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Morpholino Publication Database

This database contains citations and abstracts for research using Morpholino oligos, as well as some review articles incorporating Morpholino data. You can search the content using the filter boxes below.

There are 12218 scientific papers returned from the database with the search filters currently being used below.

A Combination of Variants in SEPTIN9 and MSX1 Genes Leads to the Formation of Orofacial Clefts

Authors:
Uuganbayar U, Manojlovic Z, Ito N, Yamaguchi R, Ninomiya H, Shimada IS, Yamada C, Feigelson D, Schulz G, Auslander A, Rakotoarison S, Magee W 3rd, Hashimoto Y, Kato Y
Citation:
Genes Cells. 2026 Jul;31(4):e70138. doi: 10.1111/gtc.70138. PMID: 42429105; PMCID: PMC13352469
Epub:
Not Epub
Abstract:
Nonsyndromic cleft lip with or without palate (nCL/P) is a common congenital anomaly with a complex genetic basis. Previous...
Link:
https://onlinelibrary.wiley.com/doi/10.1111/gtc.70138
Delivery Method:
microinjection
Organism or Cell Type:
Xenopus laevis
Citation Extract:
Uuganbayar U, Manojlovic Z, Ito N, Yamaguchi R, Ninomiya H, Shimada IS, Yamada C, Feigelson D, Schulz G, Auslander A, Rakotoarison S, Magee W 3rd, Hashimoto Y, Kato Y. A Combination of Variants in SEPTIN9 and MSX1 Genes Leads to the Formation of Orofacial Clefts. Genes Cells. 2026 Jul;31(4):e70138. doi: 10.1111/gtc.70138. PMID: 42429105; PMCID: PMC13352469.

Splice-altering TP53 missense mutations as drivers of dysfunction and targets for RNA-based therapy

Authors:
Chung SK, Jung HB, Baek SJ, Park SM, Kim J, Lee SY, Min B, Kang YK
Citation:
Stem Cell Res Ther. 2026 Jul 13. doi: 10.1186/s13287-026-05176-1. Epub ahead of print
Epub:
Not Epub
Abstract:
TP53 missense mutations introduce single amino acid substitutions in the p53 protein, which can lead to diverse functional...
Link:
https://link.springer.com/article/10.1186/s13287-026-05176-1
Organism or Cell Type:
TP53 knock-in cell models
Citation Extract:
Chung SK, Jung HB, Baek SJ, Park SM, Kim J, Lee SY, Min B, Kang YK. Splice-altering TP53 missense mutations as drivers of dysfunction and targets for RNA-based therapy. Stem Cell Res Ther. 2026 Jul 13. doi: 10.1186/s13287-026-05176-1. Epub ahead of print.

Targeted α-synuclein mRNA degradation by PMO-based RNA-degrading chimeras

Authors:
Wang N, Hegde S, Tang Z, Liu H, Feng G, Niu L, Liu B, Li H, Zhang X, Gadhave K, Kumbhar R, Jiang L, Liu Y, Luo M, Zhang S, Dawson TM, Pantelyat A, Rosenthal LS, Ying M, Mao X, Wang J
Citation:
Proc Natl Acad Sci U S A. 2026 Jul 21;123(29):e2526461123. doi: 10.1073/pnas.2526461123. Epub 2026 Jul 14
Epub:
Not Epub
Abstract:
α-Synucleinopathies are devastating neurodegenerative diseases characterized by pathological accumulation of a neuronal protein...
Link:
https://www.pnas.org/doi/10.1073/pnas.2526461123
Delivery Method:
PMO-based RNA-degrading chimeras; motor cortex infusion for mice
Organism or Cell Type:
cell culture: HEK293T cells, primary cortical neurons from humanized SNCA mice and human IPSC–derived cortical neurons; humanized SNCA mice
Citation Extract:
Wang N, Hegde S, Tang Z, Liu H, Feng G, Niu L, Liu B, Li H, Zhang X, Gadhave K, Kumbhar R, Jiang L, Liu Y, Luo M, Zhang S, Dawson TM, Pantelyat A, Rosenthal LS, Ying M, Mao X, Wang J . Targeted α-synuclein mRNA degradation by PMO-based RNA-degrading chimeras. Proc Natl Acad Sci U S A. 2026 Jul 21;123(29):e2526461123. doi: 10.1073/pnas.2526461123. Epub 2026 Jul 14.

Oxidized PDI promotes thrombus formation in oxidative stress

Authors:
Yang M, Owegie OC, Patel A, Kennedy QP, Flaumenhaft JT, Chinnaraj M, Ponzar N, Fulcidor EM, Rico MC, Bhowmik A, Carroll KS, Handy DE, Loscalzo J, Essex DW, Pozzi N, Flaumenhaft R
Citation:
Blood. 2026 Jul 16;148(3):376-388. doi: 10.1182/blood.2025031756. PMID: 41785329; PMCID: PMC13098563
Epub:
Not Epub
Abstract:
Protein disulfide isomerase (PDI) functions in thrombus formation in vivo and represents a viable target for antithrombotic...
Link:
https://ashpublications.org/blood/article-abstract/148/3/376/566933/Oxidized-PDI-promotes-thrombus-formation-in
Delivery Method:
intravenous (i.v.) injection
Organism or Cell Type:
C57Bl/6J and R120D PDI mutant mice
Citation Extract:
Yang M, Owegie OC, Patel A, Kennedy QP, Flaumenhaft JT, Chinnaraj M, Ponzar N, Fulcidor EM, Rico MC, Bhowmik A, Carroll KS, Handy DE, Loscalzo J, Essex DW, Pozzi N, Flaumenhaft R. Oxidized PDI promotes thrombus formation in oxidative stress. Blood. 2026 Jul 16;148(3):376-388. doi: 10.1182/blood.2025031756. PMID: 41785329; PMCID: PMC13098563.

SIX1 branchio-oto-renal syndrome variants have different effects on embryonic craniofacial gene expression and cartilage formation

Authors:
Coppenrath K, Shaidani NI, Naert T, Majumdar HD, Horb M, Lienkamp SS, Klein SL, Moody SA
Citation:
Development. 2026 Jul 1;153(13):dev205428. doi: 10.1242/dev.205428. Epub 2026 Jul 6. PMID: 42290293
Epub:
Not Epub
Abstract:
SIX1 variants underlying branchio-oto-renal syndrome occur in the SIX domain (SD) or homeodomain (HD). We tested whether...
Link:
https://journals.biologists.com/dev/article/153/13/dev205428/372167/SIX1-branchio-oto-renal-syndrome-variants-have
Delivery Method:
microinjection
Organism or Cell Type:
Xenopus laevis
Citation Extract:
Coppenrath K, Shaidani NI, Naert T, Majumdar HD, Horb M, Lienkamp SS, Klein SL, Moody SA. SIX1 branchio-oto-renal syndrome variants have different effects on embryonic craniofacial gene expression and cartilage formation. Development. 2026 Jul 1;153(13):dev205428. doi: 10.1242/dev.205428. Epub 2026 Jul 6. PMID: 42290293.

LINC00607 facilitates endothelial VEGF-A receptor FLT1 splicing

Authors:
Lam F, Warwick T, Oo JA, Krüger AY, Kreis NN, Diagel A, Izquierdo Ponce J, Tirunagari P, Bayer ME, Nonn O, Dechend R, Walther T, Boon RA, Baker AH, Günther S, Wittig I, Chen Z, Müller-McNicoll M, Louwen F, Brandes RP, Leisegang MS
Citation:
Mol Ther. 2026 Jul 1;34(7):4323-4338. doi: 10.1016/j.ymthe.2026.03.038. Epub 2026 Apr 4. PMID: 41935951; PMCID: PMC13330067
Epub:
Not Epub
Abstract:
Angiogenesis is a key function of vascular endothelial cells and becomes aberrant in pathologies such as preeclampsia. An...
Link:
https://www.cell.com/molecular-therapy-family/molecular-therapy/fulltext/S1525-0016(26)00265-0
Delivery Method:
electroporation
Organism or Cell Type:
human umbilical vein endothelial cells (HUVECs)
Citation Extract:
Lam F, Warwick T, Oo JA, Krüger AY, Kreis NN, Diagel A, Izquierdo Ponce J, Tirunagari P, Bayer ME, Nonn O, Dechend R, Walther T, Boon RA, Baker AH, Günther S, Wittig I, Chen Z, Müller-McNicoll M, Louwen F, Brandes RP, Leisegang MS. LINC00607 facilitates endothelial VEGF-A receptor FLT1 splicing. Mol Ther. 2026 Jul 1;34(7):4323-4338. doi: 10.1016/j.ymthe.2026.03.038. Epub 2026 Apr 4. PMID: 41935951; PMCID: PMC13330067.

ATP6V1B2 Regulating Autophagy Flux To Affect Abnormal Auditory Development

Authors:
Feng Z, Li J, Yang Y, Chen M, Wu X, Zhou C
Citation:
Appl Biochem Biotechnol. 2026 Jul;198(7):5330-5345. doi: 10.1007/s12010-025-05579-5. Epub 2026 Apr 17. PMID: 41995948
Epub:
Not Epub
Abstract:
To investigate the expression changes of ATP6V1B2 downregulation in Dominant Deafness-Onychodystrophy syndrome (DDOD syndrome...
Link:
https://link.springer.com/article/10.1007/s12010-025-05579-5
Delivery Method:
cochlear microinjection
Organism or Cell Type:
mice
Citation Extract:
Feng Z, Li J, Yang Y, Chen M, Wu X, Zhou C. ATP6V1B2 Regulating Autophagy Flux To Affect Abnormal Auditory Development. Appl Biochem Biotechnol. 2026 Jul;198(7):5330-5345. doi: 10.1007/s12010-025-05579-5. Epub 2026 Apr 17. PMID: 41995948.

Exploring neutral backbones in phosphorodiamidate morpholino oligomers: synthesis and biophysical properties

Authors:
Das A, Kuilya D, Sharma SN, Sinha S
Citation:
Chem Commun (Camb). 2026 Jun 25. doi: 10.1039/d6cc01842d. Epub ahead of print. PMID: 42347830
Epub:
Not Epub
Abstract:
The synthesis of morpholino dimer chlorophosphoramidates and phosphoramidites has been successfully achieved and the method has...
Link:
https://pubs.rsc.org/en/content/articlelanding/2026/cc/d6cc01842d
Delivery Method:
none
Organism or Cell Type:
PMO-DNA and PMO-RNA
Citation Extract:
Das A, Kuilya D, Sharma SN, Sinha S. Exploring neutral backbones in phosphorodiamidate morpholino oligomers: synthesis and biophysical properties. Chem Commun (Camb). 2026 Jun 25. doi: 10.1039/d6cc01842d. Epub ahead of print. PMID: 42347830.

Rapid and sensitive detection of RNA biomarkers using morpholino-functionalized organic electrochemical transistor

Authors:
Zhou R, Yang Q, Yang Q, Yu J, Zheng J, Yan H, Jiang X, Chen M, Liang Z, Jia Y, Segal E, Dong H, Guo K
Citation:
Chemical Engineering Journal. Volume 533, 2026, 174656. ISSN 1385-8947. doi: 10.1016/j.cej.2026.174656
Epub:
Not Epub
Abstract:
Ribonucleic acid (RNA) biomarkers have emerged as vital molecular indicators in precision medicine, with accurate detection...
Link:
https://www.sciencedirect.com/science/article/pii/S1385894726021157
Delivery Method:
none
Organism or Cell Type:
SARS-CoV-2 viral RNA
Citation Extract:
Zhou R, Yang Q, Yang Q, Yu J, Zheng J, Yan H, Jiang X, Chen M, Liang Z, Jia Y, Segal E, Dong H, Guo K. Rapid and sensitive detection of RNA biomarkers using morpholino-functionalized organic electrochemical transistor. Chemical Engineering Journal. Volume 533, 2026, 174656. ISSN 1385-8947. doi: 10.1016/j.cej.2026.174656.

A Splice-Site Variant in ACY1 Associated with Congenital Hearing Loss: Clinical, Biochemical, and Zebrafish Functional Evidence

Authors:
Yu S, Xu Z, Wang H, Chen L, Hu SW, Zhang Y, Lyu H, Wu H, Wu M, Shu Y, Chen W
Citation:
Biochem Genet. 2026 Jun 20. doi: 10.1007/s10528-026-11417-y. Epub ahead of print. PMID: 42322530
Epub:
Not Epub
Abstract:
Variants in the aminoacylase 1 (ACY1) gene are associated with diverse clinical phenotypes, but their roles in hearing loss...
Link:
https://link.springer.com/article/10.1007/s10528-026-11417-y
Delivery Method:
microinjection
Organism or Cell Type:
zebrafish
Citation Extract:
Yu S, Xu Z, Wang H, Chen L, Hu SW, Zhang Y, Lyu H, Wu H, Wu M, Shu Y, Chen W. A Splice-Site Variant in ACY1 Associated with Congenital Hearing Loss: Clinical, Biochemical, and Zebrafish Functional Evidence. Biochem Genet. 2026 Jun 20. doi: 10.1007/s10528-026-11417-y. Epub ahead of print. PMID: 42322530.

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