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Morpholino Publication Database

This database contains citations and abstracts for research using Morpholino oligos, as well as some review articles incorporating Morpholino data. You can search the content using the filter boxes below.

There are 12171 scientific papers returned from the database with the search filters currently being used below.

Marcksb plays a key role in the secretory pathway of zebrafish Bmp2b

Authors:
Ye D, Wang X, Wei C, He M, Wang H, Wang Y, Zhu Z, Sun Y
Citation:
PLoS Genet. 2019 Sep 23;15(9):e1008306. doi: 10.1371/journal.pgen.1008306. [Epub ahead of print]
Epub:
Yes
Abstract:
During vertebrate early embryogenesis, the ventral development is directed by the ventral-to-dorsal activity gradient of the...
Link:
https://journals.plos.org/plosgenetics/article?id=10.1371/journal.pgen.1008306
Delivery Method:
microinjection
Organism or Cell Type:
zebrafish
Citation Extract:
Ye D, Wang X, Wei C, He M, Wang H, Wang Y, Zhu Z, Sun Y. Marcksb plays a key role in the secretory pathway of zebrafish Bmp2b. PLoS Genet. 2019 Sep 23;15(9):e1008306. doi: 10.1371/journal.pgen.1008306. [Epub ahead of print].

Cadherin switch marks germ layer formation in the diploblastic sea anemone Nematostella vectensis

Authors:
Pukhlyakova EA, Kirillova AO, Kraus YA, Zimmermann B, Technau U
Citation:
Development. 2019 Sep 20. pii: dev.174623. doi: 10.1242/dev.174623. [Epub ahead of print]
Epub:
Yes
Abstract:
Morphogenesis is a shape-building process during development of multicellular organisms. During this process the establishment...
Link:
https://dev.biologists.org/content/early/2019/09/19/dev.174623.long
Delivery Method:
microinjection
Organism or Cell Type:
Nematostella vectensis (sea anemone)
Citation Extract:
Pukhlyakova EA, Kirillova AO, Kraus YA, Zimmermann B, Technau U. Cadherin switch marks germ layer formation in the diploblastic sea anemone Nematostella vectensis. Development. 2019 Sep 20. pii: dev.174623. doi: 10.1242/dev.174623. [Epub ahead of print].

Hexose potentiates peptide-conjugated morpholino oligomer efficacy in cardiac muscles of dystrophic mice in an age-dependent manner

Authors:
Han G, Gu B, Lin C, Ning H, Song J, Gao X, Moulton HM, Yin HF
Citation:
Mol Ther Nucl Acids. 2019 Sep 23;18:341-350. doi: 10.1016/j.omtn.2019.09.012. [Epub ahead of print]
Epub:
Not Epub
Abstract:
Insufficient delivery of oligonucleotides to muscle and heart remains a barrier for clinical implementation of antisense...
Link:
http://www.sciencedirect.com/science/article/pii/S2162253119302598
Delivery Method:
peptide-linked; intravenous (i.v.)
Organism or Cell Type:
mice mdx
Citation Extract:
Han G, Gu B, Lin C, Ning H, Song J, Gao X, Moulton HM, Yin HF. Hexose potentiates peptide-conjugated morpholino oligomer efficacy in cardiac muscles of dystrophic mice in an age-dependent manner. Mol Ther Nucl Acids. 2019 Sep 23;18:341-350. doi: 10.1016/j.omtn.2019.09.012. [Epub ahead of print].

Gene- and tissue-level interactions in normal gastrointestinal development and Hirschsprung disease

Authors:
Chatterjee S, Nandakumar P, Auer DR, Gabriel SB, Chakravarti A
Citation:
Proc Natl Acad Sci U S A. 2019 Dec 26;116(52):26697-26708. doi: 10.1073/pnas.1908756116. Epub 2019 Dec 9. PMID: 31818953; PMCID: PMC6936708
Epub:
Not Epub
Abstract:
The development of the gut from endodermal tissue to an organ with multiple distinct structures and functions occurs over a...
Link:
https://pmc.ncbi.nlm.nih.gov/articles/PMC6936708/
Delivery Method:
microinjection
Organism or Cell Type:
zebrafish
Citation Extract:
Chatterjee S, Nandakumar P, Auer DR, Gabriel SB, Chakravarti A. Gene- and tissue-level interactions in normal gastrointestinal development and Hirschsprung disease. Proc Natl Acad Sci U S A. 2019 Dec 26;116(52):26697-26708. doi: 10.1073/pnas.1908756116. Epub 2019 Dec 9. PMID: 31818953; PMCID: PMC6936708.

Supramolecular Assembly of Aminoethylene‐Lipopeptide PMO Conjugates into RNA Splice‐Switching Nanomicelles

Authors:
Kuhn J, Klein PM, Al Danaf N, Nordin JZ, Reinhard S, Loy DM, Höhn M, El Andaloussi S, Lamb DC, Wagner E, Aoki Y, Lehto T, Lächelt U
Citation:
Adv Funct Mater. 2019;[Epub] doi:10.1002/adfm.201906432
Epub:
Not Epub
Abstract:
Phosphorodiamidate morpholino oligomers (PMOs) are oligonucleotide analogs that can be used for therapeutic modulation of pre‐...
Link:
https://onlinelibrary.wiley.com/doi/full/10.1002/adfm.201906432
Delivery Method:
nanoparticle
Organism or Cell Type:
cell culture: HeLa pLuc/705, mdx52 skeletal myotubes
Citation Extract:
Kuhn J, Klein PM, Al Danaf N, Nordin JZ, Reinhard S, Loy DM, Höhn M, El Andaloussi S, Lamb DC, Wagner E, Aoki Y, Lehto T, Lächelt U. Supramolecular Assembly of Aminoethylene‐Lipopeptide PMO Conjugates into RNA Splice‐Switching Nanomicelles. Adv Funct Mater. 2019;[Epub] doi:10.1002/adfm.201906432.

Maternal pluripotency factors initiate extensive chromatin remodelling to predefine first response to inductive signals

Authors:
Gentsch GE, Spruce T, Owens NDL, Smith JC
Citation:
Nat Comm. 2019;10(1):4269. doi:10.1038/s41467-019-12263-w
Epub:
Not Epub
Abstract:
Embryonic development yields many different cell types in response to just a few families of inductive signals. The property of...
Link:
https://www.nature.com/articles/s41467-019-12263-w
Delivery Method:
microinjection
Organism or Cell Type:
Xenopus laevis
Citation Extract:
Gentsch GE, Spruce T, Owens NDL, Smith JC. Maternal pluripotency factors initiate extensive chromatin remodelling to predefine first response to inductive signals. Nat Comm. 2019;10(1):4269. doi:10.1038/s41467-019-12263-w.

Investigation of the role of VHL-HIF signaling in DNA repair and apoptosis in zebrafish

Authors:
Kim HR, Santhakumar K, Markham E, Baldera D, Greenald D, Bryant HE, El-Khamisy SF, van Eeden FJ
Citation:
Oncotarget. 2020 Mar 31;11(13):1109-1130. doi: 10.18632/oncotarget.27521. PMID: 32284789; PMCID: PMC7138166
Epub:
Not Epub
Abstract:
pVHL is a tumor suppressor. The lack of its function leads to various tumors, among which ccRCC (clear cell renal cell...
Link:
https://www.oncotarget.com/article/27521/text/
Delivery Method:
microinjection
Organism or Cell Type:
zebrafish
Citation Extract:
Kim HR, Santhakumar K, Markham E, Baldera D, Greenald D, Bryant HE, El-Khamisy SF, van Eeden FJ. Investigation of the role of VHL-HIF signaling in DNA repair and apoptosis in zebrafish. Oncotarget. 2020 Mar 31;11(13):1109-1130. doi: 10.18632/oncotarget.27521. PMID: 32284789; PMCID: PMC7138166.

Rgma-induced Neo1 proteolysis promotes neural tube morphogenesis

Authors:
Brown S, Jayachandran P, Negesse M, Olmo V, Vital E, Brewster R
Citation:
J Neurosci. 2019 Aug 9. pii: 3262-18. doi: 10.1523/JNEUROSCI.3262-18.2019. [Epub ahead of print]
Epub:
Yes
Abstract:
Neuroepithelial cell (NEC) elongation is one of several key cell behaviors that mediate the tissue-level morphogenetic...
Link:
https://www.jneurosci.org/content/39/38/7465
Organism or Cell Type:
zebrafish
Citation Extract:
Brown S, Jayachandran P, Negesse M, Olmo V, Vital E, Brewster R. Rgma-induced Neo1 proteolysis promotes neural tube morphogenesis. J Neurosci. 2019 Aug 9. pii: 3262-18. doi: 10.1523/JNEUROSCI.3262-18.2019. [Epub ahead of print].

The evolution of a new cell type was associated with competition for a signaling ligand

Authors:
Ettensohn CA, Adomako-Ankomah A
Citation:
PLoS Biol. 2019;17(9):e3000460. doi:10.1371/journal.pbio.3000460
Epub:
Not Epub
Abstract:
There is presently a very limited understanding of the mechanisms that underlie the evolution of new cell types. The skeleton-...
Link:
https://journals.plos.org/plosbiology/article?id=10.1371/journal.pbio.3000460
Delivery Method:
microinjection
Organism or Cell Type:
Lytechinus variegatus (sea urchin)
Citation Extract:
Ettensohn CA, Adomako-Ankomah A. The evolution of a new cell type was associated with competition for a signaling ligand. PLoS Biol. 2019;17(9):e3000460. doi:10.1371/journal.pbio.3000460.

BAP1 regulates epigenetic switch from pluripotency to differentiation in developmental lineages giving rise to BAP1-mutant cancers

Authors:
Kuznetsov JN, Aguero TH, Owens DA, Kurtenbach S, Field MG, Durante MA
Citation:
Sci Adv. 2019;5(9):eaax1734. doi:10.1126/sciadv.aax1738
Epub:
Not Epub
Abstract:
The BAP1 tumor suppressor is mutated in many human cancers such as uveal melanoma, leading to poor patient outcome. It remains...
Link:
https://advances.sciencemag.org/content/5/9/eaax1738
Delivery Method:
microinjection
Organism or Cell Type:
Xenopus laevis
Citation Extract:
Kuznetsov JN, Aguero TH, Owens DA, Kurtenbach S, Field MG, Durante MA. BAP1 regulates epigenetic switch from pluripotency to differentiation in developmental lineages giving rise to BAP1-mutant cancers. Sci Adv. 2019;5(9):eaax1734. doi:10.1126/sciadv.aax1738.

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