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Morpholino Publication Database

This database contains citations and abstracts for research using Morpholino oligos, as well as some review articles incorporating Morpholino data. You can search the content using the filter boxes below.

There are 12376 scientific papers returned from the database with the search filters currently being used below.

Fbrsl1 is required for heart development in Xenopus laevis and de novo variants in FBRSL1 can cause human heart defects

Authors:
Berger H, Gerstner S, Horstmann MF, Pauli S, Borchers A
Citation:
Dis Model Mech. 2024 Jun 1;17(6):dmm050507. doi: 10.1242/dmm.050507. Epub 2024 May 14. PMID: 38501224; PMCID: PMC11128277.
Epub:
Not Epub
Abstract:
De novo truncating variants in fibrosin-like 1 (FBRSL1), a member of the AUTS2 gene family, cause a disability syndrome,...
Link:
https://journals.biologists.com/dmm/article/17/6/dmm050507/347305/
Delivery Method:
Microinjection
Organism or Cell Type:
Xenopus laevis
Citation Extract:
Berger H, Gerstner S, Horstmann MF, Pauli S, Borchers A. Fbrsl1 is required for heart development in Xenopus laevis and de novo variants in FBRSL1 can cause human heart defects. Dis Model Mech. 2024 Jun 1;17(6):dmm050507. doi: 10.1242/dmm.050507. Epub 2024 May 14. PMID: 38501224; PMCID: PMC11128277..

An antisense oligonucleotide efficiently suppresses splicing of an alternative exon in vascular smooth muscle in vivo

Authors:
Damacena de Angelis C, Meddeb M, Chen N, Fisher SA
Citation:
Am J Physiol Heart Circ Physiol. 2024 Mar 1;326(3):H860-H869. doi: 10.1152/ajpheart.00745.2023
Epub:
Not Epub
Abstract:
Targeting alternative exons for therapeutic gain has been achieved in a few instances and potentially could be applied more...
Link:
https://journals.physiology.org/doi/full/10.1152/ajpheart.00745.2023
Delivery Method:
Vivo Morpholino
Organism or Cell Type:
Cell Culture
Citation Extract:
Damacena de Angelis C, Meddeb M, Chen N, Fisher SA. An antisense oligonucleotide efficiently suppresses splicing of an alternative exon in vascular smooth muscle in vivo. Am J Physiol Heart Circ Physiol. 2024 Mar 1;326(3):H860-H869. doi: 10.1152/ajpheart.00745.2023.

Catechol-Siderophore Mimics Convey Nucleic Acid Therapeutics into Bacteria

Authors:
Pals M, Wijnberg L, Yildiz C, Velema WA
Citation:
Angew Chem Int Ed Engl. 2024 Feb 26:e202402405. doi: 10.1002/anie.202402405. Online ahead of print
Epub:
Not Epub
Abstract:
Antibacterial resistance is a major threat for human health. There is a need for new antibacterials to stay ahead of constantly...
Link:
https://onlinelibrary.wiley.com/doi/10.1002/anie.202402405
Delivery Method:
siderophore conjugate
Organism or Cell Type:
Escherichia coli K12 MG1655 and Acinetobacter baumannii (ATCC19606)
Citation Extract:
Pals M, Wijnberg L, Yildiz C, Velema WA. Catechol-Siderophore Mimics Convey Nucleic Acid Therapeutics into Bacteria. Angew Chem Int Ed Engl. 2024 Feb 26:e202402405. doi: 10.1002/anie.202402405. Online ahead of print.

A comparative analysis of peptide-delivered antisense antibiotics employing diverse nucleotide mimics

Authors:
Ghosh C, Popella L, Dhamodharan V, Jung J, Dietzsch J, Barquist L, Höbartner C, Vogel J
Citation:
RNA. 2024 Feb 27:rna.079969.124. doi: 10.1261/rna.079969.124. Online ahead of print
Epub:
Not Epub
Abstract:
Antisense oligomer (ASO)-based antibiotics that target mRNAs of essential bacterial genes have great potential for...
Link:
https://rnajournal.cshlp.org/content/early/2024/02/27/rna.079969.124.long
Delivery Method:
peptide-linked
Organism or Cell Type:
Salmonella
Citation Extract:
Ghosh C, Popella L, Dhamodharan V, Jung J, Dietzsch J, Barquist L, Höbartner C, Vogel J. A comparative analysis of peptide-delivered antisense antibiotics employing diverse nucleotide mimics. RNA. 2024 Feb 27:rna.079969.124. doi: 10.1261/rna.079969.124. Online ahead of print.

Structural insights into the morpholino nucleic acid/RNA duplex using the new XNA builder Ducque in a molecular modeling pipeline

Authors:
Rihon J, Mattelaer CA, Montalvão RW, Froeyen M, Pinheiro VB, Lescrinier E
Citation:
Nucleic Acids Res. 2024 Feb 27:gkae135. doi: 10.1093/nar/gkae135. Online ahead of print
Epub:
Not Epub
Abstract:
The field of synthetic nucleic acids with novel backbone structures [xenobiotic nucleic acids (XNAs)] has flourished due to the...
Link:
https://academic.oup.com/nar/advance-article/doi/10.1093/nar/gkae135/7614861
Citation Extract:
Rihon J, Mattelaer CA, Montalvão RW, Froeyen M, Pinheiro VB, Lescrinier E. Structural insights into the morpholino nucleic acid/RNA duplex using the new XNA builder Ducque in a molecular modeling pipeline. Nucleic Acids Res. 2024 Feb 27:gkae135. doi: 10.1093/nar/gkae135. Online ahead of print.

Direct Activation of Nucleobases with Small Molecules for the Conditional Control of Antisense Function

Authors:
Bardhan A, Brown W, Albright S, Tsang M, Davidson L, Deiters A
Citation:
Angew Chem Int Ed Engl. 2024 Feb 27:e202318773. doi: 10.1002/anie.202318773. Online ahead of print
Epub:
Not Epub
Abstract:
Conditionally controlled antisense oligonucleotides provide precise interrogation of gene function at different developmental...
Link:
https://onlinelibrary.wiley.com/doi/10.1002/anie.202318773
Delivery Method:
Endo-Porter PEG, microinjection
Organism or Cell Type:
cell culture: HEK293T zebrafish Xenopus laevis
Citation Extract:
Bardhan A, Brown W, Albright S, Tsang M, Davidson L, Deiters A. Direct Activation of Nucleobases with Small Molecules for the Conditional Control of Antisense Function. Angew Chem Int Ed Engl. 2024 Feb 27:e202318773. doi: 10.1002/anie.202318773. Online ahead of print.

A vertebrate Vangl2 translational variant required for planar cell polarity

Authors:
Walton A, Thomé V, Revinski D, Marchetto S, Puvirajesinghe TM, Audebert S, Camoin L, Bailly E, Kodjabachian L, Borg JP
Citation:
J Biol Chem. 2024 Feb 23:106792. doi: 10.1016/j.jbc.2024.106792. Online ahead of print
Epub:
Not Epub
Abstract:
First described in the milkweed bug Oncopeltus Fasciatus, planar cell polarity (PCP) is a developmental process essential for...
Link:
https://www.jbc.org/article/S0021-9258(24)01265-1/fulltext
Delivery Method:
microinjection
Organism or Cell Type:
Xenopus
Citation Extract:
Walton A, Thomé V, Revinski D, Marchetto S, Puvirajesinghe TM, Audebert S, Camoin L, Bailly E, Kodjabachian L, Borg JP. A vertebrate Vangl2 translational variant required for planar cell polarity. J Biol Chem. 2024 Feb 23:106792. doi: 10.1016/j.jbc.2024.106792. Online ahead of print.

Elucidation of the genetic causes of bicuspid aortic valve disease

Authors:
Gehlen J, Stundl A, Debiec R, Fontana F, Krane M, Sharipova D, Nelson CP, Al-Kassou B, Giel AS, Sinning JM, Bruenger CMH, Zelck CF, Koebbe LL, Braund PS, Webb TR, Hetherington S, Ensminger S, Fujita B, Mohamed SA, Shrestha M, Krueger H, Siepe M, Kari FA, Nordbeck P, Buravezky L, Kelm M, Veulemans V, Adam M, Baldus S, Laugwitz KL, Haas Y, Karck M, Mehlhorn U, Conzelmann LO, Breitenbach I, Lebherz C, Urbanski P, Kim WK, Kandels J, Ellinghaus D, Nowak-Goettl U, Hoffmann P, Wirth F, Doppler S, Lahm H, Dreßen M, von Scheidt M, Knoll K, Kessler T, Hengstenberg C, Schunkert H, Nickenig G, Nöthen MM, Bolger AP, Abdelilah-Seyfried S, Samani NJ, Erdmann J, Trenkwalder T, Schumacher J
Citation:
Cardiovasc Res. 2023 May 2;119(3):857-866. doi: 10.1093/cvr/cvac099
Epub:
Not Epub
Abstract:
Aims: The present study aims to characterize the genetic risk architecture of bicuspid aortic valve (BAV) disease, the most...
Link:
https://academic.oup.com/cardiovascres/article/119/3/857/6612701
Delivery Method:
microinjection
Organism or Cell Type:
zebrafish
Citation Extract:
Gehlen J, Stundl A, Debiec R, Fontana F, Krane M, Sharipova D, Nelson CP, Al-Kassou B, Giel AS, Sinning JM, Bruenger CMH, Zelck CF, Koebbe LL, Braund PS, Webb TR, Hetherington S, Ensminger S, Fujita B, Mohamed SA, Shrestha M, Krueger H, Siepe M, Kari FA, Nordbeck P, Buravezky L, Kelm M, Veulemans V, Adam M, Baldus S, Laugwitz KL, Haas Y, Karck M, Mehlhorn U, Conzelmann LO, Breitenbach I, Lebherz C, Urbanski P, Kim WK, Kandels J, Ellinghaus D, Nowak-Goettl U, Hoffmann P, Wirth F, Doppler S, Lahm H, Dreßen M, von Scheidt M, Knoll K, Kessler T, Hengstenberg C, Schunkert H, Nickenig G, Nöthen MM, Bolger AP, Abdelilah-Seyfried S, Samani NJ, Erdmann J, Trenkwalder T, Schumacher J. Elucidation of the genetic causes of bicuspid aortic valve disease. Cardiovasc Res. 2023 May 2;119(3):857-866. doi: 10.1093/cvr/cvac099.

Schwann cells have a limited window of time in which to initiate myelination program during early migration in vivo

Authors:
El Hage O, Mikdache A, Boueid MJ, Degerny C, Tawk M
Citation:
bioRxiv. 2024;[preprint] doi:10.1101/2024.02.19.580938
Epub:
Not Epub
Abstract:
The temporal control of mitotic exit of individual Schwann cells (SCs) is essential for radial sorting and peripheral...
Link:
https://www.biorxiv.org/content/10.1101/2024.02.19.580938v1
Delivery Method:
microinjection
Organism or Cell Type:
zebrafish
Citation Extract:
El Hage O, Mikdache A, Boueid MJ, Degerny C, Tawk M. Schwann cells have a limited window of time in which to initiate myelination program during early migration in vivo. bioRxiv. 2024;[preprint] doi:10.1101/2024.02.19.580938.

Noncanonical function of folate through folate receptor 1 during neural tube formation

Authors:
Balashova OA, Panoutsopoulos AA, Visina O, Selhub J, Knoepfler PS, Borodinsky LN
Citation:
Nat Comm. 2024;15:1642. doi:10.1038/s41467-024-45775-1
Epub:
Not Epub
Abstract:
Folate supplementation reduces the occurrence of neural tube defects (NTDs), birth defects consisting in the failure of the...
Link:
https://www.nature.com/articles/s41467-024-45775-1
Delivery Method:
Vivo-Morpholino
Organism or Cell Type:
cell culture: WTC-11 hiPSC
Citation Extract:
Balashova OA, Panoutsopoulos AA, Visina O, Selhub J, Knoepfler PS, Borodinsky LN. Noncanonical function of folate through folate receptor 1 during neural tube formation. Nat Comm. 2024;15:1642. doi:10.1038/s41467-024-45775-1.

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