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Morpholino Publication Database

This database contains citations and abstracts for research using Morpholino oligos, as well as some review articles incorporating Morpholino data. You can search the content using the filter boxes below.

There are 12371 scientific papers returned from the database with the search filters currently being used below.

G-protein-independent coupling of MC4R to Kir7.1 in hypothalamic neurons

Authors:
Ghamari-Langroudi M, Digby GJ, Sebag JA, Millhauser GL, Palomino R, Matthews R, Gillyard T, Panaro BL, Tough IR, Cox HM, Denton JS, Cone RD
Citation:
Nature. 2015 Jan 19. doi: 10.1038/nature14051. [Epub ahead of print]
Epub:
Yes
Abstract:
The regulated release of anorexigenic α-melanocyte stimulating hormone (α-MSH) and orexigenic Agouti-related protein (AgRP)...
Delivery Method:
microinjection
Organism or Cell Type:
zebrafish
Citation Extract:
Ghamari-Langroudi M, Digby GJ, Sebag JA, Millhauser GL, Palomino R, Matthews R, Gillyard T, Panaro BL, Tough IR, Cox HM, Denton JS, Cone RD. G-protein-independent coupling of MC4R to Kir7.1 in hypothalamic neurons. Nature. 2015 Jan 19. doi: 10.1038/nature14051. [Epub ahead of print].

PFKFB4 controls embryonic patterning via Akt signalling independently of glycolysis

Authors:
Pegoraro C, Figueiredo AL, Maczkowiak F, Pouponnot C, Eychène A, Monsoro-Burq AH
Citation:
Nat Comm. 2015;6:5953. doi:10.1038/ncomms6953
Epub:
Not Epub
Abstract:
How metabolism regulators play roles during early development remains elusive. Here we show that ​PFKFB4 (​6-phosphofructo-2-...
Delivery Method:
microinjection
Organism or Cell Type:
Xenopus laevis
Citation Extract:
Pegoraro C, Figueiredo AL, Maczkowiak F, Pouponnot C, Eychène A, Monsoro-Burq AH. PFKFB4 controls embryonic patterning via Akt signalling independently of glycolysis. Nat Comm. 2015;6:5953. doi:10.1038/ncomms6953.

Nucleoporin 62-like protein activates canonical Wnt signaling through facilitating the nuclear import of β-catenin in zebrafish

Authors:
Yang X, Gu Q, Lin L, Li S, Zhong S, Li Q, Cui Z
Citation:
Mol Cell Biol. 2015 Jan 20. pii: MCB.01181-14. [Epub ahead of print]
Epub:
Yes
Abstract:
Nucleoporin p62 (Nup62) localizes in the central channel of nuclear pore complexes (NPCs) and regulates nuclear pore...
Organism or Cell Type:
zebrafish
Citation Extract:
Yang X, Gu Q, Lin L, Li S, Zhong S, Li Q, Cui Z. Nucleoporin 62-like protein activates canonical Wnt signaling through facilitating the nuclear import of β-catenin in zebrafish. Mol Cell Biol. 2015 Jan 20. pii: MCB.01181-14. [Epub ahead of print].

Tgfβ1a regulates zebrafish posterior lateral line formation via Smad5 mediated pathway

Authors:
Xing C, Gong B, Xue Y, Han Y, Wang Y, Meng A, Jia S
Citation:
J Mol Cell Biol. 2015 Jan 20. pii: mjv004. [Epub ahead of print]
Epub:
Yes
Abstract:
The zebrafish sensory posterior lateral line (pLL) has become an attractive model for studying collective cell migration and...
Organism or Cell Type:
zebrafish
Citation Extract:
Xing C, Gong B, Xue Y, Han Y, Wang Y, Meng A, Jia S. Tgfβ1a regulates zebrafish posterior lateral line formation via Smad5 mediated pathway. J Mol Cell Biol. 2015 Jan 20. pii: mjv004. [Epub ahead of print].

Involvement of TLR7 and TLR8 in Conceptus Development and Establishment of Pregnancy in Sheep

Authors:
Ruiz-González I, Minten M, Wang X, Dunlap K, Bazer FW
Citation:
Reproduction. 2015 Apr;149(4):305-16. doi: 10.1530/REP-14-0537. Epub 2015 Jan 19.
Epub:
Not Epub
Abstract:
Toll-like receptors (TLRs) belong to the innate immune system and regulate inflammatory events that impact mammalian...
Organism or Cell Type:
Ovis aries (sheep)
Citation Extract:
Ruiz-González I, Minten M, Wang X, Dunlap K, Bazer FW. Involvement of TLR7 and TLR8 in Conceptus Development and Establishment of Pregnancy in Sheep. Reproduction. 2015 Apr;149(4):305-16. doi: 10.1530/REP-14-0537. Epub 2015 Jan 19..

Peptide Nanoparticle Delivery of Charge-Neutral Splice-Switching Morpholino Oligonucleotides

Authors:
Järver P, Zaghloul EM, Arzumanov AA, Saleh AF, McClorey G, Hammond SM, Hällbrink M, Langel Ü, Smith CI, Wood MJ, Gait MJ, Andaloussi SE
Citation:
Nucleic Acid Ther. 2015 Jan 16. [Epub ahead of print]
Epub:
Yes
Abstract:
Oligonucleotide analogs have provided novel therapeutics targeting various disorders. However, their poor cellular uptake...
Delivery Method:
peptide nanoparticle
Organism or Cell Type:
cell culture: U2OS cells, murine H2K mdx myotubes, human SMA type 1 fibroblasts
Citation Extract:
Järver P, Zaghloul EM, Arzumanov AA, Saleh AF, McClorey G, Hammond SM, Hällbrink M, Langel Ü, Smith CI, Wood MJ, Gait MJ, Andaloussi SE. Peptide Nanoparticle Delivery of Charge-Neutral Splice-Switching Morpholino Oligonucleotides. Nucleic Acid Ther. 2015 Jan 16. [Epub ahead of print].

Mitochondrial Ca2+ uptake by the voltage-dependent anion channel 2 regulates cardiac rhythmicity

Authors:
Shimizu H, Schredelseker J, Huang J, Lu K, Naghdi S, Lu F, Franklin S, Fiji HDG, Wang K, Zhu H, Tian C, Lin B, Nakano H, Ehrlich A, Nakai J, Stieg AZ, Gimzewski JK, Nakano A, Goldhaber JI, Vondriska TM, Hajnóczky G, Kwon O, Chen J-N
Citation:
eLife. 2015;4:e04801 doi:10.7554/eLife.04801
Epub:
Not Epub
Abstract:
Tightly regulated Ca2+ homeostasis is a prerequisite for proper cardiac function. To dissect the regulatory network of cardiac...
Delivery Method:
microinjection
Organism or Cell Type:
zebrafish
Citation Extract:
Shimizu H, Schredelseker J, Huang J, Lu K, Naghdi S, Lu F, Franklin S, Fiji HDG, Wang K, Zhu H, Tian C, Lin B, Nakano H, Ehrlich A, Nakai J, Stieg AZ, Gimzewski JK, Nakano A, Goldhaber JI, Vondriska TM, Hajnóczky G, Kwon O, Chen J-N. Mitochondrial Ca2+ uptake by the voltage-dependent anion channel 2 regulates cardiac rhythmicity. eLife. 2015;4:e04801 doi:10.7554/eLife.04801.

A novel function for Egr4 in posterior hindbrain development

Authors:
Bae CJ, Jeong J, Saint-Jeannet JP
Citation:
Sci Rep. 2015 Jan 13;5:7750. doi: 10.1038/srep07750
Epub:
Not Epub
Abstract:
Segmentation of the vertebrate hindbrain is an evolutionarily conserved process. Here, we identify the transcription factor...
Delivery Method:
microinjection
Organism or Cell Type:
Xenopus laevis
Citation Extract:
Bae CJ, Jeong J, Saint-Jeannet JP. A novel function for Egr4 in posterior hindbrain development. Sci Rep. 2015 Jan 13;5:7750. doi: 10.1038/srep07750.

Otoferlin Deficiency In Zebrafish Results In Defects In Balance And Hearing: Rescue Of The Balance And Hearing Phenotype With Full-length And Truncated Forms Of Mouse Otoferlin

Authors:
Chatterjee P, Padmanarayana M, Abdullah N, Holman CL, LaDu J, Tanguay RL, Johnson CP
Citation:
Mol Cell Biol. 2015 Jan 12. pii: MCB.01439-14. [Epub ahead of print]
Epub:
Yes
Abstract:
Sensory hair cells convert mechanical motion into chemical signals. Otoferlin, a six-C2 domain transmembrane protein linked to...
Delivery Method:
microinjection
Organism or Cell Type:
zebrafish
Citation Extract:
Chatterjee P, Padmanarayana M, Abdullah N, Holman CL, LaDu J, Tanguay RL, Johnson CP. Otoferlin Deficiency In Zebrafish Results In Defects In Balance And Hearing: Rescue Of The Balance And Hearing Phenotype With Full-length And Truncated Forms Of Mouse Otoferlin. Mol Cell Biol. 2015 Jan 12. pii: MCB.01439-14. [Epub ahead of print].

Low-dose exposure to bisphenol A and replacement bisphenol S induces precocious hypothalamic neurogenesis in embryonic zebrafish

Authors:
Kinch CD, Ibhazehiebo K, Jeong J-H, Habibi HR, Kurrasch DM
Citation:
Proc Natl Acad Sci U S A. 2015;[Epub ahead of print] doi:10.1073/pnas.1417731112
Epub:
Yes
Abstract:
Bisphenol A (BPA), a ubiquitous endocrine disruptor that is present in many household products, has been linked to obesity,...
Delivery Method:
microinjection
Organism or Cell Type:
zebrafish
Citation Extract:
Kinch CD, Ibhazehiebo K, Jeong J-H, Habibi HR, Kurrasch DM. Low-dose exposure to bisphenol A and replacement bisphenol S induces precocious hypothalamic neurogenesis in embryonic zebrafish. Proc Natl Acad Sci U S A. 2015;[Epub ahead of print] doi:10.1073/pnas.1417731112.

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