reveal underlying defects in notochord morphogenesis. Development. 2024 Nov 1;151(21):dev202829. doi: 10.1242/dev.202829. Epub 2024 Nov 12. PMID: 39417583.

Epigenetic regulation by polycomb repressive complex 1 promotes cerebral cavernous malformations

Authors:
Pham VC, Rödel CJ, Valentino M, Malinverno M, Paolini A, Münch J, Pasquier C, Onyeogaziri FC, Lazovic B, Girard R, Koskimäki J, Hußmann M, Keith B, Jachimowicz D, Kohl F, Hagelkruys A, Penninger JM, Schulte-Merker S, Awad IA, Hicks R, Magnusson PU, Faurobert E, Pagani M, Abdelilah-Seyfried S
Citation:
EMBO Mol Med. 2024 Nov;16(11):2827-2855. doi: 10.1038/s44321-024-00152-9. Epub 2024 Oct 14. PMID: 39402138; PMCID: PMC11555420
Epub:
Not Epub
Abstract:
Cerebral cavernous malformations (CCMs) are anomalies of the cerebral vasculature. Loss of the CCM proteins CCM1/KRIT1, CCM2,...
Link:
https://pmc.ncbi.nlm.nih.gov/articles/PMC11555420/
Delivery Method:
microinjection
Organism or Cell Type:
zebrafish
Citation Extract:
Pham VC, Rödel CJ, Valentino M, Malinverno M, Paolini A, Münch J, Pasquier C, Onyeogaziri FC, Lazovic B, Girard R, Koskimäki J, Hußmann M, Keith B, Jachimowicz D, Kohl F, Hagelkruys A, Penninger JM, Schulte-Merker S, Awad IA, Hicks R, Magnusson PU, Faurobert E, Pagani M, Abdelilah-Seyfried S. Epigenetic regulation by polycomb repressive complex 1 promotes cerebral cavernous malformations. EMBO Mol Med. 2024 Nov;16(11):2827-2855. doi: 10.1038/s44321-024-00152-9. Epub 2024 Oct 14. PMID: 39402138; PMCID: PMC11555420.

Foxi1 regulates multiple steps of mucociliary development and ionocyte specification through transcriptional and epigenetic mechanisms

Authors:
Bowden S, Brislinger-Engelhardt MM, Hansen M, Temporal-Plo A, Weber D, Hägele S, Lorenz F, Litwin T, Kreutz C, Walentek P
Citation:
bioRxiv [Preprint]. 2024 Nov 4:2024.10.27.620464. doi: 10.1101/2024.10.27.620464. PMID: 39484493; PMCID: PMC11527170
Epub:
Not Epub
Abstract:
Foxi1 is a master regulator of ionocytes (ISCs / INCs) across species and organs. Two subtypes of ISCs exist, and both α- and...
Link:
https://pmc.ncbi.nlm.nih.gov/articles/PMC11527170/
Delivery Method:
microinjection
Organism or Cell Type:
Xenopus laevis
Citation Extract:
Bowden S, Brislinger-Engelhardt MM, Hansen M, Temporal-Plo A, Weber D, Hägele S, Lorenz F, Litwin T, Kreutz C, Walentek P. Foxi1 regulates multiple steps of mucociliary development and ionocyte specification through transcriptional and epigenetic mechanisms. bioRxiv [Preprint]. 2024 Nov 4:2024.10.27.620464. doi: 10.1101/2024.10.27.620464. PMID: 39484493; PMCID: PMC11527170.

Proliferation associated 2G4 is required for the ciliation of vertebrate motile cilia

Authors:
Lee M, Carpenter C, Hwang YS, Yoon J, Lu Q, Westlake CJ, Moody SA, Yamaguchi TP, Daar IO
Citation:
Commun Biol. 2024 Nov 4;7(1):1430. doi: 10.1038/s42003-024-07150-0. PMID: 39496919; PMCID: PMC11535434
Epub:
Not Epub
Abstract:
Motile cilia are critical structures that regulate early embryonic development and tissue homeostasis through synchronized...
Link:
https://www.nature.com/articles/s42003-024-07150-0
Delivery Method:
microinjection
Organism or Cell Type:
Xenopus laevis
Citation Extract:
Lee M, Carpenter C, Hwang YS, Yoon J, Lu Q, Westlake CJ, Moody SA, Yamaguchi TP, Daar IO. Proliferation associated 2G4 is required for the ciliation of vertebrate motile cilia. Commun Biol. 2024 Nov 4;7(1):1430. doi: 10.1038/s42003-024-07150-0. PMID: 39496919; PMCID: PMC11535434.

The Heterotaxy Gene CCDC11 Is Important for Cytokinesis via RhoA Regulation. Cytoskeleton (Hoboken)

Authors:
Kulkarni SS, Stephenson RE, Amalraj S, Arrigo A, Betleja E, Moresco JJ, Yates JR 3rd, Mahjoub MR, Miller AL, Khokha MK
Citation:
2024 Oct 31. doi: 10.1002/cm.21952. Epub ahead of print. PMID: 39479942
Epub:
Not Epub
Abstract:
Mutations in CCDC11 (cfap53) have been identified in multiple patients with heterotaxy (Htx), a disorder of left–right (LR)...
Link:
https://onlinelibrary.wiley.com/doi/10.1002/cm.21952
Delivery Method:
microinjection
Organism or Cell Type:
Xenopus tropicalis
Citation Extract:
Kulkarni SS, Stephenson RE, Amalraj S, Arrigo A, Betleja E, Moresco JJ, Yates JR 3rd, Mahjoub MR, Miller AL, Khokha MK . The Heterotaxy Gene CCDC11 Is Important for Cytokinesis via RhoA Regulation. Cytoskeleton (Hoboken). 2024 Oct 31. doi: 10.1002/cm.21952. Epub ahead of print. PMID: 39479942.

Mitochondrial calcium uptake orchestrates vertebrate pigmentation via transcriptional regulation of keratin filaments

Authors:
Tanwar J, Ahuja K, Sharma A, Sehgal P, Ranjan G, Sultan F, Agrawal A, D'Angelo D, Priya A, Yenamandra VK, Singh A, Raffaello A, Madesh M, Rizzuto R, Sivasubbu S, Motiani RK
Citation:
PLoS Biol. 2024 Nov 11;22(11):e3002895. doi: 10.1371/journal.pbio.3002895. Epub ahead of print. PMID: 39527653
Epub:
Not Epub
Abstract:
Mitochondria regulate several physiological functions through mitochondrial Ca2+ dynamics. However, role of mitochondrial Ca2+...
Link:
https://journals.plos.org/plosbiology/article?id=10.1371/journal.pbio.3002895
Delivery Method:
microinjection
Organism or Cell Type:
zebrafish
Citation Extract:
Tanwar J, Ahuja K, Sharma A, Sehgal P, Ranjan G, Sultan F, Agrawal A, D'Angelo D, Priya A, Yenamandra VK, Singh A, Raffaello A, Madesh M, Rizzuto R, Sivasubbu S, Motiani RK. Mitochondrial calcium uptake orchestrates vertebrate pigmentation via transcriptional regulation of keratin filaments. PLoS Biol. 2024 Nov 11;22(11):e3002895. doi: 10.1371/journal.pbio.3002895. Epub ahead of print. PMID: 39527653.

Manic Fringe promotes endothelial-to-mesenchymal transition mediated by the Notch signalling pathway during heart valve development

Authors:
Yang J, Wang Z, Zhou Y, Jiang S, Qin X, Xu Z, Wang Y, Zuo M, Meng Z, Chen S, Wang Q, Wang J, Sun K
Citation:
J Mol Med (Berl). 2024 Nov 11. doi: 10.1007/s00109-024-02492-y. Epub ahead of print. PMID: 39528804
Epub:
Not Epub
Abstract:
A fundamental event in the formation of heart valves involves the transformation of endocardial cells within the outflow...
Link:
https://link.springer.com/article/10.1007/s00109-024-02492-y
Delivery Method:
microinjection
Organism or Cell Type:
zebrafish
Citation Extract:
Yang J, Wang Z, Zhou Y, Jiang S, Qin X, Xu Z, Wang Y, Zuo M, Meng Z, Chen S, Wang Q, Wang J, Sun K. Manic Fringe promotes endothelial-to-mesenchymal transition mediated by the Notch signalling pathway during heart valve development. J Mol Med (Berl). 2024 Nov 11. doi: 10.1007/s00109-024-02492-y. Epub ahead of print. PMID: 39528804.

Characterization of Nonclinical Drug Metabolism and Pharmacokinetic Properties of Phosphorodiamidate Morpholino Oligonucleotides, A Novel Drug Class for Duchenne Muscular Dystrophy

Authors:
Goey A, Mukashyaka MC, Patel Y, Rodino-Klapac LR, East L
Citation:
Drug Metab Dispos. 2024 Nov 8:DMD-AR-2024-001819. doi: 10.1124/dmd.124.001819. Epub ahead of print. PMID: 39516029
Epub:
Not Epub
Abstract:
Eteplirsen, golodirsen, and casimersen are phosphorodiamidate morpholino oligomers (PMOs) that are approved in the United...
Link:
https://dmd.aspetjournals.org/article/S0090-9556(24)15943-0/abstract
Delivery Method:
intravenous (i.v.) bolus
Organism or Cell Type:
in vivo: CByB6F1 & mdx mice, Sprague Dawley rats & cynomolgus monkeys; in vitro: hepatic microsomes from CD-1 mice, Sprague Dawley rats, cynomolgus monkeys and humans; cell culture: Caco-2, CHO & HEK293
Citation Extract:
Goey A, Mukashyaka MC, Patel Y, Rodino-Klapac LR, East L. Characterization of Nonclinical Drug Metabolism and Pharmacokinetic Properties of Phosphorodiamidate Morpholino Oligonucleotides, A Novel Drug Class for Duchenne Muscular Dystrophy. Drug Metab Dispos. 2024 Nov 8:DMD-AR-2024-001819. doi: 10.1124/dmd.124.001819. Epub ahead of print. PMID: 39516029.

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