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Morpholino Publication Database

This database contains citations and abstracts for research using Morpholino oligos, as well as some review articles incorporating Morpholino data. You can search the content using the filter boxes below.

There are 12376 scientific papers returned from the database with the search filters currently being used below.

A Morpholino Oligomer Therapy Regime That Restores Mitochondrial Function and Prevents mdx Cardiomyopathy

Authors:
Viola HM, Johnstone VPA, Adams AM, Fletcher S, Hool LC
Citation:
JACC Basic Transl Sci. 2018 Jun 25;3(3):391-402. doi: 10.1016/j.jacbts.2018.03.007. eCollection 2018 Jun
Epub:
Not Epub
Abstract:
Current clinical trials demonstrate Duchenne muscular dystrophy (DMD) patients receiving phosphorodiamidate morpholino oligomer...
Link:
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6059013/
Delivery Method:
subcutaneous (s.c.) injection
Organism or Cell Type:
mice mdx
Citation Extract:
Viola HM, Johnstone VPA, Adams AM, Fletcher S, Hool LC. A Morpholino Oligomer Therapy Regime That Restores Mitochondrial Function and Prevents mdx Cardiomyopathy. JACC Basic Transl Sci. 2018 Jun 25;3(3):391-402. doi: 10.1016/j.jacbts.2018.03.007. eCollection 2018 Jun.

The genetic program of oocytes can be modified in vivo in the zebrafish ovary

Authors:
Wu X, Shen W, Zhang B, Meng A
Citation:
J Mol Cell Biol. 2018 Jul 28. doi: 10.1093/jmcb/mjy044. [Epub ahead of print]
Epub:
Yes
Abstract:
Oocytes, the irreplaceable gametes for generating a new organism, are matured in the ovary of living female animals. It is...
Link:
https://academic.oup.com/jmcb/article-lookup/doi/10.1093/jmcb/mjy044
Delivery Method:
in ovo oocyte microinjection
Organism or Cell Type:
zebrafish
Citation Extract:
Wu X, Shen W, Zhang B, Meng A. The genetic program of oocytes can be modified in vivo in the zebrafish ovary. J Mol Cell Biol. 2018 Jul 28. doi: 10.1093/jmcb/mjy044. [Epub ahead of print].

Functional analysis of KCNH2 gene mutations of type 2 long QT syndrome in larval zebrafish using microscopy and electrocardiography

Authors:
Tanaka Y, Hayashi K, Fujino N, Konno T, Tada H, Nakanishi C, Hodatsu A, Tsuda T, Nagata Y, Teramoto R, Yoshida S, Nomura A, Kawashiri MA, Yamagishi M
Citation:
Heart Vessels. 2018 Jul 25. doi: 10.1007/s00380-018-1231-4. [Epub ahead of print]
Epub:
Yes
Abstract:
Heterologous expression systems play a vital role in the characterization of potassium voltage-gated channel subfamily H member...
Link:
https://link.springer.com/article/10.1007%2Fs00380-018-1231-4
Delivery Method:
microinjection
Organism or Cell Type:
zebrafish
Citation Extract:
Tanaka Y, Hayashi K, Fujino N, Konno T, Tada H, Nakanishi C, Hodatsu A, Tsuda T, Nagata Y, Teramoto R, Yoshida S, Nomura A, Kawashiri MA, Yamagishi M. Functional analysis of KCNH2 gene mutations of type 2 long QT syndrome in larval zebrafish using microscopy and electrocardiography. Heart Vessels. 2018 Jul 25. doi: 10.1007/s00380-018-1231-4. [Epub ahead of print].

Long-Term Morpholino Oligomers in Hexose Elicits Long-Lasting Therapeutic Improvements in mdx Mice

Authors:
Han G. Lin L, Ning H, Gao X, Yin HF
Citation:
Molec Ther Nucl Acids. 2018;12(7):478-89. doi:10.1016/j.omtn.2018.06.005
Epub:
Not Epub
Abstract:
Approval of antisense oligonucleotide eteplirsen highlights the promise of exon-skipping therapeutics for Duchenne muscular...
Link:
https://www.cell.com/molecular-therapy-family/nucleic-acids/pdf/S2162-2531(18)30132-X.pdf
Delivery Method:
i.v. injection
Organism or Cell Type:
mice mdx
Citation Extract:
Han G. Lin L, Ning H, Gao X, Yin HF. Long-Term Morpholino Oligomers in Hexose Elicits Long-Lasting Therapeutic Improvements in mdx Mice. Molec Ther Nucl Acids. 2018;12(7):478-89. doi:10.1016/j.omtn.2018.06.005.

Mutant MAPK7-Induced Idiopathic Scoliosis is Linked to Impaired Osteogenesis

Authors:
Zhou T, Chen C, Xu C, Zhou H, Gao B, Su D, Liao Z, Li Y, Yang S, Su P
Citation:
Cell Physiol Biochem. 2018 Jul 20;48(3):880-890. doi: 10.1159/000491956. [Epub ahead of print]
Epub:
Not Epub
Abstract:
BACKGROUND/AIMS: Three rare MAPK7 variants that predispose individuals to adolescent idiopathic scoliosis have previously been...
Link:
https://www.karger.com/Article/FullText/491956
Delivery Method:
microinjection
Organism or Cell Type:
zebrafish
Citation Extract:
Zhou T, Chen C, Xu C, Zhou H, Gao B, Su D, Liao Z, Li Y, Yang S, Su P. Mutant MAPK7-Induced Idiopathic Scoliosis is Linked to Impaired Osteogenesis. Cell Physiol Biochem. 2018 Jul 20;48(3):880-890. doi: 10.1159/000491956. [Epub ahead of print].

Detection of unique Ebola virus oligonucleotides using fluorescently-labeled phosphorodiamidate morpholino oligonucleotide probe pairs

Authors:
Xiong Y, McQuistan TJ, Stanek JW, Summerton JE, Mata JE, Squier TC
Citation:
Anal Biochem. 2018 Sep 15;557:84-90. doi: 10.1016/j.ab.2018.07.006. Epub 2018 Jul 18. PMID: 30030994
Epub:
Not Epub
Abstract:
Here we identify a low-cost diagnostic platform using fluorescently-labeled phosphorodiamidate morpholino oligonucleotide (PMO...
Link:
https://www.sciencedirect.com/science/article/abs/pii/S0003269718306249
Citation Extract:
Xiong Y, McQuistan TJ, Stanek JW, Summerton JE, Mata JE, Squier TC. Detection of unique Ebola virus oligonucleotides using fluorescently-labeled phosphorodiamidate morpholino oligonucleotide probe pairs. Anal Biochem. 2018 Sep 15;557:84-90. doi: 10.1016/j.ab.2018.07.006. Epub 2018 Jul 18. PMID: 30030994.

Generation and Validation of a Complete Knockout Model of abcc6a In Zebrafish

Authors:
Van Gils M, Willaert A, De Vilder EYG, Coucke P, Vanakker OM
Citation:
J Invest Dermatol. 2018 Jul 17. pii: S0022-202X(18)32326-1. doi: 10.1016/j.jid.2018.06.183. [Epub ahead of print]
Epub:
Yes
Abstract:
Pseudoxanthoma elasticum is an ectopic mineralization disease due to biallelic ABCC6 mutations. As no treatment options are...
Link:
https://www.jidonline.org/article/S0022-202X(18)32326-1/pdf
Organism or Cell Type:
zebrafish
Citation Extract:
Van Gils M, Willaert A, De Vilder EYG, Coucke P, Vanakker OM. Generation and Validation of a Complete Knockout Model of abcc6a In Zebrafish. J Invest Dermatol. 2018 Jul 17. pii: S0022-202X(18)32326-1. doi: 10.1016/j.jid.2018.06.183. [Epub ahead of print].

Investigating the Role of G Protein βγ in Kv7-Dependent Relaxations of the Rat Vasculature

Authors:
Stott JB, Barrese V, Suresh M, Masoodi S, Greenwood IA
Citation:
Arterioscler Thromb Vasc Biol. 2018 Jul 12. pii: ATVBAHA.118.311360. doi: 10.1161/ATVBAHA.118.311360. [Epub ahead of print]
Epub:
Yes
Abstract:
OBJECTIVE: In renal arteries, inhibitors of G protein βγ subunits (Gβγ) reduce Kv7 activity and inhibit Kv7-dependent receptor-...
Link:
https://www.ahajournals.org/doi/10.1161/ATVBAHA.118.311360
Delivery Method:
Lipofectamine 2000
Organism or Cell Type:
cell culture: rat dissected renal artery, mesenteric artery and cerebral artery
Citation Extract:
Stott JB, Barrese V, Suresh M, Masoodi S, Greenwood IA. Investigating the Role of G Protein βγ in Kv7-Dependent Relaxations of the Rat Vasculature. Arterioscler Thromb Vasc Biol. 2018 Jul 12. pii: ATVBAHA.118.311360. doi: 10.1161/ATVBAHA.118.311360. [Epub ahead of print].

Polarity and morphogenesis of the eye epithelium requires the adhesion junction associated adaptor protein Traf4

Authors:
Hehr CL, Halabi R, McFarlane S
Citation:
Cell Adh Migr. 2018 Jul 31:1-14. doi: 10.1080/19336918.2018.1477900. [Epub ahead of print]
Epub:
Not Epub
Abstract:
During development, neuroepithelial progenitors acquire apico-basal polarity and adhere to one another via apically located...
Link:
https://www.tandfonline.com/doi/abs/10.1080/19336918.2018.1477900
Organism or Cell Type:
zebrafish
Citation Extract:
Hehr CL, Halabi R, McFarlane S. Polarity and morphogenesis of the eye epithelium requires the adhesion junction associated adaptor protein Traf4. Cell Adh Migr. 2018 Jul 31:1-14. doi: 10.1080/19336918.2018.1477900. [Epub ahead of print].

Alternative splicing of (ppp1r12a/mypt1) in zebrafish produces a novel myosin phosphatase targeting subunit

Authors:
LaFlamme A, Young KE, Lang I, Weiser DC
Citation:
Gene. 2018 Jun 27. pii: S0378-1119(18)30753-4. doi: 10.1016/j.gene.2018.06.092. [Epub ahead of print]
Epub:
Yes
Abstract:
Myosin phosphatase is an evolutionarily conserved regulator of actomyosin contractility, comprised of a regulatory subunit (...
Link:
https://www.sciencedirect.com/science/article/pii/S0378111918307534?via%3Dihub
Delivery Method:
microinjection
Organism or Cell Type:
zebrafish
Citation Extract:
LaFlamme A, Young KE, Lang I, Weiser DC. Alternative splicing of (ppp1r12a/mypt1) in zebrafish produces a novel myosin phosphatase targeting subunit. Gene. 2018 Jun 27. pii: S0378-1119(18)30753-4. doi: 10.1016/j.gene.2018.06.092. [Epub ahead of print].

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