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Morpholino Publication Database

This database contains citations and abstracts for research using Morpholino oligos, as well as some review articles incorporating Morpholino data. You can search the content using the filter boxes below.

There are 12171 scientific papers returned from the database with the search filters currently being used below.

Non-invasive monitoring of alternative splicing outcomes to identify candidate therapies for myotonic dystrophy type 1

Authors:
Hu N, Antoury L, Baran TM, Mitra S, Bennett CF, Rigo F, Foster TH, Wheeler TM
Citation:
Nat Commun. 2018 Dec 7;9(1):5227. doi: 10.1038/s41467-018-07517-y
Epub:
Not Epub
Abstract:
During drug development, tissue samples serve as indicators of disease activity and pharmacodynamic responses. Reliable non-...
Link:
https://www.nature.com/articles/s41467-018-07517-y
Delivery Method:
Vivo-Morpholino
Organism or Cell Type:
mice
Citation Extract:
Hu N, Antoury L, Baran TM, Mitra S, Bennett CF, Rigo F, Foster TH, Wheeler TM. Non-invasive monitoring of alternative splicing outcomes to identify candidate therapies for myotonic dystrophy type 1. Nat Commun. 2018 Dec 7;9(1):5227. doi: 10.1038/s41467-018-07517-y.

Syntaxin 1B Mediates Berberine's Roles in Epilepsy-Like Behavior in a Pentylenetetrazole-Induced Seizure Zebrafish Model

Authors:
Zheng YM, Chen B, Jiang JD, Zhang JP
Citation:
Front Mol Neurosci. 2018 Nov 26;11:378. doi: 10.3389/fnmol.2018.00378. eCollection 2018
Epub:
Not Epub
Abstract:
Epilepsy is a neuronal dysfunction syndrome characterized by transient and diffusely abnormal discharges of neurons in the...
Link:
https://www.frontiersin.org/articles/10.3389/fnmol.2018.00378/full
Delivery Method:
microinjection
Organism or Cell Type:
zebrafish
Citation Extract:
Zheng YM, Chen B, Jiang JD, Zhang JP. Syntaxin 1B Mediates Berberine's Roles in Epilepsy-Like Behavior in a Pentylenetetrazole-Induced Seizure Zebrafish Model. Front Mol Neurosci. 2018 Nov 26;11:378. doi: 10.3389/fnmol.2018.00378. eCollection 2018.

A transcriptomics analysis of the Tbx5 paralogues in zebrafish

Authors:
Boyle Anderson EAT, Ho RK
Citation:
PLoS ONE. 2018;13(12):e0208766. doi:10.1371/journal.pone.0208766
Epub:
Not Epub
Abstract:
TBX5 is essential for limb and heart development. Mutations in TBX5 are associated with Holt-Oram syndrome in humans. Due to...
Link:
https://journals.plos.org/plosone/article?id=10.1371/journal.pone.0208766
Delivery Method:
microinjection
Organism or Cell Type:
zebrafish
Citation Extract:
Boyle Anderson EAT, Ho RK. A transcriptomics analysis of the Tbx5 paralogues in zebrafish. PLoS ONE. 2018;13(12):e0208766. doi:10.1371/journal.pone.0208766.

Regional Gene Expression Profile Comparison Reveals the Unique Transcriptome of the Optic Fissure

Authors:
Cao M, Ouyang J, Liang H, Guo J, Lin S, Yang S, Xie T, Chen S
Citation:
Invest Ophthalmol Vis Sci. 2018 Dec 3;59(15):5773-5784. doi: 10.1167/iovs.18-23962
Epub:
Not Epub
Abstract:
Purpose: The optic fissure (OF) is a transient opening in the ventral optic cup (OC) that acts as a passage for blood vessels...
Link:
https://iovs.arvojournals.org/article.aspx?articleid=2718275
Delivery Method:
microinjection
Organism or Cell Type:
zebrafish
Citation Extract:
Cao M, Ouyang J, Liang H, Guo J, Lin S, Yang S, Xie T, Chen S. Regional Gene Expression Profile Comparison Reveals the Unique Transcriptome of the Optic Fissure. Invest Ophthalmol Vis Sci. 2018 Dec 3;59(15):5773-5784. doi: 10.1167/iovs.18-23962.

Inhibition of dengue virus replication in monocyte-derived dendritic cells by vivo-morpholino oligomers

Authors:
Phumesin P, Junking M, Panya A, Yongpitakwattana P, Noisakran S, Limjindaporn T, Yenchitsomanus PT
Citation:
Virus Res. 2019 Jan 15;260:123-128. doi: 10.1016/j.virusres.2018.11.014. Epub 2018 Nov 29. PMID: 30503719
Epub:
Yes
Abstract:
Skin dendritic cells (DCs) are primary target cells of dengue virus (DENV) infection and they play an important role in its...
Link:
https://linkinghub.elsevier.com/retrieve/pii/S0168-1702(18)30380-0
Delivery Method:
Vivo-Morpholino
Organism or Cell Type:
cell culture: human monocyte-derived dendritic cells (MDDC)
Citation Extract:
Phumesin P, Junking M, Panya A, Yongpitakwattana P, Noisakran S, Limjindaporn T, Yenchitsomanus PT. Inhibition of dengue virus replication in monocyte-derived dendritic cells by vivo-morpholino oligomers. Virus Res. 2019 Jan 15;260:123-128. doi: 10.1016/j.virusres.2018.11.014. Epub 2018 Nov 29. PMID: 30503719.

Physiological effects of KDM5C on neural crest migration and eye formation during vertebrate development

Authors:
Kim Y, Jeong Y, Kwon K, Ismail T, Lee H-K, Kim C, Park J-W, Kwon O-S, Kang B-S, Lee D-S, Park TJ, Kwon T, Lee H-S
Citation:
Epigenet & Chromatin. 2018;11:72 doi:10.1186/s13072-018-0241-x
Epub:
Not Epub
Abstract:
Background: Lysine-specific histone demethylase 5C (KDM5C) belongs to the jumonji family of demethylases and is specific for...
Link:
https://epigeneticsandchromatin.biomedcentral.com/articles/10.1186/s13072-018-0241-x
Delivery Method:
microinjection
Organism or Cell Type:
Xenopus laevis
Citation Extract:
Kim Y, Jeong Y, Kwon K, Ismail T, Lee H-K, Kim C, Park J-W, Kwon O-S, Kang B-S, Lee D-S, Park TJ, Kwon T, Lee H-S. Physiological effects of KDM5C on neural crest migration and eye formation during vertebrate development. Epigenet & Chromatin. 2018;11:72 doi:10.1186/s13072-018-0241-x.

Fer1l6 Is Essential for the Development of Vertebrate Muscle Tissue in Zebrafish

Authors:
Bonventre JA, Holman C, Manchanda A, Codding SJ, Chau T, Huegel J, Barton C, Tanguay R, Johnson CP
Citation:
Mol Biol Cell. 2018 Dec 5:mbcE18060401. doi: 10.1091/mbc.E18-06-0401. [Epub ahead of print]
Epub:
Yes
Abstract:
The precise spatial and temporal expression of genes is essential for proper organismal development. Despite their importance...
Link:
https://www.molbiolcell.org/doi/abs/10.1091/mbc.E18-06-0401
Delivery Method:
microinjection
Organism or Cell Type:
zebrafish
Citation Extract:
Bonventre JA, Holman C, Manchanda A, Codding SJ, Chau T, Huegel J, Barton C, Tanguay R, Johnson CP. Fer1l6 Is Essential for the Development of Vertebrate Muscle Tissue in Zebrafish. Mol Biol Cell. 2018 Dec 5:mbcE18060401. doi: 10.1091/mbc.E18-06-0401. [Epub ahead of print].

Dysregulation of NRAP degradation by KLHL41 contributes to pathophysiology in nemaline myopathy

Authors:
Jirka C, Pak JH, Grosgogeat CA, Marchetii MM, Gupta VA
Citation:
Hum Mol Genet. 2019 Aug 1;28(15):2549-2560. doi: 10.1093/hmg/ddz078. PMID: 30986853; PMCID: PMC6644164
Epub:
Not Epub
Abstract:
Nemaline myopathy (NM) is the most common form of congenital myopathy that results in hypotonia and muscle weakness. This...
Link:
https://pmc.ncbi.nlm.nih.gov/articles/PMC6644164/
Delivery Method:
microinjection
Organism or Cell Type:
zebrafish
Citation Extract:
Jirka C, Pak JH, Grosgogeat CA, Marchetii MM, Gupta VA. Dysregulation of NRAP degradation by KLHL41 contributes to pathophysiology in nemaline myopathy. Hum Mol Genet. 2019 Aug 1;28(15):2549-2560. doi: 10.1093/hmg/ddz078. PMID: 30986853; PMCID: PMC6644164.

Tfap2a is a novel gatekeeper of nephron differentiation during kidney development

Authors:
Chambers BE, Gerlach GF, Clark EG, Chen KH, Levesque AE, Leshchiner I, Goessling W, Wingert RA
Citation:
Development. 2019 Jul 10;146(13):dev172387. doi: 10.1242/dev.172387. PMID: 31160420; PMCID: PMC6633607
Epub:
Yes
Abstract:
Renal functional units known as nephrons undergo patterning events during development that create a segmental array of cellular...
Link:
https://pmc.ncbi.nlm.nih.gov/articles/PMC6633607/
Delivery Method:
microinjection
Organism or Cell Type:
zebrafish
Citation Extract:
Chambers BE, Gerlach GF, Clark EG, Chen KH, Levesque AE, Leshchiner I, Goessling W, Wingert RA. Tfap2a is a novel gatekeeper of nephron differentiation during kidney development. Development. 2019 Jul 10;146(13):dev172387. doi: 10.1242/dev.172387. PMID: 31160420; PMCID: PMC6633607.

Fgf3 is crucial for the generation of monoaminergic cerebrospinal fluid contacting cells in zebrafish

Authors:
Reuter I, Jäckels J, Kneitz S, Kuper J, Lesch KP, Lillesaar C
Citation:
Biol Open. 2019 Jun 5;8(6):bio040683. doi: 10.1242/bio.040683. PMID: 31036752; PMCID: PMC6602327
Epub:
Yes
Abstract:
In most vertebrates, including zebrafish, the hypothalamic serotonergic cerebrospinal fluid-contacting (CSF-c) cells constitute...
Link:
https://pmc.ncbi.nlm.nih.gov/articles/PMC6602327/
Delivery Method:
microinjection
Organism or Cell Type:
zebrafish
Citation Extract:
Reuter I, Jäckels J, Kneitz S, Kuper J, Lesch KP, Lillesaar C. Fgf3 is crucial for the generation of monoaminergic cerebrospinal fluid contacting cells in zebrafish. Biol Open. 2019 Jun 5;8(6):bio040683. doi: 10.1242/bio.040683. PMID: 31036752; PMCID: PMC6602327.

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