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Morpholino Publication Database

This database contains citations and abstracts for research using Morpholino oligos, as well as some review articles incorporating Morpholino data. You can search the content using the filter boxes below.

There are 12402 scientific papers returned from the database with the search filters currently being used below.

GAA-TTC repeat expansion in human cells is mediated by mismatch repair complex MutLγ and depends upon the endonuclease domain in MLH3 isoform one

Authors:
Halabi A, Fuselier KTB, Grabczyk E
Citation:
Nucl Acid Res. 2018;[Epub ahead of print] doi:/10.1093/nar/gky143
Epub:
Yes
Abstract:
DNA repeat expansion underlies dozens of progressive neurodegenerative disorders. While the mechanisms driving repeat expansion...
Link:
https://academic.oup.com/nar/advance-article/doi/10.1093/nar/gky143/4909995
Delivery Method:
Vivo-Morpholino
Organism or Cell Type:
cell culture: HEK293
Citation Extract:
Halabi A, Fuselier KTB, Grabczyk E. GAA-TTC repeat expansion in human cells is mediated by mismatch repair complex MutLγ and depends upon the endonuclease domain in MLH3 isoform one. Nucl Acid Res. 2018;[Epub ahead of print] doi:/10.1093/nar/gky143.

Overexpression of preeclampsia induced microRNA-26a-5p leads to proteinuria in zebrafish

Authors:
Müller-Deile J, Schröder P, Beverly-Staggs L, Hiss R, Fiedler J, Nyström J, Thum T, Haller H, Schiffer M
Citation:
Sci Rep. 2018;8:3621. doi:10.1038/s41598-018-22070-w
Epub:
Not Epub
Abstract:
So far the pathomechanism of preeclampsia in pregnancy is focussed on increased circulating levels of soluble fms-like tyrosin...
Link:
https://www.nature.com/articles/s41598-018-22070-w
Delivery Method:
microinjection
Organism or Cell Type:
zebrafish
Citation Extract:
Müller-Deile J, Schröder P, Beverly-Staggs L, Hiss R, Fiedler J, Nyström J, Thum T, Haller H, Schiffer M. Overexpression of preeclampsia induced microRNA-26a-5p leads to proteinuria in zebrafish. Sci Rep. 2018;8:3621. doi:10.1038/s41598-018-22070-w.

Perfluoroaryl Bicyclic Cell-Penetrating Peptides for Delivery of Antisense Oligonucleotides

Authors:
Wolfe JM, Fadzen CM, Holden RL, Yao M, Hanson GJ, Pentelute B
Citation:
Angew Chem Int Ed. 2018;[Epub ahead of print] doi:10.1002/anie.201801167
Epub:
Yes
Abstract:
Exon-skipping antisense oligonucleotides are effective treatments for genetic diseases, yet exon-skipping activity requires...
Link:
http://onlinelibrary.wiley.com/wol1/doi/10.1002/anie.201801167/abstract
Delivery Method:
peptide-linked
Organism or Cell Type:
cell culture: HeLa-654
Citation Extract:
Wolfe JM, Fadzen CM, Holden RL, Yao M, Hanson GJ, Pentelute B. Perfluoroaryl Bicyclic Cell-Penetrating Peptides for Delivery of Antisense Oligonucleotides. Angew Chem Int Ed. 2018;[Epub ahead of print] doi:10.1002/anie.201801167.

Glial cell line-derived neurotrophic factor supplementation promotes bovine in vitro oocyte maturation and early embryo development

Authors:
Wang DH, Zhou HX, Liu SJ, Zhou CJ, Kong XW, Han Z, Liang CG
Citation:
Theriogenology. 2018 Feb 19;113:92-101. doi: 10.1016/j.theriogenology.2018.02.015. [Epub ahead of print]
Epub:
Not Epub
Abstract:
Paracrine factors such as glial cell line-derived neurotrophic factor (GDNF), which was originally derived from the...
Link:
http://www.theriojournal.com/article/S0093-691X(18)30071-2/fulltext
Organism or Cell Type:
Bos taurus (bovine)
Citation Extract:
Wang DH, Zhou HX, Liu SJ, Zhou CJ, Kong XW, Han Z, Liang CG. Glial cell line-derived neurotrophic factor supplementation promotes bovine in vitro oocyte maturation and early embryo development. Theriogenology. 2018 Feb 19;113:92-101. doi: 10.1016/j.theriogenology.2018.02.015. [Epub ahead of print].

Regulation of Tak1 alternative splicing by splice-switching oligonucleotides

Authors:
Zhou D, Shao Q, Fan X, Wu P, Lin W, Wei H, He F, Jiang Y
Citation:
Biochem Biophys Res Commun. 2018 Feb 20. pii: S0006-291X(18)30397-8. doi: 10.1016/j.bbrc.2018.02.160. [Epub ahead of print]
Epub:
Yes
Abstract:
Alternative splicing (AS) generates multiple isoforms from a single precursor mRNA, and these isoforms usually exhibit...
Link:
https://www.sciencedirect.com/science/article/pii/S0006291X18303978
Delivery Method:
Vivo-Morpholino
Organism or Cell Type:
mice
Citation Extract:
Zhou D, Shao Q, Fan X, Wu P, Lin W, Wei H, He F, Jiang Y. Regulation of Tak1 alternative splicing by splice-switching oligonucleotides. Biochem Biophys Res Commun. 2018 Feb 20. pii: S0006-291X(18)30397-8. doi: 10.1016/j.bbrc.2018.02.160. [Epub ahead of print].

Extracellular bone morphogenetic protein modulator BMPER and twisted gastrulation homolog 1 preserve arterial venous specification in zebrafish blood vessel development and regulate Notch signaling in endothelial cells

Authors:
Esser JS, Steiner RE, Deckler M, Schmitt H, Engert B, Link S, Charlet A, Patterson C, Bode C, Zhou Q, Moser M
Citation:
FEBS J. 2018 Feb 23. doi: 10.1111/febs.14414. [Epub ahead of print]
Epub:
Yes
Abstract:
The bone morphogenetic protein (BMP) signaling pathway plays a central role during vasculature development. Mutations or...
Link:
http://onlinelibrary.wiley.com/doi/10.1111/febs.14414/abstract
Delivery Method:
microinjection
Organism or Cell Type:
zebrafish
Citation Extract:
Esser JS, Steiner RE, Deckler M, Schmitt H, Engert B, Link S, Charlet A, Patterson C, Bode C, Zhou Q, Moser M. Extracellular bone morphogenetic protein modulator BMPER and twisted gastrulation homolog 1 preserve arterial venous specification in zebrafish blood vessel development and regulate Notch signaling in endothelial cells. FEBS J. 2018 Feb 23. doi: 10.1111/febs.14414. [Epub ahead of print].

A Conserved Role of the Unconventional Myosin 1d in Laterality Determination

Authors:
Tingler M, Kurz S, Maerker M, Ott T, Fuhl F, Schweickert A, LeBlanc-Straceski JM, Noselli S, Blum M
Citation:
Curr Biol. 2018;[Epub ahead of print] doi:10.1016/j.cub.2018.01.075
Epub:
Yes
Abstract:
Anatomical and functional asymmetries are widespread in the animal kingdom [1, 2]. In vertebrates, many visceral organs are...
Link:
www.cell.com/current-biology/fulltext/S0960-9822(18)30108-8
Delivery Method:
microinjection
Organism or Cell Type:
Xenopus laevis
Citation Extract:
Tingler M, Kurz S, Maerker M, Ott T, Fuhl F, Schweickert A, LeBlanc-Straceski JM, Noselli S, Blum M. A Conserved Role of the Unconventional Myosin 1d in Laterality Determination. Curr Biol. 2018;[Epub ahead of print] doi:10.1016/j.cub.2018.01.075.

Innate Immune Response and Off-Target Mis-splicing Are Common Morpholino-Induced Side Effects in Xenopus

Authors:
Gentsch GE, Spruce T, Monteiro RS, Owens NDL, Martin SR, Smith JC
Citation:
Dev Cell. 2018;[Epub ahead of print] doi:10.1016/j.devcel.2018.01.022
Epub:
Yes
Abstract:
Antisense morpholino oligomers (MOs) have been indispensable tools for developmental biologists to transiently knock down (KD)...
Link:
http://www.cell.com/developmental-cell/fulltext/S1534-5807(18)30057-1
Delivery Method:
microinjection
Organism or Cell Type:
Xenopus
Citation Extract:
Gentsch GE, Spruce T, Monteiro RS, Owens NDL, Martin SR, Smith JC. Innate Immune Response and Off-Target Mis-splicing Are Common Morpholino-Induced Side Effects in Xenopus. Dev Cell. 2018;[Epub ahead of print] doi:10.1016/j.devcel.2018.01.022.

Nrf2 activation attenuates genetic endoplasmic reticulum stress induced by a mutation in the phosphomannomutase 2 gene in zebrafish

Authors:
Mukaigasa K, Tsujita T, Nguyen VT, Li L, Yagi H, Fuse Y, Nakajima-Takagi Y, Kato K, Yamamoto M, Kobayashi M
Citation:
PNAS. 2018;[Epub ahead of print] doi:10.1073/pnas.1714056115
Epub:
Yes
Abstract:
Nrf2 plays critical roles in animals’ defense against electrophiles and oxidative stress by orchestrating the induction of...
Link:
http://www.pnas.org/content/early/2018/02/21/1714056115
Delivery Method:
microinjection
Organism or Cell Type:
zebrafish
Citation Extract:
Mukaigasa K, Tsujita T, Nguyen VT, Li L, Yagi H, Fuse Y, Nakajima-Takagi Y, Kato K, Yamamoto M, Kobayashi M. Nrf2 activation attenuates genetic endoplasmic reticulum stress induced by a mutation in the phosphomannomutase 2 gene in zebrafish. PNAS. 2018;[Epub ahead of print] doi:10.1073/pnas.1714056115.

The ancestral retinoic acid receptor was a low-affinity sensor triggering neuronal differentiation

Authors:
Handberg-Thorsager M, Gutierrez-Mazariegos J, Arold ST, Nadendla EK, Bertucci PY, Germain P, Tomançak P, Pierzchalski K, Jones JW, Albalat R, Kane MA, Bourguet W, Laudet V, Arendt D, Schubert M
Citation:
Sci Adv. 2018;4:eaao1261 doi:10.1126/sciadv.aao1261
Epub:
Not Epub
Abstract:
Retinoic acid (RA) is an important intercellular signaling molecule in vertebrate development, with a well-established role in...
Link:
http://advances.sciencemag.org/content/4/2/eaao1261
Delivery Method:
microinjection
Organism or Cell Type:
Platynereis dumerilii (annelid)
Citation Extract:
Handberg-Thorsager M, Gutierrez-Mazariegos J, Arold ST, Nadendla EK, Bertucci PY, Germain P, Tomançak P, Pierzchalski K, Jones JW, Albalat R, Kane MA, Bourguet W, Laudet V, Arendt D, Schubert M. The ancestral retinoic acid receptor was a low-affinity sensor triggering neuronal differentiation. Sci Adv. 2018;4:eaao1261 doi:10.1126/sciadv.aao1261.

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