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Morpholino Publication Database

This database contains citations and abstracts for research using Morpholino oligos, as well as some review articles incorporating Morpholino data. You can search the content using the filter boxes below.

There are 12376 scientific papers returned from the database with the search filters currently being used below.

Cilia-localized GID/CTLH ubiquitin ligase complex regulates protein homeostasis of sonic hedgehog signaling components

Authors:
Hantel F, Liu H, Fechtner L, Neuhaus H, Ding J, Arlt D, Walentek P, Villavicencio-Lorini P, Gerhardt C, Hollemann T, Pfirrmann T
Citation:
J Cell Sci. 2022 May 1;135(9):jcs259209. doi: 10.1242/jcs.259209. Epub 2022 May 11
Epub:
Not Epub
Abstract:
Cilia are evolutionarily conserved organelles that orchestrate a variety of signal transduction pathways, such as sonic...
Link:
https://journals.biologists.com/jcs/article/135/9/jcs259209/275349/Cilia-localized-GID-CTLH-ubiquitin-ligase-complex
Delivery Method:
microinjection
Organism or Cell Type:
Xenopus laevis
Citation Extract:
Hantel F, Liu H, Fechtner L, Neuhaus H, Ding J, Arlt D, Walentek P, Villavicencio-Lorini P, Gerhardt C, Hollemann T, Pfirrmann T. Cilia-localized GID/CTLH ubiquitin ligase complex regulates protein homeostasis of sonic hedgehog signaling components. J Cell Sci. 2022 May 1;135(9):jcs259209. doi: 10.1242/jcs.259209. Epub 2022 May 11.

FMNL2 regulates gliovascular interactions and is associated with vascular risk factors and cerebrovascular pathology in Alzheimer's disease

Authors:
Lee AJ, Raghavan NS, Bhattarai P, Siddiqui T, Sariya S, Reyes-Dumeyer D, Flowers XE, Cardoso SAL, De Jager PL, Bennett DA, Schneider JA, Menon V, Wang Y, Lantigua RA, Medrano M, Rivera D, Jiménez-Velázquez IZ, Kukull WA, Brickman AM, Manly JJ, Tosto G, Kizil C, Vardarajan BN, Mayeux R
Citation:
Acta Neuropathol. 2022 May 24. doi: 10.1007/s00401-022-02431-6. Online ahead of print
Epub:
Not Epub
Abstract:
Alzheimer's disease (AD) has been associated with cardiovascular and cerebrovascular risk factors (CVRFs) during middle...
Link:
https://link.springer.com/article/10.1007/s00401-022-02431-6
Delivery Method:
microinjection
Organism or Cell Type:
zebrafish
Citation Extract:
Lee AJ, Raghavan NS, Bhattarai P, Siddiqui T, Sariya S, Reyes-Dumeyer D, Flowers XE, Cardoso SAL, De Jager PL, Bennett DA, Schneider JA, Menon V, Wang Y, Lantigua RA, Medrano M, Rivera D, Jiménez-Velázquez IZ, Kukull WA, Brickman AM, Manly JJ, Tosto G, Kizil C, Vardarajan BN, Mayeux R. FMNL2 regulates gliovascular interactions and is associated with vascular risk factors and cerebrovascular pathology in Alzheimer's disease. Acta Neuropathol. 2022 May 24. doi: 10.1007/s00401-022-02431-6. Online ahead of print.

FTO mediates LINE1 m6A demethylation and chromatin regulation in mESCs and mouse development

Authors:
Wei J, Yu X, Yang L, Liu X, Gao B, Huang B, Dou X, Liu J, Zou Z, Cui XL, Zhang LS, Zhao X, Liu Q, He PC, Sepich-Poore C, Zhong N, Liu W, Li Y, Kou X, Zhao Y, Wu Y, Cheng X, Chen C, An Y, Dong X, Wang H, Shu Q, Hao Z, Duan T, He YY, Li X, Gao S, Gao Y, He C
Citation:
Science. 2022 May 27;376(6596):968-973. doi: 10.1126/science.abe9582. Epub 2022 May 5
Epub:
Not Epub
Abstract:
N6-methyladenosine (m6A) is the most abundant internal modification on mammalian messenger RNA. It is installed by a writer...
Link:
https://www.science.org/doi/10.1126/science.abe9582
Delivery Method:
electroporation
Organism or Cell Type:
cell culture: mESC and Mel624
Citation Extract:
Wei J, Yu X, Yang L, Liu X, Gao B, Huang B, Dou X, Liu J, Zou Z, Cui XL, Zhang LS, Zhao X, Liu Q, He PC, Sepich-Poore C, Zhong N, Liu W, Li Y, Kou X, Zhao Y, Wu Y, Cheng X, Chen C, An Y, Dong X, Wang H, Shu Q, Hao Z, Duan T, He YY, Li X, Gao S, Gao Y, He C. FTO mediates LINE1 m6A demethylation and chromatin regulation in mESCs and mouse development. Science. 2022 May 27;376(6596):968-973. doi: 10.1126/science.abe9582. Epub 2022 May 5.

Isolation and Characterization of Germline Stem Cells in Protogynous Hermaphroditic Monopterus albus

Authors:
Sun X, Tao B, Wang Y, Hu W, Sun Y
Citation:
Int J Mol Sci. 2022;23:5861. doi:10.3390/ijms23115861
Epub:
Not Epub
Abstract:
Germline stem cells (GSCs) are a group of unique adult stem cells in gonads that act as important transmitters for genetic...
Link:
https://www.mdpi.com/1422-0067/23/11/5861
Delivery Method:
microinjection
Organism or Cell Type:
Monopterus albus (rice field eel)
Citation Extract:
Sun X, Tao B, Wang Y, Hu W, Sun Y. Isolation and Characterization of Germline Stem Cells in Protogynous Hermaphroditic Monopterus albus. Int J Mol Sci. 2022;23:5861. doi:10.3390/ijms23115861.

Long-Term Functional Efficacy and Safety of Viltolarsen in Patients with Duchenne Muscular Dystrophy

Authors:
Clemens PR, Rao VK, Connolly AM, Harper AD, Mah JK, McDonald CM, Smith EC, Zaidman CM, Nakagawa T; CINRG DNHS Investigators, Hoffman EP
Citation:
J Neuromuscul Dis. 2022 May 24. doi: 10.3233/JND-220811. Online ahead of print
Epub:
Yes
Abstract:
Background: Duchenne muscular dystrophy (DMD) is a rare, genetic disease caused by mutations in the DMD gene resulting in an...
Link:
https://content.iospress.com/articles/journal-of-neuromuscular-diseases/jnd220811
Delivery Method:
i.v. infusion
Organism or Cell Type:
human
Citation Extract:
Clemens PR, Rao VK, Connolly AM, Harper AD, Mah JK, McDonald CM, Smith EC, Zaidman CM, Nakagawa T; CINRG DNHS Investigators, Hoffman EP. Long-Term Functional Efficacy and Safety of Viltolarsen in Patients with Duchenne Muscular Dystrophy. J Neuromuscul Dis. 2022 May 24. doi: 10.3233/JND-220811. Online ahead of print.

Temporal cell fate determination in the spinal cord is mediated by the duration of Notch signalling

Authors:
Jacobs CT, Kejriwal A, Kocha KM, Jin KY, Huang P
Citation:
Dev Biol. 2022 May 24:S0012-1606(22)00098-7. doi: 10.1016/j.ydbio.2022.05.010. Online ahead of print
Epub:
Yes
Abstract:
During neural development, progenitor cells generate different types of neurons in specific time windows. Despite the...
Link:
https://www.sciencedirect.com/science/article/abs/pii/S0012160622000987
Delivery Method:
microinjection
Organism or Cell Type:
zebrafish
Citation Extract:
Jacobs CT, Kejriwal A, Kocha KM, Jin KY, Huang P. Temporal cell fate determination in the spinal cord is mediated by the duration of Notch signalling. Dev Biol. 2022 May 24:S0012-1606(22)00098-7. doi: 10.1016/j.ydbio.2022.05.010. Online ahead of print.

N-methyl-N-nitrosourea induces zebrafish anomalous angiogenesis through Wnt/β-catenin pathway

Authors:
Fu S, Tan R, Feng Y, Yu P, Mo Y, Xiao W, Wang S, Zhang J
Citation:
Ecotoxicol Environ Saf. 2022 May 24;239:113674. doi: 10.1016/j.ecoenv.2022.113674. Online ahead of print
Epub:
Not Epub
Abstract:
N-methyl-N-nitrosourea (MNU) is a prevalent environmental carcinogen, which leads to tumors in various organs in animal models...
Link:
https://www.sciencedirect.com/science/article/pii/S0147651322005140
Delivery Method:
microinjection
Organism or Cell Type:
zebrafish
Citation Extract:
Fu S, Tan R, Feng Y, Yu P, Mo Y, Xiao W, Wang S, Zhang J. N-methyl-N-nitrosourea induces zebrafish anomalous angiogenesis through Wnt/β-catenin pathway. Ecotoxicol Environ Saf. 2022 May 24;239:113674. doi: 10.1016/j.ecoenv.2022.113674. Online ahead of print.

Orphan G-Protein Coupled Receptor GPRC5B Is Critical for Lymphatic Development

Authors:
Xu W, Nelson-Maney NP, Bálint L, Kwon HB, Davis RB, Dy DCM, Dunleavey JM, St Croix B, Caron KM
Citation:
Int J Mol Sci. 2022 May 20;23(10):5712. doi: 10.3390/ijms23105712
Epub:
Not Epub
Abstract:
Numerous studies have focused on the molecular signaling pathways that govern the development and growth of lymphatics in the...
Link:
https://www.mdpi.com/1422-0067/23/10/5712
Delivery Method:
microinjection
Organism or Cell Type:
zebrafish
Citation Extract:
Xu W, Nelson-Maney NP, Bálint L, Kwon HB, Davis RB, Dy DCM, Dunleavey JM, St Croix B, Caron KM. Orphan G-Protein Coupled Receptor GPRC5B Is Critical for Lymphatic Development. Int J Mol Sci. 2022 May 20;23(10):5712. doi: 10.3390/ijms23105712.

U1 snRNP regulates early spliceosome assembly by disrupting the interaction between SR proteins and the pre-mRNA

Authors:
Saha K, Ghosh G
Citation:
bioRxiv. 2021;[preprint] doi:10.1101/2021.12.01.470860
Epub:
Not Epub
Abstract:
The pre-mRNA features that define the splice signals at or near exon-intron junctions for assembly of the early spliceosome are...
Link:
https://www.biorxiv.org/content/10.1101/2021.12.01.470860v3
Organism or Cell Type:
cell culture: HeLa
Citation Extract:
Saha K, Ghosh G. U1 snRNP regulates early spliceosome assembly by disrupting the interaction between SR proteins and the pre-mRNA. bioRxiv. 2021;[preprint] doi:10.1101/2021.12.01.470860.

Transcription factors that specify cell fate activate cell cycle regulator genes to determine cell numbers in ascidian larval tissues

Authors:
Kobayashi K, Tokuoka M, Sato H, Ariyoshi M, Kawahara S, Fujiwara S, Kishimoto T, Satou Y
Citation:
bioRxiv. 2022;[preprint] doi:10.1101/2022.05.16.492211
Epub:
Not Epub
Abstract:
In animal development, most cell types stop dividing before terminal differentiation; thus, cell cycle control is tightly...
Link:
https://www.biorxiv.org/content/10.1101/2022.05.16.492211v1
Delivery Method:
microinjection
Organism or Cell Type:
Ciona savignyi (ascidian)
Citation Extract:
Kobayashi K, Tokuoka M, Sato H, Ariyoshi M, Kawahara S, Fujiwara S, Kishimoto T, Satou Y. Transcription factors that specify cell fate activate cell cycle regulator genes to determine cell numbers in ascidian larval tissues. bioRxiv. 2022;[preprint] doi:10.1101/2022.05.16.492211 .

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