You are here

Morpholino Publication Database

This database contains citations and abstracts for research using Morpholino oligos, as well as some review articles incorporating Morpholino data. You can search the content using the filter boxes below.

There are 12371 scientific papers returned from the database with the search filters currently being used below.

Systemic Intravenous Administration of Antisense Therapeutics for Combinatorial Dystrophin and Myostatin Exon Splice Modulation

Authors:
Lu-Nguyen N, Dickson G, Malerba A
Citation:
Methods Mol Biol. 2018;1828:343-354. doi: 10.1007/978-1-4939-8651-4_21
Epub:
Not Epub
Abstract:
Using antisense oligonucleotides (AOs) to reframe mutated dystrophin, a recently developed therapeutic approach for Duchenne...
Link:
https://link.springer.com/protocol/10.1007%2F978-1-4939-8651-4_21
Organism or Cell Type:
mice mdx
Citation Extract:
Lu-Nguyen N, Dickson G, Malerba A. Systemic Intravenous Administration of Antisense Therapeutics for Combinatorial Dystrophin and Myostatin Exon Splice Modulation. Methods Mol Biol. 2018;1828:343-354. doi: 10.1007/978-1-4939-8651-4_21.

Antisense Oligonucleotide Targeting of 3'-UTR of mRNA for Expression Knockdown

Authors:
Golshirazi G, Ciszewski L, Lu-Nguyen N, Popplewell L
Citation:
Methods Mol Biol. 2018;1828:91-124. doi: 10.1007/978-1-4939-8651-4_6
Epub:
Not Epub
Abstract:
With the recent conditional approval of an antisense oligonucleotide (AON) that restores the reading frame of DMD transcript in...
Link:
https://link.springer.com/protocol/10.1007%2F978-1-4939-8651-4_6
Citation Extract:
Golshirazi G, Ciszewski L, Lu-Nguyen N, Popplewell L. Antisense Oligonucleotide Targeting of 3'-UTR of mRNA for Expression Knockdown. Methods Mol Biol. 2018;1828:91-124. doi: 10.1007/978-1-4939-8651-4_6.

14-3-3εa directs the pulsatile transport of basal factors toward the apical domain for lumen growth in tubulogenesis

Authors:
Mizotani Y, Suzuki M, Hotta K, Watanabe H, Shiba K, Inaba K, Tashiro E, Oka K, Imoto M
Citation:
Proc Natl Acad Sci U S A. 2018 Aug 29. pii: 201808756. doi: 10.1073/pnas.1808756115. [Epub ahead of print]
Epub:
Yes
Abstract:
The Ciona notochord has emerged as a simple and tractable in vivo model for tubulogenesis. Here, using a chemical genetics...
Link:
Proc Natl Acad Sci U S A. 2018 Aug 29. pii: 201808756. doi: 10.1073/pnas.1808756115. [Epub ahead of print]
Delivery Method:
microinjection
Organism or Cell Type:
Ciona intestinalis (ascidian)
Citation Extract:
Mizotani Y, Suzuki M, Hotta K, Watanabe H, Shiba K, Inaba K, Tashiro E, Oka K, Imoto M. 14-3-3εa directs the pulsatile transport of basal factors toward the apical domain for lumen growth in tubulogenesis. Proc Natl Acad Sci U S A. 2018 Aug 29. pii: 201808756. doi: 10.1073/pnas.1808756115. [Epub ahead of print].

Dnd is required for primordial germ cell specification in Oryzias celebensis

Authors:
Zhu T, Gui L, Zhu Y, Li Y, Li M
Citation:
Gene. 2018 Aug 29. pii: S0378-1119(18)30928-4. doi: 10.1016/j.gene.2018.08.068. [Epub ahead of print]
Epub:
Yes
Abstract:
Dead end (dnd) is a germ plasm component that plays an essential role for primordial germ cell (PGC) development in vertebrates...
Link:
https://www.sciencedirect.com/science/article/pii/S0378111918309284?via%3Dihub
Delivery Method:
microinjection
Organism or Cell Type:
Oryzias celebensis (Celebes ricefish)
Citation Extract:
Zhu T, Gui L, Zhu Y, Li Y, Li M. Dnd is required for primordial germ cell specification in Oryzias celebensis. Gene. 2018 Aug 29. pii: S0378-1119(18)30928-4. doi: 10.1016/j.gene.2018.08.068. [Epub ahead of print].

Exon Skipping Using Antisense Oligonucleotides for Laminin-Alpha2-Deficient Muscular Dystrophy

Authors:
Hara Y, Mizobe Y, Miyatake S, Takizawa H, Nagata T, Yokota T, Takeda S, Aoki Y
Citation:
Methods Mol Biol. 2018;1828:553-564. doi: 10.1007/978-1-4939-8651-4_36
Epub:
Not Epub
Abstract:
Phosphorodiamidate morpholino oligomer (PMO)-mediated exon skipping is among the more promising approaches available for the...
Link:
https://link.springer.com/protocol/10.1007%2F978-1-4939-8651-4_36
Organism or Cell Type:
mice laminin-α2-deficient dy 3K/dy 3K
Citation Extract:
Hara Y, Mizobe Y, Miyatake S, Takizawa H, Nagata T, Yokota T, Takeda S, Aoki Y. Exon Skipping Using Antisense Oligonucleotides for Laminin-Alpha2-Deficient Muscular Dystrophy. Methods Mol Biol. 2018;1828:553-564. doi: 10.1007/978-1-4939-8651-4_36.

Morpholino-Mediated Exon Skipping Targeting Human ACVR1/ALK2 for Fibrodysplasia Ossificans Progressiva

Authors:
Maruyama R, Yokota T
Citation:
Methods Mol Biol. 2018;1828:497-502. doi: 10.1007/978-1-4939-8651-4_32
Epub:
Not Epub
Abstract:
Fibrodysplasia ossificans progressiva (FOP) is a rare autosomal-dominant disorder characterized by progressive heterotopic...
Link:
https://link.springer.com/protocol/10.1007%2F978-1-4939-8651-4_32
Organism or Cell Type:
cell culture: Fibrodysplasia ossificans progressiva human primary cells
Citation Extract:
Maruyama R, Yokota T. Morpholino-Mediated Exon Skipping Targeting Human ACVR1/ALK2 for Fibrodysplasia Ossificans Progressiva. Methods Mol Biol. 2018;1828:497-502. doi: 10.1007/978-1-4939-8651-4_32.

Exon Skipping by Ultrasound-Enhanced Delivery of Morpholino with Bubble Liposomes for Myotonic Dystrophy Model Mice

Authors:
Negishi Y, Endo-Takahashi Y, Ishiura S
Citation:
Methods Mol Biol. 2018;1828:481-487. doi: 10.1007/978-1-4939-8651-4_30
Epub:
Not Epub
Abstract:
Abnormal splicing of the chloride channel 1 (CLCN1) gene causes myotonic dystrophy type 1 (DM1). Therefore, controlling the...
Link:
https://link.springer.com/protocol/10.1007%2F978-1-4939-8651-4_30
Delivery Method:
bubble liposome ultrasonic
Organism or Cell Type:
mice
Citation Extract:
Negishi Y, Endo-Takahashi Y, Ishiura S. Exon Skipping by Ultrasound-Enhanced Delivery of Morpholino with Bubble Liposomes for Myotonic Dystrophy Model Mice. Methods Mol Biol. 2018;1828:481-487. doi: 10.1007/978-1-4939-8651-4_30.

Morpholino-Mediated Exon Inclusion for SMA

Authors:
Zhou H, Muntoni F
Citation:
Methods Mol Biol. 2018;1828:467-477. doi: 10.1007/978-1-4939-8651-4_29
Epub:
Not Epub
Abstract:
The application of antisense oligonucleotides (AONs) to modify pre-messenger RNA splicing has great potential for treating...
Link:
https://link.springer.com/protocol/10.1007%2F978-1-4939-8651-4_29
Organism or Cell Type:
mice SMA
Citation Extract:
Zhou H, Muntoni F. Morpholino-Mediated Exon Inclusion for SMA. Methods Mol Biol. 2018;1828:467-477. doi: 10.1007/978-1-4939-8651-4_29.

Systemic and ICV Injections of Antisense Oligos into SMA Mice and Evaluation

Authors:
Aslesh T, Maruyama R, Yokota T
Citation:
Methods Mol Biol. 2018;1828:455-465. doi: 10.1007/978-1-4939-8651-4_28
Epub:
Not Epub
Abstract:
Spinal muscular atrophy (SMA) is the most common genetic cause of infantile death caused by mutations in the SMN1 gene....
Link:
https://link.springer.com/protocol/10.1007%2F978-1-4939-8651-4_28
Organism or Cell Type:
mice severe SMA model
Citation Extract:
Aslesh T, Maruyama R, Yokota T. Systemic and ICV Injections of Antisense Oligos into SMA Mice and Evaluation. Methods Mol Biol. 2018;1828:455-465. doi: 10.1007/978-1-4939-8651-4_28.

In Vitro Evaluation of Antisense-Mediated Exon Inclusion for Spinal Muscular Atrophy

Authors:
Touznik A, Maruyama R, Yokota T
Citation:
Methods Mol Biol. 2018;1828:439-454. doi: 10.1007/978-1-4939-8651-4_27
Epub:
Not Epub
Abstract:
Spinal muscular atrophy (SMA), the most common gentic cause of infantile death caused by mutations in the SMN1 gene, presents a...
Link:
https://link.springer.com/protocol/10.1007%2F978-1-4939-8651-4_27
Organism or Cell Type:
cell culture: type I SMA patient fibroblast cell lines
Citation Extract:
Touznik A, Maruyama R, Yokota T. In Vitro Evaluation of Antisense-Mediated Exon Inclusion for Spinal Muscular Atrophy. Methods Mol Biol. 2018;1828:439-454. doi: 10.1007/978-1-4939-8651-4_27.

Pages