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Morpholino Publication Database

This database contains citations and abstracts for research using Morpholino oligos, as well as some review articles incorporating Morpholino data. You can search the content using the filter boxes below.

There are 12390 scientific papers returned from the database with the search filters currently being used below.

Zinc finger protein Znf296 is a cardiac-specific splicing regulator required for cardiomyocyte formation

Authors:
Li X, Yang S, Wang L, Zhang X, Zhang A, Wang Y, Shi DL, Li H
Citation:
Am J Pathol. 2025 Mar 21:S0002-9440(25)00078-1. doi: 10.1016/j.ajpath.2025.02.006. Epub ahead of print. PMID: 40122456
Epub:
Not Epub
Abstract:
Heart formation and function are tightly regulated at transcriptional and post-transcriptional levels. The dysfunction of...
Link:
https://ajp.amjpathol.org/article/S0002-9440(25)00078-1/abstract
Delivery Method:
microinjection
Organism or Cell Type:
zebrafish
Citation Extract:
Li X, Yang S, Wang L, Zhang X, Zhang A, Wang Y, Shi DL, Li H. Zinc finger protein Znf296 is a cardiac-specific splicing regulator required for cardiomyocyte formation. Am J Pathol. 2025 Mar 21:S0002-9440(25)00078-1. doi: 10.1016/j.ajpath.2025.02.006. Epub ahead of print. PMID: 40122456.

The Interaction Between the asb5a and asb5b Subtypes Jointly Regulates the L-R Asymmetrical Development of the Heart in Zebrafish

Authors:
Zhou W, Cai W, Li Y, Gao L, Liu X, Liu S, Lei J, Zhang J, Wang Y, Jiang Z, Wu X, Fan X, Li F, Zheng L, Yuan W
Citation:
Int. J. Mol. Sci. 2025, 26, 2765. https://doi.org/10.3390/ijms26062765
Epub:
Not Epub
Abstract:
The asb5 gene, a member of the Asb protein subfamily characterized by six ankyrin repeat domains, is highly conserved and...
Link:
https://www.mdpi.com/1422-0067/26/6/2765
Delivery Method:
microinjection
Organism or Cell Type:
zebrafish
Citation Extract:
Zhou W, Cai W, Li Y, Gao L, Liu X, Liu S, Lei J, Zhang J, Wang Y, Jiang Z, Wu X, Fan X, Li F, Zheng L, Yuan W. The Interaction Between the asb5a and asb5b Subtypes Jointly Regulates the L-R Asymmetrical Development of the Heart in Zebrafish. Int. J. Mol. Sci. 2025, 26, 2765. https://doi.org/10.3390/ijms26062765.

TRAP1 functions in the morphogenesis of the embryonic kidney

Authors:
Kim HE, Kwon T, Sim HJ, Park TJ
Citation:
Anim Cells Syst (Seoul). 2025 Mar 12;29(1):9-18. doi: 10.1080/19768354.2025.2477789. PMID: 40098710; PMCID: PMC11912273
Epub:
Not Epub
Abstract:
TNF receptor-associated protein1 (TRAP1) is a mitochondrial molecular chaperon with high homology with a cytosolic chaperon...
Link:
https://pmc.ncbi.nlm.nih.gov/articles/PMC11912273/
Delivery Method:
microinjection
Organism or Cell Type:
Xenopus laevis
Citation Extract:
Kim HE, Kwon T, Sim HJ, Park TJ . TRAP1 functions in the morphogenesis of the embryonic kidney. Anim Cells Syst (Seoul). 2025 Mar 12;29(1):9-18. doi: 10.1080/19768354.2025.2477789. PMID: 40098710; PMCID: PMC11912273.

Elf1 Deficiency Impairs Macrophage Development in Zebrafish Model Organism

Authors:
Tan Q, Wang J, Hao Y, Yang S, Cao B, Pan W, Cao M
Citation:
International Journal of Molecular Sciences. 2025; 26(6):2537. https://doi.org/10.3390/ijms26062537
Epub:
Not Epub
Abstract:
The Ets (E-twenty-six) family of transcription factors plays a critical role in hematopoiesis and myeloid differentiation....
Link:
https://www.mdpi.com/1422-0067/26/6/2537
Delivery Method:
microinjection
Organism or Cell Type:
zebrafish
Citation Extract:
Tan Q, Wang J, Hao Y, Yang S, Cao B, Pan W, Cao M. Elf1 Deficiency Impairs Macrophage Development in Zebrafish Model Organism . International Journal of Molecular Sciences. 2025; 26(6):2537. https://doi.org/10.3390/ijms26062537.

TBK1 is involved in programmed cell death and ALS-related pathways in novel zebrafish models

Authors:
Raas Q, Haouy G, de Calbiac H, Pasho E, Marian A, Guerrera IC, Rosello M, Oeckl P, Del Bene F, Catanese A, Ciura S, Kabashi E
Citation:
Cell Death Discov. 2025 Mar 12;11(1):98. doi: 10.1038/s41420-025-02374-3. PMID: 40075110; PMCID: PMC11903655
Epub:
Not Epub
Abstract:
Pathogenic mutations within the TBK1 gene leading to haploinsufficiency are causative of amyotrophic lateral sclerosis (ALS)....
Link:
https://pmc.ncbi.nlm.nih.gov/articles/PMC11903655/
Delivery Method:
microinjection
Organism or Cell Type:
zebrafish
Citation Extract:
Raas Q, Haouy G, de Calbiac H, Pasho E, Marian A, Guerrera IC, Rosello M, Oeckl P, Del Bene F, Catanese A, Ciura S, Kabashi E. TBK1 is involved in programmed cell death and ALS-related pathways in novel zebrafish models. Cell Death Discov. 2025 Mar 12;11(1):98. doi: 10.1038/s41420-025-02374-3. PMID: 40075110; PMCID: PMC11903655.

PRMT5-mediated arginine methylation stabilizes GPX4 to suppress ferroptosis in cancer

Authors:
Fan Y, Wang Y, Dan W, Zhang Y, Nie L, Ma Z, Zhuang Y, Liu B, Li M, Liu T, Wang Z, Ye L, Wei Y, Lei Y, Guo C, An J, Wang C, Zhang Y, Zeng J, Wei W, Gan B, Li L
Citation:
Nat Cell Biol. 2025 Mar 3. doi: 10.1038/s41556-025-01610-3. Epub ahead of print. PMID: 40033101
Epub:
Not Epub
Abstract:
The activation of ferroptosis has shown great potential for cancer therapy from an unconventional perspective, but revealing...
Link:
https://www.nature.com/articles/s41556-025-01610-3
Delivery Method:
microinjection
Organism or Cell Type:
zebrafish
Citation Extract:
Fan Y, Wang Y, Dan W, Zhang Y, Nie L, Ma Z, Zhuang Y, Liu B, Li M, Liu T, Wang Z, Ye L, Wei Y, Lei Y, Guo C, An J, Wang C, Zhang Y, Zeng J, Wei W, Gan B, Li L. PRMT5-mediated arginine methylation stabilizes GPX4 to suppress ferroptosis in cancer. Nat Cell Biol. 2025 Mar 3. doi: 10.1038/s41556-025-01610-3. Epub ahead of print. PMID: 40033101.

Zebrafish (Danio rerio) TDP43 negatively regulates PKZ-IRF3–mediated IFN I response

Authors:
Yu T, Li M-M, Li M-F, Wang S, Feng Z, Zhang H, Liu J, Mao H, Li D, Hu C, Xu X
Citation:
The Journal of Immunology, 2025;, vkae035, https://doi.org/10.1093/jimmun/vkae035
Epub:
Not Epub
Abstract:
Transactive response DNA binding protein 43 kD (TDP43), encoded by the tardbp gene, is a member of heterogenous nuclear...
Link:
https://academic.oup.com/jimmunol/advance-article/doi/10.1093/jimmun/vkae035/8052977
Delivery Method:
microinjection
Organism or Cell Type:
zebrafish
Citation Extract:
Yu T, Li M-M, Li M-F, Wang S, Feng Z, Zhang H, Liu J, Mao H, Li D, Hu C, Xu X. Zebrafish (Danio rerio) TDP43 negatively regulates PKZ-IRF3–mediated IFN I response. The Journal of Immunology, 2025;, vkae035, https://doi.org/10.1093/jimmun/vkae035.

Novel MYH10 heterozygous variants associated to a syndrome combining mainly ptosis and ocular coloboma expand the MYH10 related phenotypes

Authors:
Scheidecker S, Bär S, Kröll-Hermi A, Delvallée C, Rinaldi B, Korpioja A, Geoffroy V, Schaefer E, Secula S, Jaeger C, Stoetzel C, Kassel O, Straehle U, Bertoli-Avella A, Zonic E, Lamouche JB, Zanlonghi X, Etard C, Muller J, Rahikkala E, Friant S, Dollfus H
Citation:
Eur J Hum Genet. 2025 Mar 5. doi: 10.1038/s41431-025-01803-2. Epub ahead of print. PMID: 40044823
Epub:
Not Epub
Abstract:
Syndromes associating both eyeball and periocular developmental anomalies, combining iris chorioretinal (ocular) coloboma and...
Link:
https://www.nature.com/articles/s41431-025-01803-2
Delivery Method:
microinjection
Organism or Cell Type:
zebrafish
Citation Extract:
Scheidecker S, Bär S, Kröll-Hermi A, Delvallée C, Rinaldi B, Korpioja A, Geoffroy V, Schaefer E, Secula S, Jaeger C, Stoetzel C, Kassel O, Straehle U, Bertoli-Avella A, Zonic E, Lamouche JB, Zanlonghi X, Etard C, Muller J, Rahikkala E, Friant S, Dollfus H. Novel MYH10 heterozygous variants associated to a syndrome combining mainly ptosis and ocular coloboma expand the MYH10 related phenotypes. Eur J Hum Genet. 2025 Mar 5. doi: 10.1038/s41431-025-01803-2. Epub ahead of print. PMID: 40044823.

Trivalent siRNA-Conjugates with Guanosine as ASGPR-Binder Show Potent Knock-Down In Vivo

Authors:
Hofmeister A, Jahn-Hofmann K, Brunner B, Helms M, Metz-Weidmann C, Poeverlein C, Zech G, Li Z, Hessler G, Schreuder H, Elshorst B, Krack A, Kurz M, Heubel C, Scheidler S
Citation:
J Med Chem. 2025 Mar 7. doi: 10.1021/acs.jmedchem.4c02275. Epub ahead of print. PMID: 40052708
Epub:
Not Epub
Abstract:
To increase the chemical space around the well-known GalNAc-ligand as ASGPR-binder, a high-throughput screening campaign was...
Link:
https://pubs.acs.org/doi/10.1021/acs.jmedchem.4c02275
Citation Extract:
Hofmeister A, Jahn-Hofmann K, Brunner B, Helms M, Metz-Weidmann C, Poeverlein C, Zech G, Li Z, Hessler G, Schreuder H, Elshorst B, Krack A, Kurz M, Heubel C, Scheidler S. Trivalent siRNA-Conjugates with Guanosine as ASGPR-Binder Show Potent Knock-Down In Vivo. J Med Chem. 2025 Mar 7. doi: 10.1021/acs.jmedchem.4c02275. Epub ahead of print. PMID: 40052708.

Antisense oligonucleotide-mediated exon 27 skipping restores dysferlin function in dysferlinopathy patient-derived muscle cells

Authors:
Anwar S, Roshmi RR, Woo S, Haque US, Arthur Lee JJ, Duddy WJ, Bigot A, Maruyama R, Yokota T
Citation:
Mol Ther Nucleic Acids. 2024 Dec 21;36(1):102443. doi: 10.1016/j.omtn.2024.102443. PMID: 39967852; PMCID: PMC11834094
Epub:
Not Epub
Abstract:
Dysferlinopathies are debilitating autosomal recessive muscular dystrophies caused by mutations in the DYSF gene, encoding...
Link:
https://pmc.ncbi.nlm.nih.gov/articles/PMC11834094/
Delivery Method:
Endo-Porter
Organism or Cell Type:
patient-derived myoblasts and differentiated myotubes
Citation Extract:
Anwar S, Roshmi RR, Woo S, Haque US, Arthur Lee JJ, Duddy WJ, Bigot A, Maruyama R, Yokota T. Antisense oligonucleotide-mediated exon 27 skipping restores dysferlin function in dysferlinopathy patient-derived muscle cells. Mol Ther Nucleic Acids. 2024 Dec 21;36(1):102443. doi: 10.1016/j.omtn.2024.102443. PMID: 39967852; PMCID: PMC11834094.

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