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Morpholino Publication Database

This database contains citations and abstracts for research using Morpholino oligos, as well as some review articles incorporating Morpholino data. You can search the content using the filter boxes below.

There are 12378 scientific papers returned from the database with the search filters currently being used below.

The H2A.Z and NuRD associated protein HMG20A controls early head and heart developmental transcription programs

Authors:
Herchenröther A, Gossen S, Friedrich T, Reim A, Daus N, Diegmüller F, Leers J, Sani HM, Gerstner S, Schwarz L, Stellmacher I, Szymkowiak LV, Nist A, Stiewe T, Borggrefe T, Mann M, Mackay JP, Bartkuhn M, Borchers A, Lan J, Hake SB
Citation:
Nat Commun. 2023 Jan 28;14(1):472. doi: 10.1038/s41467-023-36114-x
Epub:
Not Epub
Abstract:
Specialized chromatin-binding proteins are required for DNA-based processes during development. We recently established PWWP2A...
Link:
https://www.nature.com/articles/s41467-023-36114-x
Delivery Method:
microinjection
Organism or Cell Type:
Xenopus laevis
Citation Extract:
Herchenröther A, Gossen S, Friedrich T, Reim A, Daus N, Diegmüller F, Leers J, Sani HM, Gerstner S, Schwarz L, Stellmacher I, Szymkowiak LV, Nist A, Stiewe T, Borggrefe T, Mann M, Mackay JP, Bartkuhn M, Borchers A, Lan J, Hake SB. The H2A.Z and NuRD associated protein HMG20A controls early head and heart developmental transcription programs. Nat Commun. 2023 Jan 28;14(1):472. doi: 10.1038/s41467-023-36114-x.

The involvement and therapeutic potential of lncRNA Kcnq1ot1/miR-34a-5p/Sirt1 pathway in arsenic trioxide-induced cardiotoxicity

Authors:
Shen X, Zhi F, Shi C, Xu J, Chao Y, Xu J, Bai Y, Jiang Y, Yang B
Citation:
J Transl Med. 2023 Jan 28;21(1):52. doi: 10.1186/s12967-023-03895-0
Epub:
Not Epub
Abstract:
Background/aims: Arsenic trioxide (ATO) is the first-line therapeutic drug for acute promyelocytic leukemia. However, the...
Link:
https://translational-medicine.biomedcentral.com/articles/10.1186/s12967-023-03895-0
Delivery Method:
X-tremeGENE siRNA Transfection Reagent
Organism or Cell Type:
cell culture: neonatal mouse cardiomyocytes
Citation Extract:
Shen X, Zhi F, Shi C, Xu J, Chao Y, Xu J, Bai Y, Jiang Y, Yang B. The involvement and therapeutic potential of lncRNA Kcnq1ot1/miR-34a-5p/Sirt1 pathway in arsenic trioxide-induced cardiotoxicity. J Transl Med. 2023 Jan 28;21(1):52. doi: 10.1186/s12967-023-03895-0.

Identification of selective hepatitis delta virus ribozyme inhibitors by high-throughput screening of small molecule libraries

Authors:
Tseligka ED, Conzelmann S, Cambet Y, Schaer T, Negro F, Clément S
Citation:
JHEP Rep. 2022 Dec 17;5(3):100652. doi:10.1016/j.jhepr.2022.100652. eCollection 2023 Mar
Epub:
Not Epub
Abstract:
Background & aims: Chronic hepatitis delta is the most severe form of chronic viral hepatitis and is associated with faster...
Link:
https://www.jhep-reports.eu/article/S2589-5559(22)00224-5/fulltext
Delivery Method:
jetPRIMER transfection reagent
Organism or Cell Type:
cell culture: Huh7 human hepatoma
Citation Extract:
Tseligka ED, Conzelmann S, Cambet Y, Schaer T, Negro F, Clément S. Identification of selective hepatitis delta virus ribozyme inhibitors by high-throughput screening of small molecule libraries. JHEP Rep. 2022 Dec 17;5(3):100652. doi:10.1016/j.jhepr.2022.100652. eCollection 2023 Mar.

Crb3 stabilizes activated Ezrin-Radixin-Moesin to organize the apical domain of multiciliated cells

Authors:
Burckle C, Raitiere J, Kodjabachian L, Le-Bivic A
Citation:
bioRxiv. 2023;[preprint] doi:10.1101/2023.01.24.525309
Epub:
Not Epub
Abstract:
Cell shape changes mainly rely on the remodeling of the actin cytoskeleton. Multiciliated cells (MCCs) of the mucociliary...
Link:
https://www.biorxiv.org/content/10.1101/2023.01.24.525309v1
Delivery Method:
microinjection
Organism or Cell Type:
Xenopus laevis
Citation Extract:
Burckle C, Raitiere J, Kodjabachian L, Le-Bivic A. Crb3 stabilizes activated Ezrin-Radixin-Moesin to organize the apical domain of multiciliated cells. bioRxiv. 2023;[preprint] doi:10.1101/2023.01.24.525309.

Endoderm-derived islet1-expressing cells differentiate into endothelial cells to function as the vascular HSPC niche in zebrafish

Authors:
Nakajima H, Ishikawa H, Yamamoto T, Chiba A, Fukui H, Sako K, Fukumoto M, Mattonet K, Kwon H-B, Hui SP, Dobreva GD, Kikuchi K, Helker CSM, Stainier DYR, Mochizuki N
Citation:
Dev Cell. 2023;[Epub ahead of print] doi:10.1016/j.devcel.2022.12.013
Epub:
Not Epub
Abstract:
Endothelial cells (ECs) line blood vessels and serve as a niche for hematopoietic stem and progenitor cells (HSPCs). Recent...
Link:
https://www.sciencedirect.com/science/article/pii/S1534580722008954
Delivery Method:
microinjection
Organism or Cell Type:
zebrafish
Citation Extract:
Nakajima H, Ishikawa H, Yamamoto T, Chiba A, Fukui H, Sako K, Fukumoto M, Mattonet K, Kwon H-B, Hui SP, Dobreva GD, Kikuchi K, Helker CSM, Stainier DYR, Mochizuki N. Endoderm-derived islet1-expressing cells differentiate into endothelial cells to function as the vascular HSPC niche in zebrafish. Dev Cell. 2023;[Epub ahead of print] doi:10.1016/j.devcel.2022.12.013.

Wnt4 and ephrinB2 instruct apical constriction via Dishevelled and non-canonical signaling

Authors:
Yoon J, Sun J, Lee M, Hwang YS, Daar IO
Citation:
Nat Commun. 2023 Jan 20;14(1):337. doi: 10.1038/s41467-023-35991-6
Epub:
Not Epub
Abstract:
Apical constriction is a cell shape change critical to vertebrate neural tube closure, and the contractile force required for...
Link:
https://www.nature.com/articles/s41467-023-35991-6
Delivery Method:
microinjection
Organism or Cell Type:
Xenopus laevis
Citation Extract:
Yoon J, Sun J, Lee M, Hwang YS, Daar IO. Wnt4 and ephrinB2 instruct apical constriction via Dishevelled and non-canonical signaling. Nat Commun. 2023 Jan 20;14(1):337. doi: 10.1038/s41467-023-35991-6.

Integrative genetic analysis illuminates ALS heritability and identifies risk genes

Authors:
Megat S, Mora N, Sanogo J, Roman O, Catanese A, Alami NO, Freischmidt A, Mingaj X, De Calbiac H, Muratet F, Dirrig-Grosch S, Dieterle S, Van Bakel N, Müller K, Sieverding K, Weishaupt J, Andersen PM, Weber M, Neuwirth C, Margelisch M, Sommacal A, Van Eijk KR, Veldink JH; Project Mine Als Sequencing Consortium; Lautrette G, Couratier P, Camuzat A, Le Ber I, Grassano M, Chio A, Boeckers T, Ludolph AC, Roselli F, Yilmazer-Hanke D, Millecamps S, Kabashi E, Storkebaum E, Sellier C, Dupuis L
Citation:
Nat Commun. 2023 Jan 20;14(1):342. doi: 10.1038/s41467-022-35724-1
Epub:
Not Epub
Abstract:
Amyotrophic lateral sclerosis (ALS) has substantial heritability, in part shared with fronto-temporal dementia (FTD). We show...
Link:
https://www.nature.com/articles/s41467-022-35724-1
Delivery Method:
microinjection
Organism or Cell Type:
zebrafish
Citation Extract:
Megat S, Mora N, Sanogo J, Roman O, Catanese A, Alami NO, Freischmidt A, Mingaj X, De Calbiac H, Muratet F, Dirrig-Grosch S, Dieterle S, Van Bakel N, Müller K, Sieverding K, Weishaupt J, Andersen PM, Weber M, Neuwirth C, Margelisch M, Sommacal A, Van Eijk KR, Veldink JH; Project Mine Als Sequencing Consortium; Lautrette G, Couratier P, Camuzat A, Le Ber I, Grassano M, Chio A, Boeckers T, Ludolph AC, Roselli F, Yilmazer-Hanke D, Millecamps S, Kabashi E, Storkebaum E, Sellier C, Dupuis L. Integrative genetic analysis illuminates ALS heritability and identifies risk genes. Nat Commun. 2023 Jan 20;14(1):342. doi: 10.1038/s41467-022-35724-1.

Structural remodeling of AAA+ ATPase p97 by adaptor protein ASPL facilitates posttranslational methylation by METTL21D

Authors:
Petrović S, Roske Y, Rami B, Phan MHQ, Panáková D, Heinemann U
Citation:
Proc Natl Acad Sci U S A. 2023 Jan 24;120(4):e2208941120. doi:10.1073/pnas.2208941120. Epub 2023 Jan 19
Epub:
Yes
Abstract:
p97 is an essential AAA+ ATPase that extracts and unfolds substrate proteins from membranes and protein complexes. Through its...
Link:
https://www.pnas.org/doi/10.1073/pnas.2208941120
Delivery Method:
microinjection
Organism or Cell Type:
zebrafish
Citation Extract:
Petrović S, Roske Y, Rami B, Phan MHQ, Panáková D, Heinemann U. Structural remodeling of AAA+ ATPase p97 by adaptor protein ASPL facilitates posttranslational methylation by METTL21D. Proc Natl Acad Sci U S A. 2023 Jan 24;120(4):e2208941120. doi:10.1073/pnas.2208941120. Epub 2023 Jan 19.

Morpholino-Mediated Exons 28-29 Skipping of Dysferlin and Characterization of Multiexon-skipped Dysferlin using RT-PCR, Immunoblotting, and Membrane Wounding Assay

Authors:
Anwar S, Yokota T
Citation:
Methods in Molecular Biology . 2023;2587. In: Maruyama R, Yokota T. (eds) Muscular Dystrophy Therapeutics. Humana, New York, NY. doi:10.1007/978-1-0716-2772-3_11
Epub:
Not Epub
Abstract:
Dysferlinopathies are a group of disabling muscular dystrophies that includes limb girdle muscular dystrophy type 2B (LGMD2B...
Link:
https://link.springer.com/protocol/10.1007/978-1-0716-2772-3_11
Organism or Cell Type:
cell culture: fibroblasts
Citation Extract:
Anwar S, Yokota T. Morpholino-Mediated Exons 28-29 Skipping of Dysferlin and Characterization of Multiexon-skipped Dysferlin using RT-PCR, Immunoblotting, and Membrane Wounding Assay. Methods in Molecular Biology . 2023;2587. In: Maruyama R, Yokota T. (eds) Muscular Dystrophy Therapeutics. Humana, New York, NY. doi:10.1007/978-1-0716-2772-3_11.

Unraveling Presenilin 2 Functions in a Knockout Zebrafish Line to Shed Light into Alzheimer’s Disease Pathogenesis

Authors:
Barazzuol L, Cieri D, Facchinello N, Calì T, Washbourne P, Argenton F, Pizzo P
Citation:
Cells. 2023;12(3):376. doi:10.3390/cells12030376
Epub:
Not Epub
Abstract:
Mutations in presenilin 2 (PS2) have been causally linked to the development of inherited Alzheimer’s disease (AD). Besides its...
Link:
https://www.mdpi.com/2073-4409/12/3/376/htm
Delivery Method:
microinjection
Organism or Cell Type:
zebrafish
Citation Extract:
Barazzuol L, Cieri D, Facchinello N, Calì T, Washbourne P, Argenton F, Pizzo P. Unraveling Presenilin 2 Functions in a Knockout Zebrafish Line to Shed Light into Alzheimer’s Disease Pathogenesis. Cells. 2023;12(3):376. doi:10.3390/cells12030376.

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