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Morpholino Publication Database
This database contains citations and abstracts for research using Morpholino oligos, as well as some review articles incorporating Morpholino data. You can search the content using the filter boxes below.
There are 12378 scientific papers returned from the database with the search filters currently being used below.
There are 12378 scientific papers returned from the database with the search filters currently being used below.
NANOG is required to establish the competence for germ-layer differentiation in the basal tetrapod axolotl
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Citation:
PLoS Biol. 2023;21(6):e3002121. doi:10.1371/journal.pbio.3002121 Epub:
Not Epub Abstract:
Pluripotency defines the unlimited potential of individual cells of vertebrate embryos, from which all adult somatic cells and... Delivery Method:
microinjection Organism or Cell Type:
Ambystoma mexicanum (Axolotl) Citation Extract: Simpson LA, Crowley D, Forey T, Acosta H, Ferjentsik Z, Chatfield J, Payne A, Simpson BS, Redwood C, Dixon JE, Holmes N, Sang F, Alberio R, Loose M, Johnson AD. NANOG is required to establish the competence for germ-layer differentiation in the basal tetrapod axolotl. PLoS Biol. 2023;21(6):e3002121. doi:10.1371/journal.pbio.3002121. |
In silico transcriptome screens identify epidermal growth factor receptor inhibitors as therapeutics for noise-induced hearing loss
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Citation:
Sci Adv. 2024 Jun 21;10(25):eadk2299. doi: 10.1126/sciadv.adk2299. Epub 2024 Jun 19. PMID: 38896614; PMCID: PMC11186505. Epub:
Not Epub Abstract:
Noise-induced hearing loss (NIHL) is a common sensorineural hearing impairment that lacks U.S. Food and Drug Administration–... Delivery Method:
microinjection Organism or Cell Type:
zebrafish Citation Extract: Vijayakumar S, DiGuiseppi JA, Dabestani PJ, Ryan WG, Quevedo RV, Li Y, Diers J, Tu S, Fleegel J, Nguyen C, Rhoda LM, Imami AS, Hamoud AA, Lovas S, McCullumsmith RE, Zallocchi M, Zuo J. In silico transcriptome screens identify epidermal growth factor receptor inhibitors as therapeutics for noise-induced hearing loss. Sci Adv. 2024 Jun 21;10(25):eadk2299. doi: 10.1126/sciadv.adk2299. Epub 2024 Jun 19. PMID: 38896614; PMCID: PMC11186505.. |
Nerve-independent formation of membrane infoldings at topologically complex postsynaptic apparatus by caveolin-3
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Citation:
Sci Adv. 2023 Jun 16;9(24):eadg0183. doi: 10.1126/sciadv.adg0183. Epub 2023 Jun 16 Epub:
Not Epub Abstract:
Junctional folds are unique membrane specializations developed progressively during the postnatal maturation of vertebrate... Delivery Method:
microinjection Organism or Cell Type:
Xenopus laevis Citation Extract: Kwan HR, Chan ZC, Bi X, Kutkowska J, Prószyński TJ, Chan CB, Lee CW. Nerve-independent formation of membrane infoldings at topologically complex postsynaptic apparatus by caveolin-3. Sci Adv. 2023 Jun 16;9(24):eadg0183. doi: 10.1126/sciadv.adg0183. Epub 2023 Jun 16. |
Antisense Oligonucleotide Activation via Enzymatic Antibiotic Resistance Mechanism
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Citation:
ACS Chem Biol. 2023 Jun 16. doi: 10.1021/acschembio.3c00027. Online ahead of print Epub:
Yes Abstract:
The structure and mechanism of the bacterial enzyme β-lactamase have been well-studied due to its clinical role in antibiotic... Delivery Method:
microinjection Organism or Cell Type:
zebrafish Citation Extract: Darrah KE, Albright S, Kumbhare R, Tsang M, Chen JK, Deiters A. Antisense Oligonucleotide Activation via Enzymatic Antibiotic Resistance Mechanism. ACS Chem Biol. 2023 Jun 16. doi: 10.1021/acschembio.3c00027. Online ahead of print. |
Sfxn5 Regulation of Actin Polymerization for Neutrophil Spreading Depends on a Citrate-Cholesterol-PI(4,5)P2 Pathway
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Citation:
J Immunol. 2023 Jun 16:ji2200863. doi: 10.4049/jimmunol.2200863. Online ahead of print Epub:
Yes Abstract:
Cell spreading is an initial and critical step in neutrophil adhesion and migration, leading to neutrophil recruitment to... Delivery Method:
microinjection Organism or Cell Type:
zebrafish Citation Extract: Zhang H, Meng L, Liu Y, Jiang J, He Z, Qin J, Wang C, Yang M, He K, Yang J, Chen K, He Q, Tang W, Fan S, Ren C. Sfxn5 Regulation of Actin Polymerization for Neutrophil Spreading Depends on a Citrate-Cholesterol-PI(4,5)P2 Pathway. J Immunol. 2023 Jun 16:ji2200863. doi: 10.4049/jimmunol.2200863. Online ahead of print. |
Targeted tissue delivery of RNA therapeutics using antibody-oligonucleotide conjugates (AOCs)
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Citation:
Nucleic Acids Res. 2023 May 24:gkad415. doi: 10.1093/nar/gkad415. Online ahead of print Epub:
Yes Abstract:
Although targeting TfR1 to deliver oligonucleotides to skeletal muscle has been demonstrated in rodents, effectiveness and... Delivery Method:
antibody-linked Organism or Cell Type:
mice Citation Extract: Malecova B, Burke RS, Cochran M, Hood MD, Johns R, Kovach PR, Doppalapudi VR, Erdogan G, Arias JD, Darimont B, Miller CD, Huang H, Geall A, Younis HS, Levin AA. Targeted tissue delivery of RNA therapeutics using antibody-oligonucleotide conjugates (AOCs). Nucleic Acids Res. 2023 May 24:gkad415. doi: 10.1093/nar/gkad415. Online ahead of print. |
The novel KV7 channel activator URO-K10 exerts enhanced pulmonary vascular effects independent of the KCNE4 regulatory subunit
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Citation:
Biomed Pharmacother. 2023 Jun 7;164:114952. doi: 10.1016/j.biopha.2023.114952. Online ahead of print Epub:
Not Epub Abstract:
KV7 channels exert a pivotal role regulating vascular tone in several vascular beds. In this context, KV7 channel agonists... Delivery Method:
Lipofectamine Organism or Cell Type:
cell culture: isolated pulmonary artery (PA) cells Citation Extract: Villegas-Esguevillas M, Cho S, Vera-Zambrano A, Kwon JW, Barreira B, Telli G, Navarro-Dorado J, Morales-Cano D, de Olaiz B, Moreno L, Greenwood I, Pérez-Vizcaíno F, Kim SJ, Climent B, Cogolludo A. The novel KV7 channel activator URO-K10 exerts enhanced pulmonary vascular effects independent of the KCNE4 regulatory subunit. Biomed Pharmacother. 2023 Jun 7;164:114952. doi: 10.1016/j.biopha.2023.114952. Online ahead of print. |
Plexina4 and cell survival in the developing zebrafish hindbrain
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Citation:
Dev Dyn. 2023 Jun 7. doi: 10.1002/dvdy.633. Online ahead of print Epub:
Not Epub Abstract:
Background: Growth factors are important in the developing and mature nervous system to support the survival of neurons.... Delivery Method:
microinjection Organism or Cell Type:
zebrafish Citation Extract: Nurcombe ZW, Hehr CL, McFarlane S. Plexina4 and cell survival in the developing zebrafish hindbrain. Dev Dyn. 2023 Jun 7. doi: 10.1002/dvdy.633. Online ahead of print. |
Downregulation of Yap1 during limb regeneration results in defective bone formation in axolotl
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Citation:
Dev Biol. 2023 Jun 2;500:31-39. doi: 10.1016/j.ydbio.2023.06.001. Online ahead of print Epub:
Not Epub Abstract:
The Hippo pathway plays an imperative role in cellular processes such as differentiation, regeneration, cell migration, organ... Delivery Method:
injection then electroporation Organism or Cell Type:
Ambystoma mexicanum (Axolotl) Citation Extract: Bay S, Öztürk G, Emekli N, Demircan T. Downregulation of Yap1 during limb regeneration results in defective bone formation in axolotl. Dev Biol. 2023 Jun 2;500:31-39. doi: 10.1016/j.ydbio.2023.06.001. Online ahead of print. |
Association analysis and functional follow-up identified common variants of JAG1 accounting for risk to biliary atresia
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Citation:
Front Genet. 2023 May 15;14:1186882. doi: 10.3389/fgene.2023.1186882. eCollection 2023 Epub:
Not Epub Abstract:
Background: Biliary atresia (BA) is a destructive, obliterative cholangiopathy characterized by progressive fibro-inflammatory... Delivery Method:
microinjection Organism or Cell Type:
zebrafish Citation Extract: Bai MR, Pei HY, Zhou Y, Song HL, Pan WH, Gong YM, Wu WJ, Yu WW, Cui MM, Gu BL, Chu X, Cai W. Association analysis and functional follow-up identified common variants of JAG1 accounting for risk to biliary atresia. Front Genet. 2023 May 15;14:1186882. doi: 10.3389/fgene.2023.1186882. eCollection 2023. |