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Morpholino Publication Database

This database contains citations and abstracts for research using Morpholino oligos, as well as some review articles incorporating Morpholino data. You can search the content using the filter boxes below.

There are 12390 scientific papers returned from the database with the search filters currently being used below.

Alternative splicing dysregulation across tissue and therapeutic approaches in a mouse model of myotonic dystrophy type 1

Authors:
Hicks SM, Frias JA, Mishra SK, Scotti M, Muscato DR, Valero MC, Adams LM, Cleary JD, Nakamori M, Wang E, Berglund JA
Citation:
Mol Ther Nucleic Acids. 2024 Sep 13;35(4):102338. doi: 10.1016/j.omtn.2024.102338. PMID: 39391766; PMCID: PMC11465180
Epub:
Not Epub
Abstract:
Myotonic dystrophy type 1 (DM1), the leading cause of adult-onset muscular dystrophy, is caused by a CTG repeat expansion....
Link:
https://www.cell.com/molecular-therapy-family/nucleic-acids/fulltext/S2162-2531(24)00225-7
Delivery Method:
peptide-linked; intramuscular
Organism or Cell Type:
HSA(LR) mice
Citation Extract:
Hicks SM, Frias JA, Mishra SK, Scotti M, Muscato DR, Valero MC, Adams LM, Cleary JD, Nakamori M, Wang E, Berglund JA. Alternative splicing dysregulation across tissue and therapeutic approaches in a mouse model of myotonic dystrophy type 1. Mol Ther Nucleic Acids. 2024 Sep 13;35(4):102338. doi: 10.1016/j.omtn.2024.102338. PMID: 39391766; PMCID: PMC11465180.

Genetic requirement of dact1/2 to regulate noncanonical Wnt signaling and calpain 8 during embryonic convergent extension and craniofacial morphogenesis

Authors:
Carroll SH, Schafer S, Kawasaki K, Tsimbal C, Jule AM, Hallett SA, Li E, Liao EC
Citation:
Elife. 2024 Nov 21;13:RP91648. doi: 10.7554/eLife.91648. PMID: 39570288; PMCID: PMC11581427
Epub:
Not Epub
Abstract:
Wnt signaling plays crucial roles in embryonic patterning including the regulation of convergent extension (CE) during...
Link:
https://elifesciences.org/articles/91648
Delivery Method:
microinjection
Organism or Cell Type:
zebrafish
Citation Extract:
Carroll SH, Schafer S, Kawasaki K, Tsimbal C, Jule AM, Hallett SA, Li E, Liao EC. Genetic requirement of dact1/2 to regulate noncanonical Wnt signaling and calpain 8 during embryonic convergent extension and craniofacial morphogenesis. Elife. 2024 Nov 21;13:RP91648. doi: 10.7554/eLife.91648. PMID: 39570288; PMCID: PMC11581427.

Linking planar polarity signalling to actomyosin contractility during vertebrate neurulation

Authors:
Novotna S, Maia LA, Radaszkiewicz KA, Roudnicky P, Harnos J
Citation:
Open Biol. 2024 Nov;14(11):240251. doi: 10.1098/rsob.240251. Epub 2024 Nov 20. PMID: 39561813; PMCID: PMC11576107
Epub:
Not Epub
Abstract:
Actomyosin contractility represents an ancient feature of eukaryotic cells participating in many developmental and homeostasis...
Link:
https://royalsocietypublishing.org/doi/10.1098/rsob.240251
Delivery Method:
microinjection
Organism or Cell Type:
Xenopus laevis
Citation Extract:
Novotna S, Maia LA, Radaszkiewicz KA, Roudnicky P, Harnos J. Linking planar polarity signalling to actomyosin contractility during vertebrate neurulation. Open Biol. 2024 Nov;14(11):240251. doi: 10.1098/rsob.240251. Epub 2024 Nov 20. PMID: 39561813; PMCID: PMC11576107.

Genetic inactivation of the β1 adrenergic receptor prevents cerebral cavernous malformations in zebrafish

Authors:
Li W, McCurdy S, Lopez-Ramirez MA, Lee HS, Ginsberg MH
Citation:
Elife. 2025 Feb 24;13:RP99455. doi: 10.7554/eLife.99455. PMID: 39991834; PMCID: PMC11849999
Epub:
Not Epub
Abstract:
Previously, we showed that propranolol reduces experimental murine cerebral cavernous malformations (CCMs) and prevents...
Link:
https://pmc.ncbi.nlm.nih.gov/articles/PMC11849999/
Delivery Method:
microinjection
Organism or Cell Type:
zebrafish
Citation Extract:
Li W, McCurdy S, Lopez-Ramirez MA, Lee HS, Ginsberg MH. Genetic inactivation of the β1 adrenergic receptor prevents cerebral cavernous malformations in zebrafish. Elife. 2025 Feb 24;13:RP99455. doi: 10.7554/eLife.99455. PMID: 39991834; PMCID: PMC11849999.

A Unified Phosphoramidite Platform for the Synthesis of Morpholino Oligonucleotides and Diverse Chimeric Backbones

Authors:
Ghosh A, Banerjee A, Gupta S, Sinha S
Citation:
J Am Chem Soc. 2024 Nov 19. doi: 10.1021/jacs.4c09510. Epub ahead of print. PMID: 39561294
Epub:
Not Epub
Abstract:
Phosphorodiamidate Morpholino Oligonucleotides (PMOs) have been well established in the milieu of FDA-approved oligonucleotide-...
Link:
https://pubs.acs.org/doi/10.1021/jacs.4c09510
Organism or Cell Type:
cell culture: Peripheral blood mononuclear cells (PBMCs)
Citation Extract:
Ghosh A, Banerjee A, Gupta S, Sinha S. A Unified Phosphoramidite Platform for the Synthesis of Morpholino Oligonucleotides and Diverse Chimeric Backbones. J Am Chem Soc. 2024 Nov 19. doi: 10.1021/jacs.4c09510. Epub ahead of print. PMID: 39561294.

Identification of Eukaryotic Translation Initiation Factor 4B as a Novel Candidate Gene for Congenital Hypothyroidism

Authors:
Sun F, Zhang RJ, Fang Y, Yan CY, Zhang CR, Wu FY, Yang RM, Han B, Song HD, Zhao SX
Citation:
J Clin Endocrinol Metab. 2024 Nov 18;109(12):3282-3292. doi: 10.1210/clinem/dgae270. PMID: 38654471
Epub:
Not Epub
Abstract:
Context Congenital hypothyroidism (CH) is the most common endocrine disorder in neonates, but its etiology is still poorly...
Link:
https://academic.oup.com/jcem/article-abstract/109/12/3282/7657055
Delivery Method:
microinjection
Organism or Cell Type:
zebrafish
Citation Extract:
Sun F, Zhang RJ, Fang Y, Yan CY, Zhang CR, Wu FY, Yang RM, Han B, Song HD, Zhao SX. Identification of Eukaryotic Translation Initiation Factor 4B as a Novel Candidate Gene for Congenital Hypothyroidism. J Clin Endocrinol Metab. 2024 Nov 18;109(12):3282-3292. doi: 10.1210/clinem/dgae270. PMID: 38654471.

The role of ATP-binding Cassette subfamily B member 6 in the inner ear

Authors:
Baril SA, Wilson KA, Shaik MM, Fukuda Y, Umans RA, Barbieri A, Lynch J, Gose T, Myasnikov A, Oldham ML, Wang Y, Zhu J, Fang J, Zuo J, Kalathur RC, Ford RC, Coffin A, Taylor MR, O'Mara ML, Schuetz JD
Citation:
Nat Commun. 2024 Nov 18;15(1):9885. doi: 10.1038/s41467-024-53663-x. PMID: 39557842; PMCID: PMC11574312
Epub:
Not Epub
Abstract:
ABCB6 has been implicated in dyschromatosis universalis hereditaria, a condition characterized by hyperpigmented and...
Link:
https://pmc.ncbi.nlm.nih.gov/articles/PMC11574312/
Delivery Method:
microinjection
Organism or Cell Type:
zebrafish
Citation Extract:
Baril SA, Wilson KA, Shaik MM, Fukuda Y, Umans RA, Barbieri A, Lynch J, Gose T, Myasnikov A, Oldham ML, Wang Y, Zhu J, Fang J, Zuo J, Kalathur RC, Ford RC, Coffin A, Taylor MR, O'Mara ML, Schuetz JD. The role of ATP-binding Cassette subfamily B member 6 in the inner ear. Nat Commun. 2024 Nov 18;15(1):9885. doi: 10.1038/s41467-024-53663-x. PMID: 39557842; PMCID: PMC11574312.

Identification and functional characterization of CD209 homologous genes in zebrafish

Authors:
Yang XJ, Huang ZH, Liu W, Zhang WQ, Huang ZB
Citation:
Yi Chuan. 2024 Nov;46(11):947-957. doi: 10.16288/j.yczz.24-181. PMID: 39557479
Epub:
Not Epub
Abstract:
Innate immune responses play a crucial role in maintaining homeostasis, their initiation closely related to pattern recognition...
Link:
https://doi.org/10.16288/j.yczz.24-181
Delivery Method:
microinjection
Organism or Cell Type:
zebrafish
Citation Extract:
Yang XJ, Huang ZH, Liu W, Zhang WQ, Huang ZB. Identification and functional characterization of CD209 homologous genes in zebrafish. Yi Chuan. 2024 Nov;46(11):947-957. doi: 10.16288/j.yczz.24-181. PMID: 39557479.

Spatiotemporal requirements of nuclear β-catenin define early sea urchin embryogenesis

Authors:
Lhomond G, Schubert M, Croce J
Citation:
PLoS Biol. 2024 Nov 12;22(11):e3002880. doi: 10.1371/journal.pbio.3002880. Epub ahead of print. PMID: 39531468
Epub:
Not Epub
Abstract:
Establishment of the 3 primordial germ layers (ectoderm, endoderm, and mesoderm) during early animal development represents an...
Link:
https://journals.plos.org/plosbiology/article?id=10.1371/journal.pbio.3002880
Delivery Method:
microinjection; UV-photocleavable Morpholino
Organism or Cell Type:
Paracentrotus lividus (sea urchin)
Citation Extract:
Lhomond G, Schubert M, Croce J. Spatiotemporal requirements of nuclear β-catenin define early sea urchin embryogenesis. PLoS Biol. 2024 Nov 12;22(11):e3002880. doi: 10.1371/journal.pbio.3002880. Epub ahead of print. PMID: 39531468.

The nutrient sensor CRTC and Sarcalumenin/thinman represent an alternate pathway in cardiac hypertrophy

Authors:
Dondi C, Vogler G, Gupta A, Walls SM, Kervadec A, Marchant J, Romero MR, Diop S, Goode J, Thomas JB, Colas AR, Bodmer R, Montminy M, Ocorr K
Citation:
Cell Rep. 2024 Aug 27;43(8):114549. doi: 10.1016/j.celrep.2024.114549. Epub 2024 Aug 1. PMID: 39093699; PMCID: PMC11402474
Epub:
Not Epub
Abstract:
CREB-regulated transcription co-activator (CRTC) is activated by Calcineurin (CaN) to regulate gluconeogenic genes. CaN also...
Link:
https://pmc.ncbi.nlm.nih.gov/articles/PMC11402474/
Delivery Method:
microinjection
Organism or Cell Type:
zebrafish
Citation Extract:
Dondi C, Vogler G, Gupta A, Walls SM, Kervadec A, Marchant J, Romero MR, Diop S, Goode J, Thomas JB, Colas AR, Bodmer R, Montminy M, Ocorr K. The nutrient sensor CRTC and Sarcalumenin/thinman represent an alternate pathway in cardiac hypertrophy. Cell Rep. 2024 Aug 27;43(8):114549. doi: 10.1016/j.celrep.2024.114549. Epub 2024 Aug 1. PMID: 39093699; PMCID: PMC11402474.

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