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Morpholino Publication Database

This database contains citations and abstracts for research using Morpholino oligos, as well as some review articles incorporating Morpholino data. You can search the content using the filter boxes below.

There are 12390 scientific papers returned from the database with the search filters currently being used below.

The Autoimmune Susceptibility Gene C5orf30 Regulates Macrophage-Mediated Resolution of Inflammation

Authors:
Dorris ER, Tazzyman SJ, Moylett J, Ramamoorthi N, Hackney J, Townsend M, Muthana M, Lewis MJ, Pitzalis C, Wilson AG
Citation:
J Immunol. 2019 Jan 18. pii: ji1801155. doi: 10.4049/jimmunol.1801155. [Epub ahead of print]
Epub:
Yes
Abstract:
Genetic variants in C5orf30 have been associated with development of the autoimmune conditions primary biliary cirrhosis and...
Link:
http://www.jimmunol.org/content/early/2019/01/17/jimmunol.1801155
Delivery Method:
microinjection
Organism or Cell Type:
zebrafish
Citation Extract:
Dorris ER, Tazzyman SJ, Moylett J, Ramamoorthi N, Hackney J, Townsend M, Muthana M, Lewis MJ, Pitzalis C, Wilson AG. The Autoimmune Susceptibility Gene C5orf30 Regulates Macrophage-Mediated Resolution of Inflammation. J Immunol. 2019 Jan 18. pii: ji1801155. doi: 10.4049/jimmunol.1801155. [Epub ahead of print].

N-Myc promotes therapeutic resistance development of neuroendocrine prostate cancer by differentially regulating miR-421/ATM pathway

Authors:
Yin Y, Xu L, Chang Y, Zeng T, Chen X, Wang A, Groth J, Foo WC, Liang C, Hu H, Huang J
Citation:
Mol Cancer. 2019 Jan 18;18(1):11. doi: 10.1186/s12943-019-0941-2
Epub:
Not Epub
Abstract:
BACKGROUND: MYCN amplification or N-Myc overexpression is found in approximately 40% NEPC and up to 20% CRPC patients. N-Myc...
Link:
https://molecular-cancer.biomedcentral.com/articles/10.1186/s12943-019-0941-2
Delivery Method:
Vivo-Morpholino
Organism or Cell Type:
cell culture: LNCaP
Citation Extract:
Yin Y, Xu L, Chang Y, Zeng T, Chen X, Wang A, Groth J, Foo WC, Liang C, Hu H, Huang J. N-Myc promotes therapeutic resistance development of neuroendocrine prostate cancer by differentially regulating miR-421/ATM pathway. Mol Cancer. 2019 Jan 18;18(1):11. doi: 10.1186/s12943-019-0941-2.

Krüppel-like factor gene function in the ctenophore Mnemiopsis suggests an ancient role in promoting cell proliferation in metazoan stem cell niches

Authors:
Presnell JS, Browne WE
Citation:
bioRxiv. 2018;[Preprint] doi:10.1101/527002
Epub:
Not Epub
Abstract:
All animals possess pluripotent stem cells that during an organism's lifespan give rise to differentiated cell types and...
Link:
https://www.biorxiv.org/content/early/2019/01/21/527002
Delivery Method:
microinjection
Organism or Cell Type:
Mnemiopsis leidyi (ctenophore)
Citation Extract:
Presnell JS, Browne WE. Krüppel-like factor gene function in the ctenophore Mnemiopsis suggests an ancient role in promoting cell proliferation in metazoan stem cell niches. bioRxiv. 2018;[Preprint] doi:10.1101/527002 .

Paternal genome rescues mouse preimplantation embryo development in the absence of maternally-recruited EZH2 activity

Authors:
Wang H, Paulson EE, Ma L, Ross PJ, Schultz RM
Citation:
Epigenetics. 2019 Jan 19. doi: 10.1080/15592294.2019.1570771. [Epub ahead of print]
Epub:
Yes
Abstract:
Enhancer of zeste homolog 2 (EZH2), a component of the PRC2 complex, trimethylates H3K27, a transcriptionally repressive...
Link:
https://www.tandfonline.com/doi/abs/10.1080/15592294.2019.1570771
Organism or Cell Type:
mouse eggs & diploidized parthenotes
Citation Extract:
Wang H, Paulson EE, Ma L, Ross PJ, Schultz RM. Paternal genome rescues mouse preimplantation embryo development in the absence of maternally-recruited EZH2 activity. Epigenetics. 2019 Jan 19. doi: 10.1080/15592294.2019.1570771. [Epub ahead of print].

A dual function of FGF signaling in Xenopus left-right axis formation

Authors:
Schneider I, Kreis J, Schweickert A, Blum M, Vick P
Citation:
bioRxiv. 2018;[Preprint] doi:10.1101/469791
Epub:
Not Epub
Abstract:
Organ left-right (LR) asymmetry is a conserved vertebrate feature, which is regulated by left-sided activation of Nodal...
Link:
https://www.biorxiv.org/content/early/2018/11/13/469791
Delivery Method:
microinjection
Organism or Cell Type:
Xenopus laevis
Citation Extract:
Schneider I, Kreis J, Schweickert A, Blum M, Vick P. A dual function of FGF signaling in Xenopus left-right axis formation. bioRxiv. 2018;[Preprint] doi:10.1101/469791.

De Novo SOX4 Variants Cause a Neurodevelopmental Disease Associated with Mild Dysmorphism

Authors:
Zawerton A, Yao B, Yeager JP, Pippucci T, Haseeb A, Smith JD, Wischmann L, Kühl SJ, Dean JCS, Pilz DT, Holder SE, Deciphering Developmental Disorders Study, University of Washington Center for Mendelian Genomics, McNeill A, Graziano C, Lefebvre V
Citation:
Am J Hum Genet. 2019;[Epub ahead of print] doi:10.1016/j.ajhg.2018.12.014
Epub:
Yes
Abstract:
SOX4, together with SOX11 and SOX12, forms group C of SRY-related (SOX) transcription factors. They play key roles, often in...
Link:
https://www.cell.com/ajhg/pdfExtended/S0002-9297(18)30467-1
Delivery Method:
microinjection
Organism or Cell Type:
Xenopus
Citation Extract:
Zawerton A, Yao B, Yeager JP, Pippucci T, Haseeb A, Smith JD, Wischmann L, Kühl SJ, Dean JCS, Pilz DT, Holder SE, Deciphering Developmental Disorders Study, University of Washington Center for Mendelian Genomics, McNeill A, Graziano C, Lefebvre V. De Novo SOX4 Variants Cause a Neurodevelopmental Disease Associated with Mild Dysmorphism. Am J Hum Genet. 2019;[Epub ahead of print] doi:10.1016/j.ajhg.2018.12.014.

TETs Regulate Proepicardial Cell Migration through Extracellular Matrix Organization during Zebrafish Cardiogenesis

Authors:
Lan Y, Pan H, Li C, Banks KM, Sam J, Ding B, Elemento O, Goll MG, Evans T
Citation:
Cell Rep. 2019;26:720-32. doi:10.1016/j.celrep.2018.12.076
Epub:
Not Epub
Abstract:
Ten-eleven translocation (Tet) enzymes (Tet1/2/3) mediate 5-methylcytosine (5mC) hydroxylation, which can facilitate DNA...
Link:
https://www.cell.com/cell-reports/fulltext/S2211-1247(18)32021-7
Delivery Method:
microinjection
Organism or Cell Type:
zebrafish
Citation Extract:
Lan Y, Pan H, Li C, Banks KM, Sam J, Ding B, Elemento O, Goll MG, Evans T. TETs Regulate Proepicardial Cell Migration through Extracellular Matrix Organization during Zebrafish Cardiogenesis. Cell Rep. 2019;26:720-32. doi:10.1016/j.celrep.2018.12.076.

A new transgenic reporter line reveals Wnt-dependent Snail2 re-expression and cranial neural crest differentiation in Xenopus

Authors:
Li J, Perfetto M, Materna C, Li R, Tran HT, Vleminckx K, Duncan MK, Wei S
Citation:
bioRxiv. 2019;[Preprint] doi:10.1101/520726
Epub:
Not Epub
Abstract:
During vertebrate embryogenesis, the cranial neural crest (CNC) forms at the neural plate border and subsequently migrates and...
Link:
https://www.biorxiv.org/content/early/2019/01/15/520726
Delivery Method:
microinjection
Organism or Cell Type:
Xenopus tropicalis
Citation Extract:
Li J, Perfetto M, Materna C, Li R, Tran HT, Vleminckx K, Duncan MK, Wei S. A new transgenic reporter line reveals Wnt-dependent Snail2 re-expression and cranial neural crest differentiation in Xenopus. bioRxiv. 2019;[Preprint] doi:10.1101/520726 .

Peri-arterial specification of vascular mural cells from naïve mesenchyme requires Notch signaling

Authors:
Ando K, Wang W, Peng D, Ayano Chiba, Lagendijk A, Barske L, Crump JG, Stainier DYR, Lendahl U, Koltowska K, Hogan BM, Fukuhara S, Mochizuki N, Betsholtz C
Citation:
Development. 2019;[Epub ahead of print] doi:10.1242/dev.165589
Epub:
Yes
Abstract:
Mural cells (MCs) are essential for blood vessel stability and function; however, the mechanisms regulating MC development...
Link:
http://dev.biologists.org/content/early/2019/01/09/dev.165589
Organism or Cell Type:
zebrafish
Citation Extract:
Ando K, Wang W, Peng D, Ayano Chiba, Lagendijk A, Barske L, Crump JG, Stainier DYR, Lendahl U, Koltowska K, Hogan BM, Fukuhara S, Mochizuki N, Betsholtz C. Peri-arterial specification of vascular mural cells from naïve mesenchyme requires Notch signaling. Development. 2019;[Epub ahead of print] doi:10.1242/dev.165589.

Drug-free macromolecular therapeutics induce apoptosis in cells isolated from patients with B cell malignancies with enhanced apoptosis induction by pretreatment with gemcitabine

Authors:
Wang J, Li L, Yang J, Clair PM, Glenn MJ, Stephens DM, Christopher Radford D, Kosak KM, Deininger MW, Shami PJ, Kopeček J
Citation:
Nanomedicine. 2019 Jan 9. pii: S1549-9634(19)30004-8. doi: 10.1016/j.nano.2018.12.011. [Epub ahead of print]
Epub:
Yes
Abstract:
Drug-free macromolecular therapeutics (DFMT) is a new paradigm for the treatment of B cell malignancies. Apoptosis is initiated...
Link:
https://www.sciencedirect.com/science/article/pii/S1549963419300048
Organism or Cell Type:
cell culture: primary cultures from B-cell malignancies
Citation Extract:
Wang J, Li L, Yang J, Clair PM, Glenn MJ, Stephens DM, Christopher Radford D, Kosak KM, Deininger MW, Shami PJ, Kopeček J. Drug-free macromolecular therapeutics induce apoptosis in cells isolated from patients with B cell malignancies with enhanced apoptosis induction by pretreatment with gemcitabine. Nanomedicine. 2019 Jan 9. pii: S1549-9634(19)30004-8. doi: 10.1016/j.nano.2018.12.011. [Epub ahead of print].

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