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Morpholino Publication Database

This database contains citations and abstracts for research using Morpholino oligos, as well as some review articles incorporating Morpholino data. You can search the content using the filter boxes below.

There are 12371 scientific papers returned from the database with the search filters currently being used below.

Sterol carrier protein 2 regulates proximal tubule size in the Xenopus pronephric kidney by modulating lipid rafts

Authors:
Cerqueira DM, Tran U, Romaker D, Abreu JG, Wessely O
Citation:
Dev Biol. 2014 Aug 12. pii: S0012-1606(14)00377-7. doi: 10.1016/j.ydbio.2014.07.025. [Epub ahead of print]
Epub:
Yes
Abstract:
The kidney is a homeostatic organ required for waste excretion and reabsorption of water, salts and other macromolecules. To...
Link:
http://www.sciencedirect.com/science/article/pii/S0012160614003777
Delivery Method:
microinjection
Organism or Cell Type:
Xenopus
Citation Extract:
Cerqueira DM, Tran U, Romaker D, Abreu JG, Wessely O. Sterol carrier protein 2 regulates proximal tubule size in the Xenopus pronephric kidney by modulating lipid rafts. Dev Biol. 2014 Aug 12. pii: S0012-1606(14)00377-7. doi: 10.1016/j.ydbio.2014.07.025. [Epub ahead of print].

Upregulation of Functional Kv11.1 Isoform Expression by Inhibition of Intronic Polyadenylation with Antisense Morpholino Oligonucleotides

Authors:
Gong Q, Stump MR, Zhou Z
Citation:
J Mol Cell Cardiol. 2014;76:26-32. doi:10.1016/j.yjmcc.2014.08.007
Epub:
Yes
Abstract:
The KCNH2 gene encodes the Kv11.1 potassium channel that conducts the rapidly activating delayed rectifier current in the heart...
Link:
http://www.jmmc-online.com/article/S0022-2828%2814%2900254-5/abstract
Citation Extract:
Gong Q, Stump MR, Zhou Z. Upregulation of Functional Kv11.1 Isoform Expression by Inhibition of Intronic Polyadenylation with Antisense Morpholino Oligonucleotides. J Mol Cell Cardiol. 2014;76:26-32. doi:10.1016/j.yjmcc.2014.08.007.

A Self-Organizing miR-132/Ctbp2 Circuit Regulates Bimodal Notch Signals and Glial Progenitor Fate Choice during Spinal Cord Maturation

Authors:
Salta E, Lau P, Frigerio CS, Coolen M, Bally-Cuif L, De Strooperemail B
Citation:
Dev Cell. 2014;[Epub ahead of print] doi:10.1016/j.devcel.2014.07.006
Epub:
Yes
Abstract:
Radial glial progenitors play pivotal roles in the development and patterning of the spinal cord, and their fate is controlled...
Link:
http://www.cell.com/developmental-cell/abstract/S1534-5807%2814%2900448-1
Delivery Method:
microinjection
Organism or Cell Type:
zebrafish
Citation Extract:
Salta E, Lau P, Frigerio CS, Coolen M, Bally-Cuif L, De Strooperemail B. A Self-Organizing miR-132/Ctbp2 Circuit Regulates Bimodal Notch Signals and Glial Progenitor Fate Choice during Spinal Cord Maturation. Dev Cell. 2014;[Epub ahead of print] doi:10.1016/j.devcel.2014.07.006.

Hypomorphism in human NSMCE2 linked to primordial dwarfism and insulin resistance

Authors:
Payne F, Colnaghi R, Rocha N, Seth A, Harris J, Carpenter G, Bottomley WE, Wheeler E, Wong S, Saudek V, Savage D, O'Rahilly S, Carel JC, Barroso I, O'Driscoll M, Semple R
Citation:
J Clin Invest. 2014 Aug 8. pii: 73264. doi: 10.1172/JCI73264. [Epub ahead of print]
Epub:
Yes
Abstract:
Structural maintenance of chromosomes (SMC) complexes are essential for maintaining chromatin structure and regulating gene...
Link:
http://www.jci.org/articles/view/73264
Delivery Method:
microinjection
Organism or Cell Type:
zebrafish
Citation Extract:
Payne F, Colnaghi R, Rocha N, Seth A, Harris J, Carpenter G, Bottomley WE, Wheeler E, Wong S, Saudek V, Savage D, O'Rahilly S, Carel JC, Barroso I, O'Driscoll M, Semple R. Hypomorphism in human NSMCE2 linked to primordial dwarfism and insulin resistance. J Clin Invest. 2014 Aug 8. pii: 73264. doi: 10.1172/JCI73264. [Epub ahead of print].

Overlapping and Opposing Functions of GRK2 and GRK5 during Heart Development

Authors:
Philipp M, Berger IM, Just S, Caron MG
Citation:
J Biol Chem. 2014 Aug 7. pii: jbc.M114.551952. [Epub ahead of print]
Epub:
Yes
Abstract:
G protein-coupled receptor kinases 2 (GRK2) and 5 (GRK5) are fundamental regulators of cardiac performance in adults, but are...
Link:
http://www.jbc.org/content/early/2014/08/07/jbc.M114.551952.abstract
Delivery Method:
microinjection
Organism or Cell Type:
zebrafish
Citation Extract:
Philipp M, Berger IM, Just S, Caron MG. Overlapping and Opposing Functions of GRK2 and GRK5 during Heart Development. J Biol Chem. 2014 Aug 7. pii: jbc.M114.551952. [Epub ahead of print].

Out with the old, in with the new: reassessing morpholino knockdowns in light of genome editing technology

Authors:
Schulte-Merker S, Stainier DY
Citation:
Development. 2014 Aug;141(16):3103-4. doi: 10.1242/dev.112003
Epub:
Not Epub
Abstract:
Morpholino oligomers have been used widely and for many years in the zebrafish community to transiently knock down the function...
Link:
http://dev.biologists.org/content/141/16/3103.long
Citation Extract:
Schulte-Merker S, Stainier DY. Out with the old, in with the new: reassessing morpholino knockdowns in light of genome editing technology. Development. 2014 Aug;141(16):3103-4. doi: 10.1242/dev.112003.

Critical roles of DNase1l3l in lens nuclear degeneration in zebrafish

Authors:
Iida A, Tabata Y, Baba Y, Fujii T, Watanabe S
Citation:
Biochimie. 2014;[Epub ahead of print] doi:10.1016/j.biochi.2014.07.025
Epub:
Yes
Abstract:
The vertebrate lens undergoes organelle and nuclear degradation during lens development, allowing the lens to become...
Link:
http://www.sciencedirect.com/science/article/pii/S0300908414002168
Organism or Cell Type:
zebrafish
Citation Extract:
Iida A, Tabata Y, Baba Y, Fujii T, Watanabe S. Critical roles of DNase1l3l in lens nuclear degeneration in zebrafish. Biochimie. 2014;[Epub ahead of print] doi:10.1016/j.biochi.2014.07.025.

Regulation of the extrinsic apoptotic pathway by microRNA-21 in alcoholic liver injury

Authors:
Francis H, McDaniel K, Han Y, Liu X, Kennedy L, Yang F, McCarra J, Zhou T, Glaser S, Venter J, Huang L, Levine P, Lai J-M, Liu C-G, Alpini G, Meng F
Citation:
J Biol Chem. 2014;[Epub ahead of print] doi:10.1074/jbc.M114.602383
Epub:
Yes
Abstract:
IL-6/Stat3 is associated with the regulation of transcription of key cellular regulatory genes [microRNAs (miRNAs)] during...
Link:
http://www.jbc.org/content/early/2014/08/12/jbc.M114.602383.abstract
Delivery Method:
Vivo-Morpholino
Organism or Cell Type:
mice
Citation Extract:
Francis H, McDaniel K, Han Y, Liu X, Kennedy L, Yang F, McCarra J, Zhou T, Glaser S, Venter J, Huang L, Levine P, Lai J-M, Liu C-G, Alpini G, Meng F. Regulation of the extrinsic apoptotic pathway by microRNA-21 in alcoholic liver injury. J Biol Chem. 2014;[Epub ahead of print] doi:10.1074/jbc.M114.602383 .

An Otx/Nodal Regulatory Signature for Posterior Neural Development in Ascidians

Authors:
Roure A, Lemaire P, Darras S
Citation:
PLoS Genet. 2014;10(8):e1004548. doi:10.1371/journal.pgen.1004548
Epub:
Not Epub
Abstract:
In chordates, neural induction is the first step of a complex developmental process through which ectodermal cells acquire a...
Link:
http://www.plosgenetics.org/article/info%3Adoi%2F10.1371%2Fjournal.pgen.1004548#pgen-1004548-g004
Delivery Method:
microinjection
Organism or Cell Type:
Ciona intestinalis
Citation Extract:
Roure A, Lemaire P, Darras S. An Otx/Nodal Regulatory Signature for Posterior Neural Development in Ascidians. PLoS Genet. 2014;10(8):e1004548. doi:10.1371/journal.pgen.1004548.

CRISPR-Mediated Genomic Deletion of Sox2 in the Axolotl Shows a Requirement in Spinal Cord Neural Stem Cell Amplification during Tail Regeneration

Authors:
Fei J-F, Schuez M, Tazaki A, Taniguchi Y, Roensch K, Tanaka EM
Citation:
Stem Cell Rep. 2014 Sep 9;3(3):444-59. doi: 10.1016/j.stemcr.2014.06.018. Epub 2014 Aug 7.
Epub:
Not Epub
Abstract:
The salamander is the only tetrapod that functionally regenerates all cell types of the limb and spinal cord (SC) and thus...
Link:
http://www.cell.com/stem-cell-reports/abstract/S2213-6711%2814%2900204-5
Delivery Method:
microinjection
Organism or Cell Type:
Ambystoma mexicanum (axolotl)
Citation Extract:
Fei J-F, Schuez M, Tazaki A, Taniguchi Y, Roensch K, Tanaka EM. CRISPR-Mediated Genomic Deletion of Sox2 in the Axolotl Shows a Requirement in Spinal Cord Neural Stem Cell Amplification during Tail Regeneration. Stem Cell Rep. 2014 Sep 9;3(3):444-59. doi: 10.1016/j.stemcr.2014.06.018. Epub 2014 Aug 7..

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