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Morpholino Publication Database

This database contains citations and abstracts for research using Morpholino oligos, as well as some review articles incorporating Morpholino data. You can search the content using the filter boxes below.

There are 12179 scientific papers returned from the database with the search filters currently being used below.

Probe-Screened Carbon Nanotube Field-Effect Transistor Biosensor to Enhance Breast Cancer-Related Gene Assay

Authors:
Liu P, Liu Y, Cai B, Li J, Zhang G-J
Citation:
Green Analytical Chemistry (2025) 100267, ISSN 2772-5774, doi.org/10.1016/j.greeac.2025.100267
Epub:
Not Epub
Abstract:
BRCA1 gene testing is a trump card for liquid biopsy and early diagnosis in breast cancer, which has been limited, however, by...
Link:
/www.sciencedirect.com/science/article/pii/S2772577425000631
Delivery Method:
None
Organism or Cell Type:
DNA samples extracted from BRCA1-mutated breast cancer patients and healthy controls
Citation Extract:
Liu P, Liu Y, Cai B, Li J, Zhang G-J. Probe-Screened Carbon Nanotube Field-Effect Transistor Biosensor to Enhance Breast Cancer-Related Gene Assay. Green Analytical Chemistry (2025) 100267, ISSN 2772-5774, doi.org/10.1016/j.greeac.2025.100267.

SMC2 and Condensin II Subunits Are Essential for the Development of Hematopoietic Stem and Progenitor Cells in Zebrafish

Authors:
Oh CK, Kim MS, Shin U, Kang JW, Kim YH, Ko HS, Ra JS, Ahn S, Choi EY, Yu S, Nam U, Choi T, Myung K, Lee Y
Citation:
J Cell Physiol. 2025 Mar;240(3):e70023. doi: 10.1002/jcp.70023. PMID: 40134128; PMCID: PMC11937623
Epub:
Not Epub
Abstract:
Hematopoietic stem and progenitor cells (HSPCs) play a pivotal role in blood cell production, maintaining the health and...
Link:
https://onlinelibrary.wiley.com/doi/10.1002/jcp.70023
Delivery Method:
microinjection
Organism or Cell Type:
zebrafish
Citation Extract:
Oh CK, Kim MS, Shin U, Kang JW, Kim YH, Ko HS, Ra JS, Ahn S, Choi EY, Yu S, Nam U, Choi T, Myung K, Lee Y. SMC2 and Condensin II Subunits Are Essential for the Development of Hematopoietic Stem and Progenitor Cells in Zebrafish. J Cell Physiol. 2025 Mar;240(3):e70023. doi: 10.1002/jcp.70023. PMID: 40134128; PMCID: PMC11937623.

Zebrafish TDP43 positively regulates p65-mediated apoptotic pathway

Authors:
Yu T, Li M, Li M, Zhang Q, Zhang H, Jiang Z, Wang S, Mao H, Li D, Fan L, Hu C, Xu X
Citation:
Int J Biol Macromol. 2025 Mar 27:142599. doi: 10.1016/j.ijbiomac.2025.142599. Epub ahead of print. PMID: 40157684
Epub:
Not Epub
Abstract:
TAR DNA-binding protein 43 (TDP43) is a multifunctional RNA/DNA binding protein that serves as a hallmark of neurodegeneration...
Link:
https://www.sciencedirect.com/science/article/abs/pii/S0141813025031514
Delivery Method:
microinjection
Organism or Cell Type:
zebrafish
Citation Extract:
Yu T, Li M, Li M, Zhang Q, Zhang H, Jiang Z, Wang S, Mao H, Li D, Fan L, Hu C, Xu X. Zebrafish TDP43 positively regulates p65-mediated apoptotic pathway. Int J Biol Macromol. 2025 Mar 27:142599. doi: 10.1016/j.ijbiomac.2025.142599. Epub ahead of print. PMID: 40157684.

OPN3-mediated positive regulation of angiogenesis in HUVECs through VEGFR2 interaction

Authors:
Luo H, Zhang W, Zeng W, Wang Y, Feng J, Lan Y, Dong X, Liu T, Sun Y, Lu H
Citation:
Commun Biol. 2025 Mar 31;8(1):529. doi: 10.1038/s42003-025-07958-4. PMID: 40164822; PMCID: PMC11958745
Epub:
Not Epub
Abstract:
Many rhodopsin-like G-protein-coupled receptors (Rh-GPCRs) are known to either promote or inhibit angiogenesis. Among these,...
Link:
https://pmc.ncbi.nlm.nih.gov/articles/PMC11958745/
Delivery Method:
microinjection
Organism or Cell Type:
zebrafish
Citation Extract:
Luo H, Zhang W, Zeng W, Wang Y, Feng J, Lan Y, Dong X, Liu T, Sun Y, Lu H. OPN3-mediated positive regulation of angiogenesis in HUVECs through VEGFR2 interaction. Commun Biol. 2025 Mar 31;8(1):529. doi: 10.1038/s42003-025-07958-4. PMID: 40164822; PMCID: PMC11958745.

Cryo-EM structure of the BLOC-3 complex provides insights into the pathogenesis of Hermansky-Pudlak syndrome

Authors:
Yong X, Jia G, Yang Q, Zhou C, Zhang S, Deng H, Billadeau DD, Su Z, Jia D
Citation:
Nat Commun. 2025 Mar 26;16(1):2967. doi: 10.1038/s41467-025-58235-1. PMID: 40140412; PMCID: PMC11947305
Epub:
Not Epub
Abstract:
Biogenesis of lysosome-related organelle complex-3 (BLOC-3) is pivotal in vesicle trafficking and has been linked to Hermansky-...
Link:
https://www.nature.com/articles/s41467-025-58235-1
Delivery Method:
microinjection
Organism or Cell Type:
zebrafish
Citation Extract:
Yong X, Jia G, Yang Q, Zhou C, Zhang S, Deng H, Billadeau DD, Su Z, Jia D. Cryo-EM structure of the BLOC-3 complex provides insights into the pathogenesis of Hermansky-Pudlak syndrome. Nat Commun. 2025 Mar 26;16(1):2967. doi: 10.1038/s41467-025-58235-1. PMID: 40140412; PMCID: PMC11947305.

Cell-penetrating peptide-conjugated, splice-switching oligonucleotides mitigate the phenotype in BTK/Tec double deficient X-linked agammaglobulinemia model

Authors:
Bestas B, Estupiñán HY, Wang Q, Kharazi S, He C, K Mohammad D, Gupta D, Wiklander OPB, Lehto T, Lundin KE, Berglöf A, Karlsson MCI, Abendroth F, El Andaloussi S, Gait MJ, Wood MJA, Leumann CJ, Stetsenko DA, Månsson R, Wengel J, Zain R, Smith CIE
Citation:
RSC Chem Biol. 2025 Mar 31. doi: 10.1039/d4cb00312h. Epub ahead of print. PMID: 40171248; PMCID: PMC11955834
Epub:
Not Epub
Abstract:
Splice-switching oligonucleotides (SSOs) have been developed as a treatment for various disorders, including Duchenne muscular...
Link:
https://pmc.ncbi.nlm.nih.gov/articles/PMC11955834/
Delivery Method:
Pip6a peptide-linked; intravenous (i.v.) injection for mice
Organism or Cell Type:
cell culture: 2OS luciferase reporter cell line containing a mutated BTK intron 4, primary B cells with mutant BTK transcript; mice: BAC transgenic mice with full-length mutated human BTK pre-mRNA
Citation Extract:
Bestas B, Estupiñán HY, Wang Q, Kharazi S, He C, K Mohammad D, Gupta D, Wiklander OPB, Lehto T, Lundin KE, Berglöf A, Karlsson MCI, Abendroth F, El Andaloussi S, Gait MJ, Wood MJA, Leumann CJ, Stetsenko DA, Månsson R, Wengel J, Zain R, Smith CIE. Cell-penetrating peptide-conjugated, splice-switching oligonucleotides mitigate the phenotype in BTK/Tec double deficient X-linked agammaglobulinemia model. RSC Chem Biol. 2025 Mar 31. doi: 10.1039/d4cb00312h. Epub ahead of print. PMID: 40171248; PMCID: PMC11955834.

Wdr5-mediated H3K4 methylation facilitates HSPC development via maintenance of genomic stability in zebrafish

Authors:
Wang X, Liu M, Zhang Y, Ma D, Wang L, Liu F
Citation:
Proc Natl Acad Sci U S A. 2025 Mar 25;122(12):e2420534122. doi: 10.1073/pnas.2420534122. Epub 2025 Mar 20. PMID: 40112113
Epub:
Not Epub
Abstract:
During fetal stage, hematopoietic stem and progenitor cells (HSPCs) undergo rapid proliferation with a tight control of genomic...
Link:
https://www.pnas.org/doi/10.1073/pnas.2420534122
Delivery Method:
microinjection
Organism or Cell Type:
zebrafish
Citation Extract:
Wang X, Liu M, Zhang Y, Ma D, Wang L, Liu F. Wdr5-mediated H3K4 methylation facilitates HSPC development via maintenance of genomic stability in zebrafish. Proc Natl Acad Sci U S A. 2025 Mar 25;122(12):e2420534122. doi: 10.1073/pnas.2420534122. Epub 2025 Mar 20. PMID: 40112113.

A Robust Strategy for Introducing Amino-Modifiers in Nucleic Acids: Enabling Novel Amino Tandem Oligonucleotide Synthesis in DNA and RNA

Authors:
Saraya JS, Horton NG, Sammons SR, O'Flaherty DK
Citation:
Chemistry. 2025 Mar 24:e202500448. doi: 10.1002/chem.202500448. Epub ahead of print. PMID: 40127302
Epub:
Not Epub
Abstract:
Amino-modifiers are pivotal chemical modifications in nucleic acid scaffolds, serving applications ranging from (bio)...
Link:
https://chemistry-europe.onlinelibrary.wiley.com/doi/10.1002/chem.202500448
Delivery Method:
None
Organism or Cell Type:
None
Citation Extract:
Saraya JS, Horton NG, Sammons SR, O'Flaherty DK. A Robust Strategy for Introducing Amino-Modifiers in Nucleic Acids: Enabling Novel Amino Tandem Oligonucleotide Synthesis in DNA and RNA. Chemistry. 2025 Mar 24:e202500448. doi: 10.1002/chem.202500448. Epub ahead of print. PMID: 40127302.

Long-Term Dystrophin Replacement Therapy in Duchenne Muscular Dystrophy Causes Cardiac Inflammation

Authors:
Forand A, Moog S, Mougenot N, Lemaitre M, Sevoz-Couche C, Guesmia Z, Virtanen L, Giordani L, Muchir A, Pietri-Rouxel F
Citation:
J Am Coll Cardiol Basic Trans Science. null2025, 0 (0). https://doi.org/10.1016/j.jacbts.2024.12.015
Epub:
Not Epub
Abstract:
Micro-dystrophin replacement gene therapy is currently under clinical trials in Duchenne muscular dystrophy (DMD) patients....
Link:
https://www.jacc.org/doi/10.1016/j.jacbts.2024.12.015
Delivery Method:
peptide-linked combined therapy with AAV-U7; retro-orbital & intravenous (i.v.) injection
Organism or Cell Type:
mice: C57BL/6J, dystrophin−/−; utrophin−/− dKO, mdx (utrophin−/−)
Citation Extract:
Forand A, Moog S, Mougenot N, Lemaitre M, Sevoz-Couche C, Guesmia Z, Virtanen L, Giordani L, Muchir A, Pietri-Rouxel F. Long-Term Dystrophin Replacement Therapy in Duchenne Muscular Dystrophy Causes Cardiac Inflammation. J Am Coll Cardiol Basic Trans Science. null2025, 0 (0). https://doi.org/10.1016/j.jacbts.2024.12.015.

A nucleus-encoded dynamin-like protein controls endosymbiont division in the trypanosomatid Angomonas deanei

Authors:
Maurya AK, Kröninger L, Ehret G, Bäumers M, Marson M, Scheu S, Nowack ECM
Citation:
Sci Adv. 2025 Mar 21;11(12):eadp8518. doi: 10.1126/sciadv.adp8518. Epub 2025 Mar 19. PMID: 40106558
Epub:
Not Epub
Abstract:
Angomonas deanei is a trypanosomatid of the Strigomonadinae. All members of this subfamily contain a single β-proteobacterial...
Link:
https://www.science.org/doi/10.1126/sciadv.adp8518
Delivery Method:
electroporation
Organism or Cell Type:
Angomonas deanei (trypanosoma)
Citation Extract:
Maurya AK, Kröninger L, Ehret G, Bäumers M, Marson M, Scheu S, Nowack ECM. A nucleus-encoded dynamin-like protein controls endosymbiont division in the trypanosomatid Angomonas deanei. Sci Adv. 2025 Mar 21;11(12):eadp8518. doi: 10.1126/sciadv.adp8518. Epub 2025 Mar 19. PMID: 40106558.

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