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Morpholino Publication Database

This database contains citations and abstracts for research using Morpholino oligos, as well as some review articles incorporating Morpholino data. You can search the content using the filter boxes below.

There are 12378 scientific papers returned from the database with the search filters currently being used below.

Investigating the role of dachshund b in the development of the pancreatic islet in zebrafish

Authors:
Yang L, Webb SE, Jin N, Lee HM, Chan TF, Xu G, Chan JCN, Miller AL, Ma RCW
Citation:
J Diabetes Investig. 2021 Jan 15. doi: 10.1111/jdi.13503. Online ahead of print
Epub:
Yes
Abstract:
Aims/introduction: β-cell dysfunction is a hallmark of type 2 diabetes. In a previous pilot study, we identified an association...
Delivery Method:
microinjection
Organism or Cell Type:
zebrafish
Citation Extract:
Yang L, Webb SE, Jin N, Lee HM, Chan TF, Xu G, Chan JCN, Miller AL, Ma RCW. Investigating the role of dachshund b in the development of the pancreatic islet in zebrafish. J Diabetes Investig. 2021 Jan 15. doi: 10.1111/jdi.13503. Online ahead of print.

Single-cell analysis of non-human primate preimplantation development in comparison to humans and mice

Authors:
Hu Y, Huang K, Zeng Q, Feng Y, Ke Q, An Q, Qin LJ, Cui Y, Guo Y, Zhao D, Peng Y, Tian D, Xia K, Chen Y, Ni B, Wang J, Zhu X, Wei L, Liu Y, Xiang P, Liu JY, Xue Z, Fan G
Citation:
Dev Dyn. 2021 Jan 15. doi: 10.1002/dvdy.295. Online ahead of print
Epub:
Yes
Abstract:
Genetic programs underlying preimplantation development and early lineage segregation are highly conserved across mammals. It...
Organism or Cell Type:
cynomolgus monkey embryo
Citation Extract:
Hu Y, Huang K, Zeng Q, Feng Y, Ke Q, An Q, Qin LJ, Cui Y, Guo Y, Zhao D, Peng Y, Tian D, Xia K, Chen Y, Ni B, Wang J, Zhu X, Wei L, Liu Y, Xiang P, Liu JY, Xue Z, Fan G. Single-cell analysis of non-human primate preimplantation development in comparison to humans and mice. Dev Dyn. 2021 Jan 15. doi: 10.1002/dvdy.295. Online ahead of print.

Synthesis of triazole-linked morpholino oligonucleotides via CuI catalysed cycloaddition

Authors:
Palframan MJ, Alharthy RD, Powalowska PK, Hayes CJ
Citation:
Org Biomol Chem. 2016;14(11):3112-3119. doi:10.1039/C6OB00007J
Epub:
Not Epub
Abstract:
Triazole-linked morpholino (TLMO) oligonucleic acids were synthesised using the CuI catalysed (3 + 2) azide–alkyne...
Citation Extract:
Palframan MJ, Alharthy RD, Powalowska PK, Hayes CJ. Synthesis of triazole-linked morpholino oligonucleotides via CuI catalysed cycloaddition. Org Biomol Chem. 2016;14(11):3112-3119. doi:10.1039/C6OB00007J.

Cell Proliferation and Collective Cell Migration During Zebrafish Lateral Line System Development Are Regulated by Ncam/Fgf-Receptor Interactions

Authors:
Dries R, Lange A, Heiny S, Berghaus KI., Bastmeyer M, Bentrop J
Citation:
Front Cell Devel Biol. 2021;8:1579. doi:10.3389/fcell.2020.591011
Epub:
Not Epub
Abstract:
The posterior lateral line system (pLLS) of aquatic animals comprises small clustered mechanosensory organs along the side of...
Delivery Method:
microinjection
Organism or Cell Type:
zebrafish
Citation Extract:
Dries R, Lange A, Heiny S, Berghaus KI., Bastmeyer M, Bentrop J. Cell Proliferation and Collective Cell Migration During Zebrafish Lateral Line System Development Are Regulated by Ncam/Fgf-Receptor Interactions. Front Cell Devel Biol. 2021;8:1579. doi:10.3389/fcell.2020.591011 .

Development of antisense-mediated myostatin knockdown for the treatment of insulin resistance

Authors:
Eilers W, Cleasby M, Foster K
Citation:
Sci Rep. 2021;11:1604. doi:10.1038/s41598-021-81222-7
Epub:
Not Epub
Abstract:
Myostatin is a negative regulator of muscle mass and its inhibition represents a promising strategy for the treatment of muscle...
Delivery Method:
intramuscular i.m. or intravenous i.v. injection
Organism or Cell Type:
mice C57/Bl6
Citation Extract:
Eilers W, Cleasby M, Foster K. Development of antisense-mediated myostatin knockdown for the treatment of insulin resistance. Sci Rep. 2021;11:1604. doi:10.1038/s41598-021-81222-7.

Stimulation of hepatocarcinogenesis by activated cholangiocytes via Il17a/f1 pathway in kras transgenic zebrafish model

Authors:
Helal M, Yan C, Gong Z
Citation:
Sci Rep. 2021;11:1372. doi:10.1038/s41598-020-80621-6
Epub:
Not Epub
Abstract:
It has been well known that tumor progression is dependent on secreted factors not only from tumor cells but also from other...
Delivery Method:
microinjection
Organism or Cell Type:
zebrafish
Citation Extract:
Helal M, Yan C, Gong Z. Stimulation of hepatocarcinogenesis by activated cholangiocytes via Il17a/f1 pathway in kras transgenic zebrafish model. Sci Rep. 2021;11:1372. doi:10.1038/s41598-020-80621-6.

Peptide-Conjugated Phosphorodiamidate Morpholino Oligomers Retain Activity against Multidrug-Resistant Pseudomonas aeruginosa In Vitro and In Vivo

Authors:
Moustafa DA, Wu AW, Zamora D, Daly SM, Sturge CR, Pybus C, Geller BL, Goldberg JB, Greenberg DE
Citation:
mBio. 2021;12(1):e02411-20. doi:10.1128/mBio.02411-20
Epub:
Not Epub
Abstract:
Most antimicrobials currently in the clinical pipeline are modifications of existing classes of antibiotics and are considered...
Delivery Method:
peptide-linked
Organism or Cell Type:
Pseudomonas aeruginosa as biofilm or murine pneumonial infection
Citation Extract:
Moustafa DA, Wu AW, Zamora D, Daly SM, Sturge CR, Pybus C, Geller BL, Goldberg JB, Greenberg DE. Peptide-Conjugated Phosphorodiamidate Morpholino Oligomers Retain Activity against Multidrug-Resistant Pseudomonas aeruginosa In Vitro and In Vivo. mBio. 2021;12(1):e02411-20. doi:10.1128/mBio.02411-20.

Sulf2a controls Shh-dependent neural fate specification in the developing spinal cord

Authors:
Danesin C, Darche-Gabinaud R, Escalas N, Bouguetoch V, Cochard P, Al Oustah A, Ohayon D, Glise B, Soula C
Citation:
Sci Rep. 2021;11:118 doi:10.1038/s41598-020-80455-2
Epub:
Not Epub
Abstract:
Sulf2a belongs to the Sulf family of extracellular sulfatases which selectively remove 6-O-sulfate groups from heparan sulfates...
Delivery Method:
microinjection
Organism or Cell Type:
zebrafish
Citation Extract:
Danesin C, Darche-Gabinaud R, Escalas N, Bouguetoch V, Cochard P, Al Oustah A, Ohayon D, Glise B, Soula C. Sulf2a controls Shh-dependent neural fate specification in the developing spinal cord. Sci Rep. 2021;11:118 doi:10.1038/s41598-020-80455-2.

The tight junction protein Claudin-5 limits endothelial cell motility

Authors:
Yang Z, Wu S, Fontana F, Li Y, Xiao W, Gao Z, Krudewig A, Affolter M, Belting H-G, Abdelilah-Seyfried S, Zhang J
Citation:
J Cell Sci. 2021;134:jcs248237 doi:10.1242/jcs.248237
Epub:
Not Epub
Abstract:
Steinberg's differential adhesion hypothesis suggests that adhesive mechanisms are important for sorting of cells and...
Delivery Method:
microinjection
Organism or Cell Type:
zebrafish
Citation Extract:
Yang Z, Wu S, Fontana F, Li Y, Xiao W, Gao Z, Krudewig A, Affolter M, Belting H-G, Abdelilah-Seyfried S, Zhang J. The tight junction protein Claudin-5 limits endothelial cell motility. J Cell Sci. 2021;134:jcs248237 doi:10.1242/jcs.248237.

Use of a carbonic anhydrase Ca17a knockout to investigate mechanisms of ion uptake in zebrafish (Danio rerio)

Authors:
Zimmer AM, Mandic M, Yew HM, Kunert E, Pan YK, Ha J, Kwong RWM, Gilmour KM, Perry SF
Citation:
Am J Physiol Regul Integr Comp Physiol. 2021;320(1):R55-R68. doi:10.1152/ajpregu.00215.2020
Epub:
Not Epub
Abstract:
In fishes, branchial cytosolic carbonic anhydrase (CA) plays an important role in ion and acid-base regulation. The Ca17a...
Delivery Method:
microinjection
Organism or Cell Type:
zebrafish
Citation Extract:
Zimmer AM, Mandic M, Yew HM, Kunert E, Pan YK, Ha J, Kwong RWM, Gilmour KM, Perry SF. Use of a carbonic anhydrase Ca17a knockout to investigate mechanisms of ion uptake in zebrafish (Danio rerio). Am J Physiol Regul Integr Comp Physiol. 2021;320(1):R55-R68. doi:10.1152/ajpregu.00215.2020.

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