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Morpholino Publication Database

This database contains citations and abstracts for research using Morpholino oligos, as well as some review articles incorporating Morpholino data. You can search the content using the filter boxes below.

There are 12387 scientific papers returned from the database with the search filters currently being used below.

Morpholino-mediated in vivo silencing of Cryptosporidium parvum lactate dehydrogenase decreases oocyst shedding and infectivity

Authors:
Zhang X, Kim CY, Worthen T, Witola WH
Citation:
Int J Parasitol. 2018 Mar 9. pii: S0020-7519(18)30056-0. doi: 10.1016/j.ijpara.2018.01.005. [Epub ahead of print]
Epub:
Yes
Abstract:
Cryptosporidium is a highly prevalent protozoan parasite that is the second leading cause of childhood morbidity and mortality...
Link:
https://www.sciencedirect.com/science/article/pii/S0020751918300560
Delivery Method:
Vivo-Morpholino
Organism or Cell Type:
Cryptosporidium parvum
Citation Extract:
Zhang X, Kim CY, Worthen T, Witola WH. Morpholino-mediated in vivo silencing of Cryptosporidium parvum lactate dehydrogenase decreases oocyst shedding and infectivity. Int J Parasitol. 2018 Mar 9. pii: S0020-7519(18)30056-0. doi: 10.1016/j.ijpara.2018.01.005. [Epub ahead of print].

A Dominant Negative Antisense Approach Targeting β-Catenin

Authors:
Vonbrüll M, Riegel E, Halter C, Aigner M, Bock H, Werner B, Lindhorst T, Czerny T
Citation:
Mol Biotechnol. 2018 Mar 9. doi: 10.1007/s12033-018-0058-7. [Epub ahead of print]
Epub:
Yes
Abstract:
There have been many attempts to unveil the therapeutic potential of antisense molecules during the last decade. Due to its...
Link:
https://link.springer.com/article/10.1007%2Fs12033-018-0058-7
Delivery Method:
cell scraping, electroporation
Organism or Cell Type:
cell culture: SW480, HeLa pSplice3βcat Ex13 SD
Citation Extract:
Vonbrüll M, Riegel E, Halter C, Aigner M, Bock H, Werner B, Lindhorst T, Czerny T. A Dominant Negative Antisense Approach Targeting β-Catenin. Mol Biotechnol. 2018 Mar 9. doi: 10.1007/s12033-018-0058-7. [Epub ahead of print].

C9orf72 is essential for neurodevelopment and motility mediated by cyclin G1

Authors:
Yeh TH, Liu HF, Li YW, Lu CS, Shih HY, Chiu CC, Lin SJ, Huang YC, Cheng YC
Citation:
Exp Neurol. 2018 Mar 6. pii: S0014-4886(18)30064-5. doi: 10.1016/j.expneurol.2018.03.002. [Epub ahead of print]
Epub:
Yes
Abstract:
Hexanucleotide repeat expansions in the C9orf72 gene are a common genetic cause of familial and sporadic amyotrophic lateral...
Link:
https://www.sciencedirect.com/science/article/pii/S0014488618300645
Delivery Method:
microinjection
Organism or Cell Type:
zebrafish
Citation Extract:
Yeh TH, Liu HF, Li YW, Lu CS, Shih HY, Chiu CC, Lin SJ, Huang YC, Cheng YC. C9orf72 is essential for neurodevelopment and motility mediated by cyclin G1. Exp Neurol. 2018 Mar 6. pii: S0014-4886(18)30064-5. doi: 10.1016/j.expneurol.2018.03.002. [Epub ahead of print].

Song X, Gao X, Lu J, Liang H, Su P, Li Q, Pang Y

Authors:
High mobility group box transcription factor 1 (HBP1) from Lampetra japonica affects cell cycle regulation
Citation:
Develop Growth Differ. 2018;[Epub] doi:10.1111/dgd.12426
Epub:
Yes
Abstract:
High mobility group (HMG) box-containing protein 1 (HBP1) is a member of the HMG family of chromosomal proteins. Previous...
Link:
http://onlinelibrary.wiley.com/doi/10.1111/dgd.12426/abstract
Organism or Cell Type:
cell culture: Lampetra japonica cells
Citation Extract:
High mobility group box transcription factor 1 (HBP1) from Lampetra japonica affects cell cycle regulation. Song X, Gao X, Lu J, Liang H, Su P, Li Q, Pang Y. Develop Growth Differ. 2018;[Epub] doi:10.1111/dgd.12426.

Morphogenetic defects underlie Superior Coloboma, a newly identified closure disorder of the dorsal eye

Authors:
Hocking JC, Famulski JK, Yoon KH, Widen SA, Bernstein CS, Koch S, Weiss O, FORGE Canada Consortium, Agarwala S, Inbal A, Lehmann OJ, Waskiewicz AJ
Citation:
PLoS Genet. 2018;14(3):e1007246. doi:10.1371/journal.pgen.1007246
Epub:
Not Epub
Abstract:
The eye primordium arises as a lateral outgrowth of the forebrain, with a transient fissure on the inferior side of the optic...
Link:
http://journals.plos.org/plosgenetics/article?id=10.1371%2Fjournal.pgen.1007246
Delivery Method:
microinjection
Organism or Cell Type:
zebrafish
Citation Extract:
Hocking JC, Famulski JK, Yoon KH, Widen SA, Bernstein CS, Koch S, Weiss O, FORGE Canada Consortium, Agarwala S, Inbal A, Lehmann OJ, Waskiewicz AJ. Morphogenetic defects underlie Superior Coloboma, a newly identified closure disorder of the dorsal eye. PLoS Genet. 2018;14(3):e1007246. doi:10.1371/journal.pgen.1007246.

GATA4 as a novel regulator involved in the development of the neural crest and craniofacial skeleton via Barx1

Authors:
Guo S, Zhang Y, Zhou T, Wang D, Weng Y, Chen Q, Ma J, Li Y-P, Wang L
Citation:
Cell Death Differ. 2018;[Epub] doi:10.1038/s41418-018-0083-x
Epub:
Yes
Abstract:
The role of GATA-binding protein 4 (GATA4) in neural crest cells (NCCs) is poorly defined. Here we showed that mouse NCCs...
Link:
https://www.nature.com/articles/s41418-018-0083-x
Delivery Method:
microinjection
Organism or Cell Type:
zebrafish
Citation Extract:
Guo S, Zhang Y, Zhou T, Wang D, Weng Y, Chen Q, Ma J, Li Y-P, Wang L. GATA4 as a novel regulator involved in the development of the neural crest and craniofacial skeleton via Barx1. Cell Death Differ. 2018;[Epub] doi:10.1038/s41418-018-0083-x.

Axon-Axon Interactions Regulate Topographic Optic Tract Sorting via CYFIP2-Dependent WAVE Complex Function

Authors:
Cioni J-M, Wong HH-W, Bressan D, Kodama L, Harris WA, Holt CE
Citation:
Neuron. 2018;97(5)1078-93.e6. doi:10.1016/j.neuron.2018.01.027
Epub:
Not Epub
Abstract:
The axons of retinal ganglion cells (RGCs) are topographically sorted before they arrive at the optic tectum. This pre-target...
Link:
http://www.cell.com/neuron/abstract/S0896-6273(18)30052-7
Delivery Method:
microinjection
Organism or Cell Type:
Xenopus
Citation Extract:
Cioni J-M, Wong HH-W, Bressan D, Kodama L, Harris WA, Holt CE. Axon-Axon Interactions Regulate Topographic Optic Tract Sorting via CYFIP2-Dependent WAVE Complex Function. Neuron. 2018;97(5)1078-93.e6. doi:10.1016/j.neuron.2018.01.027.

Loss of cardiac Wnt/β-catenin signalling in Desmoplakin-deficient AC8 zebrafish models is rescuable by genetic and pharmacological intervention

Authors:
Giuliodori A, Beffagna G, Marchetto G, Fornetto C, Vanzi F, Toppo S, Facchinello N, Santimaria M, Vettori A, Rizzo S, Barbera MD, Pilichou K, Argenton F, Thiene G, Tiso N, Basso C
Citation:
Cardiovasc Res. 2018;[Epub] doi.org/10.1093/cvr/cvy057
Epub:
Yes
Abstract:
Aims: Arrhythmogenic cardiomyopathy (AC) is an inherited heart disease characterized by life-threatening ventricular...
Link:
https://academic.oup.com/cardiovascres/advance-article-abstract/doi/10.1093/cvr/cvy057/4924336
Organism or Cell Type:
zebrafish
Citation Extract:
Giuliodori A, Beffagna G, Marchetto G, Fornetto C, Vanzi F, Toppo S, Facchinello N, Santimaria M, Vettori A, Rizzo S, Barbera MD, Pilichou K, Argenton F, Thiene G, Tiso N, Basso C. Loss of cardiac Wnt/β-catenin signalling in Desmoplakin-deficient AC8 zebrafish models is rescuable by genetic and pharmacological intervention. Cardiovasc Res. 2018;[Epub] doi.org/10.1093/cvr/cvy057.

Identification of a rare BMP pathway mutation in a non-syndromic human brain arteriovenous malformation via exome sequencing

Authors:
Walcott BP, Winkler EA, Zhou S, Birk H, Guo D, Koch MJ, Stapleton CJ, Spiegelman D, Dionne-Laporte A, Dion PA, Kahle KT, Rouleau GA, Lawton MT
Citation:
Hum Genome Var. 2018;5:18001. doi:10.1038/hgv.2018.1
Epub:
Not Epub
Abstract:
Brain arteriovenous malformations (AVMs) are abnormal connections between arteries and veins that can result in hemorrhagic...
Link:
https://www.nature.com/articles/hgv20181
Delivery Method:
microinjection
Organism or Cell Type:
zebrafish
Citation Extract:
Walcott BP, Winkler EA, Zhou S, Birk H, Guo D, Koch MJ, Stapleton CJ, Spiegelman D, Dionne-Laporte A, Dion PA, Kahle KT, Rouleau GA, Lawton MT. Identification of a rare BMP pathway mutation in a non-syndromic human brain arteriovenous malformation via exome sequencing. Hum Genome Var. 2018;5:18001. doi:10.1038/hgv.2018.1.

The ADAMTS5 Metzincin Regulates Zebrafish Somite Differentiation

Authors:
Dancevic CM, Gibert Y, Berger J, Smith AD, Liongue C, Stupka N, Ward AC, McCulloch DR
Citation:
Int J Mol Sci. 2018;19(3):766. doi:10.3390/ijms19030766
Epub:
Yes
Abstract:
The ADAMTS5 metzincin, a secreted zinc-dependent metalloproteinase, modulates the extracellular matrix (ECM) during limb...
Link:
http://www.mdpi.com/1422-0067/19/3/766
Delivery Method:
microinjection
Organism or Cell Type:
zebrafish
Citation Extract:
Dancevic CM, Gibert Y, Berger J, Smith AD, Liongue C, Stupka N, Ward AC, McCulloch DR. The ADAMTS5 Metzincin Regulates Zebrafish Somite Differentiation. Int J Mol Sci. 2018;19(3):766. doi:10.3390/ijms19030766.

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