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Morpholino Publication Database

This database contains citations and abstracts for research using Morpholino oligos, as well as some review articles incorporating Morpholino data. You can search the content using the filter boxes below.

There are 12371 scientific papers returned from the database with the search filters currently being used below.

Down-regulation of ATM protein sensitizes human prostate cancer cells to radiation-induced apoptosis

Authors:
Truman JP, Gueven N, Lavin M, Leibel S, Kolesnick R, Fuks Z, Haimovitz-Friedman A
Citation:
J Biol Chem. 2005 Jun 17;280(24):23262-72. Epub 2005 Apr 18
Epub:
Not Epub
Abstract:
Treatment with the protein kinase C activator 12-O-tetradecanoylphorbol 12-acetate (TPA) enables radiation-resistant LNCaP...
Delivery Method:
Scrape Delivery
Organism or Cell Type:
Cell culture: Human prostate cancer LNCaP, PC-3, DU 145 and CWR22-Rv1
Citation Extract:
Truman JP, Gueven N, Lavin M, Leibel S, Kolesnick R, Fuks Z, Haimovitz-Friedman A. Down-regulation of ATM protein sensitizes human prostate cancer cells to radiation-induced apoptosis. J Biol Chem. 2005 Jun 17;280(24):23262-72. Epub 2005 Apr 18.

Dual suppression of hemangiogenesis and lymphangiogenesis by splice-shifting morpholinos targeting vascular endothelial growth factor receptor 2 (KDR)

Authors:
Uehara H, Cho Y, Simonis J, Cahoon J, Archer B, Luo L, Das SK, Singh N, Ambati J, Ambati BK
Citation:
FASEB J, 2013 Jan; 27(1):76–85. doi:10.1096/fj.12-213835
Epub:
Not Epub
Abstract:
The KDR gene, which participates in angiogenesis and lymphangiogenesis, produces two functionally distinct protein products,...
Link:
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3528308/
Delivery Method:
in vitro nucleifection; in vivo intravitreal or subconjunctival Vivo-Morpholino injection
Organism or Cell Type:
cell culture, mouse cornea
Citation Extract:
Uehara H, Cho Y, Simonis J, Cahoon J, Archer B, Luo L, Das SK, Singh N, Ambati J, Ambati BK. Dual suppression of hemangiogenesis and lymphangiogenesis by splice-shifting morpholinos targeting vascular endothelial growth factor receptor 2 (KDR). FASEB J, 2013 Jan; 27(1):76–85. doi:10.1096/fj.12-213835 .

Effects of Stanniocalcin 1 on calcium uptake in zebrafish (Danio rerio) embryo

Authors:
Tseng DY, Chou MY, Tseng YC, Hsiao CD, Huang CJ, Kaneko T, Hwang PP
Citation:
Am J Physiol Regul Integr Comp Physiol. 2008 Dec 10. [Epub ahead of print]
Epub:
Not Epub
Abstract:
Stanniocalcin (STC, formerly called hypocalcin or teleocalcin) is a 50-kDa disulfide-linked homodimeric glycoprotein that was...
Delivery Method:
Microinjection
Organism or Cell Type:
zebrafish
Citation Extract:
Tseng DY, Chou MY, Tseng YC, Hsiao CD, Huang CJ, Kaneko T, Hwang PP. Effects of Stanniocalcin 1 on calcium uptake in zebrafish (Danio rerio) embryo. Am J Physiol Regul Integr Comp Physiol. 2008 Dec 10. [Epub ahead of print] .

Efficient coupling of Sec23-Sec24 to Sec13-Sec31 drives COPII-dependent collagen secretion and is essential for normal craniofacial development

Authors:
Townley AK, Feng Y, Schmidt K, Carter DA, Porter R, Verkade P, Stephens DJ
Citation:
J Cell Sci. 2008 Aug 19. [Epub ahead of print]
Epub:
Not Epub
Abstract:
The COPII coat assembles on endoplasmic reticulum membranes to coordinate the collection of secretory cargo with the formation...
Citation Extract:
Townley AK, Feng Y, Schmidt K, Carter DA, Porter R, Verkade P, Stephens DJ. Efficient coupling of Sec23-Sec24 to Sec13-Sec31 drives COPII-dependent collagen secretion and is essential for normal craniofacial development. J Cell Sci. 2008 Aug 19. [Epub ahead of print].

Embryonic and tumorigenic pathways converge via Nodal signaling: role in melanoma aggressiveness

Authors:
Topczewska JM, Postovit LM, Margaryan NV, Sam A, Hess AR, Wheaton WW, Nickoloff BJ, Topczewski J, Hendrix MJ
Citation:
Nat Med. 2006 Aug;12(8):925-32. Epub 2006 Jul 30
Epub:
Not Epub
Abstract:
Bidirectional cellular communication is integral to both cancer progression and embryological development. In addition,...
Organism or Cell Type:
zebrafish
Citation Extract:
Topczewska JM, Postovit LM, Margaryan NV, Sam A, Hess AR, Wheaton WW, Nickoloff BJ, Topczewski J, Hendrix MJ. Embryonic and tumorigenic pathways converge via Nodal signaling: role in melanoma aggressiveness. Nat Med. 2006 Aug;12(8):925-32. Epub 2006 Jul 30.

Enhancement of axonal regeneration by in vitro conditioning and its inhibition by cyclopentenone prostaglandins

Authors:
Tonge D, Chan K, Zhu N, Panjwani A, Arno M, Lynham S, Ward M, Snape A, Pizzey J
Citation:
J Cell Sci. 2008 Aug 1;121(Pt 15):2565-77
Epub:
Not Epub
Abstract:
Axonal regeneration is enhanced by the prior ;conditioning' of peripheral nerve lesions. Here we show that Xenopus dorsal...
Organism or Cell Type:
Xenopus
Citation Extract:
Tonge D, Chan K, Zhu N, Panjwani A, Arno M, Lynham S, Ward M, Snape A, Pizzey J. Enhancement of axonal regeneration by in vitro conditioning and its inhibition by cyclopentenone prostaglandins. J Cell Sci. 2008 Aug 1;121(Pt 15):2565-77.

Epithelial organization and cyst lumen expansion require efficient Sec13-Sec31-driven secretion

Authors:
Townley AK, Schmidt K, Hodgson L, Stephens DJ
Citation:
J Cell Sci. 2012 February 1; 125(3): 673–684. doi:10.1242/jcs.091355
Epub:
Not Epub
Abstract:
Epithelial morphogenesis is directed by interactions with the underlying extracellular matrix. Secretion of collagen and other...
Delivery Method:
Microinjection
Organism or Cell Type:
zebrafish
Citation Extract:
Townley AK, Schmidt K, Hodgson L, Stephens DJ. Epithelial organization and cyst lumen expansion require efficient Sec13-Sec31-driven secretion. J Cell Sci. 2012 February 1; 125(3): 673–684. doi:10.1242/jcs.091355.

Erythropoiesis failure due to RPS19 deficiency is independent of an activated Tp53 response in a zebrafish model of Diamond-Blackfan anaemia

Authors:
Torihara H, Uechi T, Chakraborty A, Shinya M, Sakai N, Kenmochi N
Citation:
Br J Haematol. 2011 Jan 12. doi: 10.1111/j.1365-2141.2010.08535.x. [Epub ahead of print]
Epub:
Not Epub
Abstract:
Diamond-Blackfan anaemia (DBA) is a cancer-prone genetic disorder characterized by pure red-cell aplasia and associated...
Organism or Cell Type:
zebrafish
Citation Extract:
Torihara H, Uechi T, Chakraborty A, Shinya M, Sakai N, Kenmochi N. Erythropoiesis failure due to RPS19 deficiency is independent of an activated Tp53 response in a zebrafish model of Diamond-Blackfan anaemia. Br J Haematol. 2011 Jan 12. doi: 10.1111/j.1365-2141.2010.08535.x. [Epub ahead of print].

Essential role of beta 1,4-galactosyltransferase 2 during medaka (Oryzias latipes) gastrulation

Authors:
Tonoyama Y, Anzai D, Ikeda A, Kakuda S, Kinoshita M, Kawasaki T, Oka S
Citation:
Mech Dev. 2009 Mar 23. [Epub ahead of print]
Epub:
Not Epub
Abstract:
Glycans are known to play important roles in vertebrate development; however, it is difficult to analyze in mammals because it...
Delivery Method:
Microinjection
Organism or Cell Type:
medaka
Citation Extract:
Tonoyama Y, Anzai D, Ikeda A, Kakuda S, Kinoshita M, Kawasaki T, Oka S. Essential role of beta 1,4-galactosyltransferase 2 during medaka (Oryzias latipes) gastrulation. Mech Dev. 2009 Mar 23. [Epub ahead of print].

Ethanol metabolism and oxidative stress are required for unfolded protein response activation and steatosis in zebrafish with alcoholic liver disease

Authors:
Tsedensodnom O, Vacaru AM, Howarth DL, Yin C, Sadler KC
Citation:
Dis Model Mech. 2013 Jul 18. [Epub ahead of print]
Epub:
Not Epub
Abstract:
Secretory pathway dysfunction and lipid accumulation (steatosis) are the two most common responses of hepatocytes to ethanol...
Delivery Method:
Microinjection
Organism or Cell Type:
zebrafish
Citation Extract:
Tsedensodnom O, Vacaru AM, Howarth DL, Yin C, Sadler KC. Ethanol metabolism and oxidative stress are required for unfolded protein response activation and steatosis in zebrafish with alcoholic liver disease. Dis Model Mech. 2013 Jul 18. [Epub ahead of print].

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