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Morpholino Publication Database
This database contains citations and abstracts for research using Morpholino oligos, as well as some review articles incorporating Morpholino data. You can search the content using the filter boxes below.
There are 12184 scientific papers returned from the database with the search filters currently being used below.
There are 12184 scientific papers returned from the database with the search filters currently being used below.
Integrative genetic analysis illuminates ALS heritability and identifies risk genes
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Citation:
Nat Commun. 2023 Jan 20;14(1):342. doi: 10.1038/s41467-022-35724-1 Epub:
Not Epub Abstract:
Amyotrophic lateral sclerosis (ALS) has substantial heritability, in part shared with fronto-temporal dementia (FTD). We show... Delivery Method:
microinjection Organism or Cell Type:
zebrafish Citation Extract: Megat S, Mora N, Sanogo J, Roman O, Catanese A, Alami NO, Freischmidt A, Mingaj X, De Calbiac H, Muratet F, Dirrig-Grosch S, Dieterle S, Van Bakel N, Müller K, Sieverding K, Weishaupt J, Andersen PM, Weber M, Neuwirth C, Margelisch M, Sommacal A, Van Eijk KR, Veldink JH; Project Mine Als Sequencing Consortium; Lautrette G, Couratier P, Camuzat A, Le Ber I, Grassano M, Chio A, Boeckers T, Ludolph AC, Roselli F, Yilmazer-Hanke D, Millecamps S, Kabashi E, Storkebaum E, Sellier C, Dupuis L. Integrative genetic analysis illuminates ALS heritability and identifies risk genes. Nat Commun. 2023 Jan 20;14(1):342. doi: 10.1038/s41467-022-35724-1. |
Structural remodeling of AAA+ ATPase p97 by adaptor protein ASPL facilitates posttranslational methylation by METTL21D
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Citation:
Proc Natl Acad Sci U S A. 2023 Jan 24;120(4):e2208941120. doi:10.1073/pnas.2208941120. Epub 2023 Jan 19 Epub:
Yes Abstract:
p97 is an essential AAA+ ATPase that extracts and unfolds substrate proteins from membranes and protein complexes. Through its... Delivery Method:
microinjection Organism or Cell Type:
zebrafish Citation Extract: Petrović S, Roske Y, Rami B, Phan MHQ, Panáková D, Heinemann U. Structural remodeling of AAA+ ATPase p97 by adaptor protein ASPL facilitates posttranslational methylation by METTL21D. Proc Natl Acad Sci U S A. 2023 Jan 24;120(4):e2208941120. doi:10.1073/pnas.2208941120. Epub 2023 Jan 19. |
Morpholino-Mediated Exons 28-29 Skipping of Dysferlin and Characterization of Multiexon-skipped Dysferlin using RT-PCR, Immunoblotting, and Membrane Wounding Assay
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Citation:
Methods in Molecular Biology . 2023;2587. In: Maruyama R, Yokota T. (eds) Muscular Dystrophy Therapeutics. Humana, New York, NY. doi:10.1007/978-1-0716-2772-3_11 Epub:
Not Epub Abstract:
Dysferlinopathies are a group of disabling muscular dystrophies that includes limb girdle muscular dystrophy type 2B (LGMD2B... Organism or Cell Type:
cell culture: fibroblasts Citation Extract: Anwar S, Yokota T. Morpholino-Mediated Exons 28-29 Skipping of Dysferlin and Characterization of Multiexon-skipped Dysferlin using RT-PCR, Immunoblotting, and Membrane Wounding Assay. Methods in Molecular Biology . 2023;2587. In: Maruyama R, Yokota T. (eds) Muscular Dystrophy Therapeutics. Humana, New York, NY. doi:10.1007/978-1-0716-2772-3_11. |
Unraveling Presenilin 2 Functions in a Knockout Zebrafish Line to Shed Light into Alzheimer’s Disease Pathogenesis
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Citation:
Cells. 2023;12(3):376. doi:10.3390/cells12030376 Epub:
Not Epub Abstract:
Mutations in presenilin 2 (PS2) have been causally linked to the development of inherited Alzheimer’s disease (AD). Besides its... Delivery Method:
microinjection Organism or Cell Type:
zebrafish Citation Extract: Barazzuol L, Cieri D, Facchinello N, Calì T, Washbourne P, Argenton F, Pizzo P. Unraveling Presenilin 2 Functions in a Knockout Zebrafish Line to Shed Light into Alzheimer’s Disease Pathogenesis. Cells. 2023;12(3):376. doi:10.3390/cells12030376. |
Multiple pkd and piezo gene family members are required for atrioventricular valve formation
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Citation:
Nat Commun. 2023;14(1):214. doi:10.1038/s41467-023-35843-3 Epub:
Not Epub Abstract:
Cardiac valves ensure unidirectional blood flow through the heart, and altering their function can result in heart failure.... Delivery Method:
microinjection Organism or Cell Type:
zebrafish Citation Extract: Juan T, Ribeiro da Silva A, Cardoso B, Lim SE, Charteau V, Stainier DYR. Multiple pkd and piezo gene family members are required for atrioventricular valve formation. Nat Commun. 2023;14(1):214. doi:10.1038/s41467-023-35843-3. |
Identification of the Time Period during Which BMP Signaling Regulates Proliferation of Neural Progenitor Cells in Zebrafish
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Citation:
Int J Mol Sci. 2023;24(2):1733. doi:10.3390/ijms24021733 Epub:
Not Epub Abstract:
Bone morphogenetic protein (BMP) signaling regulates neural induction, neuronal specification, and neuronal differentiation.... Delivery Method:
microinjection Organism or Cell Type:
zebrafish Citation Extract: Shih H-Y, Chang C-W, Chen Y-C, Cheng Y-C. Identification of the Time Period during Which BMP Signaling Regulates Proliferation of Neural Progenitor Cells in Zebrafish. Int J Mol Sci. 2023;24(2):1733. doi:10.3390/ijms24021733 . |
Endothelial cells require functional FLVCR1a during developmental and adult angiogenesis
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Citation:
Angiogenesis. 2023 Aug;26(3):365-384. doi: 10.1007/s10456-023-09865-w. Epub 2023 Jan 11. PMID: 36631598; PMCID: PMC10328904 Epub:
Not Epub Abstract:
The Feline Leukemia Virus Subgroup C Receptor 1a (FLVCR1a) is a transmembrane heme exporter essential for embryonic vascular... Delivery Method:
microinjection Organism or Cell Type:
zebrafish Citation Extract: Petrillo S, De Giorgio F, Bertino F, Garello F, Bitonto V, Longo DL, Mercurio S, Ammirata G, Allocco AL, Fiorito V, Chiabrando D, Altruda F, Terreno E, Provero P, Munaron L, Genova T, Nóvoa A, Carlos AR, Cardoso S, Mallo M, Soares MP, Tolosano E. Endothelial cells require functional FLVCR1a during developmental and adult angiogenesis. Angiogenesis. 2023 Aug;26(3):365-384. doi: 10.1007/s10456-023-09865-w. Epub 2023 Jan 11. PMID: 36631598; PMCID: PMC10328904. |
Channel Function of Polycystin-2 in the Endoplasmic Reticulum Protects against Autosomal Dominant Polycystic Kidney Disease
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Citation:
J Am Soc Nephrol. 2022 Aug;33(8):1501-1516. doi: 10.1681/ASN.2022010053. Epub 2022 Jul 14 Epub:
Not Epub Abstract:
Background: Mutations of PKD2, which encodes polycystin-2, cause autosomal dominant polycystic kidney disease (ADPKD). The... Link:
Delivery Method:
microinjection Organism or Cell Type:
zebrafish Citation Extract: Padhy B, Xie J, Wang R, Lin F, Huang CL. Channel Function of Polycystin-2 in the Endoplasmic Reticulum Protects against Autosomal Dominant Polycystic Kidney Disease. J Am Soc Nephrol. 2022 Aug;33(8):1501-1516. doi: 10.1681/ASN.2022010053. Epub 2022 Jul 14. |
Somitic mesoderm morphogenesis is necessary for neural tube closure during Xenopus development
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Citation:
Front Cell Dev Biol. 2023;10:1091629. doi:10.3389/fcell.2022.1091629 Epub:
Not Epub Abstract:
Neural tube closure is a fundamental process during vertebrate embryogenesis, which leads to the formation of the central... Delivery Method:
microinjection Organism or Cell Type:
Xenopus laevis Citation Extract: Christodoulou N, Skourides PA. Somitic mesoderm morphogenesis is necessary for neural tube closure during Xenopus development. Front Cell Dev Biol. 2023;10:1091629. doi:10.3389/fcell.2022.1091629. |
Repeat-associated non-AUG translation induces cytoplasmic aggregation of CAG repeat-containing RNAs
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Citation:
Proc Natl Acad Sci U S A. 2023 Jan 17;120(3):e2215071120. doi: 10.1073/pnas.2215071120. Epub 2023 Jan 9 Epub:
Not Epub Abstract:
CAG trinucleotide repeat expansions cause several neurodegenerative diseases, including Huntington's disease and... Delivery Method:
Endo-Porter Organism or Cell Type:
cell culture: U-2OS cells (ATCC, HTB-96) Citation Extract: Das MR, Chang Y, Anderson R, Saunders RA, Zhang N, Tomberlin CP, Vale RD, Jain A. Repeat-associated non-AUG translation induces cytoplasmic aggregation of CAG repeat-containing RNAs. Proc Natl Acad Sci U S A. 2023 Jan 17;120(3):e2215071120. doi: 10.1073/pnas.2215071120. Epub 2023 Jan 9. |