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Morpholino Publication Database

This database contains citations and abstracts for research using Morpholino oligos, as well as some review articles incorporating Morpholino data. You can search the content using the filter boxes below.

There are 12184 scientific papers returned from the database with the search filters currently being used below.

Amelioration of Large Bile Duct Damage by Histamine-2 Receptor Vivo-Morpholino Treatment

Authors:
Kennedy L, Meadows V, Kyritsi K, Pham L, Kundu D, Kulkarni R, Cerritos K, Demieville J, Hargrove L, Glaser S, Zhou T, Jaeger V, Alpini G, Francis H
Citation:
Am J Pathol. 2020;190( 5):1018–29 doi:10.1016/j.ajpath.2020.01.013
Epub:
Not Epub
Abstract:
Histamine binds to one of the four G-protein–coupled receptors expressed by large cholangiocytes. Histamine specifically...
Link:
https://ajp.amjpathol.org/article/S0002-9440(20)30093-6/fulltext
Delivery Method:
Vivo-Morpholino
Organism or Cell Type:
mice
Citation Extract:
Kennedy L, Meadows V, Kyritsi K, Pham L, Kundu D, Kulkarni R, Cerritos K, Demieville J, Hargrove L, Glaser S, Zhou T, Jaeger V, Alpini G, Francis H. Amelioration of Large Bile Duct Damage by Histamine-2 Receptor Vivo-Morpholino Treatment. Am J Pathol. 2020;190( 5):1018–29 doi:10.1016/j.ajpath.2020.01.013.

Cell-type specific global reprogramming of the transcriptome and epigenome in induced neurons with the 16p11.2 neuropsychiatric CNVs

Authors:
Ward TR, Qu PP, Leung LC, Zhou B, Muench KL, Khechaduri A, Plastini MJ, Charlton CA, Pattni R, Ho S, Ho M, Huang Y, Zhou P, Hallmayer JF, Mourrain P, Palmer TD, Zhang X, Urban AE
Citation:
Eur J Hum Genet. 2025 Dec;33(12):1698-1707. doi: 10.1038/s41431-025-01856-3. Epub 2025 May 15. PMID: 40374944; PMCID: PMC12341848
Epub:
Not Epub
Abstract:
Copy number variants (CNVs), either deletions or duplications, at the 16p11.2 locus in the human genome are known to increase...
Link:
https://www.nature.com/articles/s41431-025-01856-3
Delivery Method:
microinjection
Organism or Cell Type:
zebrafish
Citation Extract:
Ward TR, Qu PP, Leung LC, Zhou B, Muench KL, Khechaduri A, Plastini MJ, Charlton CA, Pattni R, Ho S, Ho M, Huang Y, Zhou P, Hallmayer JF, Mourrain P, Palmer TD, Zhang X, Urban AE. Cell-type specific global reprogramming of the transcriptome and epigenome in induced neurons with the 16p11.2 neuropsychiatric CNVs. Eur J Hum Genet. 2025 Dec;33(12):1698-1707. doi: 10.1038/s41431-025-01856-3. Epub 2025 May 15. PMID: 40374944; PMCID: PMC12341848.

Single-cell reconstruction with spatial context of migrating neural crest cells and their microenvironments during vertebrate head and neck formation

Authors:
Morrison JA, McLennan R, Teddy JM, Scott AR, Kasemeier-Kulesa JC, Gogol MM, Kulesa PM
Citation:
Development. 2021 Nov 15;148(22):dev199468. doi: 10.1242/dev.199468. Epub 2021 Nov 17. PMID: 35020873
Epub:
Not Epub
Abstract:
The dynamics of multipotent neural crest cell differentiation and invasion as cells travel throughout the vertebrate embryo...
Link:
https://journals.biologists.com/dev/article/148/22/dev199468/273452/Single-cell-reconstruction-with-spatial-context-of
Delivery Method:
electroporation
Organism or Cell Type:
Gallus gallus (chick)
Citation Extract:
Morrison JA, McLennan R, Teddy JM, Scott AR, Kasemeier-Kulesa JC, Gogol MM, Kulesa PM. Single-cell reconstruction with spatial context of migrating neural crest cells and their microenvironments during vertebrate head and neck formation. Development. 2021 Nov 15;148(22):dev199468. doi: 10.1242/dev.199468. Epub 2021 Nov 17. PMID: 35020873.

Zebrafish miR-462-731 is required for digestive organs development

Authors:
Huang Y, Huang C-X, Wang W-F, Liu H, Wang H-L
Citation:
Comp Biochem Physiol Part D Genomics Proteomics. 2020 Feb 29;34:100679. doi: 10.1016/j.cbd.2020.100679. [Epub ahead of print]
Epub:
Not Epub
Abstract:
With-no-lysine (K)-1 (WNK1) is the founding member of family of four protein kinases with atypical placement of catalytic...
Link:
https://www.sciencedirect.com/science/article/pii/S1744117X20300265
Delivery Method:
microinjection
Organism or Cell Type:
zebrafish
Citation Extract:
Huang Y, Huang C-X, Wang W-F, Liu H, Wang H-L. Zebrafish miR-462-731 is required for digestive organs development. Comp Biochem Physiol Part D Genomics Proteomics. 2020 Feb 29;34:100679. doi: 10.1016/j.cbd.2020.100679. [Epub ahead of print].

WNK1 Kinase Stimulates Angiogenesis to Promote Tumor Growth and Metastasis

Authors:
Sie Z-L, Li R-Y, Sampurna PB, Hsu P-J, Liu S-C, Wang H-D, Huang C-L, Yuh C-H
Citation:
Cancers. 2020;12(3):[Epub] doi:0.3390/cancers12030575
Epub:
Not Epub
Abstract:
With-no-lysine (K)-1 (WNK1) is the founding member of family of four protein kinases with atypical placement of catalytic...
Link:
https://www.mdpi.com/2072-6694/12/3/575
Delivery Method:
microinjection
Organism or Cell Type:
zebrafish
Citation Extract:
Sie Z-L, Li R-Y, Sampurna PB, Hsu P-J, Liu S-C, Wang H-D, Huang C-L, Yuh C-H. WNK1 Kinase Stimulates Angiogenesis to Promote Tumor Growth and Metastasis. Cancers. 2020;12(3):[Epub] doi:0.3390/cancers12030575.

Aberrant Expression of a Non-muscle RBFOX2 Isoform Triggers Cardiac Conduction Defects in Myotonic Dystrophy

Authors:
Misra C, Bangru S, Lin F, Lam K, Koenig SN, Lubbers ER, Hedhli J, Murphy NP, Parker DJ, Dobrucki LW, Cooper TA, Tajkhorshid E, Mohler PJ, Kalsotra A
Citation:
Dev Cell. 2020;[Epub ahead of print] doi:10.1016/j.devcel.2020.01.037
Epub:
Yes
Abstract:
Myotonic dystrophy type 1 (DM1) is a multisystemic genetic disorder caused by the CTG repeat expansion in the 3′-untranslated...
Link:
https://www.sciencedirect.com/science/article/abs/pii/S1534580720300691
Delivery Method:
Endo-Porter
Organism or Cell Type:
cell culture: HL-1
Citation Extract:
Misra C, Bangru S, Lin F, Lam K, Koenig SN, Lubbers ER, Hedhli J, Murphy NP, Parker DJ, Dobrucki LW, Cooper TA, Tajkhorshid E, Mohler PJ, Kalsotra A. Aberrant Expression of a Non-muscle RBFOX2 Isoform Triggers Cardiac Conduction Defects in Myotonic Dystrophy. Dev Cell. 2020;[Epub ahead of print] doi:10.1016/j.devcel.2020.01.037.

Wip1 regulates Smad4 phosphorylation and inhibits TGF‐β signaling

Authors:
Park D-S, Yoon G-H, Kim E-Y, Lee T, Kim K, Lee PCW, Chang E-J, Choi S-C
Citation:
EMBO Rep. 2020;[Epub] doi:10.15252/embr.201948693
Epub:
Yes
Abstract:
The tumor suppressor Smad4, a key mediator of the TGF‐β/BMP pathways, is essential for development and tissue homeostasis....
Link:
https://www.embopress.org/doi/abs/10.15252/embr.201948693
Organism or Cell Type:
Xenopus
Citation Extract:
Park D-S, Yoon G-H, Kim E-Y, Lee T, Kim K, Lee PCW, Chang E-J, Choi S-C. Wip1 regulates Smad4 phosphorylation and inhibits TGF‐β signaling. EMBO Rep. 2020;[Epub] doi:10.15252/embr.201948693.

Comparison of the efficacy of MOE and PMO modifications of systemic antisense oligonucleotides in a severe SMA mouse model

Authors:
Sheng L, Rigo F, Bennett CF, Krainer AR, Hua Y
Citation:
Nucl Acids Res. 2020;[Epub ahead of print] doi:10.1093/nar/gkaa126
Epub:
Yes
Abstract:
Spinal muscular atrophy (SMA) is a motor neuron disease. Nusinersen, a splice-switching antisense oligonucleotide (ASO), was...
Link:
https://academic.oup.com/nar/advance-article/doi/10.1093/nar/gkaa126/5760755
Delivery Method:
subcutaneous (s.c.) injection
Organism or Cell Type:
mice
Citation Extract:
Sheng L, Rigo F, Bennett CF, Krainer AR, Hua Y. Comparison of the efficacy of MOE and PMO modifications of systemic antisense oligonucleotides in a severe SMA mouse model. Nucl Acids Res. 2020;[Epub ahead of print] doi:10.1093/nar/gkaa126.

pmar1/phb homeobox genes and the evolution of the double-negative gate for endomesoderm specification in echinoderms

Authors:
Yamazaki A, Morino Y, Urata M, Yamaguchi M, Minokawa T, Furukawa R, Kondo M, Wada H
Citation:
Development. 2020;147:[Epub ahead of print] doi:10.1242/dev.182139
Epub:
Not Epub
Abstract:
In several model animals, the earliest phases of embryogenesis are regulated by lineage-specific genes, such as Drosophila...
Link:
https://dev.biologists.org/content/147/4/dev182139
Delivery Method:
microinjection
Organism or Cell Type:
Patria pectinifera (sea star)
Citation Extract:
Yamazaki A, Morino Y, Urata M, Yamaguchi M, Minokawa T, Furukawa R, Kondo M, Wada H. pmar1/phb homeobox genes and the evolution of the double-negative gate for endomesoderm specification in echinoderms. Development. 2020;147:[Epub ahead of print] doi:10.1242/dev.182139.

Active acetylcholine receptors prevent the atrophy of skeletal muscles and favor reinnervation

Authors:
Cisterna BA, Vargas AA, Puebla C, Fernández P, Escamilla R, Lagos CF, Matus MF, Vilos C, Cea LA, Barnafi E, Gaete H, Escobar DF, Cardozo CP, Sáez JC
Citation:
Nat Commun. 2020;11:1073 doi:s41467-019-14063-8
Epub:
Not Epub
Abstract:
Denervation of skeletal muscles induces severe muscle atrophy, which is preceded by cellular alterations such as increased...
Link:
https://www.nature.com/articles/s41467-019-14063-8
Delivery Method:
lipofectamine 2000
Organism or Cell Type:
cell culture: myofibrils
Citation Extract:
Cisterna BA, Vargas AA, Puebla C, Fernández P, Escamilla R, Lagos CF, Matus MF, Vilos C, Cea LA, Barnafi E, Gaete H, Escobar DF, Cardozo CP, Sáez JC. Active acetylcholine receptors prevent the atrophy of skeletal muscles and favor reinnervation. Nat Commun. 2020;11:1073 doi:s41467-019-14063-8.

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