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Morpholino Publication Database
This database contains citations and abstracts for research using Morpholino oligos, as well as some review articles incorporating Morpholino data. You can search the content using the filter boxes below.
There are 12376 scientific papers returned from the database with the search filters currently being used below.
There are 12376 scientific papers returned from the database with the search filters currently being used below.
Gene Silencing with Morpholinos
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Citation:
JoVE. 2017. doi:10.3791/5326 Epub:
Not Epub Abstract:
Morpholino-mediated gene silencing is a common technique used to study roles of specific genes during development. Morpholinos... Delivery Method:
microinjection Organism or Cell Type:
zebrafish Citation Extract: JoVE Science Education Database. Gene Silencing with Morpholinos. JoVE. 2017. doi:10.3791/5326. |
A missense mutation in zbtb17 blocks the earliest steps of T cell differentiation in zebrafish
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Citation:
Sci Rep. 2017;7:44145. doi:10.1038/srep44145 Epub:
Not Epub Abstract:
T cells are an evolutionarily conserved feature of the adaptive immune systems of vertebrates. Comparative studies using... Delivery Method:
microinjection Organism or Cell Type:
zebrafish Citation Extract: Lawir D-F, Iwanami N, Schorpp M, Boehm T. A missense mutation in zbtb17 blocks the earliest steps of T cell differentiation in zebrafish. Sci Rep. 2017;7:44145. doi:10.1038/srep44145. |
Loss of DDRGK1 modulates SOX9 ubiquitination in spondyloepimetaphyseal dysplasia
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Citation:
J Clin Invest. 2017 Mar 6. pii: 90193. doi: 10.1172/JCI90193. [Epub ahead of print] Epub:
Not Epub Abstract:
Shohat-type spondyloepimetaphyseal dysplasia (SEMD) is a skeletal dysplasia that affects cartilage development. Similar... Delivery Method:
microinjection Organism or Cell Type:
zebrafish Citation Extract: Egunsola AT, Bae Y, Jiang MM, Liu DS, Chen-Evenson Y, Bertin T, Chen S, Lu JT, Nevarez L, Magal N, Raas-Rothschild A, Swindell EC, Cohn DH, Gibbs RA, Campeau PM, Shohat M, Lee BH. Loss of DDRGK1 modulates SOX9 ubiquitination in spondyloepimetaphyseal dysplasia. J Clin Invest. 2017 Mar 6. pii: 90193. doi: 10.1172/JCI90193. [Epub ahead of print]. |
A truncating mutation in CEP55 is the likely cause of MARCH, a novel syndrome affecting neuronal mitosis
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Citation:
J Med Genet. 2017;[Epub ahead of print] doi:10.1136/jmedgenet-2016-104296 Epub:
Yes Abstract:
Background Hydranencephaly is a congenital anomaly leading to replacement of the cerebral hemispheres with a fluid-filled cyst... Delivery Method:
microinjection Organism or Cell Type:
zebrafish Citation Extract: Frosk P, Arts HH, Philippe J, Gunn CS, Brown EL, Chodirker B, Simard L, Majewski J, Fahiminiya S, Russell C, Liu YP, FORGE Canada Consortium, Canadian Rare Diseases: Models & Mechanisms Network, Hegele R, Katsanis N, Goerz C, Del Bigio MR, Davis EE. A truncating mutation in CEP55 is the likely cause of MARCH, a novel syndrome affecting neuronal mitosis. J Med Genet. 2017;[Epub ahead of print] doi:10.1136/jmedgenet-2016-104296. |
Uncoupling of neurogenesis and differentiation during retinal development
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Citation:
EMBO J. 2017 Mar 3. pii: e201694230. doi: 10.15252/embj.201694230. [Epub ahead of print] Epub:
Not Epub Abstract:
Conventionally, neuronal development is regarded to follow a stereotypic sequence of neurogenesis, migration, and... Delivery Method:
microinjection Organism or Cell Type:
zebrafish Citation Extract: Engerer P, Suzuki SC, Yoshimatsu T, Chapouton P, Obeng N, Odermatt B, Williams PR, Misgeld T, Godinho L. Uncoupling of neurogenesis and differentiation during retinal development. EMBO J. 2017 Mar 3. pii: e201694230. doi: 10.15252/embj.201694230. [Epub ahead of print]. |
Folate receptor 1 is necessary for neural plate cell apical constriction during Xenopus neural tube formation
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Citation:
Development. 2017;144:1518-30. doi: 10.1242/dev.137315 Epub:
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Folate supplementation prevents up to 70% of neural tube defects (NTDs), which result from a failure of neural tube closure... Delivery Method:
microinjection Organism or Cell Type:
Xenopus laevis Citation Extract: Balashova OA, Visina O, Borodinsky LN. Folate receptor 1 is necessary for neural plate cell apical constriction during Xenopus neural tube formation. Development. 2017;144:1518-30. doi: 10.1242/dev.137315. |
Antisense Oligonucleotides Used to Target the DUX4 mRNA as Therapeutic Approaches in FaciosScapuloHumeral Muscular Dystrophy (FSHD)
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Citation:
Genes. 2017;8(3):93 doi:10.3390/genes8030093 Epub:
Not Epub Abstract:
FacioScapuloHumeral muscular Dystrophy (FSHD) is one of the most prevalent hereditary myopathies and is generally characterized... Delivery Method:
Vivo-Morpholino Organism or Cell Type:
mouse Citation Extract: Ansseau E, Vanderplanck C, Wauters A, Harper SQ, Coppée F, Belayew A. Antisense Oligonucleotides Used to Target the DUX4 mRNA as Therapeutic Approaches in FaciosScapuloHumeral Muscular Dystrophy (FSHD). Genes. 2017;8(3):93 doi:10.3390/genes8030093. |
The protein tyrosine phosphatase 1B inhibitor MSI-1436 stimulates regeneration of heart and multiple other tissues
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Citation:
npj Regen Med. 2017;2:4. doi:10.1038/s41536-017-0008-1 Epub:
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Regenerative medicine holds substantial promise for repairing or replacing tissues and organs damaged by disease, injury, and... Delivery Method:
Vivo-Morpholino Organism or Cell Type:
zebrafish Citation Extract: Smith AM, Maguire-Nguyen KK, Rando TA, Zasloff MA, Strange KB, Yin VP. The protein tyrosine phosphatase 1B inhibitor MSI-1436 stimulates regeneration of heart and multiple other tissues. npj Regen Med. 2017;2:4. doi:10.1038/s41536-017-0008-1. |
The pro-inflammatory signalling regulator Stat4 promotes vasculogenesis of great vessels derived from endothelial precursors
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Citation:
Nat Comm. 2017;8:14640 doi:10.1038/ncomms14640 Epub:
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Vasculogenic defects of great vessels (GVs) are a major cause of congenital cardiovascular diseases. However, genetic... Delivery Method:
microinjection Organism or Cell Type:
zebrafish Citation Extract: Meng Z-Z, Liu W, Xia Y, Yin H-M, Zhang C-Y, Su D, Yan L-F, Gu A-H, Zhou Y. The pro-inflammatory signalling regulator Stat4 promotes vasculogenesis of great vessels derived from endothelial precursors. Nat Comm. 2017;8:14640 doi:10.1038/ncomms14640. |
Sox10 contributes to the balance of fate choice in dorsal root ganglion progenitors
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Citation:
PLoS One. 2017 Mar 2;12(3):e0172947. doi: 10.1371/journal.pone.0172947 Epub:
Not Epub Abstract:
The development of functional peripheral ganglia requires a balance of specification of both neuronal and glial components. In... Delivery Method:
microinjection Organism or Cell Type:
zebrafish Citation Extract: Delfino-Machín M, Madelaine R, Busolin G, Nikaido M, Colanesi S, Camargo-Sosa K, Law EW, Toppo S, Blader P, Tiso N, Kelsh RN. Sox10 contributes to the balance of fate choice in dorsal root ganglion progenitors. PLoS One. 2017 Mar 2;12(3):e0172947. doi: 10.1371/journal.pone.0172947. |