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Morpholino Publication Database

This database contains citations and abstracts for research using Morpholino oligos, as well as some review articles incorporating Morpholino data. You can search the content using the filter boxes below.

There are 12376 scientific papers returned from the database with the search filters currently being used below.

Transient grb10a Knockdown Permanently Alters Growth, Cardiometabolic Phenotype and the Transcriptome in Danio rerio

Authors:
Evans BL, Garner T, De Leonibus C, Wearing OH, Shiels HA, Hurlstone AFL, Clayton PE, Stevens A
Citation:
bioRxiv. 2020;[preprint] doi:/10.1101/2020.12.06.413633
Epub:
Not Epub
Abstract:
Embryonic growth trajectory is a risk factor for chronic metabolic and cardiovascular disorder. Grb10 is a negative regulator...
Link:
https://www.biorxiv.org/content/10.1101/2020.12.06.413633v2
Delivery Method:
microinjection
Organism or Cell Type:
zebrafish
Citation Extract:
Evans BL, Garner T, De Leonibus C, Wearing OH, Shiels HA, Hurlstone AFL, Clayton PE, Stevens A. Transient grb10a Knockdown Permanently Alters Growth, Cardiometabolic Phenotype and the Transcriptome in Danio rerio. bioRxiv. 2020;[preprint] doi:/10.1101/2020.12.06.413633 .

ASB2 is a novel E3 ligase of SMAD9 required for cardiogenesis

Authors:
Min KD, Asakura M, Shirai M, Yamazaki S, Ito S, Fu HY, Asanuma H, Asano Y, Minamino T, Takashima S, Kitakaze M
Citation:
Sci Rep. 2021 Nov 29;11(1):23056. doi: 10.1038/s41598-021-02390-0
Epub:
Not Epub
Abstract:
Cardiogenesis requires the orchestrated spatiotemporal tuning of BMP signalling upon the balance between induction and counter-...
Link:
https://www.nature.com/articles/s41598-021-02390-0
Delivery Method:
microinjection
Organism or Cell Type:
zebrafish
Citation Extract:
Min KD, Asakura M, Shirai M, Yamazaki S, Ito S, Fu HY, Asanuma H, Asano Y, Minamino T, Takashima S, Kitakaze M. ASB2 is a novel E3 ligase of SMAD9 required for cardiogenesis. Sci Rep. 2021 Nov 29;11(1):23056. doi: 10.1038/s41598-021-02390-0.

A Novel Germline Heterozygous BCL11B Variant Causing Severe Atopic Disease and Immune Dysregulation

Authors:
Lu HY, Sertori R, Contreras AV, Hamer M, Messing M, Del Bel KL, Lopez-Rangel E, Chan ES, Rehmus W, Milner JD, McNagny KM, Lehman A, Wiest DL, Turvey SE
Citation:
Front Immunol. 2021;12:4895. doi:10.3389/fimmu.2021.788278
Epub:
Not Epub
Abstract:
B-cell lymphoma/leukemia 11B (BCL11B) is a C2H2 zinc finger transcription factor that is critically important for regulating...
Link:
https://www.frontiersin.org/articles/10.3389/fimmu.2021.788278/full
Delivery Method:
microinjection
Organism or Cell Type:
zebrafish
Citation Extract:
Lu HY, Sertori R, Contreras AV, Hamer M, Messing M, Del Bel KL, Lopez-Rangel E, Chan ES, Rehmus W, Milner JD, McNagny KM, Lehman A, Wiest DL, Turvey SE. A Novel Germline Heterozygous BCL11B Variant Causing Severe Atopic Disease and Immune Dysregulation. Front Immunol. 2021;12:4895. doi:10.3389/fimmu.2021.788278 .

LUBAC regulates ciliogenesis by promoting CP110 removal from the mother centriole

Authors:
Shen X-L, Yuan J-F, Qin X-E, Song G-P, Hu H-B, Tu H-Q, Song Z-Q, Li P-Y, Xu Y-L, Sen Li, Jian X-X, Li J-N, He C-Y, Yu X-P, Liang L-Y, Wu M, Han Q-Y, Wang K, Li A-L, Zhou T, Zhang Y-C, Wang N, Li H-Y
Citation:
J Cell Biol. 2021;221(1):e202105092. doi:10.1083/jcb.202105092
Epub:
Not Epub
Abstract:
Primary cilia transduce diverse signals in embryonic development and adult tissues. Defective ciliogenesis results in a series...
Link:
https://rupress.org/jcb/article-abstract/221/1/e202105092/212875/LUBAC-regulates-ciliogenesis-by-promoting-CP110
Delivery Method:
microinjection
Organism or Cell Type:
zebrafish
Citation Extract:
Shen X-L, Yuan J-F, Qin X-E, Song G-P, Hu H-B, Tu H-Q, Song Z-Q, Li P-Y, Xu Y-L, Sen Li, Jian X-X, Li J-N, He C-Y, Yu X-P, Liang L-Y, Wu M, Han Q-Y, Wang K, Li A-L, Zhou T, Zhang Y-C, Wang N, Li H-Y. LUBAC regulates ciliogenesis by promoting CP110 removal from the mother centriole. J Cell Biol. 2021;221(1):e202105092. doi:10.1083/jcb.202105092.

Identification of ZBTB26 as a Novel Risk Factor for Congenital Hypothyroidism

Authors:
Vick P, Eberle B, Choukair D, Weiss B, Roeth R, Schneider I, Paramasivam N, Bettendorf M, Rappold GA
Citation:
Genes. 2021;12(12):1862. doi:10.3390/genes12121862
Epub:
Not Epub
Abstract:
Congenital primary hypothyroidism (CH; OMIM 218700) is characterized by an impaired thyroid development, or dyshormonogenesis,...
Link:
https://www.mdpi.com/2073-4425/12/12/1862
Delivery Method:
microinjection
Organism or Cell Type:
Xenopus laevis
Citation Extract:
Vick P, Eberle B, Choukair D, Weiss B, Roeth R, Schneider I, Paramasivam N, Bettendorf M, Rappold GA. Identification of ZBTB26 as a Novel Risk Factor for Congenital Hypothyroidism. Genes. 2021;12(12):1862. doi:10.3390/genes12121862.

Modulation of PKM1/2 levels by steric blocking morpholinos alters the metabolic and pluripotent state of murine pluripotent stem cells

Authors:
Dierolf JG, Hunter HLM, Watson AJ, Betts DH
Citation:
bioRxiv. 2021;[preprint] doi:10.1101/2021.11.23.469697
Epub:
Not Epub
Abstract:
Cellular metabolism plays both an active and passive role in embryonic development, pluripotency, and cell-fate decisions....
Link:
https://www.biorxiv.org/content/10.1101/2021.11.23.469697v1
Delivery Method:
scrape loading
Organism or Cell Type:
cell culture: murine embryonic stem cells
Citation Extract:
Dierolf JG, Hunter HLM, Watson AJ, Betts DH. Modulation of PKM1/2 levels by steric blocking morpholinos alters the metabolic and pluripotent state of murine pluripotent stem cells. bioRxiv. 2021;[preprint] doi:10.1101/2021.11.23.469697.

Plasma obtained following murine hindlimb ischemic conditioning protects against oxidative stress in zebrafish models through activation of nrf2a and downregulation of duox

Authors:
Guan R, Wen XY, Leung CH, Ciano-Oliveira CD, Lam S, Dai SY, Karbassi F, Mauro A, Wang Y, Rotstein O
Citation:
PLoS One. 2021 Nov 24;16(11):e0260442. doi:10.1371/journal.pone.0260442. eCollection 2021
Epub:
Not Epub
Abstract:
Ischemia/reperfusion of organ systems in trauma patients with resuscitated hemorrhagic shock (HSR) contributes to tissue injury...
Link:
https://journals.plos.org/plosone/article?id=10.1371/journal.pone.0260442
Delivery Method:
microinjection
Organism or Cell Type:
zebrafish
Citation Extract:
Guan R, Wen XY, Leung CH, Ciano-Oliveira CD, Lam S, Dai SY, Karbassi F, Mauro A, Wang Y, Rotstein O. Plasma obtained following murine hindlimb ischemic conditioning protects against oxidative stress in zebrafish models through activation of nrf2a and downregulation of duox. PLoS One. 2021 Nov 24;16(11):e0260442. doi:10.1371/journal.pone.0260442. eCollection 2021.

Lysosomal Function Impacts the Skeletal Muscle Extracellular Matrix

Authors:
Coffey EC, Astumian M, Alrowaished SS, Schaffer C, Henry CA
Citation:
J Dev Biol. 2021;9(4):52. doi:10.3390/jdb9040052
Epub:
Not Epub
Abstract:
Muscle development and homeostasis are critical for normal muscle function. A key aspect of muscle physiology during...
Link:
https://www.mdpi.com/2221-3759/9/4/52
Delivery Method:
microinjection
Organism or Cell Type:
zebrafish
Citation Extract:
Coffey EC, Astumian M, Alrowaished SS, Schaffer C, Henry CA. Lysosomal Function Impacts the Skeletal Muscle Extracellular Matrix. J Dev Biol. 2021;9(4):52. doi:10.3390/jdb9040052.

INTS7-ABCD3 Interaction Stimulates the Proliferation and Osteoblastic Differentiation of Mouse Bone Marrow Mesenchymal Stem Cells by Suppressing Oxidative Stress

Authors:
Liu Y, Yu X, Huang A, Zhang X, Wang Y, Geng W, Xu R, Li S, He H, Zheng B, Chen G, Xu Y
Citation:
Front Physiol. 2021;12:2004. doi:10.3389/fphys.2021.758607
Epub:
Not Epub
Abstract:
Increased adipocyte and decreased osteoblast differentiation, combined with the ectopic proliferation of bone marrow...
Link:
https://www.frontiersin.org/articles/10.3389/fphys.2021.758607/full
Delivery Method:
Vivo-Morpholino
Organism or Cell Type:
cell cultue: Oricell Strain C57BL/6 Mouse BM-MSCs
Citation Extract:
Liu Y, Yu X, Huang A, Zhang X, Wang Y, Geng W, Xu R, Li S, He H, Zheng B, Chen G, Xu Y. INTS7-ABCD3 Interaction Stimulates the Proliferation and Osteoblastic Differentiation of Mouse Bone Marrow Mesenchymal Stem Cells by Suppressing Oxidative Stress. Front Physiol. 2021;12:2004. doi:10.3389/fphys.2021.758607.

5' Half of specific tRNAs feeds back to promote corresponding tRNA gene transcription in vertebrate embryos

Authors:
Chen L, Xu W, Liu K, Jiang Z, Han Y, Jin H, Zhang L, Shen W, Jia S, Sun Q, Meng A
Citation:
Sci Adv. 2021 Nov 19;7(47):eabh0494. doi: 10.1126/sciadv.abh0494. Epub 2021 Nov 19
Epub:
Not Epub
Abstract:
5′tRFls are small transfer RNA (tRNA) fragments derived from 5′ half of mature tRNAs. However, it is unknown whether 5′tRFls...
Link:
https://www.science.org/doi/10.1126/sciadv.abh0494
Delivery Method:
microinjection
Organism or Cell Type:
zebrafish
Citation Extract:
Chen L, Xu W, Liu K, Jiang Z, Han Y, Jin H, Zhang L, Shen W, Jia S, Sun Q, Meng A. 5' Half of specific tRNAs feeds back to promote corresponding tRNA gene transcription in vertebrate embryos. Sci Adv. 2021 Nov 19;7(47):eabh0494. doi: 10.1126/sciadv.abh0494. Epub 2021 Nov 19.

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