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Morpholino Publication Database

This database contains citations and abstracts for research using Morpholino oligos, as well as some review articles incorporating Morpholino data. You can search the content using the filter boxes below.

There are 12353 scientific papers returned from the database with the search filters currently being used below.

A Splice Intervention Therapy for Autosomal Recessive Juvenile Parkinson’s Disease Arising from Parkin Mutations

Authors:
Li D, Aung-Htut MT, Ham KA, Fletcher S, Wilton SD
Citation:
Int J Mol Sci. 2020;21(19):7282. doi:10.3390/ijms21197282
Epub:
Not Epub
Abstract:
Parkin-type autosomal recessive juvenile-onset Parkinson’s disease is caused by mutations in the PRKN gene and accounts for 50...
Link:
https://www.mdpi.com/1422-0067/21/19/7282/htm#
Delivery Method:
Endo-Porter
Organism or Cell Type:
cell culture: PRKN patient-derived fibroblasts
Citation Extract:
Li D, Aung-Htut MT, Ham KA, Fletcher S, Wilton SD. A Splice Intervention Therapy for Autosomal Recessive Juvenile Parkinson’s Disease Arising from Parkin Mutations. Int J Mol Sci. 2020;21(19):7282. doi:10.3390/ijms21197282.

Beta-Galactosylceramidase Promotes Melanoma Growth via Modulation of Ceramide Metabolism

Authors:
Belleri M, Paganini G, Coltrini D, Ronca R, Zizioli D, Corsini M, Barbieri A, Grillo E, Calza S, Bresciani R, Maiorano E, Mastropasqua MG, Annese T, Giacomini A, Ribatti D, Casas J, Levade T, Fabrias G, Presta M
Citation:
Cancer Res. 2020;[Epub] doi:10.1158/0008-5472.CAN-19-3382
Epub:
Not Epub
Abstract:
Disturbance of sphingolipid metabolism may represent a novel therapeutic target in metastatic melanoma, the most lethal form of...
Link:
https://cancerres.aacrjournals.org/content/early/2020/09/30/0008-5472.CAN-19-3382
Organism or Cell Type:
zebrafish
Citation Extract:
Belleri M, Paganini G, Coltrini D, Ronca R, Zizioli D, Corsini M, Barbieri A, Grillo E, Calza S, Bresciani R, Maiorano E, Mastropasqua MG, Annese T, Giacomini A, Ribatti D, Casas J, Levade T, Fabrias G, Presta M. Beta-Galactosylceramidase Promotes Melanoma Growth via Modulation of Ceramide Metabolism. Cancer Res. 2020;[Epub] doi:10.1158/0008-5472.CAN-19-3382.

Hmx3a has essential functions in zebrafish spinal cord, ear and lateral line development

Authors:
England SJ, Cerda GA, Kowalchuk AM, Sorice T, Grieb GM, Lewis KE
Citation:
bioRxiv 2020.01.23.917468; doi: https://doi.org/10.1101/2020.01.23.917468
Epub:
Not Epub
Abstract:
Transcription factors that contain a homeodomain DNA-binding domain have crucial functions in most aspects of cellular function...
Link:
https://www.biorxiv.org/content/10.1101/2020.01.23.917468v4
Delivery Method:
microinjection
Organism or Cell Type:
zebrafish
Citation Extract:
England SJ, Cerda GA, Kowalchuk AM, Sorice T, Grieb GM, Lewis KE. Hmx3a has essential functions in zebrafish spinal cord, ear and lateral line development. bioRxiv 2020.01.23.917468; doi: https://doi.org/10.1101/2020.01.23.917468 .

Fmn2 regulates growth cone motility by mediating a molecular clutch to generate traction forces

Authors:
Ghate K, Mutalik SP, Sthanam LK, Sen S, Ghose A
Citation:
Neuroscience. 2020;[Epub ahead of print] doi:10.1016/j.neuroscience.2020.09.046
Epub:
Yes
Abstract:
Growth cone - mediated axonal outgrowth and accurate synaptic targeting are central to brain morphogenesis. Translocation of...
Link:
https://www.sciencedirect.com/science/article/abs/pii/S0306452220306291
Delivery Method:
electroporation
Organism or Cell Type:
Gallus gallus (chick) spinal cord explants
Citation Extract:
Ghate K, Mutalik SP, Sthanam LK, Sen S, Ghose A. Fmn2 regulates growth cone motility by mediating a molecular clutch to generate traction forces. Neuroscience. 2020;[Epub ahead of print] doi:10.1016/j.neuroscience.2020.09.046.

VBP1 modulates Wnt/β-catenin signaling by mediating the stability of the transcription factors TCF/LEFs

Authors:
Zhang H, Rong X, Wang C, Liu Y, Lu L, Li Y, Zhao C, Zhou J
Citation:
J Biol Chem. 2020;[Epub ahead of print] doi:10.1074/jbc.RA120.015282
Epub:
Yes
Abstract:
The Wnt/β-catenin pathway is one of the major pathways that regulates embryonic development, adult homeostasis, and stem cell...
Link:
https://www.jbc.org/content/early/2020/09/28/jbc.RA120.015282
Delivery Method:
microinjection
Organism or Cell Type:
zebrafish
Citation Extract:
Zhang H, Rong X, Wang C, Liu Y, Lu L, Li Y, Zhao C, Zhou J. VBP1 modulates Wnt/β-catenin signaling by mediating the stability of the transcription factors TCF/LEFs. J Biol Chem. 2020;[Epub ahead of print] doi:10.1074/jbc.RA120.015282.

Nephronophthisis gene products display RNA-binding properties and are recruited to stress granules

Authors:
Mallarino LE, Engel C, Ilık İA, Maticzka D, Heyl F, Müller B, Toma A. Yakulov TA, Dengjel J, Backofen R, Akhtar A, Gerd Walz G
Citation:
Sci Rep. 2020;10:15954 doi:10.1038/s41598-020-72905-8
Epub:
Not Epub
Abstract:
Mutations of cilia-associated molecules cause multiple developmental defects that are collectively termed ciliopathies. However...
Link:
https://www.nature.com/articles/s41598-020-72905-8
Delivery Method:
microinjection
Organism or Cell Type:
zebrafish
Citation Extract:
Mallarino LE, Engel C, Ilık İA, Maticzka D, Heyl F, Müller B, Toma A. Yakulov TA, Dengjel J, Backofen R, Akhtar A, Gerd Walz G. Nephronophthisis gene products display RNA-binding properties and are recruited to stress granules. Sci Rep. 2020;10:15954 doi:10.1038/s41598-020-72905-8.

LRRC17 Is Linked to Prognosis of Ovarian Cancer Through a p53-dependent Anti-apoptotic Function

Authors:
Oh C-K, Park JJ, Ha M, Heo HJ, Kang J, Kwon EJ, Kang JW, Kim Y, Kang JM, Yoon SZ, KO Y, Ko DS, Kim YH
Citation:
Anticancer Res. 2020;40(10):5601-9. doi:10.21873/anticanres.14573
Epub:
Not Epub
Abstract:
Background/Aim: Since pathways involving LRRC17 are related to the survival of patients with various cancers, we analyzed...
Link:
http://ar.iiarjournals.org/content/40/10/5601.abstract
Delivery Method:
microinjection
Organism or Cell Type:
zebrafish
Citation Extract:
Oh C-K, Park JJ, Ha M, Heo HJ, Kang J, Kwon EJ, Kang JW, Kim Y, Kang JM, Yoon SZ, KO Y, Ko DS, Kim YH. LRRC17 Is Linked to Prognosis of Ovarian Cancer Through a p53-dependent Anti-apoptotic Function. Anticancer Res. 2020;40(10):5601-9. doi:10.21873/anticanres.14573.

ndufa7 plays a critical role in cardiac hypertrophy

Authors:
Shi X, Zhang Y, Chen R, Gong Y, Zhang M, Guan R, Rotstein OD, Liu X, Wen X-Y
Citation:
J Cell Molec Med. 2020;[Epub ahead of print] doi:10.1111/jcmm.15921
Epub:
Yes
Abstract:
Cardiac hypertrophy is a common pathological change in patients with progressive cardiac function failure, which can be caused...
Link:
https://onlinelibrary.wiley.com/doi/full/10.1111/jcmm.15921
Delivery Method:
microinjection
Organism or Cell Type:
zebrafish
Citation Extract:
Shi X, Zhang Y, Chen R, Gong Y, Zhang M, Guan R, Rotstein OD, Liu X, Wen X-Y. ndufa7 plays a critical role in cardiac hypertrophy. J Cell Molec Med. 2020;[Epub ahead of print] doi:10.1111/jcmm.15921.

Multilineage murine stem cells generate complex organoids to model distal lung development and disease

Authors:
Vazquez‐Armendariz AI, Heiner M, El Agha E, Salwig I, Hoek A, Hessler MC, Shalashova I, Shrestha A, Carraro G, Mengel JP, Günther A, Morty RE, Vadász I, Schwemmle M, Kummer W, Hain T, Goesmann A, Bellusci S, Seeger W, Braun T, Herold S
Citation:
EMBO J. 2020;e103476 [Epub] doi:10.15252/embj.2019103476
Epub:
Not Epub
Abstract:
Organoids derived from mouse and human stem cells have recently emerged as a powerful tool to study organ development and...
Link:
https://www.embopress.org/doi/full/10.15252/embj.2019103476
Delivery Method:
cell bathing
Organism or Cell Type:
cell culture: murine bronchioalveolar lung organoid (BALO)
Citation Extract:
Vazquez‐Armendariz AI, Heiner M, El Agha E, Salwig I, Hoek A, Hessler MC, Shalashova I, Shrestha A, Carraro G, Mengel JP, Günther A, Morty RE, Vadász I, Schwemmle M, Kummer W, Hain T, Goesmann A, Bellusci S, Seeger W, Braun T, Herold S. Multilineage murine stem cells generate complex organoids to model distal lung development and disease. EMBO J. 2020;e103476 [Epub] doi:10.15252/embj.2019103476.

Internal Oligoguanidinium Transporter: Mercury Free Scalable Synthesis, Improvement of Cellular Localization, Endosomal Escape, Mitochondrial Localization and Conjugation with Antisense Morpholino for NANOG Inhibition to Induce Chemosensitisation of Taxol

Authors:
Kundu J, Banerjee P, Bose C, Das U, Ghosh U, Sinha S
Citation:
Bioconjug Chem. 2020:[Epub ahead of print] doi:10.1021/acs.bioconjchem.0c00444
Epub:
Yes
Abstract:
A non toxic delivery vehicle is essential for the therapeutic applications of antisense phosphorodiamidate morpholino...
Link:
https://pubs.acs.org/doi/10.1021/acs.bioconjchem.0c00444
Delivery Method:
internal oligoguanidinium transporter (IGT)
Organism or Cell Type:
cell culture: MCF-7
Citation Extract:
Kundu J, Banerjee P, Bose C, Das U, Ghosh U, Sinha S. Internal Oligoguanidinium Transporter: Mercury Free Scalable Synthesis, Improvement of Cellular Localization, Endosomal Escape, Mitochondrial Localization and Conjugation with Antisense Morpholino for NANOG Inhibition to Induce Chemosensitisation of Taxol. Bioconjug Chem. 2020:[Epub ahead of print] doi:10.1021/acs.bioconjchem.0c00444.

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