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Morpholino Publication Database

This database contains citations and abstracts for research using Morpholino oligos, as well as some review articles incorporating Morpholino data. You can search the content using the filter boxes below.

There are 12378 scientific papers returned from the database with the search filters currently being used below.

Poly- and Perfluoroalkyl Substances Induce Immunotoxicity via the TLR Pathway in Zebrafish: Links to Carbon Chain Length

Authors:
Tang L, Qiu W, Zhang S, Wang J, Yang X, Xu B, Magnuson JT, Xu EG, Wu M, Zheng C
Citation:
Environ Sci Technol. 2023;57(15): 6139–49. doi:10.1021/acs.est.2c09716. Online ahead of print
Epub:
Not Epub
Abstract:
Previous studies have reported the immunotoxicity of per- and polyfluoroalkyl substances (PFASs), but it remains a significant...
Link:
https://pubs.acs.org/doi/10.1021/acs.est.2c09716
Organism or Cell Type:
zebrafish
Citation Extract:
Tang L, Qiu W, Zhang S, Wang J, Yang X, Xu B, Magnuson JT, Xu EG, Wu M, Zheng C. Poly- and Perfluoroalkyl Substances Induce Immunotoxicity via the TLR Pathway in Zebrafish: Links to Carbon Chain Length. Environ Sci Technol. 2023;57(15): 6139–49. doi:10.1021/acs.est.2c09716. Online ahead of print.

BDNF signaling in correlation-dependent structural plasticity in the developing visual system

Authors:
Kutsarova E, Schohl A, Munz M, Wang A, Zhang YY, Bilash OM, Ruthazer ES
Citation:
PLoS Biol. 2023;21(4):e3002070. doi:10.1371/journal.pbio.3002070
Epub:
Not Epub
Abstract:
During development, patterned neural activity instructs topographic map refinement. Axons with similar patterns of neural...
Link:
https://journals.plos.org/plosbiology/article?id=10.1371/journal.pbio.3002070
Delivery Method:
microinjection
Organism or Cell Type:
Xenopus laevis
Citation Extract:
Kutsarova E, Schohl A, Munz M, Wang A, Zhang YY, Bilash OM, Ruthazer ES. BDNF signaling in correlation-dependent structural plasticity in the developing visual system. PLoS Biol. 2023;21(4):e3002070. doi:10.1371/journal.pbio.3002070.

Abnormal autophagy is a critical mechanism in TANGO2-related rhabdomyolysis

Authors:
Montealegre S, de Calbiac H, Straube M, Debruge H, Chentout L, Ciura S, Imbard A, Le Guillou E, Marian A, Goudin N, Caccavelli L, Fabrega S, Hubas A, van Endert P, Dupont N, Diana J, Kabashi E, de Lonlay P
Citation:
bioRxiv. 2023;[preprint] doi:10.1101/2023.03.29.534583
Epub:
Not Epub
Abstract:
Patients with pathogenic variants in the TANGO2 gene suffer from severe and recurrent rhabdomyolysis (RM) episodes precipitated...
Link:
https://www.biorxiv.org/content/10.1101/2023.03.29.534583v1
Delivery Method:
microinjection
Organism or Cell Type:
zebrafish
Citation Extract:
Montealegre S, de Calbiac H, Straube M, Debruge H, Chentout L, Ciura S, Imbard A, Le Guillou E, Marian A, Goudin N, Caccavelli L, Fabrega S, Hubas A, van Endert P, Dupont N, Diana J, Kabashi E, de Lonlay P. Abnormal autophagy is a critical mechanism in TANGO2-related rhabdomyolysis. bioRxiv. 2023;[preprint] doi:10.1101/2023.03.29.534583.

Nuclear SUN1 stabilizes endothelial cell junctions via microtubules to regulate blood vessel formation

Authors:
Buglak DB, Bougaran P, Kulikauskas MR, Liu Z, Monaghan-Benson E, Gold AL, Marvin AP, Burciu A, Tanke NT, Oatley M, Ricketts SN, Kinghorn K, Johnson BN, Shiau CE, Rogers S, Guilluy C, Bautch VL
Citation:
eLife. 2023;12:e83652. doi:10.7554/eLife.83652
Epub:
Not Epub
Abstract:
Endothelial cells line all blood vessels, where they coordinate blood vessel formation and the blood-tissue barrier via...
Link:
https://elifesciences.org/articles/83652
Delivery Method:
microinjection
Organism or Cell Type:
zebrafish
Citation Extract:
Buglak DB, Bougaran P, Kulikauskas MR, Liu Z, Monaghan-Benson E, Gold AL, Marvin AP, Burciu A, Tanke NT, Oatley M, Ricketts SN, Kinghorn K, Johnson BN, Shiau CE, Rogers S, Guilluy C, Bautch VL. Nuclear SUN1 stabilizes endothelial cell junctions via microtubules to regulate blood vessel formation. eLife. 2023;12:e83652. doi:10.7554/eLife.83652.

Inhibition of Interferon Alpha by a Peptide-Conjugated Phosphorodiamidate Morpholino Oligomer Increases Influenza Virus Replication in Chicken Embryo Fibroblast (DF-1) Cells; An Alternative Strategy to Increasing Vaccine Production in Cell Culture

Authors:
Prescott M, Moulton H, Pastey M
Citation:
J Med Microbiol. 2024 Feb;73(2). doi: 10.1099/jmm.0.001807. PMID: 38353513
Epub:
Not Epub
Abstract:
Influenza is a global health issue causing substantial health and economic burdens in affected populations. Routine, annual...
Link:
https://www.microbiologyresearch.org/content/journal/jmm/10.1099/jmm.0.001807
Delivery Method:
peptide-linked
Organism or Cell Type:
cell culture: DF-1 chick embryo fibroblasts
Citation Extract:
Prescott M, Moulton H, Pastey M. Inhibition of Interferon Alpha by a Peptide-Conjugated Phosphorodiamidate Morpholino Oligomer Increases Influenza Virus Replication in Chicken Embryo Fibroblast (DF-1) Cells; An Alternative Strategy to Increasing Vaccine Production in Cell Culture. J Med Microbiol. 2024 Feb;73(2). doi: 10.1099/jmm.0.001807. PMID: 38353513.

Her6 and Prox1 are novel regulators of photoreceptor regeneration in the zebrafish retina

Authors:
Veen K, Krylov A, Yu S, He J, Boyd P, Hyde DR, Mantamadiotis T, Cheng LY, Jusuf PR
Citation:
bioRxiv. 2023;[preprint] doi:10.1101/2023.03.20.532714
Epub:
Not Epub
Abstract:
Damage to light-sensing photoreceptors (PRs) occurs in highly prevalent retinal diseases. As humans cannot regenerate new PRs,...
Link:
https://www.biorxiv.org/content/10.1101/2023.03.20.532714v1
Delivery Method:
retinal microinjection then electroporation
Organism or Cell Type:
zebrafish
Citation Extract:
Veen K, Krylov A, Yu S, He J, Boyd P, Hyde DR, Mantamadiotis T, Cheng LY, Jusuf PR. Her6 and Prox1 are novel regulators of photoreceptor regeneration in the zebrafish retina. bioRxiv. 2023;[preprint] doi:10.1101/2023.03.20.532714.

In Vivo Evaluation of Exon 51 Skipping in hDMD/Dmd-null Mice

Authors:
Sheri N, Yokota T
Citation:
Methods Mol Biol. 2023;2640:327-336. doi: 10.1007/978-1-0716-3036-5_23. PMID: 36995605
Epub:
Not Epub
Abstract:
Duchenne muscular dystrophy (DMD) is a fatal X-linked condition that affects 1 in 3500-6000 newborn boys a year. An out-of-...
Link:
https://link.springer.com/protocol/10.1007/978-1-0716-3036-5_23
Delivery Method:
intravenous (i.v.) and intramuscular (i.m.) injections
Organism or Cell Type:
mice
Citation Extract:
Sheri N, Yokota T. In Vivo Evaluation of Exon 51 Skipping in hDMD/Dmd-null Mice. Methods Mol Biol. 2023;2640:327-336. doi: 10.1007/978-1-0716-3036-5_23. PMID: 36995605.

Exons 45-55 Skipping Using Antisense Oligonucleotides in Immortalized Human DMD Muscle Cells

Authors:
He M, Yokota T
Citation:
Methods Mol Biol. 2023;2640:313-325. doi: 10.1007/978-1-0716-3036-5_22.
Epub:
Not Epub
Abstract:
Antisense oligonucleotides (AOs) have demonstrated high potential as a therapy for treating genetic diseases like Duchene...
Link:
https://link.springer.com/protocol/10.1007/978-1-0716-3036-5_22
Organism or Cell Type:
cell culture: immortalized DMD muscle cell lines
Citation Extract:
He M, Yokota T. Exons 45-55 Skipping Using Antisense Oligonucleotides in Immortalized Human DMD Muscle Cells. Methods Mol Biol. 2023;2640:313-325. doi: 10.1007/978-1-0716-3036-5_22..

Improved Prediction of Antisense Oligonucleotide Efficacy for Exon Skipping Using Ensemble Learning and Feature Selection

Authors:
Zhu A, Chiba S, Shimizu Y, Kunitake K, Okuno Y, Aoki Y, Yokota T
Citation:
Preprints. 2023;2023030389. doi:10.20944/preprints202303.0389.v1
Epub:
Not Epub
Abstract:
Antisense oligonucleotide (ASO)-mediated exon skipping has become a valuable tool for investigating gene function and...
Link:
https://www.preprints.org/manuscript/202303.0389/v1
Citation Extract:
Zhu A, Chiba S, Shimizu Y, Kunitake K, Okuno Y, Aoki Y, Yokota T. Improved Prediction of Antisense Oligonucleotide Efficacy for Exon Skipping Using Ensemble Learning and Feature Selection. Preprints. 2023;2023030389. doi:10.20944/preprints202303.0389.v1.

ASO targeting RBM3 temperature-controlled poison exon splicing prevents neurodegeneration in vivo

Authors:
Preußner M, Smith HL, Hughes D, Zhang M, Emmerichs AK, Scalzitti S, Peretti D, Swinden D, Neumann A, Haltenhof T, Mallucci GR, Heyd F
Citation:
EMBO Mol Med. 2023 Mar 22:e17157. doi: 10.15252/emmm.202217157. Online ahead of print
Epub:
Yes
Abstract:
Neurodegenerative diseases are increasingly prevalent in the aging population, yet no disease-modifying treatments are...
Link:
https://www.embopress.org/doi/full/10.15252/emmm.202217157
Delivery Method:
Endo-Porter
Organism or Cell Type:
cell culture: HEK293
Citation Extract:
Preußner M, Smith HL, Hughes D, Zhang M, Emmerichs AK, Scalzitti S, Peretti D, Swinden D, Neumann A, Haltenhof T, Mallucci GR, Heyd F. ASO targeting RBM3 temperature-controlled poison exon splicing prevents neurodegeneration in vivo. EMBO Mol Med. 2023 Mar 22:e17157. doi: 10.15252/emmm.202217157. Online ahead of print.

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