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Morpholino Publication Database

This database contains citations and abstracts for research using Morpholino oligos, as well as some review articles incorporating Morpholino data. You can search the content using the filter boxes below.

There are 12378 scientific papers returned from the database with the search filters currently being used below.

O.14 EEV-Conjugated PMO results in nuclear foci reduction and aberrant splicing correction in myotonic dystrophy cell and animal models

Authors:
Grigenrath M, Estrella N, Hicks A, Shen X, Wysk M, Kheirabadi M, Streeter M, Lian W, Liu N, Blake S, Brennan C, Li N, Batagui V, Oye K, Gao N, Wang D, Qian X, Sethuraman N
Citation:
Neuromuscul Disord. 2022;32(Suppl 1):S96. doi:/10.1016/j.nmd.2022.07.224
Epub:
Not Epub
Abstract:
Myotonic dystrophy type 1 (DM1) is the most common adult-onset muscular dystrophy, manifesting in multisystemic effects...
Link:
https://www.sciencedirect.com/science/article/pii/S0960896622004266
Delivery Method:
peptide-linked
Organism or Cell Type:
cell culture: patient-derived muytoubes, mice
Citation Extract:
Grigenrath M, Estrella N, Hicks A, Shen X, Wysk M, Kheirabadi M, Streeter M, Lian W, Liu N, Blake S, Brennan C, Li N, Batagui V, Oye K, Gao N, Wang D, Qian X, Sethuraman N. O.14 EEV-Conjugated PMO results in nuclear foci reduction and aberrant splicing correction in myotonic dystrophy cell and animal models. Neuromuscul Disord. 2022;32(Suppl 1):S96. doi:/10.1016/j.nmd.2022.07.224.

INTS13 variants causing a recessive developmental ciliopathy disrupt assembly of the Integrator complex

Authors:
Mascibroda LG, Shboul M, Elrod ND, Colleaux L, Hamamy H, Huang K-L, Peart N, Singh MK, Lee H, Merriman B, Jodoin JN, Sitaram P, Lee LA, Fathalla R, Al-Rawashdeh B, Ababneh O, El-Khateeb M, Escande-Beillard N, Nelson SF, Wu Y, Tong L, Kenney LJ, Roy Su, Russell WK, Amiel J, Reversade B, Wagner EJ
Citation:
Nat Commun. 2022;13(1),6054. doi:10.1038/s41467-022-33547-8
Epub:
Not Epub
Abstract:
Oral-facial-digital (OFD) syndromes are a heterogeneous group of congenital disorders characterized by malformations of the...
Link:
https://www.nature.com/articles/s41467-022-33547-8
Delivery Method:
microinjection
Organism or Cell Type:
Xenopus laevis
Citation Extract:
Mascibroda LG, Shboul M, Elrod ND, Colleaux L, Hamamy H, Huang K-L, Peart N, Singh MK, Lee H, Merriman B, Jodoin JN, Sitaram P, Lee LA, Fathalla R, Al-Rawashdeh B, Ababneh O, El-Khateeb M, Escande-Beillard N, Nelson SF, Wu Y, Tong L, Kenney LJ, Roy Su, Russell WK, Amiel J, Reversade B, Wagner EJ. INTS13 variants causing a recessive developmental ciliopathy disrupt assembly of the Integrator complex. Nat Commun. 2022;13(1),6054. doi:10.1038/s41467-022-33547-8.

Trim33 conditions the lifespan of primitive macrophages and onset of definitive macrophage production

Authors:
Demy DL, Touret A-L, Lancino M, Tauzin M, Capuana L, Pierre C, Herbomel P
Citation:
Development. 2022;149(18):dev200835. doi:10.1242/dev.200835
Epub:
Not Epub
Abstract:
Trim33 (Tif1γ) is a transcriptional regulator that is notably involved in several aspects of hematopoiesis. It is essential for...
Link:
https://journals.biologists.com/dev/article-abstract/149/18/dev200835/276648/Trim33-conditions-the-lifespan-of-primitive
Organism or Cell Type:
zebrafish
Citation Extract:
Demy DL, Touret A-L, Lancino M, Tauzin M, Capuana L, Pierre C, Herbomel P. Trim33 conditions the lifespan of primitive macrophages and onset of definitive macrophage production. Development. 2022;149(18):dev200835. doi:10.1242/dev.200835.

N-myc downstream regulated gene 1 (ndrg1) functions as a molecular switch for cellular adaptation to hypoxia

Authors:
Park JS. Gabel AM, Kassir P, Kang L, Chowdhary PK, Osei-Ntansah A, Tran ND, Viswanathan S, Canales B, Ding P, Lee Y-S, Brewster R
Citation:
eLife. 2022;11:e74031. doi:10.7554/eLife.74031
Epub:
Not Epub
Abstract:
Lack of oxygen (hypoxia and anoxia) is detrimental to cell function and survival and underlies many disease conditions. Hence,...
Link:
https://elifesciences.org/articles/74031
Delivery Method:
microinjection
Organism or Cell Type:
zebrafish
Citation Extract:
Park JS. Gabel AM, Kassir P, Kang L, Chowdhary PK, Osei-Ntansah A, Tran ND, Viswanathan S, Canales B, Ding P, Lee Y-S, Brewster R. N-myc downstream regulated gene 1 (ndrg1) functions as a molecular switch for cellular adaptation to hypoxia. eLife. 2022;11:e74031. doi:10.7554/eLife.74031.

Collective cell migration during optic cup formation features changing cell-matrix interactions linked to matrix topology

Authors:
Soans KG, Ramos AP, Sidhaye J, Krishna A, Solomatina A, Hoffmann KB, Schlüßler R, Guck J, Sbalzarini IF, Modes CD, Norden C
Citation:
Curr Biol. 2022;[Epub] doi:10.1016/j.cub.2022.09.034
Epub:
Yes
Abstract:
Cell migration is crucial for organismal development and shapes organisms in health and disease. Although a lot of research has...
Link:
https://www.cell.com/current-biology/pdf/S0960-9822(22)01503-2.pdf
Delivery Method:
microinjection
Organism or Cell Type:
zebrafish
Citation Extract:
Soans KG, Ramos AP, Sidhaye J, Krishna A, Solomatina A, Hoffmann KB, Schlüßler R, Guck J, Sbalzarini IF, Modes CD, Norden C. Collective cell migration during optic cup formation features changing cell-matrix interactions linked to matrix topology. Curr Biol. 2022;[Epub] doi:10.1016/j.cub.2022.09.034.

Simultaneous imaging of calcium and contraction in the beating heart of zebrafish larvae

Authors:
Salgado-Almario J, Vicente M, Molina Y, Martinez-Sielva A, Vincent P, Domingo B, Llopis J
Citation:
Theranostics. 2022 Jan 1;12(3):1012-1029. doi: 10.7150/thno.64734. eCollection 2022
Epub:
Not Epub
Abstract:
In vivo models of cardiac function maintain the complex relationship of cardiomyocytes with other heart cells, as well as the...
Link:
https://www.thno.org/v12p1012.htm
Delivery Method:
microinjection
Organism or Cell Type:
zebrafish
Citation Extract:
Salgado-Almario J, Vicente M, Molina Y, Martinez-Sielva A, Vincent P, Domingo B, Llopis J. Simultaneous imaging of calcium and contraction in the beating heart of zebrafish larvae. Theranostics. 2022 Jan 1;12(3):1012-1029. doi: 10.7150/thno.64734. eCollection 2022.

Common and species-specific molecular signatures, networks, and regulators of influenza virus infection in mice, ferrets, and humans

Authors:
Forst CV, Martin-Sancho L, Tripathi S, Wang G, Dos Anjos Borges LG, Wang M, Geber A, Lashua L, Ding T, Zhou X, Carter CE, Metreveli G, Rodriguez-Frandsen A, Urbanowski MD, White KM, Stein DA, Moulton H, Chanda SK, Pache L, Shaw ML, Ross TM, Ghedin E, García-Sastre A, Zhang B
Citation:
Sci Adv. 2022 Oct 7;8(40):eabm5859. doi: 10.1126/sciadv.abm5859. Epub 2022 Oct 5
Epub:
Not Epub
Abstract:
Molecular responses to influenza A virus (IAV) infections vary between mammalian species. To identify conserved and species-...
Link:
https://www.science.org/doi/10.1126/sciadv.abm5859
Delivery Method:
peptide-linked
Organism or Cell Type:
mice
Citation Extract:
Forst CV, Martin-Sancho L, Tripathi S, Wang G, Dos Anjos Borges LG, Wang M, Geber A, Lashua L, Ding T, Zhou X, Carter CE, Metreveli G, Rodriguez-Frandsen A, Urbanowski MD, White KM, Stein DA, Moulton H, Chanda SK, Pache L, Shaw ML, Ross TM, Ghedin E, García-Sastre A, Zhang B. Common and species-specific molecular signatures, networks, and regulators of influenza virus infection in mice, ferrets, and humans. Sci Adv. 2022 Oct 7;8(40):eabm5859. doi: 10.1126/sciadv.abm5859. Epub 2022 Oct 5.

Microtubules are not required to generate a nascent axon in embryonic spinal neurons in vivo

Authors:
Moore RE, Pop S, Alleyne C, Clarke JDW
Citation:
EMBO Rep. 2022 Oct 4:e52493. doi: 10.15252/embr.202152493. Online ahead of print
Epub:
Not Epub
Abstract:
Our understanding of the cell behaviours and cytoskeletal requirements of axon formation is largely derived from in vitro...
Link:
https://www.embopress.org/doi/full/10.15252/embr.202152493
Delivery Method:
microinjection
Organism or Cell Type:
zebrafish
Citation Extract:
Moore RE, Pop S, Alleyne C, Clarke JDW. Microtubules are not required to generate a nascent axon in embryonic spinal neurons in vivo. EMBO Rep. 2022 Oct 4:e52493. doi: 10.15252/embr.202152493. Online ahead of print.

Structural Fingerprinting of Antisense Oligonucleotide Therapeutics by Solution NMR Spectroscopy

Authors:
Becette OB, Marino JP, Brinson RG
Citation:
Pharm Res. 2023 Jun;40(6):1373-1382. doi: 10.1007/s11095-022-03403-x. Epub 2022 Oct 4. PMID: 36195820
Epub:
Yes
Abstract:
Purpose: Antisense oligonucleotide (ASO) therapeutics are an emerging class of biopharmaceuticals to treat and prevent diseases...
Link:
https://link.springer.com/article/10.1007/s11095-022-03403-x
Citation Extract:
Becette OB, Marino JP, Brinson RG. Structural Fingerprinting of Antisense Oligonucleotide Therapeutics by Solution NMR Spectroscopy. Pharm Res. 2023 Jun;40(6):1373-1382. doi: 10.1007/s11095-022-03403-x. Epub 2022 Oct 4. PMID: 36195820.

Zebrafish Model of Stickler Syndrome Suggests a Role for Col2a1a in the Neural Crest during Early Eye Development

Authors:
Williams AL, Bohnsack BL
Citation:
J Dev Biol 2022;10(4):42. doi:10.3390/jdb10040042
Epub:
Not Epub
Abstract:
Most cases of Stickler syndrome are due to autosomal-dominant COL2A1 gene mutations leading to abnormal type II collagen....
Link:
https://www.mdpi.com/2221-3759/10/4/42
Delivery Method:
microinjection
Organism or Cell Type:
zebrafish
Citation Extract:
Williams AL, Bohnsack BL. Zebrafish Model of Stickler Syndrome Suggests a Role for Col2a1a in the Neural Crest during Early Eye Development. J Dev Biol 2022;10(4):42. doi:10.3390/jdb10040042.

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