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Morpholino Publication Database
This database contains citations and abstracts for research using Morpholino oligos, as well as some review articles incorporating Morpholino data. You can search the content using the filter boxes below.
There are 12376 scientific papers returned from the database with the search filters currently being used below.
There are 12376 scientific papers returned from the database with the search filters currently being used below.
Neutral Surfactant Enhanced Exon-skipping of Morpholino Oligonucleotides in vitro and in mdx Mice
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Citation:
J Nanomed Nanotechnol. 2020;11(6):553. doi:10.35248/2157-7439.20.11.553 Epub:
Not Epub Abstract:
Antisense oligomers induced exon-skipping has been promising therapy for Duchenne muscular dystrophy in preclinical and... Delivery Method:
Endo-Porter (culture), local injection (mice) Organism or Cell Type:
cell culture: C2C12E50 myoblasts and C2C12E23 differentiated cells expressing human dystrophin exon 50 sequence (hDyE50), mouse dystrophin exon 23 sequence (mDyE23) in the GFP coding sequence, respectively; mdx mice Citation Extract: Wu B, Drains M, Lu P, Lu Q, Wang M. Neutral Surfactant Enhanced Exon-skipping of Morpholino Oligonucleotides in vitro and in mdx Mice. J Nanomed Nanotechnol. 2020;11(6):553. doi:10.35248/2157-7439.20.11.553. |
Sobp modulates Six1 transcriptional activation and is required during craniofacial development
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Citation:
bioRxiv. 2021;[preprint] doi:10.1101/2021.04.05.438472 Epub:
Not Epub Abstract:
Single nucleotide mutations in SIX1 are causative in some individuals diagnosed with branchio-otic/branchio-oto-renal (BOR)... Delivery Method:
microinjection Organism or Cell Type:
Xenopus laevis Citation Extract: Tavares ALP, Jourdeuil K, Neilson KM, Majumdar HD, Moody SA. Sobp modulates Six1 transcriptional activation and is required during craniofacial development. bioRxiv. 2021;[preprint] doi:10.1101/2021.04.05.438472 . |
Ciliogenesis and autophagy are coordinately regulated by EphA2 in the cornea to maintain proper epithelial architecture
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Citation:
Ocul Surf. 2021;[Epub ahead of print] doi:10.1016/j.jtos.2021.06.006 Epub:
Not Epub Abstract:
Purpose
To understand the relationship between ciliogenesis and autophagy in the corneal epithelium.
Methods
siRNAs for... Organism or Cell Type:
Xenopus Citation Extract: Kaplan N, Wang S, Wang J, Yang W, Ventrella R, Majekodunmi A, Perez White BE, Getsios S, Mitchell BJ, Peng H, Lavker RM. Ciliogenesis and autophagy are coordinately regulated by EphA2 in the cornea to maintain proper epithelial architecture. Ocul Surf. 2021;[Epub ahead of print] doi:10.1016/j.jtos.2021.06.006. |
Survival motor neuron deficiency slows myoblast fusion through reduced myomaker and myomixer expression
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Citation:
J. Cachexia Sarcopenia Muscle. 2021;[Epub] doi:10.1002/jcsm.12740 Epub:
Yes Abstract:
Background
Spinal muscular atrophy is an inherited neurodegenerative disease caused by insufficient levels of the survival... Delivery Method:
intracerebroventricular (icv) injection Organism or Cell Type:
mice Citation Extract: McCormack NM, Villalón E, Viollet C, Soltis AR, Dalgard CL, Lorson CL, Burnett BG. Survival motor neuron deficiency slows myoblast fusion through reduced myomaker and myomixer expression. J. Cachexia Sarcopenia Muscle. 2021;[Epub] doi:10.1002/jcsm.12740. |
Polarized endosome dynamics engage cytoplasmic Par-3 that recruits dynein during asymmetric cell division
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Citation:
Sci Adv. 2021;7(24):eabg1244. doi:10.1126/sciadv.abg1244 Epub:
Not Epub Abstract:
In the developing embryos, the cortical polarity regulator Par-3 is critical for establishing Notch signaling asymmetry between... Delivery Method:
microinjection Organism or Cell Type:
zebrafish Citation Extract: Zhao X, Garcia JQ, Tong K, Chen X, Yang B, Li Q, Dai Z, Shi X, Seiple IB, Huang B, Guo S. Polarized endosome dynamics engage cytoplasmic Par-3 that recruits dynein during asymmetric cell division. Sci Adv. 2021;7(24):eabg1244. doi:10.1126/sciadv.abg1244. |
Enhanced delivery of peptide-morpholino oligonucleotides with a small molecule to correct splicing defects in the lung
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Citation:
Nucleic Acids Res. 2021;49(11):6100–13. doi: 10.1093/nar/gkab488. Online ahead of print Epub:
Not Epub Abstract:
Pulmonary diseases offer many targets for oligonucleotide therapeutics. However, effective delivery of oligonucleotides to the... Delivery Method:
peptide-linked plus endosome escape reagent (OEC) Organism or Cell Type:
cell culture: HeLa EGFP654, Human Bronchial Epithelial, UNCCF8T, EGFP654 Mouse Tracheal Epithelial, mouse Citation Extract: Dang Y, van Heusden C, Nickerson V, Chung F, Wang Y, Quinney NL, Gentzsch M, Randell SH, Moulton HM, Kole R, Ni A, Juliano RL, Kreda SM. Enhanced delivery of peptide-morpholino oligonucleotides with a small molecule to correct splicing defects in the lung. Nucleic Acids Res. 2021;49(11):6100–13. doi: 10.1093/nar/gkab488. Online ahead of print. |
Safety, tolerability, and pharmacokinetics of casimersen in patients with Duchenne muscular dystrophy amenable to exon 45 skipping: A randomized, double-blind, placebo-controlled, dose-titration trial
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Citation:
Muscle Nerve. 2021 Jun 8. doi: 10.1002/mus.27347. Online ahead of print Epub:
Yes Abstract:
Introduction/aims: Duchenne muscular dystrophy (DMD) is caused by mutations in the DMD gene resulting in the absence of... Delivery Method:
i.v. infusion Organism or Cell Type:
human Citation Extract: Wagner KR, Kuntz NL, Koenig E, East L, Upadhyay S, Han B, Shieh PB. Safety, tolerability, and pharmacokinetics of casimersen in patients with Duchenne muscular dystrophy amenable to exon 45 skipping: A randomized, double-blind, placebo-controlled, dose-titration trial. Muscle Nerve. 2021 Jun 8. doi: 10.1002/mus.27347. Online ahead of print. |
The gene regulatory system for specifying germ layers in early embryos of the simple chordate
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Citation:
Sci Adv. 2021;7(24):eabf8210 doi:10.1126/sciadv.abf8210 Epub:
Not Epub Abstract:
In animal embryos, gene regulatory networks control the dynamics of gene expression in cells and coordinate such dynamics among... Delivery Method:
microinjection Organism or Cell Type:
Ciona intestinalis Citation Extract: Tokuoka M, Maeda K, Kobayashi K, Mochizuki A, Satou Y. The gene regulatory system for specifying germ layers in early embryos of the simple chordate. Sci Adv. 2021;7(24):eabf8210 doi:10.1126/sciadv.abf8210. |
Integrin intra-heterodimer affinity inversely correlates with integrin activatability
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Citation:
Cell Rep. 2021;35(10):109230. doi:10.1016/j.celrep.2021.109230 Epub:
Not Epub Abstract:
Integrins are heterodimeric cell surface receptors composed of an α and β subunit that mediate cell adhesion to extracellular... Delivery Method:
microinjection Organism or Cell Type:
zebrafish Citation Extract: Sun G, Guillon E, Holley SA. Integrin intra-heterodimer affinity inversely correlates with integrin activatability. Cell Rep. 2021;35(10):109230. doi:10.1016/j.celrep.2021.109230. |
eSkip-Finder: a machine learning-based web application and database to identify the optimal sequences of antisense oligonucleotides for exon skipping
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Citation:
Nucl Acids Res. 2021;[Epub ahead of print] doi:10.1093/nar/gkab442 Epub:
Yes Abstract:
Exon skipping using antisense oligonucleotides (ASOs) has recently proven to be a powerful tool for mRNA splicing modulation.... Organism or Cell Type:
cell culture: primary human myotubes Citation Extract: Chiba S, Lim KRQ, Sheri N, Anwar S, Erkut E, Shah MNA, Aslesh T, Woo S, Sheikh O, Maruyama R, Takano H, Kunitake K, Duddy W, Okuno Y, Aoki Y, Yokota T. eSkip-Finder: a machine learning-based web application and database to identify the optimal sequences of antisense oligonucleotides for exon skipping. Nucl Acids Res. 2021;[Epub ahead of print] doi:10.1093/nar/gkab442. |