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Morpholino Publication Database

This database contains citations and abstracts for research using Morpholino oligos, as well as some review articles incorporating Morpholino data. You can search the content using the filter boxes below.

There are 12376 scientific papers returned from the database with the search filters currently being used below.

Pth4, an ancient parathyroid hormone lost in eutherian mammals, reveals a new brain-to-bone signaling pathway

Authors:
Suarez-Bregua P, Torres-Nuñez E, Saxena A, Guerreiro P, Braasch I, Prober DA, Moran P, Cerda-Reverter JM, Du SJ, Adrio F, Power DM, Canario AV, Postlethwait JH, Bronner ME, Cañestro C, Rotllant J
Citation:
FASEB J. 2017 Feb;31(2):569-583. doi: 10.1096/fj.201600815R
Epub:
Not Epub
Abstract:
Regulation of bone development, growth, and remodeling traditionally has been thought to depend on endocrine and autocrine/...
Link:
http://www.fasebj.org/content/31/2/569.abstract
Delivery Method:
microinjection
Organism or Cell Type:
zebrafish
Citation Extract:
Suarez-Bregua P, Torres-Nuñez E, Saxena A, Guerreiro P, Braasch I, Prober DA, Moran P, Cerda-Reverter JM, Du SJ, Adrio F, Power DM, Canario AV, Postlethwait JH, Bronner ME, Cañestro C, Rotllant J. Pth4, an ancient parathyroid hormone lost in eutherian mammals, reveals a new brain-to-bone signaling pathway. FASEB J. 2017 Feb;31(2):569-583. doi: 10.1096/fj.201600815R.

Mutations in γ-secretase subunit-encoding PSENEN underlie Dowling-Degos disease associated with acne inversa

Authors:
Ralser DJ, Basmanav FB, Tafazzoli A, Wititsuwannakul J, Delker S, Danda S, Thiele H, Wolf S, Busch M, Pulimood SA, Altmüller J, Nürnberg P, Lacombe D, Hillen U, Wenzel J, Frank J, Odermatt B, Betz RC
Citation:
J Clin Invest. 2017 Mar 13. pii: 90667. doi: 10.1172/JCI90667. [Epub ahead of print]
Epub:
Yes
Abstract:
Dowling-Degos disease (DDD) is an autosomal-dominant disorder of skin pigmentation associated with mutations in keratin 5 (KRT5...
Link:
http://www.jci.org/articles/view/90667
Delivery Method:
microinjection
Organism or Cell Type:
zebrafish
Citation Extract:
Ralser DJ, Basmanav FB, Tafazzoli A, Wititsuwannakul J, Delker S, Danda S, Thiele H, Wolf S, Busch M, Pulimood SA, Altmüller J, Nürnberg P, Lacombe D, Hillen U, Wenzel J, Frank J, Odermatt B, Betz RC. Mutations in γ-secretase subunit-encoding PSENEN underlie Dowling-Degos disease associated with acne inversa. J Clin Invest. 2017 Mar 13. pii: 90667. doi: 10.1172/JCI90667. [Epub ahead of print].

Functional differences between Tcf1 isoforms in early Xenopus development

Authors:
Roël G, Van Den Broek O, Destrée O
Citation:
Int J Dev Biol. 2017;61(1-2):29-34. doi: 10.1387/ijdb.160308od
Epub:
Not Epub
Abstract:
In Xenopus gastrula stage embryos, four isoforms of Tcf1 (B, C, D and E) are present with high amino acid sequence conservation...
Link:
http://www.ijdb.ehu.es/web/paper/160308od/functional-differences-between-tcf1-isoforms-in-early-xenopus-development
Delivery Method:
microinjection
Organism or Cell Type:
Xenopus
Citation Extract:
Roël G, Van Den Broek O, Destrée O. Functional differences between Tcf1 isoforms in early Xenopus development. Int J Dev Biol. 2017;61(1-2):29-34. doi: 10.1387/ijdb.160308od.

Molecular mechanisms regulating ocular apoptosis in zebrafish gdf6a mutants

Authors:
Pant SD, March LD, Famulski JK, French CR, Lehmann OJ, Waskiewicz AJ
Citation:
Invest Ophthalmol Vis Sci. 2013 Aug 28;54(8):5871-9. doi: 10.1167/iovs.12-11315
Epub:
Not Epub
Abstract:
Purpose.: To characterize the molecular mechanisms underlying retinal apoptosis induced by loss of Gdf6, a TGFβ ligand....
Link:
http://iovs.arvojournals.org/article.aspx?articleid=2129025
Delivery Method:
microinjection
Organism or Cell Type:
zebrafish
Citation Extract:
Pant SD, March LD, Famulski JK, French CR, Lehmann OJ, Waskiewicz AJ. Molecular mechanisms regulating ocular apoptosis in zebrafish gdf6a mutants. Invest Ophthalmol Vis Sci. 2013 Aug 28;54(8):5871-9. doi: 10.1167/iovs.12-11315.

Churchill regulates cell movement and mesoderm specification by repressing Nodal signaling

Authors:
Londin ER, Mentzer L, Sirotkin HI
Citation:
BMC Dev Biol. 2007 Nov 2;7:120
Epub:
Not Epub
Abstract:
BACKGROUND: Cell movements are essential to the determination of cell fates during development. The zinc-finger transcription...
Link:
https://bmcdevbiol.biomedcentral.com/articles/10.1186/1471-213X-7-120
Delivery Method:
microinjection
Organism or Cell Type:
zebrafish
Citation Extract:
Londin ER, Mentzer L, Sirotkin HI. Churchill regulates cell movement and mesoderm specification by repressing Nodal signaling. BMC Dev Biol. 2007 Nov 2;7:120.

A splicing mutation in VPS4B causes dentin dysplasia I

Authors:
Yang Q, Chen D, Xiong F, Chen D, Liu C, Liu Y, Yu Q, Xiong J, Liu J, Li K, Zhao L, Ye Y, Zhou H, Hu L, Tian Z, Shang X, Zhang L, Wei X, Zhou W, Li D, Zhang W, Xu X
Citation:
J Med Genet. 2016 Sep;53(9):624-33. doi: 10.1136/jmedgenet-2015-103619
Epub:
Not Epub
Abstract:
BACKGROUND: Dentin dysplasia I (DDI) is a genetically heterogeneous autosomal-dominant disorder characterised by rootless teeth...
Link:
http://jmg.bmj.com/content/53/9/624
Delivery Method:
microinjection
Organism or Cell Type:
zebrafish
Citation Extract:
Yang Q, Chen D, Xiong F, Chen D, Liu C, Liu Y, Yu Q, Xiong J, Liu J, Li K, Zhao L, Ye Y, Zhou H, Hu L, Tian Z, Shang X, Zhang L, Wei X, Zhou W, Li D, Zhang W, Xu X . A splicing mutation in VPS4B causes dentin dysplasia I. J Med Genet. 2016 Sep;53(9):624-33. doi: 10.1136/jmedgenet-2015-103619.

GATA5 SUMOylation is indispensable for zebrafish cardiac development

Authors:
Wen B, Yuan H, Liu X, Wang H, Chen S, Chen Z, de The H, Zhou J, Zhu J
Citation:
Biochim Biophys Acta. 2017 Mar 8. pii: S0304-4165(17)30088-0. doi: 10.1016/j.bbagen.2017.03.005. [Epub ahead of print]
Epub:
Yes
Abstract:
BACKGROUND: SUMOylation is a critical regulatory protein modification in eukaryotic cells and plays a pivotal role in cardiac...
Link:
http://www.sciencedirect.com/science/article/pii/S0304416517300880
Delivery Method:
microinjection
Organism or Cell Type:
zebrafish
Citation Extract:
Wen B, Yuan H, Liu X, Wang H, Chen S, Chen Z, de The H, Zhou J, Zhu J. GATA5 SUMOylation is indispensable for zebrafish cardiac development. Biochim Biophys Acta. 2017 Mar 8. pii: S0304-4165(17)30088-0. doi: 10.1016/j.bbagen.2017.03.005. [Epub ahead of print].

Whole exome sequencing coupled with unbiased functional analysis reveals new Hirschsprung disease genes

Authors:
Gui H, Schriemer D, Cheng WW, Chauhan RK, Antiňolo G, Berrios C, Bleda M, Brooks AS, Brouwer RW, Burns AJ, Cherny SS, Dopazo J, Eggen BJ, Griseri P, Jalloh B, Le TL, Lui VC, Luzón-Toro B, Matera I, Ngan ES, Pelet A, Ruiz-Ferrer M, Sham PC, Shepherd IT, So MT, Sribudiani Y, Tang CS, van den Hout MC, van der Linde HC, van Ham TJ, van IJcken WF, Verheij JB, Amiel J, Borrego S, Ceccherini I, Chakravarti A, Lyonnet S, Tam PK, Garcia-Barceló MM, Hofstra RM
Citation:
Genome Biol. 2017 Mar 8;18(1):48. doi: 10.1186/s13059-017-1174-6
Epub:
Not Epub
Abstract:
BACKGROUND: Hirschsprung disease (HSCR), which is congenital obstruction of the bowel, results from a failure of enteric...
Link:
https://genomebiology.biomedcentral.com/articles/10.1186/s13059-017-1174-6
Delivery Method:
microinjection
Organism or Cell Type:
zebrafish
Citation Extract:
Gui H, Schriemer D, Cheng WW, Chauhan RK, Antiňolo G, Berrios C, Bleda M, Brooks AS, Brouwer RW, Burns AJ, Cherny SS, Dopazo J, Eggen BJ, Griseri P, Jalloh B, Le TL, Lui VC, Luzón-Toro B, Matera I, Ngan ES, Pelet A, Ruiz-Ferrer M, Sham PC, Shepherd IT, So MT, Sribudiani Y, Tang CS, van den Hout MC, van der Linde HC, van Ham TJ, van IJcken WF, Verheij JB, Amiel J, Borrego S, Ceccherini I, Chakravarti A, Lyonnet S, Tam PK, Garcia-Barceló MM, Hofstra RM. Whole exome sequencing coupled with unbiased functional analysis reveals new Hirschsprung disease genes. Genome Biol. 2017 Mar 8;18(1):48. doi: 10.1186/s13059-017-1174-6.

RCAN1.4 regulates VEGFR-2 internalisation, cell polarity and migration in human microvascular endothelial cells

Authors:
Alghanem AF, Wilkinson EL, Emmett MS, Aljasir MA, Holmes K, Rothermel BA, Simms VA, Heath VL, Cross MJ
Citation:
Angiogenesis. 2017 Mar 7. doi: 10.1007/s10456-017-9542-0. [Epub ahead of print]
Epub:
Yes
Abstract:
Regulator of calcineurin 1 (RCAN1) is an endogenous inhibitor of the calcineurin pathway in cells. It is expressed as two...
Link:
http://link.springer.com/article/10.1007%2Fs10456-017-9542-0
Delivery Method:
microinjection
Organism or Cell Type:
zebrafish
Citation Extract:
Alghanem AF, Wilkinson EL, Emmett MS, Aljasir MA, Holmes K, Rothermel BA, Simms VA, Heath VL, Cross MJ. RCAN1.4 regulates VEGFR-2 internalisation, cell polarity and migration in human microvascular endothelial cells. Angiogenesis. 2017 Mar 7. doi: 10.1007/s10456-017-9542-0. [Epub ahead of print].

Troponin-I is present as an essential component of muscles in echinoderm larvae

Authors:
Yaguchi S, Yaguchi J, Tanaka H
Citation:
Sci Rep. 2017;7:43563. doi:10.1038/srep43563
Epub:
Not Epub
Abstract:
The troponin complex, composed of Troponin-I, Troponin-T and Troponin-C, is an essential mediator of the contraction of...
Link:
http://www.nature.com/articles/srep43563
Delivery Method:
microinjection
Organism or Cell Type:
Hemicentrotus pulcherrimus (sea urchin)
Citation Extract:
Yaguchi S, Yaguchi J, Tanaka H. Troponin-I is present as an essential component of muscles in echinoderm larvae. Sci Rep. 2017;7:43563. doi:10.1038/srep43563.

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