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Morpholino Publication Database

This database contains citations and abstracts for research using Morpholino oligos, as well as some review articles incorporating Morpholino data. You can search the content using the filter boxes below.

There are 12378 scientific papers returned from the database with the search filters currently being used below.

Tacc3 modulates microtubule network dynamicity and focal adhesion remodeling to affect cranial neural crest cell migration in Xenopus laevis

Authors:
Bearce EA, Pratt B, Rutherford EL, Carandang LA, Lowery L
Citation:
bioRxiv. 2021;[preprint] doi:10.1101/2021.02.08.430297
Epub:
Not Epub
Abstract:
Coordinated cell migration is critical during embryogenesis, as cells must leave their point of origin, navigate a complex...
Link:
https://www.biorxiv.org/content/10.1101/2021.02.08.430297v1
Delivery Method:
microinjection
Organism or Cell Type:
Xenopus laevis
Citation Extract:
Bearce EA, Pratt B, Rutherford EL, Carandang LA, Lowery L. Tacc3 modulates microtubule network dynamicity and focal adhesion remodeling to affect cranial neural crest cell migration in Xenopus laevis. bioRxiv. 2021;[preprint] doi:10.1101/2021.02.08.430297 .

Bidirectional neuronal migration coordinates retinal morphogenesis by preventing spatial competition

Authors:
Rocha-Martins M, Kretzschmar J, Nerli E, Weigert M, Icha J, Myers EW, Norden C
Citation:
bioRxiv. 2021;[preprint] doi:10.1101/2021.02.08.430189
Epub:
Not Epub
Abstract:
While the design of industrial products is often optimized for the sequential assembly of single components, organismal...
Link:
https://www.biorxiv.org/content/10.1101/2021.02.08.430189v1
Delivery Method:
microinjection
Organism or Cell Type:
zebrafish
Citation Extract:
Rocha-Martins M, Kretzschmar J, Nerli E, Weigert M, Icha J, Myers EW, Norden C. Bidirectional neuronal migration coordinates retinal morphogenesis by preventing spatial competition. bioRxiv. 2021;[preprint] doi:10.1101/2021.02.08.430189.

Pancreatic progenitor epigenome maps prioritize type 2 diabetes risk genes with roles in development

Authors:
Geusz RJ, Wang A, Chiou J, Lancman JJ, Wetton N, Kefalopoulou S, Wang J, Qiu Y, Yan J, Aylward A, Ren B, Dong PDC, Gaulton KJ, Sander M
Citation:
eLife. 2021;10:e59067 doi:10.7554/eLife.59067
Epub:
Not Epub
Abstract:
Genetic variants associated with type 2 diabetes (T2D) risk affect gene regulation in metabolically relevant tissues, such as...
Link:
https://elifesciences.org/articles/59067
Delivery Method:
microinjection
Organism or Cell Type:
zebrafish
Citation Extract:
Geusz RJ, Wang A, Chiou J, Lancman JJ, Wetton N, Kefalopoulou S, Wang J, Qiu Y, Yan J, Aylward A, Ren B, Dong PDC, Gaulton KJ, Sander M. Pancreatic progenitor epigenome maps prioritize type 2 diabetes risk genes with roles in development. eLife. 2021;10:e59067 doi:10.7554/eLife.59067.

l-Isoaspartyl Methyltransferase Deficiency in Zebrafish Leads to Impaired Calcium Signaling in the Brain

Authors:
Soliman R, Cordero-Maldonado ML, Martins TG, Moein M, Conrotte JF, Warmack RA, Skupin A, Crawford AD, Clarke SG, Linster CL
Citation:
Front Genet. 2021 Jan 21;11:612343. doi: 10.3389/fgene.2020.612343. eCollection 2020
Epub:
Not Epub
Abstract:
Isomerization of l-aspartyl and l-asparaginyl residues to l-isoaspartyl residues is one type of protein damage that can occur...
Link:
https://www.frontiersin.org/articles/10.3389/fgene.2020.612343/full
Delivery Method:
microinjection
Organism or Cell Type:
zebrafish
Citation Extract:
Soliman R, Cordero-Maldonado ML, Martins TG, Moein M, Conrotte JF, Warmack RA, Skupin A, Crawford AD, Clarke SG, Linster CL. l-Isoaspartyl Methyltransferase Deficiency in Zebrafish Leads to Impaired Calcium Signaling in the Brain. Front Genet. 2021 Jan 21;11:612343. doi: 10.3389/fgene.2020.612343. eCollection 2020.

Impaired eIF5A function causes a Mendelian disorder that is partially rescued in model systems by spermidine

Authors:
Faundes V, Jennings MD, Crilly S, Legraie S, Withers SE, Cuvertino S, Davies SJ, Douglas AGL, Fry AE, Harrison V, Amiel J, Lehalle D, Newman WG, Newkirk P, Ranells J, Splitt M, Cross LA, Saunders CJ, Sullivan BR, Granadillo JL, Gordon CT, Kasher PR, Pavitt GD, Banka S
Citation:
Nat Commun. 2021 Feb 5;12(1):833. doi: 10.1038/s41467-021-21053-2
Epub:
Not Epub
Abstract:
The structure of proline prevents it from adopting an optimal position for rapid protein synthesis. Poly-proline-tract (PPT)...
Link:
https://www.nature.com/articles/s41467-021-21053-2
Delivery Method:
microinjection
Organism or Cell Type:
zebrafish
Citation Extract:
Faundes V, Jennings MD, Crilly S, Legraie S, Withers SE, Cuvertino S, Davies SJ, Douglas AGL, Fry AE, Harrison V, Amiel J, Lehalle D, Newman WG, Newkirk P, Ranells J, Splitt M, Cross LA, Saunders CJ, Sullivan BR, Granadillo JL, Gordon CT, Kasher PR, Pavitt GD, Banka S. Impaired eIF5A function causes a Mendelian disorder that is partially rescued in model systems by spermidine. Nat Commun. 2021 Feb 5;12(1):833. doi: 10.1038/s41467-021-21053-2.

Vasohibin-1 selectively regulates secondary sprouting and lymphangiogenesis in the zebrafish trunk

Authors:
Bastos de Oliveira M, Meier K, Jung S, Bartels-Klein E, Coxam B, Geudens I, Szymborska A, Skoczylas R, Fechner I, Koltowska K, Gerhardt H
Citation:
Development. 2021 Feb 5:dev.194993. doi: 10.1242/dev.194993. Online ahead of print
Epub:
Not Epub
Abstract:
Previous studies have shown that Vasohibin-1 (Vash1) is stimulated by VEGFs in endothelial cells and that its overexpression...
Link:
https://dev.biologists.org/content/early/2021/02/04/dev.194993
Delivery Method:
microinjection
Organism or Cell Type:
zebrafish
Citation Extract:
Bastos de Oliveira M, Meier K, Jung S, Bartels-Klein E, Coxam B, Geudens I, Szymborska A, Skoczylas R, Fechner I, Koltowska K, Gerhardt H. Vasohibin-1 selectively regulates secondary sprouting and lymphangiogenesis in the zebrafish trunk. Development. 2021 Feb 5:dev.194993. doi: 10.1242/dev.194993. Online ahead of print.

SNRNP200 Mutations Cause Autosomal Dominant Retinitis Pigmentosa

Authors:
Zhang T, Bai J, Zhang X, Zheng X, Lu N, Liang Z, Lin L, Chen Y
Citation:
Front Med (Lausanne). 2021 Jan 21;7:588991. doi: 10.3389/fmed.2020.588991
Epub:
Not Epub
Abstract:
The small nuclear ribonucleoprotein 200 kDa (SNRNP200) gene plays a key role in the maturation of pre-message RNA (pre-mRNA)...
Link:
https://www.frontiersin.org/articles/10.3389/fmed.2020.588991/full
Delivery Method:
microinjection
Organism or Cell Type:
zebrafish
Citation Extract:
Zhang T, Bai J, Zhang X, Zheng X, Lu N, Liang Z, Lin L, Chen Y. SNRNP200 Mutations Cause Autosomal Dominant Retinitis Pigmentosa. Front Med (Lausanne). 2021 Jan 21;7:588991. doi: 10.3389/fmed.2020.588991.

Quantitative intravital imaging reveals in vivo dynamics of physiological-stress induced mitophagy

Authors:
Wrighton PJ, Shwartz A, Heo J-M, Quenzer ED, LaBella KA, Harper JW, Goessling W
Citation:
J Cell Sci. 2021;[Epub ahead of print] doi:10.1242/jcs.256255
Epub:
Yes
Abstract:
Mitophagy, the selective recycling of mitochondria through autophagy, is a crucial metabolic process induced by cellular stress...
Link:
https://jcs.biologists.org/content/early/2021/02/01/jcs.256255
Delivery Method:
microinjection
Organism or Cell Type:
zebrafish
Citation Extract:
Wrighton PJ, Shwartz A, Heo J-M, Quenzer ED, LaBella KA, Harper JW, Goessling W. Quantitative intravital imaging reveals in vivo dynamics of physiological-stress induced mitophagy. J Cell Sci. 2021;[Epub ahead of print] doi:10.1242/jcs.256255.

A zebrafish model of granulin deficiency reveals essential roles in myeloid cell differentiation

Authors:
Campbell CA, Fursova O, Cheng X, Snella E, McCune A, Li L, Solchenberger B, Schmid B, Sahoo D, Morton M, Traver D, Palazon RE
Citation:
Blood Adv. 2021;5(3):796-811. doi:10.1182/bloodadvances.2020003096
Epub:
Not Epub
Abstract:
Granulin is a pleiotropic protein involved in inflammation, wound healing, neurodegenerative disease, and tumorigenesis. These...
Link:
https://ashpublications.org/bloodadvances/article/5/3/796/475091/A-zebrafish-model-of-granulin-deficiency-reveals
Delivery Method:
microinjection
Organism or Cell Type:
zebrafish
Citation Extract:
Campbell CA, Fursova O, Cheng X, Snella E, McCune A, Li L, Solchenberger B, Schmid B, Sahoo D, Morton M, Traver D, Palazon RE. A zebrafish model of granulin deficiency reveals essential roles in myeloid cell differentiation. Blood Adv. 2021;5(3):796-811. doi:10.1182/bloodadvances.2020003096.

Spen deficiency interferes with Connexin 43 expression and leads to heart failure in zebrafish

Authors:
Rattka M, Westphal S, Gahr BM, Just S, Rottbauer W
Citation:
J Mol Cell Cardiol. 2021;[Epub ahead of print] doi:10.1016/j.yjmcc.2021.01.006
Epub:
Yes
Abstract:
Genome-wide association studies identified Spen as a putative modifier of cardiac function, however, the precise function of...
Link:
https://www.jmcc-online.com/article/S0022-2828(21)00022-5/fulltext
Delivery Method:
microinjection
Organism or Cell Type:
zebrafish
Citation Extract:
Rattka M, Westphal S, Gahr BM, Just S, Rottbauer W. Spen deficiency interferes with Connexin 43 expression and leads to heart failure in zebrafish. J Mol Cell Cardiol. 2021;[Epub ahead of print] doi:10.1016/j.yjmcc.2021.01.006.

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